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Elsevier

Academic Press

  • Microbial Biomolecules

    Emerging Approach in Agriculture, Pharmaceuticals and Environment Management
    • 1st Edition
    • Ajay Kumar + 3 more
    • English
    Microbial Biomolecules: Emerging Approach in Agriculture, Pharmaceuticals and Environment Management explores and compiles new aspects of microbial-based biomolecules such as microbial enzymes, microbial metabolites, microbial surfactants, exopolysaccharides, and bioactive compounds and their potential applications in the field of health-related issues, sustainable agriculture and environment contamination management. Written for researchers, scientists, and graduate and PhD students in the areas of Microbiology, Biotechnology, Environmental Science and Pharmacology, this book covers the urgent need to explore eco-friendly and sustainable approaches to healthcare, agriculture and environmental contamination management.

  • Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development

    • 1st Edition
    • Volume 14
    • English
    Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development provides a valuable “go-to” reference for many difficult-to-solve challenges using pertinent chromatographic theory, first-hand case studies, and examples provided from academic and industry experts. This text also enables professors teaching an analytical instrumental course to introduce and instruct students about one of the most sustainable and powerful separation methods currently available. While the text has broad applicability across industrial sectors, it focuses primarily on application in the pharmaceutical industry. The book is designed to allow readers to align current HPLC/UHPLC capabilities with SFC as an orthogonal tool for project specific methods in the pharmaceutical industry. It highlights where SFC falls on the spectrum of useful chromatographic tools for routine and challenging separative methods. Experienced HPLC users who are interested in developing knowledge in orthogonal separation techniques, as well as newcomers to the field of separation science, will find this text particularly useful. Chapters address where SFC may fit the analytical needs of the pharmaceutical industry and alert the readers as to where the technique will not fit. Readers will gain an understanding of how and where SFC may be applied and adapted more routinely across the pharmaceutical industry as a ‘green’ way of undertaking separation opportunities and challenges. Areas within the pharmaceutical industry include early drug discovery, process chemistry, and late stage development and manufacturing.

  • Perinatal and Developmental Epigenetics

    • 1st Edition
    • Volume 35
    • Garima Singh
    • English
    Perinatal and Developmental Epigenetics, Volume 32, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for drug discovery and clinical advances. Here, over 25 international researchers examine recent steps forward in our understanding of epigenetic programming during perinatal and early development. The book opens with an in-depth introduction to known and newly discovered epigenetic marks and how they regulate various cellular processes. Later sections examine various prenatal and perinatal environmental experiences and their ability to derail the normal developmental trajectory via epigenetic reprogramming. Insights and suggestions for future research illuminate approaches for identifying individual disease susceptibility. Concluding chapters highlight preventative and targeted therapeutic pathways to improve quality of life into adulthood.

  • Fundamentals of Smart Grid Systems

    • 1st Edition
    • Muhammad Kamran
    • English
    Fundamentals of Smart Grid Systems offers an expansive introduction to the operationalization, integration, and management of smart grids—the distributed, renewable, responsive, and highly efficient power grid on the verge of radically transforming our energy system. The book reviews the design of smart grid systems, their associated technologies, and operations, helping users develop a modern foundational understanding of smart grid systems and many of their advanced implementations, where sophisticated technologies are employed. The work serves as a guidebook and primer for early career researchers, with a rich integration of current science, modern applications, and future implementations.

  • MR Linac Radiotherapy

    A New Personalized Treatment Approach
    • 1st Edition
    • Volume 8
    • Sara L. Hackett + 2 more
    • English
    MR Linac Radiotherapy: A New Personalized Treatment Approach comprises both clinical and physical aspects of this new technology. The book covers treatment planning, workflow and technical issues about MR-Linac. Specially, the clinical use of MR-Linac according to different cancer types is presented by experienced physicians. This is a unique guide for medical physicists, RTTs, dosimetrists and physicians, as well as radiation oncologists and their teams. The MR Linac combines two technologies - a magnetic resonance imaging scanner and a linear accelerator - to precisely locate tumors, tailor the shape of radiation beams in real-time, and precisely deliver doses of radiation, even to moving tumors. This highly innovative technology is very new, and the number of newly installed MR-Linac machines will gradually increase worldwide. However, as there is no published book as a guideline, this book will help new MR-Linac users and centers planning to have MR-Linac.

