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Elsevier

Books in Life and medical sciences

  • Clinical Cancer Genomic Medicine

    • 1st Edition
    • Eamonn Maher + 3 more
    • English
    Clinical Cancer Genomic Medicine: Translational and Applied covers all major aspects of genetics and genomics in cancer development, diagnosis, and management, and their use in the clinical setting. The book explores not only the genetic basis of cancer, but also the role genomics plays in understanding the molecular basis of disease and how it can aid in diagnosis and treatment. Sections discuss the basics of oncogenomic and emerging technologies and specific cancer types, such as breast, gastrointestinal, ocular, skin, and pediatric. The book also includes knowledge on diagnostic cancer genomic techniques, surgical approaches, and ethical, legal, and social implications.This is a valuable resource for oncologists, clinicians, researchers, healthcare workers, and members of the biomedical field who need to understand more about the benefits of genetics and genomics for cancer and their applications in the clinical setting.

  • Modern Bioinformatics

    From Molecular Insights to Biomedical Innovation
    • 1st Edition
    • Kolla Bhanu Prakash + 2 more
    • English
    Modern Bioinformatics: From Molecular Insights to Biomedical Innovation explores the rapidly advancing field of bioinformatics, addressing a critical gap in current literature by integrating quantum biology and quantum biosensors with computational bioinformatics. The book offers a thorough exploration of bioinformatics from foundational concepts to translational applications. It begins with molecular structures of proteins, DNA, and RNA, advancing through nano-molecular visualization and structural domain analysis. Readers gain insights into deep learning techniques like AlphaFold for protein structure prediction, AI applications in genomics, and molecular interactions critical to function. The text further covers computational methods in drug discovery, forensic bioinformatics, and molecular evolution.A unique emphasis is placed on the convergence of nanotechnology and quantum innovations in molecular diagnostics and biosensing, including quantum biosensors and quantum computing applications. The final sections focus on computational strategies for drug target identification, biomarker discovery, and clinical trial analysis, providing a holistic view of modern bioinformatics workflows. This book is an indispensable reference for advanced researchers, graduate students, and professionals in bioinformatics, molecular biology, and biomedical engineering seeking to integrate quantum computing and nanotechnology into their work.

  • A History of Angiogenesis

    Discoveries, Research and the Therapeutic Potential
    • 1st Edition
    • Gianfranco Natale + 2 more
    • English
    A History of Angiogenesis: Discoveries, Research and the Therapeutic Potential presents a recent history of discoveries in the angiogenic field that contribute to the development of the anatomical knowledge of the process, experimental models, and new pharmacological approaches in different angiogenesis-related diseases. This multifaceted book is enriched with deep scientific contents, and each chapter clearly defines historical steps, the emerging role during the years of new morphological findings, molecular pathways, and targets. Focus is also directed on key challenges associated and future directions.The history of angiogenesis research is an intriguing tool for discovering answers to a wide array of queries arising in the biological and medical world. This comprehensive resource skillfully integrates all the key aspects related to angiogenesis, and will be of immense help to students, researchers, and industry experts who want to explore the last two decades of angiogenesis discoveries and research.

  • Medical Oncology Compendium

    • 1st Edition
    • Ramon Andrade B de Mello
    • English
    Medical Oncology Compendium discusses several important topics in oncology with the help of leading experts worldwide who incorporate not only knowledge on recent developments in the field, but contextualize them within diverse socioeconomic environments to guarantee the applicability of the content in challenging scenarios. The book comprehensively discusses topics such as surgery, radiology, carcinogenesis, screening, assessment tools, evidence-based medicine, and precision oncology as applicable to different cancer types as non-small and small cell lung cancer, mesothelioma, breast cancer, gastric-rectal cancer, female specific cancers, prostate, skin and bone sarcomas.In addition, it discusses options to minimize oncology pain and palliative care. It is a valuable resource for oncologists, clinicians, researchers, healthcare workers and members of biomedical field who needs to understand more about diagnosis, treatment options and support for cancer patients.

  • Systematic Review and Meta-Analysis

    Stepwise Approach for Medical and Biomedical Researchers
    • 1st Edition
    • Mahsa Ghajarzadeh + 2 more
    • English
    Systematic Review and Meta-Analysis: Stepwise Approach for Medical and Biomedical Researchers presents a step-by-step approach to develop systematic reviews and meta-analysis for biomedical and medical research. Systematic reviews are the highest quality evidence in medical research, providing an answer to a specific question, and they can be developed in the form of comprehensive literature search, critical appraisal, and synthesis of the evidence. Systematic reviews and meta-analysis are key elements of evidence-based medicine by summarizing the results of previous studies with the use of specific and reliable methods.Initially, systematic review and meta-analysis were exclusive to clinical trials, however systematic reviews of observational and diagnostic studies have expanded, making it essential for members of the field to master those techniques. This practical reference is a valuable resource for biostaticians, researchers, students, and members of medical and biomedical fields who need to understand more about systematic reviews and meta-analysis in their research work.

