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Elsevier

Books in Pharmacology

Elsevier's Pharmacology collection studies how drugs interact with biological systems to improve health and treat disease. It covers pharmacodynamics, exploring drug effects on biology, and pharmacokinetics, studying how the body affects drugs. Branches like Pharmacogenetics. Essential for pharmacologists, this collection offers invaluable insights into drug interactions, efficacy, and safety, crucial for advancing drug development and improving patient outcomes.

  • Side Effects of Drugs Annual

    • 1st Edition
    • Volume 19
    • English
    The very latest information on adverse drug effects from the international literature, compiled by an international team of experts.New reports are presented of adverse drug effects, critically analysed in context, in terms of clinical relevance and importance, and cross-referring to previous reports where necessary. New adverse effects are reported and evaluated, and previously reported adverse effects are re-evaluated in the light of the most recent information.Unique features:Reviews in which selected adverse effects are discussed in depth.Two separate indexes enhance the use of the book, allowing the reader to access information by drug name or by, adverse effects.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 39
    • English
    Since 1959, International Review of Neurobiology has been a well known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes.

  • Drugs and Human Lactation

    A Comprehensive Guide to the Content and Consequences of Drugs, Micronutrients, Radiopharmaceuticals and Environmental and Occupational Chemicals in Human Milk
    • 2nd Edition
    • A. Astrup-Jensen + 12 more
    • P.N. Bennett
    • English
    Now in its second edition, Drugs and Human Lactation is a comprehensive guide to the content and consequences of xenobiotics and micronutrients in human milk, and remains by far the most thorough and extensive work available on this subject. The excellent methodology used for the compilation of the 1st edition has been retained.It begins with an outline of the processes by which substances enter milk during its formation, the effects of drugs on the milk production process, the main determinants of drug excretion into milk and their disposition in the child. There follows an analysis of current data on 234 individual drugs, describing the extent of their passage into human milk, and assessing the risk to the suckling infant. Vitamins and essential trace elements, and radiopharmaceuticals are similarly reviewed. Also included is an account of the factors that influence the passage of environmental and occupational chemicals into milk. The result is a complete overview of what is known and proven, with clear pointers to matters which require further study, and brings the various subject areas up to date. Risks, uncertainties and false alarms which exist have been defined in such a way that they can be avoided.Once again, Drugs and Human Lactation provides a comprehensive guide to the content and consequences of substances in milk. The volume will provide a rational basis for making therapeutic decisions in women who seek to breast-feed.Reproduc... Immunology on the first edition: ...a superbly written compendium of reliable information and sensible conclusions and recommendations.

  • In Vitro Methods in Pharmaceutical Research

    • 1st Edition
    • Jose V. Castell + 1 more
    • English
    In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 37
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Intracellular Signal Transduction

    • 1st Edition
    • Volume 36
    • English
    Signal transduction is one of the most rapidly expanding fields in biomedical research. Written by renowned experts, Intracellular Signal Transduction provides up-to-date reviews on the role of protein phosphorylation cascades, and the structure, regulation, and function of protein kinases and phosphatases. This volume was compiled in honor of Dr. Edwin Krebs' pioneering work in the field of signal transduction which earned him a Nobel Prize. It providesinformation in a variety of areas relating to the biochemistry, cell biology, and pharmacology of the signal transduction process in eukaryotic cells.

  • Phosphodiesterase Inhibitors

    • 1st Edition
    • English
    Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting.

  • Neural Networks in QSAR and Drug Design

    • 1st Edition
    • James Devillers
    • English
    Comprehensive and impeccably edited, Neural Networks in QSAR and Drug Design is the first book to present an all-inclusive coverage of the topic. The book provides a practice-oriented introduction to the different neural network paradigms, allowing the reader to easily understand and reproduce the results demonstrated. Numerous examples are detailed, demonstrating a variety of applications to QSAR and drug design.The contributors include some of the most distinguished names in the field, and the book provides an exhaustive bibliography, guiding readers to all the literature related to a particular type of application or neural network paradigm. The extensive index acts as a guide to the book, and makes retrieving information from chapters an easy task. A further research aid is a list of software with indications of availablility and price, as well as the editors scale rating the ease of use and interest/price ratio of each software package. The presentation of new, powerful tools for modeling molecular properties and the inclusion of many important neural network paradigms, coupled with extensive reference aids, makes Neural Networks in QSAR and Drug Design an essential reference source for those on the frontiers of this field.

  • Advances in DNA Sequence-Specific Agents

    • 1st Edition
    • Volume 2
    • J.B. Chaires
    • English
    DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molec... interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of Advances in DNA Sequence Specific Agents. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA.This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.

