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Elsevier

Academic Press

  • Targeting Intercellular Communication with Nanomedicine and Advanced Therapeutics

    • 1st Edition
    • Lara Scheherazade Milane + 1 more
    • English
    Targeting Intercellular Communication with Nanomedicine and Advanced Therapeutics delves into the complex world of intercellular communication biology and its implications on therapeutics. This book covers all areas of intercellular communication and therapeutics in development for different forms of communication, including their role in diseases such as cancer, neurological disorders, metabolic diseases, and inflammatory/immune diseases. Sections provide an introduction, biological targets, challenges, and approaches to overcoming biological barriers and the significance of contact points and mechanisms of internalization. Specifics of tunneling nanotubes, extracellular vesicles, and the immune and non-immune interface in various diseases are covered.Furthermore, the book explores the crosstalk of different forms of intercellular communication and the implications of mitochondrial exchange in the four primary pathological areas. This is an essential resource for researchers, students, and professionals in the field of drug development and delivery. By connecting the dots between extracellular vesicles, tunneling nanotubes, and cell-cell junctions, this book serves as a foundation for further advancements in the science of intercellular communication and it's applications to new drug discovery and delivery.

  • New Insights in Pediatric Holter Monitoring and Interpretation

    • 1st Edition
    • Gabriel Cismaru + 2 more
    • English
    New Insights in Pediatric Holter Monitoring and Interpretation is the cutting edge book required by pediatric cardiologists and other professionals who encounter arrhythmias in children. Holter ECG examination has recently undergone significant advances in technology, sensors, and software. Yet, these innovations have been considered primarily in the context of adult patients. On the contrary, New Insights in Pediatric Holter Monitoring and Interpretation uses a case-based methodology to illustrate diagnosis and management of actual pediatric patients. Further, it offers guidance in deciding when referrals are necessary for arrhythmological consultations or ablation interventions. This book also contains novel techniques for detecting and interpreting pediatric arrhythmias. These include the introduction of Poincare graphs, Lorenz plots, and other advanced methods for assessing heart rate variability. New Insights in Pediatric Holter Monitoring and Interpretation modernizes readers' understanding of arrhythmias in children, thus improving the young lives of those in their care.

  • Membrane Transporters and Drug Delivery

    A Comprehensive and Multidisciplinary Guide
    • 1st Edition
    • Elena Puris + 3 more
    • English
    Membrane Transporters and Drug Delivery: A comprehensive and multidisciplinary guide begins with a comprehensive introduction to membrane transporters, their function, structure, and regulation mechanisms. It then moves into the impact of diseases on transporters and how this may affect pharmacokinetics. The book also presents the latest advancements in transporter-mediated drug delivery. A unique feature of this book is its detailed exploration of the methodologies used in transporter research, providing readers with a comprehensive understanding of the strengths and limitations of each approach. It examines the roles of both efflux and influx transporters in drug pharmacokinetics and covers different strategies for utilizing membrane transporters for drug delivery and targeting to specific tissues and cell types. The book concludes with a discussion on regulatory and industrial aspects of transporter-related projects and explores the potential of artificial intelligence in transporter and drug delivery research.Membrane Transporters and Drug Delivery: A comprehensive and multidisciplinary guide begins with a comprehensive introduction to membrane transporters, their function, structure, and regulation mechanisms. It then moves into the impact of diseases on transporters and how this may affect pharmacokinetics. The book also presents the latest advancements in transporter-mediated drug delivery. A unique feature of this book is its detailed exploration of the methodologies used in transporter research, providing readers with a comprehensive understanding of the strengths and limitations of each approach. It examines the roles of both efflux and influx transporters in drug pharmacokinetics and covers different strategies for utilizing membrane transporters for drug delivery and targeting to specific tissues and cell types. The book concludes with a discussion on regulatory and industrial aspects of transporter-related projects and explores the potential of artificial intelligence in transporter and drug delivery research.

