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    • Metabolomics for Personalized Vaccinology

      • 1st Edition
      • July 22, 2024
      • Mahbuba Rahman
      • English
      • Paperback
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      • eBook
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      Metabolomics for Personalized Vaccinology provides insight into the importance of personalized vaccines in the clinical and research environments. It explores the development of personalized vaccines, which requires in-depth knowledge of the patient’s health status, particularly the immune system, and on metabolomics, the closest indicator of the disease phenotype. Specifically, the book provides an understanding of how metabolomics might be employed in personalized vaccinology and how the metabolic pathway of the host’s system is altered by vaccine administration.Over the past few years, researchers have published articles on personalized vaccines, but these are sparse. Therefore, compiling information on this topic gives the reader an overview of the progress of the field, despite being at its infancy.Metabolomics for Personalized Vaccinology is ideally suited for researchers and postgraduate students who are interested in clinical and nonclinical studies where metabolites are used for the identification of disease and therapeutic targets.

    • Essentials of Translational Pediatric Drug Development

      • 1st Edition
      • July 22, 2024
      • Elke Gasthuys + 3 more
      • English
      • Paperback
        9 7 8 0 3 2 3 8 8 4 5 9 4
      • eBook
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      Essentials of Translational Pediatric Drug Development: From Past Needs to Future Opportunities provides integrated and up-to-date insights relevant for both translational researchers and clinicians active in the field of pediatric drug development. The book covers all key aspects from different stakeholder perspectives, providing a literature overview and careful reflection on state-of-the-art approaches. It will be an ideal guide for researchers in the field who are designing and performing high quality, innovative pediatric-adapted drug development by helping them define needs/challenges and possible solutions that advance and harmonize pediatric drug development.Despite the broad consensus that children merit the same quality of drug treatment as any other age group, children remain frequently neglected during drug research and development. Even with the adoption of multiple legislations addressing this problem, the lack of efficacy and safety data of marketed as well as newly developed drugs still remain in the pediatric population.

    • Learning Deep Brain Stimulation Management through Clinical Cases

      • 1st Edition
      • July 20, 2024
      • Martijn Beudel
      • English
      • Paperback
        9 7 8 0 4 4 3 1 8 9 1 0 4
      • eBook
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      Learning Deep Brain Stimulation Management through Clinical Cases reviews the clinical practice of applying deep brain stimulation (DBS) to patients with movement disorders. The book explores the cardinal aspects of applying DBS in diverse movement disorders based on patient’s needs. Every case answers all questions, providing case descriptions and step-by-step procedures for optimal replication. Every chapter includes a clinical decision support system (CDSS) depicted in flowcharts that can be used for reference. Deep Brain Stimulation (DBS) uses electrical stimulation to regulate electrical signals in neural circuits to and from identified areas in the brain to improve movement symptoms.The management of DBS in a movement disorders can be challenging, optimizing patient journeys and grasping all clinical aspects of the highly technological therapy. Hence, this book provides the informaiton necessary to embrace new breakthroughs.

    • Current Status of Prostate Cancer: Diagnosis, Biomarkers and Therapies

      • 1st Edition
      • Volume 161
      • July 20, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 9 6 2 8 4
      • eBook
        9 7 8 0 4 4 3 2 9 6 2 9 1
      • eBook
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      Current Status of Prostate Cancer: Diagnosis, Biomarkers and Therapies, Volume 161 in the Advances in Cancer Research series, covers timely topics such as The Prostate Cancer Tissue N-glycome as a Source of Biomarkers, a Progression from Normal to Metastatic Disease, Multiplexed Targeted Proteomics for Prostate Cancer Biomarker Verification, MRI for the Detection of Clinically Significant Prostate Cancer: Update and Future Directions, Genetic and epigenetic factors for prostate cancer progression, Epigenetic regulation of androgen dependent and independent prostate cancer, Molecular Landscape of Prostate Cancer Bone Metastasis, Future of radioligand Therapy in PC, and more.Additional chapters of note include Advancements in Computer Vision and Pathology: Unraveling the Potential of Artificial Intelligence for Precision Diagnosis and Beyond and Extracellular Vesicles in Prostate Cancer.