  • Advances in Drug Research

    • 1st Edition
    • Volume 28
    • English
    This volume continues the trend for Advances in Drug Research of shorter, but more frequent volumes. In line with the tradition of the series, chapters on general themes are interspersed with chapters on specific drug classes and targets.

  • Primer on the Autonomic Nervous System

    • 1st Edition
    • Phillip A. Low
    • English
    Primer on the Autonomic Nervous System presents, in a readable and accessible format, key information about how the autonomic nervous system controls bodily function and dysfunction.In cooperation with the American Autonomic Society, this primer represents the largest collection of worldwide autonomic nervous system authorities ever to contribute to a single treatise. It is especially suitable for students, scientists, and physicians who wish to find, in a single location, key information about all aspects of autonomic physiology and pathology.This primer provides up-to-date knowledge about basic and clinical autonomic neuroscience in a format designed to make learning easy and fun.

  • Antidiabetic Agents: Recent Advances in their Molecular and Clinical Pharmacology

    • 1st Edition
    • Volume 27
    • English
    Volume 27, the first thematic volume in the Series, provides an overview of present knowledge with regard to the pharmacological and clinical aspects of antidiabetic drugs. It aims to stimulate further consideration of possible concepts in the development of new antidiabetic drugs.

  • Guidebook on Molecular Modeling in Drug Design

    • 1st Edition
    • N. Claude Cohen
    • English
    Specially designed computer software is revolutionizing procedures for structured or rational drug design and discovery. The Guidebook on Molecular Modeling in Drug Design serves as a manual for the analysis ofmolecular structure and the correlation of these structures with pharmacological reactions. Intended as an introductory guide for advanced students and professionals with an interest in computer-assisted modeling for drug design and discovery, this bookwill also be of interest to medicinal and organic chemists, pharmaceutical researchers, pharmacologists, and biochemists who want to gain further insight into this rapidly advancing field.Molecular modeling is assuming an important role in the understanding of three-dimensional aspects in the specificity of drug-receptor interactions at the molecular level. This research area has become a well-established discipline in pharmaceutical research. It has created unprecedented opportunities in assisting medicinal chemists in the design of new therapeutic agents. Advances made in computer hardware and in theoretical medicinal chemistry have brought high-performance computing and graphics tools within reach of most academic and industrial laboratories, facilitating the development of useful approaches to rational drug design.The Guidebook on Molecular Modeling in Drug Design serves as a manual for the analysis of the molecular structure of biological molecules and drugs and the correlation of these structures with pharmacological actions. Intended as a guide for advanced students and professionals with an interest in computer-assisted modeling for drug design and discovery, this book will also be of interest to medicinal and organic chemists, pharmaceutical researchers, pharmacologists, and biochemists who want to gain further insight into this rapidly advancing field.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 33
    • English

  • Doing What Works in Brief Therapy

    A Strategic Solution Focused Approach
    • 1st Edition
    • Ellen K. Quick
    • English
    The first of its kind, Doing What Works in Brief Therapy is a guidebook to strategic solution focused therapy, a model which combines the principles and techniques of the Mental Research Institute's brief strategic therapy and the Brief Family Therapy Center's solution focused therapy. The book explains how the strategic emphasis on clarification of the problem and interruption of what does not work can complement and enhance the solution-focused emphasis on amplification of what does work. The text reviews the theory and presents specific treatment techniques. Case examples illustrate how the model has been used in brief, intermittent, and single-session therapy in a managed care setting. Brief psychotherapy doesn't have to result in chronic frustration for the therapist or superficial, second-rate care for the client. This book presents an approach that is upbeat, practical, and eminently workable in managed care. The reader learns to focus on critical issues with exquisite precision and to construct creative, individualized interventions that amplify what works and interrupt what does not.

  • Handbook of Perception and Action

    Perception
    • 1st Edition
    • Wolfgang Prinz + 1 more
    • English
    This volume combines the classical fields of perception research with the major theoretical attitudes of today's research, distinguishing between experience- versus performance-related approaches, transformational versus interactional approaches, and approaches that rely on the processing versus discovery of information. Perception is separated into two parts. The first part deals with basic processes and mechanisms, and discusses early vision and later, yet still basic, vision. The second covers complex achievements with accounts of perceptual constancies and the perception of patterns, objects, events, and actions.

