Advances in Cancer Biomarkers Research
- 1st Edition - December 1, 2024
- Imprint: Academic Press
- Editors: Anand Narayan Singh, Seema Nayak, Rashmi Rana
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 2 5 8 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 2 5 9 - 0
Advances in Cancer Biomarkers Research provides a thorough and detailed description of cancer biomarkers for diagnostic, prognostic and therapeutics in several cancer types. The bo… Read more
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Request a sales quoteAdvances in Cancer Biomarkers Research provides a thorough and detailed description of cancer biomarkers for diagnostic, prognostic and therapeutics in several cancer types. The book presents a compendium of topics related to current advanced research, along with fundamental knowledge that will help readers fully comprehend the field of cancer biomarkers. Topics discussed include such the role of genetic mechanisms, epigenetics, DNA and microRNA in different cancers, signaling pathways and exosomes. In addition, the book discusses biomarker research applied to several cancer types, such as head and neck, urological, lung, bone tumors, hematological and neurological malignancies and breast cancers.This will be a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of biomarkers in cancer research and treatment.
- Provides a unique combination of basic and latest advancements in the field of cancer biomarkers, with a strong interdisciplinary approach
- Presents an updated roadmap for researchers, enabling them to learn the role of different biomarkers in cancer diagnosis and therapy and easily apply the knowledge gained to their work
- Discusses the complex mechanisms and pathways associated with cancer biomarkers through case studies, examples and illustrations
Researchers and graduate students on cancer research, oncologists, Clinical researchers
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Chapter 1. Emerging role of biomarker in different cancers
- Abstract
- 1.1 Introduction
- 1.2 Categories of biomarkers: Generally five categories of biomarkers
- 1.3 Biomarkers classification: Biomarkers are classified in following groups
- 1.4 Biomarkers signatures
- 1.5 Types of tumor biomarkers
- 1.6 Diagnostic markers are basically two types
- 1.7 Uses of tumor biomarkers
- 1.8 Techniques for analyzing biomarkers
- 1.9 Protein based
- 1.10 Molecular pathways in tumor development
- 1.11 Biomarkers in different cancers: comprehensive compilation of biomarkers in different cancers are describe in Table 1.1
- 1.12 Conclusion
- References
- Chapter 2. Role of genetic mechanism in cancer
- Abstract
- 2.1 Introduction
- 2.2 DNA repair mechanism in cancer
- 2.3 Molecules involved for the DNA damage response
- 2.4 Genetic mechanism of cancer
- 2.5 Oncogenes
- 2.6 Oncogene types and classification
- 2.7 The role of oncogenes in anticancer therapy
- 2.8 p53 Tumor suppressor gene
- 2.9 Noncoding RNAs in cancer
- 2.10 Role of microRNA in cancer
- 2.11 Therapeutics in cancer
- 2.12 Chemotherapy
- 2.13 Radiotherapy
- 2.14 Combined radiotherapy and chemotherapy
- 2.15 Combined radiotherapy and immunotherapy
- 2.16 Surgical approach
- 2.17 Targeted therapies
- 2.18 Conclusion
- References
- Chapter 3. Role of epigenetics, DNA methylation, histone modification, and microRNA in different cancers
- Abstract
- 3.1 Introduction
- References
- Chapter 4. Biogenesis of extracellular vesicles and their role in cancer
