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Elsevier

Academic Press

  • Mitochondrial Intoxication

    • 2nd Edition
    • Marcos Roberto de Oliveira
    • English
    Mitochondrial Intoxication, Second Edition, offers a comprehensive and fully updated exploration of the impact of toxic molecules on mitochondrial physiology and the diseases that result from their dysfunction. Divided into three sections, the book opens with a detailed overview of mitochondrial physiology, molecular markers of mitochondrial intoxication, and challenges of mitochondrial profiling during pre-clinical studies. The book then focuses on endogenous toxicants and their impact on mitochondria, including new chapters on lipids, glucose and microbiota-derived toxicants. Amyloid-β peptide and its impact on mitochondrial dysfunction is also a new addition to this book, as well as inflammation-induced mitochondrial intoxication.The final section explores exogenous toxicants, such as pollutants, food additives, illicit and pharmaceutical drugs, pesticides, and heavy metals. The effects of micro- and nanoplastics on mitochondrial function are newly covered. Furthermore, the latest computational tools in mitochondrial toxicity research are investigated. Incorporating the latest advances in the field, this new release offers cutting-edge insights on mitochondrial toxicity, serving as an invaluable resource for researchers and advanced students in cell biology, molecular biology, toxicology, biochemistry, pharmacology, and related fields.

  • Adverse Childhood Experiences

    Using Evidence to Advance Research, Practice, Policy, and Prevention
    • 2nd Edition
    • Gordon J. G. Asmundson + 1 more
    • English
    The second edition of “Adverse Childhood Experiences: Using Evidence to Advance Research, Practice, Policy, and Prevention” delves deeper into the foundational ACEs Study, providing a thorough review alongside comprehensive definitions and assessment methodologies. From mental and physical health outcomes to the neurodevelopmental mechanisms linking ACEs to psychopathology, sexual violence, and sexual health outcomes, this edition presents a nuanced understanding of the complex interplay between adverse experiences and lifelong consequences. Newly incorporated content addresses contemporary issues, redefining ACEs, exploring the appropriateness of routine screening, and contemplating ACEs from a global perspective. Professionals working with children and families, including physicians, nurses, social workers, psychologists, lawyers, judges, public health leaders, policy makers, and government delegates, will find this evidence-based resource invaluable. "Adverse Childhood Experiences" not only equips practitioners with the latest research findings but also presents strategies for preventing ACEs, fostering trauma-informed care, resilience, and emphasizing the crucial role of safe, stable, and nurturing environments for children. This second edition cements its status as an indispensable guide, addressing the evolving landscape of ACEs with precision and relevance.

  • Progress in Motor Control

    Crossroads between Neurophysiology and Applications
    • 1st Edition
    • Mark L. Latash + 4 more
    • English
    "Progress in Motor Control: Crossroads between Neurophysiology and Applications" offers an in-depth look at the evolving field of motor control, synthesizing the latest research. This volume explores the complex roles of the central nervous system in movement, featuring contributions from leading experts who use approaches ranging from basic physical principles to advanced control theory. It addresses applied aspects of motor control, focusing on recovery strategies for functional movements in patients with spinal cord injuries, subcortical disorders, and strokes. Organized into five sections, the book covers theoretical advances, neurophysiological mechanisms, motor learning, neural plasticity, and motor disorders, including topics like neural population dynamics and vestibulospinal reflexes. The final sections highlight strategies for improving recovery after neurological events. This resource bridges foundational research and clinical application, making it invaluable for researchers, clinicians, and students in motor control, neuroscience and rehabilitation.Divid... into five comprehensive parts, the book covers theoretical advances, neurophysiological mechanisms, motor learning, neural plasticity, and motor disorders, including essential topics like neural population dynamics and the dual role of vestibulospinal reflexes. Final sections highlight practical strategies for improving recovery outcomes following neurological events.

  • Insights for Researchers and Clinicians to Navigating Kidney Stone Surgery

    A Comparative Narrative of Percutaneous Nephrolithotomy and Retrograde Intrarenal Surgery for Kidney Stones
    • 1st Edition
    • Oktay Ozman + 1 more
    • English
    Insights for Researchers and Clinicians to Navigating Kidney Stone Surgery: A Comparative Narrative of Percutaneous Nephrolithotomy and Retrograde Intrarenal Surgery for Kidney Stones is the ultimate resource for healthcare professionals seeking to excel in the field of kidney stone surgery. The book provides a comparative history of RIRS and PCNL, exploring their evolution from early attempts at endoscopic stone removal to the development of flexible ureteroscopy and technique refinement. It covers instrumentation, including access sheaths, ureteroscopes, energy sources, and fluoroscopy. Patient selection criteria, anesthesia techniques, and intraoperative monitoring are thoroughly examined.The book offers detailed guidance on kidney access, including transureteral and percutaneous approaches, and discusses fragmentation and stone retrieval methods, comparing their efficacy and outcomes. Complications, management strategies, postoperative care, and long-term outcomes assessment are extensively discussed, ensuring a comprehensive understanding of patient care. With its comprehensive coverage and contributions from renowned experts, the book equips healthcare professionals with the knowledge and skills needed to excel in the rapidly evolving field of minimally invasive kidney stone management.

