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    • Waking and the Reticular Activating System in Health and Disease

      • 1st Edition
      • April 27, 2015
      • Edgar Garcia-Rill
      • English
      • Hardback
        9 7 8 0 1 2 8 0 1 3 8 5 4
      • eBook
        9 7 8 0 1 2 8 0 1 6 3 2 9
      Waking and the Reticular Activating System in Health and Disease provides a comprehensive overview on the “activating” properties of the RAS. In health, the RAS provides the basis against which we assess the external world, and in disease it distorts that world and shatters our self-image. This book describes the physiology of each process, how it is disturbed in each disorder, and what the most appropriate treatment should be. Dr. Garcia-Rill, along with contributions from leading specialists, discusses the understanding of the RAS as a system not only modulating waking, but also in charge of survival mechanisms such as fight vs flight responses and reflexes. The full spectrum of these functions helps explain the complexity of symptoms evident in such disorders as disparate as schizophrenia and Parkinson’s disease. The book reviews the mechanisms that control waking and arousal, and especially how those mechanisms malfunction in certain neurological and psychiatric disorders.

    • Design of High-Speed Railway Turnouts

      • 1st Edition
      • April 27, 2015
      • Ping Wang
      • English
      • Hardback
        9 7 8 0 3 2 3 3 9 6 1 7 2
      • eBook
        9 7 8 0 1 2 8 0 3 8 8 4 0
      High-speed turnouts, a key technology for high-speed railways, have a great influence on the safe and stable running of high-speed trains. Design of High-Speed Railway Turnouts: Theory and Applications, comprehensively introduces the technical characteristics and requirements of high-speed turnouts, including design theories and methods of turnout layout geometry, wheel and rail relations, track stiffness, welded turnout, turnout conversion, turnout components, and manufacture and laying technologies of turnouts. Analyzing the operational problems of China’s high-speed turnout in particular, this book discusses the control of structure irregularity, state irregularity, geometrical irregularity and dynamic irregularity during the design, manufacture, laying, and maintenance of turnouts. At the end of this reference book, the author provides high-speed turnouts management methods, maintenance standards, testing and monitoring technology, and maintenance technology.Design of High-Speed Railway Turnouts: Theory and Applications will enable railway technicians all over the world to develop an in-depth knowledge of the design, manufacture, laying, and maintenance technology of high-speed turnouts.

    • Advances in Clinical Chemistry

      • 1st Edition
      • Volume 69
      • April 24, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 2 6 5 8
      • eBook
        9 7 8 0 1 2 8 0 2 4 6 4 5
      Volume 69 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

    • Basic Principles of Drug Discovery and Development

      • 1st Edition
      • April 24, 2015
      • Benjamin E. Blass
      • English
      • Paperback
        9 7 8 0 1 2 4 1 1 5 0 8 8
      • eBook
        9 7 8 0 1 2 4 1 1 5 2 5 5
      Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property."

    • Advances in Applied Microbiology

      • 1st Edition
      • Volume 91
      • April 24, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 2 5 0 4
      • eBook
        9 7 8 0 1 2 8 0 2 5 1 6 1
      A compilation of up to date reviews of topics in biotechnology and the medical field.

    • The Science and Ethics of Antipsychotic Use in Children

      • 1st Edition
      • April 24, 2015
      • Nina Di Pietro + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 0 0 1 6 8
      • eBook
        9 7 8 0 1 2 8 0 0 4 8 1 4
      The Science and Ethics of Antipsychotic Use in Children reviews the latest findings for the safety and efficacy of the rapidly rising incidence of antipsychotic use in children and examines tensions that are created by off-label use, both in clinical psychiatric practice and research.In the past ten years, the number of antipsychotics prescribed to children with psychiatric disorders has skyrocketed. Despite this rapid growth, most medications have been inadequately studied in children for safety or efficacy and many have serious adverse health. Measures are needed to ensure that the health and safety of children are being protected, and debates have emerged over whether or not clinical trials in this population should be conducted.

    • Essentials of Medical Biochemistry

      • 2nd Edition
      • April 24, 2015
      • Chung Eun Ha + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 4 1 6 6 8 7 5
      • eBook
        9 7 8 0 1 2 4 1 6 6 9 7 4
      Essentials of Medical Biochemistry, Second Edition: With Clinical Cases is the most condensed, yet detailed biochemistry overview available on the topic. It presents contemporary coverage of the fundamentals of biochemistry, emphasizing relevant physiologic and pathophysiologic biochemical concepts. Pivotal clinical case studies aid in understanding basic science in the context of diagnosis and treatment of human diseases, and the text illuminates key topics in molecular immunology and hemostasis. Users will find basic and fundamental concepts that will aid students and professionals in biochemistry, medicine, and other healthcare disciplines. the text is a useful refresher that will help users meet USMLE and other professional licensing examination requirements, providing thorough introductions, key points, multicolored illustrations of chemical structures and figures, fact-filled tables, and recommended reading lists.

    • The Economics of Screening and Risk Sharing in Higher Education

      • 1st Edition
      • April 21, 2015
      • Bernhard Eckwert + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 0 3 1 9 0 2
      • eBook
        9 7 8 0 1 2 8 0 3 1 9 1 9
      The Economics of Screening and Risk Sharing in Higher Education explores advances in information technologies and in statistical and social sciences that have significantly improved the reliability of techniques for screening large populations. These advances are important for higher education worldwide because they affect many of the mechanisms commonly used for rationing the available supply of educational services. Using a single framework to study several independent questions, the authors provide a comprehensive theory in an empirically-driven field. Their answers to questions about funding structures for investments in higher education, students’ attitudes towards risk, and the availability of arrangements for sharing individual talent risks are important for understanding the theoretical underpinnings of information and uncertainty on human capital formation.

    • Advances in Agronomy

      • 1st Edition
      • Volume 131
      • April 20, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 1 3 6 1
      • eBook
        9 7 8 0 1 2 8 0 2 3 4 5 7
      Advances in Agronomy continues to be recognized as a leading reference and a first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. Five volumes are published yearly which ensures that authors’ contributions are disseminated to the readership in a timely manner. As always, the subjects covered are varied and exemplary of the myriad of subject matter dealt with by this long-running serial.

    • The Protective Arm of the Renin Angiotensin System (RAS)

      • 1st Edition
      • April 18, 2015
      • Thomas Unger + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 0 1 3 6 4 9
      • eBook
        9 7 8 0 1 2 8 0 1 4 8 5 1
      The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications.

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