- Abstract
- 4.1 Introduction
- 4.2 Extracellular vesicles classes, biogenesis, and composition
- 4.3 Biogenesis of extracellular vesicles
- 4.4 Tumor microenvironment
- 4.5 Extracellular vesicles in the microenvironment
- 4.6 Extracellular vesicles and cancer progression
- 4.7 Extracellular vesicles and tumor angiogenesis
- 4.8 Extracellular vesicles and metastasis
- 4.9 Extracellular vesicles and cancer-mediated immunosuppression
- 4.10 Clinical utility of extracellular vesicles
- 4.11 Extracellular vesicles as biomarkers
- 4.12 Extracellular vesicles in drug resistance
- 4.13 Extracellular vesicles as cancer therapeutic
- 4.14 Conclusions
- References
- Chapter 5. Cancer signaling pathways: targets and treatment
- Abstract
- 5.1 Introduction
- 5.2 JAK-STAT signaling pathway
- 5.3 Hedgehog signaling pathway
- 5.4 RAS/RAF-MEK signaling pathway
- 5.5 Wnt signaling pathway
- 5.6 PD-1 pathway
- 5.7 Mutation in signaling pathways
- 5.8 Signal inhibitors
- 5.9 Drugs targeting cancer signaling
- 5.10 Targeting the Wnt pathway
- 5.11 Anticancer activity of metformin
- 5.12 JAK/STAT signaling pathway inhibitor
- 5.13 Polyphenols and phenols
- 5.14 Hedgehog pathway
- 5.15 Drug resistance and cancer signaling
- 5.16 Alternative pathways after signal disruption
- 5.17 Conclusion
- Abbreviations
- References
- Chapter 6. Theragnostic exosomes in cancer
- Abstract
- 6.1 Introduction
- 6.2 Structure and composition of exosomes
- 6.3 Theragnostics applications
- References
- Chapter 7. Exosomes: current and novel biomarkers tools for early stage diagnosis of cancer
- Abstract
- 7.1 Introduction
- 7.2 Oncologic characterization of exosomes
- 7.3 Exosomes as diagnostic and predictive biomarkers for cancer
- 7.4 Exosomes in different cancer
- 7.5 Conclusion
- 7.6 Future perspective
- References
- Chapter 8. Genetic, epigenetic and exosomal biomarkers in neurological malignancies
- Abstract
- 8.1 Introduction
- 8.2 Neurological malignancies: an overview
- 8.3 Biomarkers: conceptual analysis
- 8.4 Genetic biomarkers in neurological malignancies
- 8.5 Epigenetic biomarkers in neurological malignancies
- 8.6 Histone modifications and mutations
- 8.7 DNA methylation
- 8.8 MicroRNAs
- 8.9 Long noncoding RNAs
- 8.10 Exosomal biomarkers in neurological malignancies
- 8.11 Challenges of biomarkers
- 8.12 Future prospects and conclusion
- References
- Chapter 9. Current epigenetic and exosomal biomarkers in head and neck cancers
- Abstract
- 9.1 Introduction
- 9.2 Genetic alterations
- 9.3 Epigenetic alterations
- 9.4 Promoter hypermethylation
- 9.5 MicroRNAs (miRNAs) and small interfering RNA (siRNA)
- 9.6 Histone acetylation
- 9.7 Exosomes as emerging biomarker in head and neck cancer
- 9.8 Biogenesis of exosomes
- 9.9 Isolation of exosomes
- 9.10 Structure of exosomes
- 9.11 Potential diagnostic and therapeutic applications of exosomes on HNSCC
- 9.12 Conclusion
- References
- Chapter 10. Role of epigenetics in breast cancer: current status and future perspectives
- Abstract
- 10.1 Introduction
- 10.2 Role of epigenetics in breast cancer
- 10.3 Methods for detection of epigenetic changes
- 10.4 Epigenetics as biomarkers
- 10.5 Epigenetics in breast cancer treatment
- 10.6 Future perspective
- 10.7 Conclusion
- AI disclosure
- References
- Chapter 11. Role of extracellular vesicles in renal cell carcinoma
- Abstract
- 11.1 Introduction
- 11.2 Extracellular vesicles: what’s more to these cell mediators?