  • Fixed Point Optimization Algorithms and Their Applications

    • 1st Edition
    • Watcharaporn Cholamjiak
    • English
    Fixed Point Optimization Algorithms and Their Applications discusses how the relationship between fixed point algorithms and optimization problems is connected and demonstrates hands-on applications of the algorithms in fields such as image restoration, signal recovery, and machine learning. The book is divided into nine chapters beginning with foundational concepts of normed linear spaces, Banach spaces, and Hilbert spaces, along with nonlinear operators and useful lemmas and theorems for proving the book’s main results. The author presents algorithms for nonexpansive and generalized nonexpansive mappings in Hilbert space, and presents solutions to many optimization problems across a range of scientific research and real-world applications. From foundational concepts, the book proceeds to present a variety of optimization algorithms, including fixed point theories, convergence theorems, variational inequality problems, minimization problems, split feasibility problems, variational inclusion problems, and equilibrium problems. Fixed Point Optimization Algorithms and Their Applications equips readers with the theoretical mathematics background and necessary tools to tackle challenging optimization problems involving a range of algebraic methods, empowering them to apply these techniques in their research, professional work, or academic pursuits.

  • Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders

    Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders
    • 1st Edition
    • Valentina Rapozzi + 2 more
    • English
    Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders: Third International Conference on Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both preclinical and clinical investigations.This book consists of the following: The program and abstracts presented at the Third International Conference in Udine, Italy, September 3-5, 2023; Parts I–V review on (I) the general properties of nitric oxide in diseases; (II) the role of nitric oxide in cancer; (III) nitric oxide and immunity; (IV) nitric oxide and aging; and (V) nitric oxide and therapeutics. In addition, part VI is an educational review on artificial intelligence and its application in diseases. These updated reviews present many examples of research investigations related to the application of novel therapeutic compounds on nitric oxide and new derivatives, as well as their significant therapeutic activities against various resistant cancers that are unresponsive to current treatments and in different inflammatory disorders.This book is a valuable resource for cancer researchers, oncologists, graduate students, and investigators from medical and biomedical fields who want to learn more about NO and its therapeutic applications in cancer and inflammatory diseases. This book is also highly useful for both clinicians and oncologists as well as pharmaceutical companies involved in the development of new anticancer/antiinfla... agents.

  • The Evolution of Immunotherapy Against Tumors

    An Historical Approach
    • 1st Edition
    • Domenico Ribatti
    • English
    The Evolution of Immunotherapy Against Tumors: An Historical Approach summarizes the literature concerning the development of the theory of immune surveillance against tumors. It discusses the evidence for and against this theory, along with the concept of immunoediting. Finally, current approaches in anti-tumor immunotherapy will be analyzed.The immune system plays a major role in the surveillance against tumors. To avoid attack from the immune system, tumor cells develop different strategies to escape immune surveillance. Evidence of immune surveillance comes from both animal models and clinical observations. Mice with a wide variety of immunodeficiencies have a high rate of tumor incidence and are more susceptible to transplanted or chemical carcinogen-induced tumors. Immunosuppressed patients have a high incidence of tumors. However, many patients develop cancer even in the presence of an apparently normal immune system. This indicates that tumor cells can escape immune surveillance.

  • Cancer Epigenetics and Nanomedicine

    Targeting the Right Player via Nanotechnology
    • 1st Edition
    • Prashant Kesharwani + 1 more
    • English
    Cancer Epigenetics and Nanomedicine: Targeting the Right Player via Nanotechnology is a complete package that provides a comprehensive and thorough understanding of the key players that modulate the various steps of carcinogenesis and malignant progression of the disease and the critical targets to be exploited for developing novel modalities of diagnosis and therapeutics.Since epigenetic aberrations can be potentially reversed and restored to their normal state through epigenetic therapy, the book also discusses the challenges and the future of the field with the cutting-edge revelations and limitations that this research endeavor can offer, thereby helping the readers to enhance their critical thinking and adopt strategies of therapeutic importance.

  • Medical Modeling

    The Application of Advanced Design and Additive Manufacturing Techniques in Medicine
    • 3rd Edition
    • Richard Bibb + 3 more
    • English
    Medical Modelling: The Application of Advanced Design and Rapid Prototyping Techniques in Medicine, Third Edition provides readers with a thorough update of the core contents, along with key information on innovative imaging techniques, additive manufacturing technologies, and a range of applied case studies. This comprehensive new edition includes new coverage of advanced technologies, such as selective laser melting, electron beam melting, multi jet fusion, and more. The extensive section of peer-reviewed case studies is thoroughly updated and includes additional clinical examples, describing the practical applications of advanced design technologies in surgical, prosthetic, orthotic, dental and research applications.Finally... the book explores the future potential of medical modeling, such as in simulations for training, the development of new medical devices, and more.