    • Quality Assurance Management

      • 1st Edition
      • July 20, 2024
      • Gayathri De Lanerolle + 3 more
      • English
      • Paperback
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      • eBook
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      Quality Assurance Management: A Comprehensive Overview of Real-World Applications for High Risk Specialties demonstrates how to best design and implement standard operating procedures (SOPs) to ensure protocol and regulation adherence. The book showcases similarities and differences between healthcare and academic quality assurance systems, resulting in counter-productivity and performance issues, in addition to regulatory inspection preparedness. It uses the processes and standards of the UK to demonstrate how to combine QA and research building into ‘building blocks’ that share a common pathway for effective project design, analysis and unbiased interpretation of collated data.This book fills a gap, providing original research in QA that especially focuses on specialist areas. It will be of use to research and clinical staff working in clinical research within healthcare, academia and industry.

    • Circuits, Signals, and Systems for Bioengineers

      • 4th Edition
      • July 19, 2024
      • John Semmlow
      • English
      • Paperback
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      • eBook
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      Circuits, Signals, and Systems for Bioengineers: A MATLAB-Based Introduction, Fourth Edition, guides the reader through the electrical engineering principles that can be applied to biological systems. It details the basic engineering concepts that underlie biomedical systems, medical devices, biocontrol, and biomedical signal analysis, providing a solid foundation for students in important bioengineering concepts. Fully revised and updated to better meet the needs of instructors and students, the fourth edition expands on concepts introduced in the previous edition through computational methods that allow students to explore operations, such as correlations, convolution, the Fourier transform, and the transfer function. New medical examples and applications are included throughout the text.

    • Advances in Agronomy

      • 1st Edition
      • Volume 187
      • July 18, 2024
      • English
      • Hardback
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      • eBook
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      Advances in Agronomy, Volume 187, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors.

    • Targeted Genome Engineering via CRISPR/Cas9 in Plants

      • 1st Edition
      • July 18, 2024
      • Alvina Gul
      • English
      • Paperback
        9 7 8 0 4 4 3 2 6 6 1 4 0
      • eBook
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      Targeted Genome Engineering via CRISPR/Cas9 in Plants provides in-depth insights into the use of the emerging “CRISPR/Cas9” technology for precise genome editing. This technology has revolutionized plant science research particularly for crop improvement owing to its simplicity and efficiency. The book provides a wide range of CRISPR/Cas9 gene editing techniques for a variety of plants. Chapters include the latest applications of CRISPR/Cas9 system in connection with abiotic stresses, biotic stresses, biofortification, yield improvement, disease modelling and prognosis and molecular diagnosis. Targeted Genome Engineering via CRISPR/Cas9 in Plants also evaluates various regulatory and ethical aspects that must be considered when implementing the CRISPR/Cas9 approach. This book is a valuable resource for professionals and researchers, as it provides effective CRISPR/Cas9-based strategies for sustainable agriculture and treatment of various diseases.

    • The Discovery of New Medicines in Academia

      • 1st Edition
      • Volume 100
      • July 18, 2024
      • English
      • Hardback
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      • eBook
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      The Discovery of New Medicines in Academia, Volume 100 highlight examples of discoveries originating in academia that have been successfully translated into promising therapeutics that have advanced into clinical trials. Chapters in this release cover Design and Discovery of Itaconate prodrugs for Alopecia Areata, Hydroxyl-Dendrimer Delivery System for Neurological Disease, Development of allosteric modulators of G protein-coupled receptors for Psychiatric Disease, Targeting the constitutively active ERK1/2 signaling kinase for cancer, mRNA reprogramming of myeloid cells for tumor immunotherapy, Development of novel drugs targeting protein-protein interactions, and much more.Additional sections cover Neuro-steroids and analogs for the treatment of epilepsy, Development of inhibitors of eukaryotic translation, Discovery/developmen... of antiviral, anticancer and/or anti-inflammatory agents, Discovery of novel anti-infective agents, Targeting proliferating cell nuclear antigen (PCNA) for cancer, and Implementation and Evolution of Quantitative Systems Pharmacology to Patient Digital Twins and Biomimetic Twins.

    • Advances in Microbial Physiology

      • 1st Edition
      • Volume 85
      • July 18, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 9 5 4 2 3
      • eBook
        9 7 8 0 4 4 3 2 9 5 4 3 0
      Advances in Microbial Physiology, Volume 85 in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Topics of interest in this update include The genetic basis of predation by myxobacteria, Vancomycin susceptibility and VISA in Staphylococcus aureus, Cytochrome bd-type oxidases and environmental stressors in microbial physiology, Bacterial heme-containing sensor proteins, Algal hemoglobins, Inter-species interactions in polymicrobial infections, Utilization of Low Methane Concentrations by Methanotrophs, and Role of sulfidogenic members of the gut microbiota in human disease.

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