  • The SV40 Replicon Model for Analysis of Anticancer Drugs

    • 1st Edition
    • Robert M. Snapka
    • English
    This book provides the most up-to-date review of the simian virus 40 (SV40) minichromosome as a model for the mammalian chromosome in studies of DNA replication. It focuses on disruption of DNA replication by anticancer drugs and DNA-damaging agents. There is a strong emphasis on the unique advantages of SV40 as an experimental system for the analysis of these classes of anticancer drug mechanisms. The new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication are covered in detail to aid readers in designing and interpreting similar experiments.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 35
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Drug Receptor Subtypes and Ingestive Behaviour

    • 1st Edition
    • Steven J. Cooper + 1 more
    • English
    Neural Mechanisms of ingestive behaviour has long been one of the most intensively investigaged areas within neuroscience. Drug studies have been introduced to develop anti-obesity compounds and, more recently, to identify nerotransmitters which might be involved in the control of ingestive behaviour. The current focus within this field is towards neurotransmitter receptors as it has become known that there are multiple receptor subtypes for each identified neurotransmitter. The study of drug receptor subtypes and ingestive behaviour is growing very rapidly, and has become quite complex. Drug Receptor Subtypes and Ingestive Behaviour is designed to guide students and investigators through a number of different neurotransmitter systems and provide them with the latest information on the identities of receptor subtypes most relevant in the study of ingestive behaviour. As such, it will prove enormously useful to all engaged in studies on appetite and obesity treatment.

  • Pharmaceutical Manufacturers

    An International Directory
    • 1st Edition
    • David D. Braun
    • English
    This international directory of pharmaceutical manufacturers includes 1,046 firms in 50 countries. They are arranged alphabetically by country and company name. In addition to name and address, other information such as telephone and fax number, and key personnel are also listed, where available.Completing the directory, is a listing of 124 Contract Manufacturers in 19 countries of ethical and/or non-prescription pharmaceuticals. These are arranged alphabetically by country and company name.

  • Biochemistry, Molecular Biology, and Therapeutic Implications

    Nitric Oxide: Biochemistry, Molecular Biology, And Therapeutic Implications
    • 1st Edition
    • Volume 34
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 64
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Every fifth volume ofAdvances in Heterocyclic Chemistry contains a cumulative subject index.

  • Immunopharmacology of Respiratory System

    • 1st Edition
    • Stephen T. Holgate
    • English
    Immunopharmacology represents the boundary between the immune system and chemical mediators of the inflammatory and neuroendocrine responses. The subject as applied to the respiratory system embraces most of the common non-malignant lung diseases of which asthma and allied disorders are the most prevalent. An understanding of the underlying mechanisms of the disorders provides rationale for prevention and drug treatment as well as creating opportunities for novel drug development. Immunopharmacology of Respiratory System embraces all of these principles and should enable the reader to become rapidly updated in an area of medical importance.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 33
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 30
    • James A. Bristol
    • English
    Praise for the Series:"This series is one of the very few annual publications which justify the title of an absolute must for the pharmacologist, chemist, or physician who is interested in the chemistry of drug development."--Enzym... book is strongly recommended for researchers, teachers, students, administrators - in short, anyone whose interests impinge on medicinal chemistry. In view of the work's documented reference value, it is a must for inlusion in the scientist's personal library."--Journal of Medicinal Chemistry"All topics are covered in sufficient depth, with extensive references, to allow either the specialist or the novice to be informed of the latest developments in a particular area of medicinal chemistry."--Norman Gilman, Hoffmann-La Roche, Inc, in the JOURNAL OF PHARMACEUTICAL SCIENCESAdvances in Medicinal Chemistry continues to provide timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

  • Advances in Pharmaceutical Sciences

    • 1st Edition
    • Volume 7
    • English
    The seventh volume of Advances in Pharmaceutical Sciences heralds a welcome continuation of this well-respected series. Acknowledged experts provide comprehensive statements of current research and development in selected fields of pharmaceutical technology. This book will be of great value to those working in academia and the pharmaceutical industry.

  • Advances in Drug Research

    • 1st Edition
    • Volume 26
    • English
    Volume 26 continues the trend of shorter, more frequent volumes. With Volume 25, the series gained a new co-editor, Urs Meyer. While retaining the commitment to publish chapters on therapeutic or chemical classes and on general topics or concepts, the series' coverage has expanded to include methodological chapters, and new areas of recognized or potential significance to drug research, especially in molecular pharmacology.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 32
    • English

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 63
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area-one of great importance to organic chemists, polymer chemists, and many biological scientists. Every fifth volume ofAdvances in Heterocyclic Chemistry contains a cumulative subject index.