  • Application of Artificial Intelligence in Early Detection of Lung Cancer

    • 1st Edition
    • Madhuchanda Kar + 3 more
    • English
    Application of Artificial Intelligence in Early Detection of Lung Cancer presents the most up-to-date computer-aided diagnosis techniques used to effectively predict and diagnose lung cancer. The presence of pulmonary nodules on lung parenchyma is often considered an early sign of lung cancer, thus using machine and deep learning technologies to identify them is key to improve patients’ outcome and decrease the lethal rate of such disease. The book discusses topics such as basics of lung cancer imaging, pattern recognition techniques, deep learning, and nodule detection and localization. In addition, the book discusses risk prediction based on radiological analysis and 3D modeling.This is a valuable resource for cancer researchers, oncologists, graduate students, radiologists, and members of biomedical field who are interested in the potential of AI technologies in the diagnosis of lung cancer.

  • Bio-Inspired Strategies for Modeling and Detection in Diabetes Mellitus Treatment

    • 1st Edition
    • Alma Y Alanis + 3 more
    • English
    Bio-Inspired Strategies for Modeling and Detection in Diabetes Mellitus Treatment focuses on bioinspired techniques such as modeling to generate control algorithms for the treatment of diabetes mellitus. The book addresses the identification of diabetes mellitus using a high-order recurrent neural network trained by an extended Kalman filter. The authors also describe the use of metaheuristic algorithms for the parametric identification of compartmental models of diabetes mellitus widely used in research works such as the Sorensen model and the Dallaman model. In addition, the book addresses the modeling of time series for the prediction of risk scenarios such as hyperglycaemia and hypoglycaemia using deep neural networks. The detection of diabetes mellitus in the early stages or when current diagnostic techniques cannot detect glucose intolerance or prediabetes is proposed, carried out by means of deep neural networks present in the literature. Readers will find leading-edge research in diabetes identification based on discrete high-order neural networks trained with an extended Kalman filter; parametric identification of compartmental models used to describe diabetes mellitus; modeling of data obtained by continuous glucose-monitoring sensors for the prediction of risk scenarios such as hyperglycaemia and hypoglycaemia; and screening for glucose intolerance using glucose-tolerance test data and deep neural networks. Application of the proposed approaches is illustrated via simulation and real-time implementations for modeling, prediction, and classification.

  • Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy

    • 1st Edition
    • Vivek Asati + 1 more
    • English
    Current Molecular Targets of Heterocyclic Compounds for Cancer Therapy discusses recently developed treatments based on molecular targets which are genetically altered in cancer cells and are essential for tumor development and survival. Considerable research effort has been devoted to the development of targeted drugs that inhibit the action of pathogenic kinases, and clinical studies performed so far have validated the positive effects of kinase inhibitors for cancer treatment. Each chapter discusses a molecular target, such as ALK2, ATR, CK, Src-Abl, EGFR, Fyn-Blk-Lyn, IGFs, and PAK1.The book's chapters are written by experts who actively work on the targets to help readers fully understand how they can be used. This is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of novel cancer therapies based on molecular targets.

  • Curcumin-Based Nanomedicines as Cancer Therapeutics

    • 1st Edition
    • Amirhossein Sahebkar + 1 more
    • English
    Curcumin-based Nanomedicines as Cancer Therapeutics presents a consistent and thorough overview of nanocurcumin applications in cancer treatments. It brings together the novel applications of nanocurcumin in biological milieu as well as helps readers to define the major gaps in knowledge that can lead to significant scientific discoveries.Nanocurc... has been widely explored for the treatment of various cancers; however, the scientific literature is inconsistent in style and structure and scattered across many sources. By providing an explicit account on vital aspects on nanocurcumin-based anticancer delivery approaches and discussing the perspectives of the technologies explored so far based upon the findings outlined, the book offers updated and in-depth knowledge on the topic in one single source written by global leading experts.In addition, the book aims to stimulate the interest of the academic researchers, industrial scientists, businessmen, and young scholars to address key multidisciplinary challenges faced by nanotechnologists to foster the desired collaboration among biologists, chemists, physicists, engineers, and clinicians to find proper and efficient new cancer treatments.