  • Omics Approaches and Technologies in COVID-19

    • 1st Edition
    • Debmalya Barh + 1 more
    • English
    The COVID-19 pandemic has affected the entire world in an unprecedented way since 2019. However, novel and innovative applications of various omics, computational, and smart technologies have helped manage the pandemic of the 21st century in a very effective manner. Omics approaches and technologies in COVID-19 presents up-to-date knowledge on omics, genetic engineering, mathematical and computational approaches, and advanced technologies in the diagnosis, prevention, monitoring, and management of COVID-19. This book contains 26 chapters written by academic and industry experts from more than 15 countries. Split into three sections (Omics; Artificial Intelligence and Bioinformatics; and Smart and Emerging Technologies), it brings an overview of novel technologies under omics such as, genomic, metagenomic, pangenomic, metabolomics and proteomics in COVID-19. In addition, it discusses hostpathogen interactions and interactomics, management options, application of genetic engineering, mathematical modeling andsimulations, systems biology, and bioinformatics approaches in COVID-19 drug discovery and vaccine development. This is a valuable resource for students, biotechnologists, bioinformaticians, virologists, clinicians, and pharmaceutical, biomedical, and healthcare industry people who want to understand the promising omics and other technologies used in combating COVID-19 from various aspects.

  • Designing and Managing Complex Systems

    • 1st Edition
    • David Moriarty
    • English
    The systems that surround us are often multidimensional, and complex, consisting of a large collection of networked components with convoluted connections between them. Designing and managing such systems can be challenging, particularly in organizations. Designing and Managing Complex Systems introduces readers to the theory of complex systems, examining the role of human within larger systems, the factors that affect system performance, and how such systems can be optimized. The first section reviews the history of one particularly fruitful approach to complexity, one based on knowledge of the human nervous system. Next, the author discusses the current understanding of complex systems in a variety of domains including physical, biological, mechanical, and organizational. Within these chapters the author also introduces the idea that there are marked similarities in how complexity is successfully managed across these different domains and how the ideas from one domain can be useful in other domains. Next, these ideas are synthesized into a framework for successfully designing and managing complex systems. The fourth section focuses on case studies concerning failures and successes within complex systems.

  • Cardiopulmonary Bypass

    Advances in Extracorporeal Life Support
    • 1st Edition
    • Kaan Kırali + 2 more
    • English
    Cardiopulmonary Bypass: Advancements in Extracorporeal Life Support provides comprehensive coverage on the technological developments and clinical applications of extracorporeal technologies, including the underlying basic science and the latest clinical advances in the field. Written by experts around the world, this book comprises all characteristics of cardiopulmonary bypass as well as chapters regarding equipment, physiology and pathology, pediatric aspects and clinical applications. Important highlights include the latest updates regarding minimal invasive cardiopulmonary bypass (MICPB), extracorporeal circulatory and respiratory support (ECCRS) in cardiac and non-cardiac patients, ECMO support in COVID-19, and updated guidelines of extracorporeal technologies. This book is an invaluable resource to clinicians, researchers and medical students in the fields of cardiothoracic surgery, cardiac anesthesiology, intensive care, and perfusion technology.

  • Mitochondrial Intoxication

    • 1st Edition
    • Marcos Roberto de Oliveira
    • English
    Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease.

  • Numerical Methods in Turbulence Simulation

    • 1st Edition
    • Robert Moser
    • English
    Numerical Methods in Turbulence Simulation provides detailed specifications of the numerical methods needed to solve important problems in turbulence simulation. Numerical simulation of turbulent fluid flows is challenging because of the range of space and time scales that must be represented. This book provides explanations of the numerical error and stability characteristics of numerical techniques, along with treatments of the additional numerical challenges that arise in large eddy simulations. Chapters are written as tutorials by experts in the field, covering specific both contexts and applications. Three classes of turbulent flow are addressed, including incompressible, compressible and reactive, with a wide range of the best numerical practices covered. A thorough introduction to the numerical methods is provided for those without a background in turbulence, as is everything needed for a thorough understanding of the fundamental equations. The small scales that must be resolved are generally not localized around some distinct small-scale feature, but instead are distributed throughout a volume. These characteristics put particular strain on the numerical methods used to simulate turbulent flows.

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