Advances in Clinical Chemistry

1st Edition - April 24, 2015

Editor: Gregory S. Makowski

Hardback ISBN:

9 7 8 - 0 - 1 2 - 8 0 2 2 6 5 - 8

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 0 2 4 6 4 - 5

Volume 69 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research… Read more

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Volume 69 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Preface
Chapter One: D-dimer: An Overview of Hemostasis and Fibrinolysis, Assays, and Clinical Applications
- Abstract
- 1 Introduction
- 2 Overview of Hemostasis
- 3 Mechanisms of Fibrinolysis
- 4 Clinical Detection of the Products of Fibrinolysis
- 5 Clinical Applications of D-dimer
- 6 Conclusions
Chapter Two: Circulating Biomarkers in Malignant Melanoma
- Abstract
- 1 Some Clinical and Epidemiological Aspects of Melanoma
- 2 Tumor Biology
- 3 Circulating Tumor Cells as Biomarkers
- 4 Circulating Nucleic Acids as Biomarkers
- 5 Proteins as Tumor Markers
- 6 Tumor Markers in Guidelines
- 7 Concluding Remarks
- Acknowledgments
Chapter Three: Cancer Therapy and Replication Stress: Forks on the Road to Perdition
- Abstract
- 1 Introduction
- 2 Eukaryotic DNA Replication
- 3 DNA-Damaging Agents and Replication Fork Progression
- 4 The Fates of the Perturbed Forks
- 5 How Does Replication Inhibition Cause Cell Death?
- 6 How Is the Replication Stress Response Altered in Cancer?
- 7 Conclusions
- Acknowledgments
Chapter Four: Soluble ST2 in Ventricular Dysfunction
- Abstract
- 1 Introduction
- 2 Biological Background and Function of ST2
- 3 sST2 in Experimental Observations
- 4 ST2 in Clinical Studies
- 5 Future Perspectives
- 6 Conclusion
Chapter Five: Biofluid Proteases Profiling in Diabetes Mellitus
- Abstract
- 1 Introduction
- 2 Proteases in the Pathogenesis of DM and its Related Complications
- 3 Biofluid Proteases as Biomarkers in Diabetes Mellitus
- 4 Methods for Screening Proteases and Their Inhibitors in Biofluids
- 5 Therapeutic Targeting of Proteases in DM
- 6 Future Directions
- Acknowledgments
Chapter Six: Biomarker Characterization by MALDI–TOF/MS
- Abstract
- 1 Introduction
- 2 Mass Spectrometry for Clinical Diagnosis
- 3 Applications of MALDI–TOF/MS in Clinical Diagnosis
- 4 Methods for Improving Detection Efficiency of Disease Biomarkers by MALDI–TOF/MS
- 5 Conclusions
- Acknowledgments
Chapter Seven: Antibody Arrays in Biomarker Discovery
- Abstract
- 1 The Origin of Biomarkers
- 2 Antibody Array Platforms and Utility
- 3 Antibody Arrays in Drug Target Discovery
- 4 Antibody Arrays in Therapeutic Biomarker Discovery
- 5 Cytokine Antibody Arrays in Asthma Biomarker Discovery
- 6 Cytokine Antibody Arrays in Neurological & Neurodegenerative Disease Biomarker Discovery
- 7 Antibody Arrays in Immune-Mediated Diseases
- 8 Antibody Array in Cancer Discovery
- 9 Kidney Diseases
- 10 Other Diseases Where Antibody Arrays Have Contributed to Biomarker Identification
- 11 Other Array Technologies
- 12 Summary
- Acknowledgments
Index