  • Targeting Angiogenesis, Inflammation and Oxidative Stress in Chronic Diseases

    Angiogenesis, Inflammation and Oxidative Stress in Chronic Diseases
    • 1st Edition
    • Tapan Behl + 2 more
    • English
    Targeting Angiogenesis, Inflammation and Oxidative Stress in Chronic Diseases presents recent advances in the vivid molecular pathways targeting angiogenesis, inflammation, and oxidative stress that contribute very widely to the genesis of chronic diseases. The books highlights drugs from natural and synthetic origins in the management/preventio... of diseases, along with the drug delivery approaches. The book’s authors from various key institutions around the globe deliver well-structured and designed chapters. The systematic presented information and knowledge will surely aid consistency and continuity. The multifaceted book is enriched with deep scientific content. Each chapter clearly defines the facts, the emerging role of molecular pathways, and targets and focus, along with key challenges and future directions that will provide new areas for researchers to explore new targets in the domain.

  • Multifunctional Nanocomposites for Targeted Drug Delivery in Cancer Therapy

    • 1st Edition
    • Awesh K. Yadav + 2 more
    • Awesh K. Yadav + 2 more
    • English
    Multifunctional Nanocomposites for Targeted Drug Delivery in Cancer Therapy explores the design, synthesis, and application of different multifunctional nanocomposites drug delivery system for cancer treatment. It encompasses initial chapters discussing introductory information about cancer, followed by chapters focusing on the detailed information about various novel drug delivery systems for treatment of several organ site cancers such as prostate, skin, breast, lung, liver, pancreas, stomach, colon, blood, mouth and throat. It is a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical research who need to understand more about novel nanotechnologies applied to cancer treatment.

  • Biomarkers in Cancer Detection and Monitoring of Therapeutics

    Volume 2: Diagnostic and Therapeutic Applications
    • 1st Edition
    • Ranbir Chander Sobti + 2 more
    • English
    Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focuses on novel diagnostic techniques based on molecular biomarkers and their impact on treatment, covering different cancer types such as tumors in the nervous system, head and neck, oral and GI tractor, lung, breast, gastric system, leukemia and urogenital tract cancers. For each type, the book discusses the best diagnostic techniques and therapeutic approaches, thus helping readers easily identify the best solution for each case. This is a valuable resource for cancer researchers, oncologists, graduate students and other members of the biomedical field who are interested in the potential of biomarkers in cancer research.

  • Recent Advances in Nanocarriers for Pancreatic Cancer Therapy

    • 1st Edition
    • Prashant Kesharwani + 1 more
    • English
    Recent Advances in Nanocarriers for Pancreatic Cancer Therapy reviews thriving strategies concerning pancreatic cancer therapy, thoroughly describing the most recent developments in emerging modern drug delivery systems focused on, and derived from, nanotechnology. By providing a holistic understanding of the molecular pathways, conventional therapy and novel nanocarriers mediated drug delivery against pancreatic cancer, this work can be considered a complete package. The book offers a solution to the dissemination of data from a broad range of resources by providing an overview of the molecular pathways and conventional therapy of pancreatic cancer, the application of various nanocarriers, and more. This book equips scientists, clinicians and students to make rational treatment approaches based on nanomedicine for improving and extending the human life against pancreatic cancer.

  • Biostatistics Manual for Health Research

    A Practical Guide to Data Analysis
    • 1st Edition
    • Nafis Faizi + 1 more
    • English
    **Selected for 2026 Doody's Core Titles in Biostatistics**Biost... Manual for Health Research: A Practical Guide to Data Analysis is a guide for researchers on how to apply biostatistics on different types of data. The book approaches biostatistics and its application from medical and health researcher’s point-of-view and has real and mostly published data for practice and understanding. The interpretation and meaning of the statistical results, reporting guidelines and mistakes are taught with real world examples. This is a valuable resource for biostaticians, students and researchers from medical and biomedical fields who need to learn how to apply statistical approaches to improve their research.

  • Nitric Oxide in Health and Disease

    Therapeutic Applications in Cancer and Inflammatory Disorders
    • 1st Edition
    • Lucia Morbidelli + 2 more
    • English
    Approx.326 pages

  • Computational Methods in Drug Discovery and Repurposing for Cancer Therapy

    • 1st Edition
    • Ganji Purnachandra Nagaraju + 2 more
    • English
    Computational Methods in Drug Discovery and Repurposing for Cancer Therapy provides knowledge about ongoing research as well as computational approaches for drug discovery and repurposing for cancer therapy. The book also provides detailed descriptions about target molecules, pathways, and their inhibitors for easy understanding and applicability. The book discusses tools and techniques such as integrated bioinformatics approaches, systems biology tools, molecular docking, computational chemistry, artificial intelligence, machine learning, structure-based virtual screening, biomarkers, and transcriptome; those are discussed in the context of different cancer types, such as colon, pancreatic, glioblastoma, endometrial, and retinoblastoma, among others. This book is a valuable resource for researchers, students, and members of the biomedical and medical fields who want to learn more about the use of computational modeling to better tailor the treatment for cancer patients.