  • Patient Treatment and Management Following an Osteoporotic Vertebral Compression Fracture

    • 1st Edition
    • Douglas P. Beall
    • English
    Worldwide, vertebral compression fractures (VCFs) continue to be the most common major fragility fracture, affecting patients over the age of 50, and osteoporosis is the most prevalent condition associated with VCFs. Patient Treatment and Management Following an Osteoporotic Vertebral Compression Fracture provides treatment and management guidance of the osteoporosis disease process in patients who have had a VCF. This book opens with a foundation of osteoporosis and VCF and then reviews clinical and radiological assessment approaches, evaluation, treatment, and ongoing management options. Subsequent chapters cover the efficacy of the different vertebral augmentation types on patient outcomes, optimization methods, decisions for osteoporosis treatment in these patients, and recommendations to improve patient outcomes. Special attention is paid to the treatment sequence and objectives following an osteoporotic VCF. This book concludes with coverage of insightful developments in clinical management and current research and features targeted case studies representing common patient characteristics that showcase varying aspects of different VCFs and the underlying osteoporosis that gives rise to these fractures. This title serves as an invaluable resource for any practitioner managing fragility fractures in older patients as well as treating their underlying osteoporosis.

  • Hybrid Fluoroscopy and Ultrasound Guided Interventional Pain Procedures

    • 1st Edition
    • Manuel Herrero Trujillano + 4 more
    • English
    Hybrid Fluoroscopy and Ultrasound Guided Interventional Pain Procedures ameliorates the dearth of literature covering interventional pain procedures under both X-ray and ultrasound guidance. While existing resources focus on either modality separately, this book fills the gap by providing a consolidated approach, leveraging the strengths of both techniques. By doing so, it ensures practitioners have access to the most versatile and effective imaging methods available. This book is inherently practical, designed to serve as a go-to guide for clinicians facing real-world challenges in pain management. Its organization by body areas facilitates quick access to relevant techniques, while step-by-step guidance and visual aids ensure clarity and ease of understanding. By focusing on clinical relevance, the book empowers practitioners to implement evidence-based imaging interventions with confidence and precision. Hybrid Fluoroscopy and Ultrasound Guided Interventional Pain Procedures has the potential to make a meaningful impact on the field of pain management. By equipping practitioners with cutting-edge imaging techniques and insights, it promises to improve patient outcomes and advance the standard of care. Moreover, its global reach ensures that its benefits extend far beyond geographical boundaries, reaching pain medicine practitioners worldwide.

  • Metabolomic Phenotyping for the Future of Personalized Medicine

    Beyond the Biomarkers
    • 1st Edition
    • Jacopo Troisi + 1 more
    • English
    Metabolomic Phenotyping for the Future of Personalized Medicine: Beyond the Biomarkers takes a critical look at the advancements in the field. It begins by explaining the essential steps of metabolomics analysis—from sample collection to data interpretation—while exploring how these workflows pave the way for targeted medical applications. With a focus on precision, it shows how metabolomics provides key insights into the mechanisms behind diverse phenotypes, making it an indispensable asset for biomedical research. The second section dives into the transformative results achieved in major medical domains through metabolomics, detailing how this emerging science contributes to understanding complex disease mechanisms.The book also outlines the international regulatory framework essential for conducting research within this field, ensuring compliance and ethical standards. By combining practical guidelines with visionary insights, this text serves as a cornerstone for future strides in personalized medicine and highlights the growing influence of metabolomics in shaping tomorrow’s healthcare systems.

  • Topical Dermal Drug Delivery

    Concepts and Advances
    • 1st Edition
    • Jitender Madan + 4 more
    • English
    Topical Dermal Drug Delivery: Concepts and Advances compiles, in a single volume, the most recent advances in topical and dermal formulations for the treatment of skin disorders.The book covers three major concepts. The skin anatomy and physiology part includes chapters focused on relevant information for drug delivery. The second part of the book deals with several recent topical dermal drug delivery systems, including computational methods, permeation enhancers, bio precursors, hydrogels, emugels, exosomes and several nanotechnology enabled systems. The third and final part covers scaling up, toxicity, clinical trials, and regulatory considerations.This is a complete reference for academic and corporate pharma researchers investigating targeted drug delivery to the skin. Medical & Health Sciences researchers would also benefit from understanding the delivery systems covered in this book.

