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Scientific Advances in Reconstructive Urology and Tissue Engineering
- 1st Edition - March 31, 2022
- Editor: Matthias D. Hofer
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 1 9 9 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 5 2 0 - 5
Scientific Advances in Reconstructive Urology and Tissue Engineering is a comprehensive overview of reconstructive urology that spans male and female, pediatric, neuro-uro… Read more
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Request a sales quoteScientific Advances in Reconstructive Urology and Tissue Engineering is a comprehensive overview of reconstructive urology that spans male and female, pediatric, neuro-urology and trauma. Traditionally, this field has been focused solely on surgical principles with little attention to basic and translational research. However, recent advances in acellular matrices, scaffolds, stem cells and tissue engineering have changed this focus. This publication is the perfect bridge and definitive tome of the advances that will move the translational and basic science of reconstructive urology forward and allow readers to implement the findings in clinical practice.
Through the use of both current case studies and future implications, the content bridges the gap from bench to bedside making it the perfect reference for translational benign urology researchers who wish to move the field of reconstructive surgery forward.
- Includes real-world applications of current research to help readers get rapidly up-to-speed on which research results are appropriate for immediate implementation
- Presents the underlying mechanism of urologic disease processes pertinent to reconstructive urology for comprehensive understanding within the field
- Provides independent guidance to manage specific clinical conditions while also presenting approaches that are applicable to all conditions
Basic scientists interested in engaging in translational urology and surgery. Urologists seeking guidance on how to implement novel research. Training courses in reconstructive urology at the annual meetings of various international and national urological associations (such as AUA, EAU, SIU)
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. The cell as a tool to understand and repair urethra
- Abstract
- Introduction
- Preclinical studies
- Need for regulatory guidelines
- Clinical application
- Oral mucosa cells for tissue-engineered urethra
- Clinical studies
- Future perspectives
- References
- Chapter 2. Development of regenerative mesenchymal stem cell-seeded scaffolds for bladder augmentation
- Abstract
- Introduction
- Combining hematopoietic stem cells with mesenchymal stem cells induces angiogenesis
- Conclusion
- Acknowledgment
- References
- Chapter 3. Pathophysiology of radiation-induced urethral strictures and therapeutic strategies optimizing outcomes of surgical repair
- Abstract
- Introduction
- Prevalence
- Normal urethra
- Stricture etiology and histology
- Radiation-induced changes of urologic tissue
- Pathways of radiation-induced endothelial cell death
- Cellular and extracellular components of fibrosis
- Radiation-induced histologic changes
- Pathogenesis of radiation strictures
- Surgical pitfalls and options for treating radiation strictures
- Endoscopic management
- Reconstructive techniques—excision and primary anastomose
- Reconstructive techniques—buccal mucosa graft urethroplasty
- Conclusions
- References
- Chapter 4. Biology of buccal mucosa in urological reconstruction
- Abstract
- Body
- Oral mucosa
- Wound healing
- Transcriptional evidence of superior healing of oral tissues with minimal scar formation
- References
- Chapter 5. Discovering the role of androgens in urethral homeostasis and regeneration
- Abstract
- Introduction
- Establishing an experimental model to analyze urethral healing
- Clinical observation of androgen deprivation leading to urethral atrophy and fragility
- Analysis of the effects of low testosterone in urethral tissue samples of humans
- Determining the effects of testosterone and estrogen supplementation on urethral regeneration in an animal model
- Analysis of the effects of testosterone and estrogen supplementation in a surgical animal model
- From the bench to the bedside
- Conclusion
- References
- Chapter 6. The molecular profile of urethral stricture disease
- Abstract
- Introduction
- Mechanisms of wound healing and fibrosis
- Hormonal influences on urethral stricture disease at a cellular level
- Conclusion
- References
- Chapter 7. New frontiers in urethral reconstructive surgery
- Abstract
- Introduction
- Alternative grafts
- Injectable agents
- Drug-coated balloon catheterization
- Conclusions
- References
- Chapter 8. Pathophysiology of urethral stricture: optimizing urethroplasty outcomes
- Abstract
- Introduction
- Urethral stricture formation startup
- Ischemia and other risk factors for urethral stricture formation
- The role of growth factors and other molecular pathways on urethral stricture disease
- Extra cellualar matrix and ultrastructural changes on urethral stricture
- The role of hydrodistension on the urethral stricture development
- Patophysiology of lichen sclerosus and urethral involvement
- References
- Chapter 9. Engineered solutions for urethral stricture disease: from bench to bedside
- Abstract
- Abbreviations
- Background
- References
- Chapter 10. Novel therapeutics for male sexual pathology: cellular and tissue-based strategies targeting form and function
- Abstract
- Introduction
- Rationale for tissue engineering in sexual medicine
- Anatomic and physiologic considerations
- Engineering of corporal tissue
- Conclusions
- References
- Chapter 11. Regenerative therapy for underactive bladder
- Abstract
- Defining underactive bladder and acontractile bladder
- Causes of underactive bladder and acontractile bladder
- Neuronal dysfunction and underactive bladder/acontractile bladder
- Clinical manifestations
- Treatment options
- Current and future research models for underactive bladder and acontractile bladder
- References
- Chapter 12. Regenerative medicine relating to urethroplasty
- Abstract
- Introduction
- Cellular grafts
- Regulatory challenges
- Translational challenges
- Summary
- References
- Chapter 13. Regenerative cell-based therapies for the treatment of stress urinary incontinence
- Abstract
- Introduction
- Current management of stress urinary incontinence
- Cell-based therapy for stress urinary incontinence in women
- Background
- Human trials on autologous muscle-derived cells for urethral sphincter regeneration
- Other human case series on autologous muscle-derived cells
- Conclusions
- References
- Index
- No. of pages: 316
- Language: English
- Edition: 1
- Published: March 31, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323911993
- eBook ISBN: 9780323915205
MH
Matthias D. Hofer
Dr. Hofer is Assistant Professor of Urology at Northwestern University Feinberg School of Medicine. He graduated magna cum laude from the University of Ulm in Ulm, Germany with both an M.D and Ph.D. and went on to complete his residency training at Northwestern University Feinberg School of Medicine. He subsequently completed a fellowship at UT Southwestern in Dallas, TX specializing in reconstruction, trauma, and prosthetics. His clinical interests include the treatment of stress urinary incontinence, which often occurs following surgery for prostate cancer. He is also an expert in the treatment of benign prostatic hyperplasia (BPH). He spent time during a postdoctoral fellowship at Harvard focusing on biomarkers of prostate cancer progression and metastasis. This included experience in clinical research, both patient-based and tissue-based, all of which he continued to implement in his research endeavors. His research efforts also include benign prostatic hyperplasia, reconstruction, and urethral wound healing.
Affiliations and expertise
Urology San Antonio, San Antonio, Texas USA