  • Health Information Exchange

    Navigating and Managing a Network of Health Information Systems
    • 2nd Edition
    • Brian Dixon
    • English
    Health Information Exchange: Navigating and Managing a Network of Health Information Systems, Second Edition, now fully updated, is a practical guide on how to understand, manage and make use of a health information exchange infrastructure, which moves patient-centered information within the health care system. The book informs and guides the development of new infrastructures as well as the management of existing and expanding infrastructures across the globe. Sections explore the reasons for the health information exchange (HIE) infrastructures, how to manage them, examines the key drivers of HIE, and barriers to their widespread use. In addition, the book explains the underlying technologies and methods for conducting HIE across communities as well as nations. Finally, the book explains the principles of governing an organization that chiefly moves protected health information around. The text unravels the complexities of HIE and provides guidance for those who need to access HIE data and support operations.

  • Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies

    • 1st Edition
    • Manzoor Ahmad Mir
    • English
    Role of Tumor Microenvironment in Breast Cancer and Targeted Therapies discusses the current understanding of breast cancer tumor microenvironment components, their role in tumorigenicity and the development of therapeutic resistance, along with updates on recent advances.

  • Contemporary Management of Metastatic Colorectal Cancer

    A Precision Medicine Approach
    • 1st Edition
    • Aslam Ejaz + 1 more
    • English
    Contemporary Management of Metastatic Colorectal Cancer: A Precision Medicine Approach summarizes current knowledge and provides evidenced-based practice recommendations on how to treat patients with metastatic colorectal cancer. The book presents topics such as pre-operating imaging, the use of molecular markers in treatment decisions, neoadjuvant therapy, synchronous colorectal liver metastasis, and minimally invasive approaches. In addition, it discusses immunotherapy, targeted therapies and survivorship. This is a valuable resource for practitioners, cancer researchers, oncologists, graduate students and members of biomedical research who need to understand more about novel treatments for colorectal cancer metastasis.

  • Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 3

    Translational and Clinical Outcomes
    • 1st Edition
    • Ganji Purnachandra Nagaraju + 1 more
    • English
    Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma: Translational and Clinical Outcomes, Volume Three provides comprehensive information about ongoing research and clinical data on liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. This updated volume discusses topics such as clinical and safety assessment of HCC patients, liver transplantation as a therapeutic option, immunotherapy interventions, and image-based surveillance. In addition, it discusses immunohistology of HCC-enabled precision medicine and artificial intelligence for hepatocellular carcinomas. This is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer to apply in their research work or clinical setting.

  • Cognitive and Soft Computing Techniques for the Analysis of Healthcare Data

    • 1st Edition
    • Akash Kumar Bhoi + 3 more
    • English
    Cognitive and Soft Computing Techniques for the Analysis of Healthcare Data discusses the insight of data processing applications in various domains through soft computing techniques and enormous advancements in the field. The book focuses on the cross-disciplinary mechanisms and ground-breaking research ideas on novel techniques and data processing approaches in handling structured and unstructured healthcare data. It also gives insight into various information-processi... models and many memories associated with it while processing the information for forecasting future trends and decision making. This book is an excellent resource for researchers and professionals who work in the Healthcare Industry, Data Science, and Machine learning.

  • Cybersecurity for Connected Medical Devices

    • 1st Edition
    • Arnab Ray
    • English
    The cybersecurity of connected medical devices is one of the biggest challenges facing healthcare today. The compromise of a medical device can result in severe consequences for both patient health and patient data.　Cybersecurity for Connected Medical Devices covers all aspects of medical device cybersecurity, with a focus on cybersecurity capability development and maintenance, system and software threat modeling, secure design of medical devices, vulnerability management, and integrating cybersecurity design aspects into a medical device manufacturer's Quality Management Systems (QMS). This book is geared towards engineers interested in the medical device cybersecurity space, regulatory, quality, and human resources specialists, and organizational leaders interested in building a medical device cybersecurity program.　

  • Nature-Inspired Computing Paradigms in Systems

    Reliability, Availability, Maintainability, Safety and Cost (RAMS+C) and Prognostics and Health Management (PHM)
    • 1st Edition
    • Mohamed Arezki Mellal + 1 more
    • English
    Nature-Inspired Computing Paradigms in Systems: Reliability, Availability, Maintainability, Safety and Cost (RAMS+C) and Prognostics and Health Management (PHM) covers several areas that include bioinspired techniques and optimization approaches for system dependability. The book addresses the issue of integration and interaction of the bioinspired techniques in system dependability computing so that intelligent decisions, design, and architectures can be supported. It brings together these emerging areas under the umbrella of bio- and nature-inspired computational intelligence. The primary audience of this book includes experts and developers who want to deepen their understanding of bioinspired computing in basic theory, algorithms, and applications. The book is also intended to be used as a textbook for masters and doctoral students who want to enhance their knowledge and understanding of the role of bioinspired techniques in system dependability.