  • Medicinal Plant Biotechnology for Ameliorated Secondary Metabolite Production

    • 1st Edition
    • Saikat Gantait + 3 more
    • English
    Medicinal Plant Biotechnology for Ameliorated Secondary Metabolite Production delivers a cutting-edge perspective on how biotechnology is reshaping the way medicinal plants are studied and utilized. By integrating advanced molecular techniques, precision genetic tools, bioprocessing strategies, and analytical platforms, this volume addresses the critical challenge of enhancing the biosynthesis and optimization of high-value bioactive compounds.The book moves beyond technical innovation to emphasize its role in meeting global demand for plant-derived therapeutics while ensuring ecological balance. It highlights how advancements can drive sustainability, reduce reliance on synthetic alternatives, and open new pathways to ensure the long-term viability of plant genetic material and biodiversity preservation. This future-oriented approach makes the volume not just a specialized reference, but a strategic guide for shaping the next generation of plant-based functional solutions.Part of the Medicinal and Industrial Plants and Products series, this state-of-the-art resource boasts a holistic approach with relevance across stakeholders in academic and industrial contexts seeking practical insights that can be adapted to diverse plant species and scaled for real-world industrial and commercial uses.

  • Intelligent Gene Editing in Plants

    The Convergence of AI and CRISPR
    • 1st Edition
    • Aftab Ahmad + 3 more
    • English
    Intelligent Gene Editing in Plants analyzes how AI-enabled design and CRISPR-based genome engineering are reshaping plant genetics, with a clear functional focus on delivering durable gains in crop productivity, stress tolerance, and nutritional quality.The work unfolds in three parts: [i] a foundational survey of genome-editing technologies and the evolving role of AI in precise trait modifications and outcome prediction; [ii] a thorough exploration of applications and synergies, including AI-assisted gRNA optimization, off-target mitigation, regulatory-network analysis, and trait enhancement for disease resistance and climate resilience; and [iii] an emerging-horizons section on cis-regulatory edits, omics integration, synthetic biology, and next-generation editing.Throughout, the volume interweaves practical experiences, cutting-edge methodologies, and case studies, alongside discussions of biosafety, ethical concerns, governance, and public perception, providing a holistic, decision-ready resource for students, researchers, practitioners, and regulatory authorities to navigate the opportunities and responsibilities of plant gene editing, with significant implications for sustainable agriculture and global food security.

  • Microglial Advances in Neurodegenerative Diseases

    • 1st Edition
    • Volume 171
    • English
    Microglial Advances in Neurodegenerative Diseases, Volume 170 in the Advances in Immunology series, presents current developments and comprehensive reviews focused on the role of microglia and neuroinflammation in neurological and psychiatric disorders. This volume brings together contributions from leading researchers, offering up-to-date insights into microglial biology in health and disease, as well as their involvement in major neurodegenerative conditions. Chapters in this new release explore Cross-talk between Tau and Neuro-glia Axis of Alzheimer’s Disease, Microglia in Health and Disease, Amyloid-beta (Aβ) and Neuroinflammation in Microglia, Chemokine Receptor CX3CR1 Interacts with Tau and Regulates Microglial Activity in Alzheimer’s Disease, and much more.Additional chapters explore Human-Induced Pluripotent Stem Cells in Psychiatric Disorders, GPCR-Mediated Internalization and Endosomal Sorting of the Tau–GPCR Complex in Microglia, iPSC-Derived Microglia: A Cellular Platform for Tau and Alzheimer’s Disease Immunotherapy, Advancements in Invasive and Non-Invasive Neuromodulation for Parkinson’s Disease, LRRK2-I1371V Disrupts Microglial Membrane Homeostasis and Enhances α-Synuclein Toxicity, Microglial Advances in Parkinson’s Disease, Microglial Advances in Alzheimer’s Disease, and more.

  • Up and Running with AutoCAD 2027

    2D and 3D Drawing, Design and Modeling
    • 1st Edition
    • Robert C. Kaebisch + 1 more
    • English
    Up and Running with AutoCAD® 2027: 2D and 3D Drawing, Design and Modeling presents a combination of step-by-step instructions, examples, and insightful explanations. The book emphasizes core concepts and practical application of AutoCAD in engineering, architecture, and design. To improve student learning, the book's early chapters have been revised and expanded with additional assignments, more explicit step-by-step guidance for the earliest assignments, improved readability, and a new concise drafting fundamentals reference section that focuses on orthographic projection, basic standards, and naming conventions.Equally useful in instructor-led classroom training, self-study, or as a professional reference, the book is written by a long-time AutoCAD professor and instructor with the user in mind

  • Handbook of the Psychology of Aging

    • 10th Edition
    • Denis Gerstorf + 1 more
    • English
    Handbook of the Psychology of Aging, Tenth Edition offers insights into emerging areas of research and practice in the field of aging. In addition to its comprehensive coverage of traditional topics such as cognitive aging and social dynamics, this edition highlights key contemporary issues. New to this edition are chapters dedicated to the understanding of emotion and stress regulation in older adults, the intricate relationship between technology and aging, the evolving landscape of work and retirement, and alternative age markers beyond chronological age. As with previous editions, this handbook remains committed to bridging the gap between theory and practice, offering evidence-based strategies.With its multidisciplinary perspective and practical insights, it continues to serve as an indispensable resource for researchers, practitioners, and students across various disciplines, from psychology and gerontology to public health and social work.

  • Pharmacological Foundations of Parkinson’s Disease

    From Mechanisms to Clinical Practice
    • 1st Edition
    • Wael Mohamed
    • English
    Pharmacological Foundations of Parkinson's Disease: From Mechanisms to Clinical Practice provides a comprehensive guide on the pharmacological treatment of Parkinson's Disease, offering students and clinicians a combination of foundational knowledge and advanced clinical insights. The book bridges theoretical concepts with real-world clinical scenarios and equips readers with the tools necessary to effectively manage Parkinson's Disease in practice. Offering a detailed review of symptoms, treatment gaps, and emerging therapies, this book delves into the pathogenesis the disease, along with dopaminergic treatments and management of motor and non-motor symptoms.Providing updates on emerging therapies, including innovative treatment approaches, this book serves as a valuable reference for continuous learning and staying current with evolving practices and research in Parkinson's Disease management.

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