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Metabolomics for Personalized Vaccinology
- 1st Edition - July 22, 2024
- Author: Mahbuba Rahman
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 5 2 6 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 5 2 7 - 7
Metabolomics for Personalized Vaccinology provides insight into the importance of personalized vaccines in the clinical and research environments. It explores the developme… Read more
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Request a sales quoteMetabolomics for Personalized Vaccinology provides insight into the importance of personalized vaccines in the clinical and research environments. It explores the development of personalized vaccines, which requires in-depth knowledge of the patient’s health status, particularly the immune system, and on metabolomics, the closest indicator of the disease phenotype. Specifically, the book provides an understanding of how metabolomics might be employed in personalized vaccinology and how the metabolic pathway of the host’s system is altered by vaccine administration.
Over the past few years, researchers have published articles on personalized vaccines, but these are sparse. Therefore, compiling information on this topic gives the reader an overview of the progress of the field, despite being at its infancy.
Metabolomics for Personalized Vaccinology is ideally suited for researchers and postgraduate students who are interested in clinical and nonclinical studies where metabolites are used for the identification of disease and therapeutic targets.
- Provides the principles of metabolomics and integration of other systems biology approach for personalized vaccine development
- Discusses vaccine manufacturing technologies and importance of metabolomics for personalized vaccine development
- Discusses the scope of personalized vaccine in relation to specific diseases
- Possible scope of metabolomics in biomarker identification and vaccine discovery
Academics, Clinicians, Researchers, and Post-graduate students in clinical and non-clinical studies, clinical microbiology, and systems biology; Industry professionals in biotechnology engaged in vaccine discovery
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1 Personalized vaccinology
- Abstract
- 1 Introduction
- 2 Factors of immunological response to vaccines
- 3 Limitations of current vaccinology
- 4 Technical advances and big data impact on vaccinology
- 5 Personalized vaccinology
- 6 Important factors, salient features, and benefits of personalized vaccinology
- 7 Current status of personalized vaccinology
- 8 Benefits of personalized vaccinology
- 9 Challenges
- 10 Conclusion
- References
- Chapter 2 Formulations and mechanisms of action of novel vaccine adjuvants
- Abstract
- 1 Introduction
- 2 Licensed adjuvants
- 3 Novel adjuvants formulation patents
- 4 Novel vaccines technologies
- 5 Vaccine adjuvants and metabolomics
- 6 Vaccine adjuvants for personalized vaccine design
- 7 Conclusion
- Conflict of interest
- References
- Chapter 3 Technologies to measure vaccine immune response against infectious diseases
- Abstract
- 1 Introduction
- 2 Types of immunization
- 3 Immune responses to vaccines
- 4 Conventional technologies to detect vaccine response
- 5 Conventional high-throughput technologies to measure vaccine immune response
- 6 High-throughput technologies to detect vaccine immune response
- 7 Metabolomics of immune cells in response to vaccination
- 8 Selected example of vaccine-induced metabolites
- 9 Current challenge and future direction
- References
- Chapter 4 A new frontier in cancer therapy: The intersection of cancer vaccines and metabolomics
- Abstract
- Acknowledgments
- 1 Introduction
- 2 Cancer statistics
- 3 Cancer treatment
- 4 Cancer treatment modalities
- 5 Overview of vaccines
- 6 Importance of vaccination
- 7 Cancer vaccines
- 8 Cancer antigen targets
- 9 The tumor-immune cycle induced by cancer vaccines
- 10 Cancer vaccine platforms
- 11 Importance of adjuvants with cancer vaccines
- 12 Classification of adjuvants
- 13 Barriers to vaccine therapy: Immune resistance
- 14 Combination approaches to increase cancer vaccine effectiveness
- 15 Metabolic profiling for vaccine development
- 16 The current status of other cancer immunotherapies
- 17 Summary and future perspectives
- References
- Chapter 5 Vaccines against autoimmune diseases
- Abstract
- 1 Introduction
- 2 Rheumatoid arthritis
- 3 Systemic lupus erythematosus
- 4 Psoriasis
- 5 Multiple sclerosis
- 6 Myasthenia gravis
- 7 Type 1 diabetes
- 8 Critical discussion
- References
- Chapter 6 Vaccines for allergy
- Abstract
- 1 Introduction
- 2 Involvement of the immune system in allergic diseases
- 3 Genetic and epigenetic factors associated with allergic disease
- 4 Therapeutic approaches for allergic diseases
- 5 Routes of administration of immunotherapy
- 6 Immune tolerance to allergens
- 7 Metabolomics of immune cells during allergy inflammation
- 8 Metabolomics for identification of biomarkers in allergic diseases
- 9 Examples of studies where metabolomics might reveal prognostic biomarkers related to AIT treatment
- 10 Conclusion
- References
- Chapter 7 Virus vaccine production using cell-based technology
- Abstract
- 1 Introduction
- 2 Vaccine manufacture based on cell culture
- 3 Process optimization and production of virus in bioreactor
- 4 Bioprocess scale up
- 5 Large-scale cultures of different types of viruses
- 6 Conclusion
- References
- Chapter 8 Dendritic cell-based cancer vaccine production
- Abstract
- 1 Introduction
- 2 Overview of DCs in the immune system
- 3 DCs in the tumor microenvironment
- 4 Vaccination for therapeutic purposes employing DCs
- 5 Challenges
- 6 Conclusion
- References
- Index
- No. of pages: 500
- Language: English
- Edition: 1
- Published: July 22, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443155260
- eBook ISBN: 9780443155277
MR
Mahbuba Rahman
Dr. Mahbuba Rahman earned her B.Sc. (Honors), M.Sc in Microbiology and an M.S. in Environmental Science. She completed her PhD in Metabolic Engineering from the Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Japan. Post Ph.D., she worked with a transgenic mice model of Smith–Lemli–Opitz syndrome, which is an inborn error of cholesterol synthesis, at Children’s Hospital Research Institute (CHORI), Oakland, California. Mahbuba has published several research articles including clinical and non-clinical research in high-impact factor journals. She also authored multiple review articles and book chapters in high-impact journals and with well-known publishers. She is also an editor of an eBook on cancer immunotherapy and an editor of a hard copy book on Metabolomics A Path Towards Personalized Medicine. She is also a special topic editor and guest editor in Frontiers in Genetics, Frontiers in Immunology, and in Journal of Microbiological Methods. At present, she is an Adjunct Assistant Professor at the Department of Biology, at McMaster University. She is investigating the role of global regulators in pathogenic and non-pathogenic microorganisms using systems biology approaches.
Affiliations and expertise
McMaster University, Hamilton, Ontario, CanadaRead Metabolomics for Personalized Vaccinology on ScienceDirect