  • Encyclopedia of Bioinformatics and Computational Biology

    ABC of Bioinformatics
    • 1st Edition
    • Shoba Ranganathan + 2 more
    • English
    Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries.

  • Principles and Practice of Clinical Research

    • 4th Edition
    • John I. Gallin + 2 more
    • English
    Principles and Practice of Clinical Research, Fourth Edition has been thoroughly revised to provide a comprehensive look at both the fundamental principles and expanding practice of clinical research. New to this edition of this highly regarded reference, authors have focused on examples that broadly reflect clinical research on a global scale while including a discussion of international regulations, studies, and implications. In addition to key topics such as bioethics, clinical outcome data, cultural diversity, protocol guidelines, and “omic” platforms, this edition contains new chapters devoted to electronic health records and information resources for clinical researchers, as well as the many opportunities associated with big data. Covering a vast number of topics and practical advice for both novice and advanced clinical investigators, this book is a highly relevant and essential resource for all those involved in conducting research.

  • Notes in the Category of C

    Reflections on Laboratory Animal Care and Use
    • 1st Edition
    • Steven M. Niemi
    • English
    Notes in the Category C: Reflections on Laboratory Animal Care and Use addresses how to improve laboratory animal care and use, also characterizing the current state of the industry and speculating on its long-term future. It offers analysis from a professional who has spent a lot of time in the trenches, also highlighting new approaches to produce further advances in the field. As the proper care and use of lab animals is critically important to scientists and those who depend on data generated from those animals, this comprehensive book is an ideal resource on the topic. Physicians, patients and their families, consumers, federal and non-profit research funding entities, health advocacy organizations, the FDA, EPA, regulatory approval agencies, and companies that invest billions in R&D to create new diagnostics, drugs, vaccines and medical devices will find this an informative addition for their work.

  • The Prevention of Cardiovascular Disease through the Mediterranean Diet

    • 1st Edition
    • Almudena Sánchez Villegas + 1 more
    • English
    The Prevention of Cardiovascular Disease through the Mediterranean Diet presents dietary habits that will have maximum impact on cardiovascular health and other major chronic diseases. Data collected through the results of large clinical trials, such as PREDIMED, one of the longest trials ever conducted, has allowed researchers to conclude that the Mediterranean Diet provides the best evidence for health benefits. Studies have shown that the Mediterranean Diet is able to reduce the risk of cardiovascular hard clinical events by 30%. This book explores the components of this diet, including the consumption of extra virgin olive oil, nuts, fresh fruits and vegetables, fatty fish, poultry and red wine for optimal health benefits.

  • Microbiology and Molecular Diagnosis in Pathology

    A Comprehensive Review for Board Preparation, Certification and Clinical Practice
    • 1st Edition
    • Audrey Wanger + 5 more
    • English
    Microbiology and Molecular Diagnosis in Pathology: A Comprehensive Review for Board Preparation, Certification and Clinical Practice reviews all aspects of microbiology and molecular diagnostics essential to successfully passing the American Board of Pathology exam. This review book will also serve as a first resource for residents who want to become familiar with the diagnostic aspects of microbiology and molecular methods, as well as a refresher course for practicing pathologists. Opening chapters discuss issues of laboratory management, including quality control, biosafety, regulations, and proper handling and reporting of laboratory specimens. Review chapters give a quick overview of specific clinical infections as well as different types of bacteria, viruses, fungal infections, and infections caused by parasites. Following these, coverage focuses on diagnostic tools and specific tests: media for clinical microbiology, specific stains and tests for microbial identifications, susceptibility testing and use of antimicrobial agents, tests for detecting antibodies, antigens, and microbial infections. Two final chapters offer overviews on molecular diagnostics principles and methods as well as the application of molecular diagnostics in clinical practice.

  • Brain-Computer Interfaces: Lab Experiments to Real-World Applications

    • 1st Edition
    • Volume 228
    • English
    Brain-Computer Interfaces: Lab Experiments to Real-World Applications, the latest volume in the Progress in Brain Research series, focuses on new trends and developments. This established international series examines major areas of basic and clinical research within the neurosciences, as well as popular and emerging subfields.

  • Biostatistics and Computer-based Analysis of Health Data using Stata

    • 1st Edition
    • Christophe Lalanne + 1 more
    • English
    This volume of the Biostatistics and Health Sciences Set focuses on statistics applied to clinical research. The use of Stata for data management and statistical modeling is illustrated using various examples. Many aspects of data processing and statistical analysis of cross-sectional and experimental medical data are covered, including regression models commonly found in medical statistics. This practical book is primarily intended for health researchers with basic knowledge of statistical methodology. Assuming basic concepts, the authors focus on the practice of biostatistical methods essential to clinical research, epidemiology and analysis of biomedical data (including comparison of two groups, analysis of categorical data, ANOVA, linear and logistic regression, and survival analysis). The use of examples from clinical trials and epideomological studies provide the basis for a series of practical exercises, which provide instruction and familiarize the reader with essential Stata packages and commands.

