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    • Regenerative Nephrology

      • 2nd Edition
      • June 12, 2021
      • Michael S. Goligorsky
      • English
      • Hardback
        9 7 8 0 1 2 8 2 3 3 1 8 4
      • eBook
        9 7 8 0 1 2 8 2 3 3 1 9 1
      Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition.

    • Clinical Studies and Therapies in Parkinson's Disease

      • 1st Edition
      • June 12, 2021
      • Juan Segura-Aguilar
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 1 2 0 4
      • eBook
        9 7 8 0 1 2 8 2 2 1 5 8 7
      More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson’s disease, but these efforts have failed　when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease.Clinical Studies and Therapies in Parkinson’s Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book’s discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine.

    • Advances in Heterocyclic Chemistry

      • 1st Edition
      • Volume 135
      • June 12, 2021
      • English
      • Hardback
        9 7 8 0 1 2 8 2 4 6 1 9 1
      • eBook
        9 7 8 0 3 2 3 8 5 1 0 3 9
      Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds.

    • Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function

      • 1st Edition
      • Volume 654
      • June 12, 2021
      • English
      • Hardback
        9 7 8 0 1 2 8 2 3 9 2 4 7
      • eBook
        9 7 8 0 1 2 8 2 3 9 2 5 4
      Ion Channels, Part C, Volume 653 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Nonsense suppression in ion channels, Engineering Ion Channels Using Protein Trans-splicing, Probing Ion Channel Neighborhoods Using APEX, STX based probes for NaVs, ANAP: a versatile, fluorescent probe of ion channel gating and regulation, High Throughput Screens for Small Molecule Ion Channel Modulators, Using toxins to study ion channels, Re/de-constructing ubiquitin regulation of ion channels, Tethered Peptide Toxins for Ion Channels, Voltage-Sensing Phosphatase Molecular Engineering, and more. Additional chapters cover Engineering excitable cells, Stretch and Poke Stimulation of Mechanically-Activat... Ion Channels, Optical Control of STIM Channels, High Throughput Electrophysiological Evaluation of Mutant Ion Channels, Evaluating BEST1 Mutations in RPE Stem Cells, Long Read Transcript Profiling of Ion Channel Splice Variants, Permeation of Connexin Channels, Ratiometric pH indicator for melanosomes and lysosomes, and Ion channels in the epithelial cells of the choroid plexus.

    • Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy

      • 1st Edition
      • Volume 181
      • June 12, 2021
      • English
      • Hardback
        9 7 8 0 3 2 3 8 5 3 2 3 1
      • eBook
        9 7 8 0 3 2 3 8 5 3 2 4 8
      Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy, presents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 is a key technology for targeted genome editing and regulation in a number of organisms including mammalian cells. It is a rapid, simple, and cost-effective solution. CRISPR-Cas system has recently gained much scientific and public attention. This volume covers CRISPR-Cas9 based mammalian genome editing, creating disease models, cancer therapy, neurological, heredity, blood disorders, defective gene correction, stem cells therapy, epigenetic modifications, patents, ethics, biosafety and regulatory issues challenges and opportunities. This book is a key source of information on mammalian genome editing available in a single volume. This book will be useful for beginners in mammalian genome editing and also students, researchers, scientists, policymakers, clinicians and stakeholders interested in genome editing in several areas.

    • Triply Periodic Minimal Surface Lattices Additively Manufactured by Selective Laser Melting

      • 1st Edition
      • June 12, 2021
      • Chunze Yan + 6 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 4 4 3 8 8
      • eBook
        9 7 8 0 1 2 8 2 4 4 3 9 5
      Triply Periodic Minimal Surface Lattices by Selective Laser Melting Additive Manufacturing presents the design, manufacturing, microstructure, mechanical properties and applications of TPMS structures fabricated by selective laser additive manufacturing technology. The title explains these complex and useful structures based on systematic work in the UK and China. Sections introduce structure design methods, assess TPMS structures, explain mathematical their modeling, present the manufacturing, microstructure, mechanical and fatigue properties of metal uniform TPMS structures, discuss manufacturing and mechanical responses for functionally graded TPMS structures, give numerical analysis methods for predicting the mechanics of uniform and functionally graded TPMS structures, and more.

    • Hydrogen Sulfide in Plant Biology

      • 1st Edition
      • June 12, 2021
      • Samiksha Singh + 5 more
      • English
      • Paperback
        9 7 8 0 3 2 3 8 5 8 6 2 5
      • eBook
        9 7 8 0 3 2 3 8 5 8 6 3 2
      Hydrogen Sulfide in Plant Biology: Past and Present includes 17 chapters, with topics from cross-talk and lateral root development under stress, to post-translational modifications and disease resistance. With emerging research on the different roles and applications of H2S, this title compiles the latest advances of this key signaling molecule. The development of a plant requires complex signaling of various molecules like H2S in order to achieve regulated and proper development, hence hydrogen sulfide (H2S) has emerged as an important signaling molecule that regulates nearly each and every stage of a plant’s lifecycle. Edited by leading experts in the field, this is a must-read for scientists and researchers interested in plant physiology, biochemistry and ecology.

    • Ultrasound Guided Musculoskeletal Procedures in Sports Medicine

      • 1st Edition
      • June 12, 2021
      • Dinesh Sirisena
      • English
      • Paperback
        9 7 8 0 3 2 3 9 1 0 1 4 9
      • eBook
        9 7 8 0 3 2 3 8 9 9 9 5 6
      Ultrasound Guided Musculoskeletal Procedures in Sports Medicine: A Practical Atlas provides the support practitioners need based on practical, first-hand experience of a Sports and Exercise Medicine Physician who trained in musculoskeletal sonography. Over the years, and with much practice, the lessons learned and techniques developed are summarized with relevant pictures that guide those undertaking the procedure. As musculoskeletal ultrasound forms an important tool for physicians working in this field of medicine, this book helps physicians provide increasing expectation for patients who want a safe, guided procedure when clinically warranted. While an understanding of ultrasound imaging is essential prior to ultrasound guided procedures, there are few practical guides that provide practicing clinicians with a quick reference when faced with a procedure. This book fills that void.

    • Advances in Agronomy

      • 1st Edition
      • Volume 168
      • June 11, 2021
      • English
      • Hardback
        9 7 8 0 1 2 8 2 4 5 8 9 7
      • eBook
        9 7 8 0 3 2 3 8 5 0 7 6 6
      Advances in Agronomy, Volume 168, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

    • Roselle (Hibiscus sabdariffa)

      • 1st Edition
      • June 11, 2021
      • Abdalbasit Adam Mariod + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 1 0 0 6
      • eBook
        9 7 8 0 1 2 8 2 2 6 9 3 3
      Roselle (Hibiscus sabdariffa) Chemistry, Production, Products, and Utilization assesses the Hibiscus sabdariffa plant for food and nonfood uses, as well as for its use as fixed or essential oils. The chapters explore Hibiscus sabdariffa breeding, production, composition, storage, and quality related to the chemistry, nutrition, antioxidant activity, and traditional uses of its bioactive components. This book also includes coverage of medicinal, pharmacological, therapeutic, and cosmetic uses of Hibiscus sabdariffa. This book will be of interest to nutritionists, food scientists, chemists, ethnobotanists, pharmacists, academics, undergraduate and graduate students, and professionals working with medicinal plants.

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