  • Empowerment Self-Defense

    Theory, Research, and Practice
    • 1st Edition
    • Lindsay M. Orchowski + 1 more
    • English
    Empowerment Self-Defense: Theory, Research, and Practice brings together scholarship on the theory, research, and practice of empowerment self-defense (ESD). ESD is an evidence-based and transformative approach to violence prevention grounded in feminism and social justice. This book assembles leading researchers and practitioners to clearly define ESD and assess its effectiveness.The contributors to this volume frame ESD as a part of a comprehensive approach to sexual assault prevention and document the worldwide implementation of ESD as a part of a larger gender justice movement. This book begins by outlining the fundamental concepts, elements, and theoretical underpinnings of ESD and situates ESD within the long history of feminist collective activism. The second section considers the role of ESD in violence prevention, including its effectiveness for survivors of trauma and its implementation around the world. The third section focuses on the research behind ESD, including an assessment of measurement tools. The fourth section focuses on applications of ESD within specific communities, including indigenous, sexual and gender minority, and disabled populations. The final section of the book addresses the future of ESD, including implementation, dissemination, and future directions for research. Together, these chapters present a compelling case for the essential role of ESD training in violence prevention efforts.

  • Plant-Induced Systemic Resistance

    Mechanisms and Applications Against Biotic and Abiotic Stressors
    • 1st Edition
    • Sengottayan Senthil-Nathan + 2 more
    • English
    Plant-Induced Systemic Resistance: Mechanisms and Applications Against Biotic and Abiotic Stressors examines how intrinsic defense signaling and state-of-the-art biotechnologies can fortify crops while reducing reliance on chemical inputs. This rigorous treatment unpacks the biochemical circuitry of induced immunity, the networks coordinating defense, and the innovative molecular biology tools that empower durable protection under a variety of stress triggers. Against the backdrop of rising pest pressures, evolving resistance patterns, and environmental concerns, it presents a forward-looking framework for integrating host defenses within comprehensive crop protection initiatives.This volume traces a clear trajectory from foundational concepts to precision management solutions, delivering data-driven methodologies, decision support tools, and scalable practices for sustainable agriculture, enriched by real-world case studies that illustrate adoption across research, extension, and industry contexts. Governance, regulatory considerations, and societal implications are woven throughout to ensure responsible innovation.Bridging lab-derived knowledge with field-ready interventions, this essential resource opens avenues for interdisciplinary collaboration to bolster plant resilience against various biotic and abiotic stressors, expanding the toolkit for integrated crop protection.

  • Next-Generation Food Preservation

    Microbial, Nano, and AI Technologies
    • 1st Edition
    • S. Rehan Ahmad + 1 more
    • English
    Next-Generation Food Preservation: Microbial, Nano, and AI Technologies is an essential resource for food scientists, microbiologists, and technologists seeking innovative solutions to extend the shelf life of food sustainably. As global food security becomes increasingly critical, traditional preservation methods often fall short in efficiency, safety, and environmental impact.This book explores how cutting-edge approaches—leveragin... beneficial microbes, green nanomaterials, and intelligent AI-driven analytics—are revolutionizing food chemistry and preservation practices. It provides a comprehensive understanding of the convergence of microbiology, nanotechnology, and artificial intelligence, offering practical insights into their application for safer, longer-lasting food products. The book is organized into five parts, covering foundational concepts, advanced modeling and optimization techniques, encapsulation and smart packaging innovations, industry case studies, and ethical and regulatory considerations. Topics include microbial synergisms, nanomaterial applications, AI-enabled fermentation control, predictive risk assessment, and sector-specific successes in nano-coatings and intelligent packaging. It also discusses societal, ethical, and legal implications, highlighting future directions for sustainable food preservation.Next-Ge... Food Preservation serves as a vital guide for researchers, industry professionals, and policymakers committed to adopting innovative, eco-friendly strategies that ensure food safety, reduce waste, and support global food security through technological advancement.

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