  • Machine Learning and Medical Imaging

    • 1st Edition
    • Guorong Wu + 2 more
    • English
    Machine Learning and Medical Imaging presents state-of- the-art machine learning methods in medical image analysis. It first summarizes cutting-edge machine learning algorithms in medical imaging, including not only classical probabilistic modeling and learning methods, but also recent breakthroughs in deep learning, sparse representation/codin... and big data hashing. In the second part leading research groups around the world present a wide spectrum of machine learning methods with application to different medical imaging modalities, clinical domains, and organs. The biomedical imaging modalities include ultrasound, magnetic resonance imaging (MRI), computed tomography (CT), histology, and microscopy images. The targeted organs span the lung, liver, brain, and prostate, while there is also a treatment of examining genetic associations. Machine Learning and Medical Imaging is an ideal reference for medical imaging researchers, industry scientists and engineers, advanced undergraduate and graduate students, and clinicians.

  • Computational Systems Biology

    Inference and Modelling
    • 1st Edition
    • Paola Lecca + 4 more
    • English
    Computational Systems Biology: Inference and Modelling provides an introduction to, and overview of, network analysis inference approaches which form the backbone of the model of the complex behavior of biological systems. This book addresses the challenge to integrate highly diverse quantitative approaches into a unified framework by highlighting the relationships existing among network analysis, inference, and modeling. The chapters are light in jargon and technical detail so as to make them accessible to the non-specialist reader. The book is addressed at the heterogeneous public of modelers, biologists, and computer scientists.

  • Emerging Trends in Applications and Infrastructures for Computational Biology, Bioinformatics, and Systems Biology

    Systems and Applications
    • 1st Edition
    • Hamid R Arabnia + 1 more
    • English
    Emerging Trends in Applications and Infrastructures for Computational Biology, Bioinformatics, and Systems Biology: Systems and Applications covers the latest trends in the field with special emphasis on their applications. The first part covers the major areas of computational biology, development and application of data-analytical and theoretical methods, mathematical modeling, and computational simulation techniques for the study of biological and behavioral systems. The second part covers bioinformatics, an interdisciplinary field concerned with methods for storing, retrieving, organizing, and analyzing biological data. The book also explores the software tools used to generate useful biological knowledge. The third part, on systems biology, explores how to obtain, integrate, and analyze complex datasets from multiple experimental sources using interdisciplinary tools and techniques, with the final section focusing on big data and the collection of datasets so large and complex that it becomes difficult to process using conventional database management systems or traditional data processing applications.

  • Medical Image Recognition, Segmentation and Parsing

    Machine Learning and Multiple Object Approaches
    • 1st Edition
    • S. Kevin Zhou
    • English
    This book describes the technical problems and solutions for automatically recognizing and parsing a medical image into multiple objects, structures, or anatomies. It gives all the key methods, including state-of- the-art approaches based on machine learning, for recognizing or detecting, parsing or segmenting, a cohort of anatomical structures from a medical image. Written by top experts in Medical Imaging, this book is ideal for university researchers and industry practitioners in medical imaging who want a complete reference on key methods, algorithms and applications in medical image recognition, segmentation and parsing of multiple objects. Learn: Research challenges and problems in medical image recognition, segmentation and parsing of multiple objects Methods and theories for medical image recognition, segmentation and parsing of multiple objects Efficient and effective machine learning solutions based on big datasets Selected applications of medical image parsing using proven algorithms

  • Applied Computing in Medicine and Health

    • 1st Edition
    • Dhiya Al-Jumeily + 3 more
    • English
    Applied Computing in Medicine and Health is a comprehensive presentation of on-going investigations into current applied computing challenges and advances, with a focus on a particular class of applications, primarily artificial intelligence methods and techniques in medicine and health. Applied computing is the use of practical computer science knowledge to enable use of the latest technology and techniques in a variety of different fields ranging from business to scientific research. One of the most important and relevant areas in applied computing is the use of artificial intelligence (AI) in health and medicine. Artificial intelligence in health and medicine (AIHM) is assuming the challenge of creating and distributing tools that can support medical doctors and specialists in new endeavors. The material included covers a wide variety of interdisciplinary perspectives concerning the theory and practice of applied computing in medicine, human biology, and health care. Particular attention is given to AI-based clinical decision-making, medical knowledge engineering, knowledge-based systems in medical education and research, intelligent medical information systems, intelligent databases, intelligent devices and instruments, medical AI tools, reasoning and metareasoning in medicine, and methodological, philosophical, ethical, and intelligent medical data analysis.