  • Side Effects of Drugs Annual

    A Worldwide Yearly Survey of New Data and Trends
    • 1st Edition
    • Volume 18
    • English
    Under the supervision of the series editors, an international team of expert authors have gathered together the latest information on adverse drug effects from the international literature. In addition to describing new reports of adverse drug effects, the authors have subjected those reports to critical analysis, setting them into context in terms of clinical relevance and importance, and cross-referring to previous reports where necessary. New adverse effects are reported and evaluated and previously reported adverse effects are re-evaluated in the light of the most recent information. A special feature is the reviews, in which selected adverse effects are discussed in depth. The use of the book is enhanced by three separate indexes, allowing the reader to enter the text by drug name, adverse effect name, or drug interaction.

  • Chemistry and Pharmacology

    • 1st Edition
    • Volume 46
    • English
    Internationally acclaimed for more than forty years, this serial, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structureelucidation... synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Pharmacology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 62
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Every fifth volume ofAdvances in Heterocyclic Chemistry contains a cumulative subject index.

  • Immunopharmacology of Free Radical Species

    • 1st Edition
    • English
    Free radicals have been implicated in a entire host of different human disease states, which suggests that although they may not have a pivotal causal role, they are involved in the perpetuation of disease. In recentyears, it has become evident that although free radicals most certainly do have this role in perpetuating inflammatory reactions, they have perhaps a far more important role in acting as second messenger systems to maintain normal cell function. It is theperturbations of these reactions which pose the most intriguing therapeutic challenges. This volume deals with various basic mechanisms of free radical processes and injury. The emphasis in each case is on potential therapeutic strategies developing fromthis new knowledge.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 32
    • English
    Volume 32 contains issues of interest to scientists working in pharmacology, biochemistry, and physiology, particularly to those in HIV, cancer, neurology, and cardio-vascular research and medicine. The chapters on new approaches to cancer therapy and schizophrenia will be of special interest to pharmacologists. Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Mechanisms and Models in Rheumatoid Arthritis

    • 1st Edition
    • B. Henderson + 2 more
    • English
    Rheumatoid arthritis is a bewilderingly complex disease involving the interactions of many, and varied, cell populations and multiple families of low and high molecular mass mediators. We are only slowly beginning to understand the mechanisms that produce the local and systematic pathology clinically recognized as rheumatoid arthritis. Increasingly, use is being made of experimental models of this disease in an effort to test hypotheses about putative pathological mechanisms and to investigate the effect of novel therapeutic agents. A major section of this book covers these experimental models in great detail from their development through to reviews of the most recent information on each model.Mechanisms and Models in Rheumatoid Arthritis brings together a group of eminent researchers from the fields of clinical rheumatology, pathology, experimental pathology, immunology, connective tissue biochemistry, microbiology, pharmacology and developmental biology to describe the current views of the cellular and humoral mechanisms that drive the pathology of rheumatoid arthritis and experimental models of rheumatoid arthritis.

  • DNA Topoisomerases: Topoisomerase-Targeting Drugs

    • 1st Edition
    • Volume 29B
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

  • Anesthesia and Cardiovascular Disease

    • 1st Edition
    • Volume 31
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Volume 31 deals with the mechanisms of anesthetic actions under normal conditions as well as pathophysiologic states.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 36
    • English
    Published since 1959, this serial presents in-depth reviews on key topics in neuroscience, from molecules to behavior. The serial stays keenly attuned to recent developments in the field through the contributions offirst-class experts. Neuroscientists as well as clinicians, psychologists, physiologists, and pharmacologists will find this serial an indispensable addition to their library.

  • DNA Topoisomearases: Biochemistry and Molecular Biology

    • 1st Edition
    • Volume 29A
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

  • Side Effects of Drugs Annual

    A Worldwide Yearly Critical Survey of New Data and Trends
    • 1st Edition
    • Volume 17
    • English
    Under the supervision of the series editors, an international team of expert authors have gathered together the latest information on adverse drug effects from the international literature. In addition to describing new reports of adverse drug effects, the authors have subjected those reports to critical analysis, setting them into context in terms of clinical relevance and importance, and cross-referring to previous reports where necessary. New adverse effects are reported and evaluated and previously reported adverse effects are re-evaluated in the light of the most recent information. A special feature is the reviews, in which selected adverse effects are discussed in depth. The use of the book is enhanced by three separate indexes, allowing the reader to enter the text by drug name, adverse effect name, or drug interaction.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 28
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 25
    • English

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 31
    • English
    This book contains six chapters, each of which is a self-contained, thorough review by an expert in the field of a particular topic in medicinal chemistry, bacteriology or pharmacology. Each topic is a currently active subject of research in either the quest for new drugs or a better understanding of the role of known biochemical phenomena. In addition, all of the chapters contain an extensive list of relevant reference books, papers and other publications. The book will be of great interest to medicinal and pharmaceutical chemists, and will serve as a valuable source of reference.