  • Morphometry of the Human Lung

    • 1st Edition
    • Ewald R. Weibel
    • English
    Morphometry of the Human Lung considers the developments in understanding the quantitative anatomy of the lung, and in the correlation of anatomy with physiology. This book is composed of 11 chapters, and begins with an overview of a systematic approach to a quantitative morphologic analysis of the architecture of the human lung, followed by a presentation of general problems of methodology and the derivation of reliable dimensional models of this organ. The subsequent chapters describe the methods of preparation of tissues, methods of random sampling, and adaptation of methodologies from other fields of science. These topics are followed by discussions the mathematical formulations for the translation of the data into the desired geometric forms and a technique of counting. The final chapters look into the mode of distribution and geometric forms that should eventually facilitate mathematical and physical considerations regarding the function of the lungs. These chapters also consider the application of these quantitative methods to the study of pathologic specimens, providing a most timely renovation of morphologic pathology. This book will be of value to pulmonologists, physiologists, and researchers who are interested in lung morphometry.

  • Computer-Aided Vaccine Design

    • 1st Edition
    • Joo Chuan Tong + 1 more
    • English
    Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.Computer-... vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.

  • From Science 2.0 to Pharma 3.0

    Semantic Search and Social Media in the Pharmaceutical industry and STM Publishing
    • 1st Edition
    • Hervé Basset + 2 more
    • English
    Science 2.0 uses the resources of Web 2.0 to communicate between scientists, and with the general public. Web 3.0, in turn, has brought disruptive technologies such as semantic search, cloud computing and mobile applications into play. The term Pharma 3.0 anticipates the future relationship between drug makers and doctors with their patients in light of such technology. From Science 2.0 to Pharma 3.0 examines these developments, discussing the best and worst of Web 2.0 in science communication and health. Successes such as the Open Access phenomena and also less successful networks are covered. This title is divided into three parts. The first part considers the Web 2.0 revolution, and the promise of its impact on science communication and the state of Science 2.0. The second part looks at impact on Pharma and Health, including attempts to utilise digital in Pharma. The last part looks at the promising disruptive technologies of Web 3.0, including semantic search in biomedicine and enterprise platforms. The book concludes by looking forward to developments of ‘3.0’ in Pharma and STM publishing.

  • Computational Systems Biology

    • 1st Edition
    • Andres Kriete + 1 more
    • English
    Systems Biology is concerned with the quantitative study of complex biosystems at the molecular, cellular, tissue, and systems scales. Its focus is on the function of the system as a whole, rather than on individual parts. This exciting new arena applies mathematical modeling and engineering methods to the study of biological systems. This book is the first of its kind to focus on the newly emerging field of systems biology with an emphasis on computational approaches. The work covers new concepts, methods for information storage, mining and knowledge extraction, reverse engineering of gene and metabolic networks, as well as modelling and simulation of multi-cellular systems. Central themes include strategies for predicting biological properties and methods for elucidating structure-function relationships.

  • Handbook of Biosurveillance

    • 1st Edition
    • Michael M. Wagner + 2 more
    • English
    Provides a coherent and comprehensive account of the theory and practice of real-time human disease outbreak detection, explicitly recognizing the revolution in practices of infection control and public health surveillance.

  • Evolutionary Computation in Bioinformatics

    • 1st Edition
    • Gary B. Fogel + 1 more
    • English
    Bioinformatics has never been as popular as it is today. The genomics revolution is generating so much data in such rapid succession that it has become difficult for biologists to decipher. In particular, there are many problems in biology that are too large to solve with standard methods. Researchers in evolutionary computation (EC) have turned their attention to these problems. They understand the power of EC to rapidly search very large and complex spaces and return reasonable solutions. While these researchers are increasingly interested in problems from the biological sciences, EC and its problem-solving capabilities are generally not yet understood or applied in the biology community.This book offers a definitive resource to bridge the computer science and biology communities. Gary Fogel and David Corne, well-known representatives of these fields, introduce biology and bioinformatics to computer scientists, and evolutionary computation to biologists and computer scientists unfamiliar with these techniques. The fourteen chapters that follow are written by leading computer scientists and biologists who examine successful applications of evolutionary computation to various problems in the biological sciences.

  • DNA Sequencing

    • 1st Edition
    • Volume 10
    • J. Hindley
    • English
    This volume provides a comprehensive description of the principles and methods used in DNA sequencing. Following a detailed introduction the chapters are: DNA sequencing; Chain terminator sequencing; Primed synthesis methods applied to DNA fragments cloned into phage M13; DNA sequencing by the Maxam-Gilbert chemical procedure; Computer methods for DNA sequencers; Appendices including contractions and special terms, cloning vectors, commercially available restriction endonucleases, and autoradiography.

  • Modelling & Data Analysis in Biotechnology & Medical Engineering

    • 1st Edition
    • G.C. Vansteenkiste + 1 more
    • English