  • Sigma Receptors

    • 1st Edition
    • Volume 12
    • English
    This is the 12th in the Neuroscience Perspectives Series. The existence of sigma receptors in the central nervous system has only relatively recently been established. In line with the aims of Neuroscience Perspectives, this volume will cover the historical background of the subject, together with the physiological, molecular biological and pharmacological aspects, with a discussion on the concept of sigma receptors subtypes and their postulated relevance for CNS disorders.

  • Immunopharmacology of Neutrophils

    • 1st Edition
    • English
    About the Series:The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid arthritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their prevention and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for the many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects of immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have a distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory mediators ("cells and mediators"). The second covers each of the major organ systems and the diseases involving the immune and inflammatory responses that can affect them ("systems"). The third covers different classes of drugs currently used to treat these diseases as well as those under development ("drugs"). About the Book:This book addresses the key issues that face neutrophils during their very short but extremely important lives. The discovery that neutrophils have the capacity to phagocytose and kill foreign organisms set the stage for a fascinating research field that continues to stimulate exciting new findings throughout the world. Neutrophils target the sites of infection or injury, and are thus equipped with sensors for soluble signals ("chemoattractants") generated in the tissue in response to tissue infection or injury, and sensors for molecules on surfaces. These receptors are important so that the cell can distinguish, for example, activated endothelium to stimulate adherence and emigration, or alternatively the bacterial surface to stimulate phagocytosis and killing. A deficiency in any of these mechanisms can result in life-threatening infection. An over-reaction can result in damage to the tissues that the neutrophil should be programmed to protect.

  • The G-Protein Linked Receptor Facts Book

    • 1st Edition
    • Steve Arkinstall
    • English
    How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact?The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common , easy–to-follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for.

  • Immunopharmacology of Joints and Connective Tissues

    • 1st Edition
    • English
    The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid athritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their preventions and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory responses that can affect them ("Systems"). The third covers different classes of diseases as well as those under development ("Drugs").

  • Immunopharmacology of the Heart

    • 1st Edition
    • English
    This volume sets out to consider a range of cardiac diseases for which drugs may play a therapeutic role by virtue of their effects on aspects of the immune system. The book reviews diseases of the heart which may involve an immunopharmacologica... component, and methods and techniques for the study of physiological and biochemical functions in the heart. An important focus is the immunopharmacology of the coronary vascular endothelium and the role of cellular and biochemical components of the immune system in the pathogenesis of atherosclerosis. The content also includes a review of the use of immunologically relevant agents in the setting of cardiac transplantation from aclinical perspective. Immunotherapy has a definite role to play in cardiology to a greater or lesser extent than other forms of intervention, depending on the type of cardiac disease. Immunopharmacology of the Heart aims to identify and clarify this role and points to potential developments of the future. Immunopharmacology of the Heart is a volume for the SYSTEMS theme of The Handbook of Pharmacology. In common with all other volumes it contains standardized illustrations and terms/abbreviations (glossaries of illustrations and terms published at the back of the volume). Other topics covered include: Leukocytes and their role in ischaemic heart disease. Complement activation. Sudden cardiac death. The stunned myocardium and reperfusion injury.

  • Immunopharmacology of Mast Cells and Basophils

    • 1st Edition
    • English
    There has been a steady and continued research effort directed to understanding both the function and the role of mast cells and basophils ever since these cells were first described at the end of the nineteenth century. One of the most significant advances has perhaps been the appreciation of the fact that mast cells do not represent a single homogenous population of cells: they display heterogeneity at the morphological, biochemical and functional levels. The one characteristic that unites all types of mast cells and basophils appears to be the possession of the high affinity membrane receptor for immunoglobulin E, through which the cells may be stimulated. This volume begins with a review of the origin and development of mast cells and basophils. It continues by reviewing our knowledge of the stimuli to mast cells and basophils and the biochemical mechanisms which link the signal generated by stimulus to the response machinery of the cell. Further chapters deal with the drug control of mast cell and basophil responses, the heterogeneity of the cells' functions and the mediators' release by the cells, along with the morphological aspects of the cells' function. This book is completed by a selection of examples which examine the role of the mast cells or basophils in lung, skin and gastrointestinal tract. However, the role of the mast cell with regard to normal physiology, remains an open question. This book aims to provide an up-to-date account of mast cell and basophil biology, together with an insight into the functional relevance of these cells in some tissue types.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 46
    • English

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