- 11.3 Extracellular vesicles biogenesis and secretion
- 11.4 Extracellular vesicles in renal cell carcinoma
- 11.5 Immune evasion
- 11.6 Tumorigenesis
- 11.7 Tumor metastasis
- 11.8 Drug resistance
- 11.9 Biomarkers for renal cell carcinoma derived from extracellular vesicles
- 11.10 Conclusion
- References
- Chapter 12. Exosomes in prostate cancer: clinical and molecular perspectives
- Abstract
- 12.1 Introduction
- 12.2 Etiology
- 12.3 Epidemiology
- 12.4 Structure and functions
- 12.5 Exosomes’ potential in diagnosis and management
- 12.6 Exosomal profiling
- 12.7 Exosomal drug delivery
- 12.8 Exosome engineering for cancer metastasis
- 12.9 Mechanism attributing to prostate cancer
- 12.10 Additional insight into the pathways of prostate cancer development
- 12.11 Treatment
- 12.12 Androgen receptor’s role in prostate cancer
- 12.13 Conclusion and future directions
- Abbreviations
- References
- Chapter 13. The role of extracellular vesicles in urological malignancies
- Abstract
- 13.1 Introduction
- 13.2 Biogenesis of extracellular vesicles
- 13.3 Prostate cancer
- 13.4 Role of extracellular vesicles in prostate cancer
- 13.5 Bladder cancer
- 13.6 Diagnostic potential of extracellular vesicles
- 13.7 Role of extracellular vesicles in bladder cancer
- 13.8 Kidney cancer
- 13.9 Diagnostic potential of extracellular vesicles
- 13.10 Role of extracellular vesicles in kidney cancer
- 13.11 Conclusion
- References
- Chapter 14. Current epigenetics and advancement of exosomal biomarkers in biliary tract cancer
- Abstract
- 14.1 Biliary tract cancer
- 14.2 Epigenetic modification
- 14.3 Exosomes
- 14.4 Conclusion and future perspective
- References
- Index
- Edition: 1
- Published: December 1, 2024
- Imprint: Academic Press
- No. of pages: 350
- Language: English
- Paperback ISBN: 9780323952583
- eBook ISBN: 9780323952590
AS
Anand Narayan Singh
Dr. Anand Narayan Singh, Professor and Head, Department of Biochemistry, GSVM Medical College, Kanpur U.P.INDIA . He completed M.Sc. from Bundelkhand University, Jhansi U.P.. He pursued PhD degree from King George Medical University Lucknow U.P.. During PhD, he also worked on an Indian Council Medical Research(ICMR) project and he had gained experience of various advance and specialized biomarkers of prostate cancer named VEGF and PSA etc. He started his carrier as Lecturer in MLN Medical College, Prayagraj. Later, he joined Department of Biochemistry in GSVM Medical College, Kanpur. He has immense teaching experience over the period of 15 years. In addition to teaching, Dr. Singh also remains immersed in research work: He has several research publications in reputed national and international journals. He has been Principal Investigator in multiple research projects relevant to pesticides and human health; Vitamin D, Oxidative stress and Antioxidant status in Ischemic Stroke Patients. Recently, some projects are also got sanctioned relevant to the biomarkers of breast cancer and Gall bladder cancer from Department of Health Research, Govt of India . Besides these projects, a Text Book of Biochemistry for MBBS Students is also published in the year 2021.
Affiliations and expertise
Associate Professor and Head, Department of Biochemistry, GSVM Medical College, IndiaSN
Seema Nayak
Dr Seema Nayak has been a Scientist of Molecular Biology and Immunology at Medanta Hospital, Lucknow since 2019. She received the women scientist fellowship from ICMR HRD-DHR in 2015. She also worked as a Research Officer in the Department of Pathology at King George’s Medical University, Lucknow. She has vast experience in oncology research, biomarkers, advanced Genetics, epigenetics, and molecular and biochemical techniques. Her PhD work was focused on biomarker research in oncology. Her post-doctoral work was on Genomics in Cancer Biomarkers. She has contributed high impact publications in PLOsOne, Oral Oncology journals and in cancer biomarkers and oncology. She is a member of several national and international academic organizations and a reviewer in various international peer reviewed journals. She has been actively involved in cancer diagnostics since 2007. She was the pioneer in starting Cancer biomarker diagnostics based on Immunohistochemistry in India.
Affiliations and expertise
Scientist of Molecular Biology and Immunology, Department of Pathology and Laboratory Medicine, Medanta Hospital, Lucknow, Uttar Pradesh, IndiaRR
Rashmi Rana
Dr. Rashmi Rana has received her PhD in Biochemistry from National Institute of Pathology, ICMR affiliated to GGSIP University, where she developed new mass spectrometry methods for analyzing phthalates in semen. She did her post-doc at All India Institute of Medical Sciences on Evaluation of antibiotic side effects. Currently she works as consultant in the department of Research at Sir Ganga Ram Hospital, New Delhi. She received Young Scientist Award in Proteomics Conference held at Dubai, UAE. She was selected for Foundations of Clinical Research (FCR) 2022 run by Harvard University, USA. She is a Principal Investigator in four research projects related to dengue exosomal proteomics, role exosomes in glioma biology, theragnostic exosomes in glioma and transcriptomics analysis of pulmonary hypertension patients. Her main research interest is to quantitatively identify the protein signatures involved in human diseases including various cancers with state-of-the-art and highly sensitive mass spectrometry-based proteomic approaches. Presently she works on identification of protein-based biomarkers for early diagnosis / post-treatment surveillance and therapeutics of brain tumor (Glioma) and biliary tract cancer.
Affiliations and expertise
Old Rajinder Nagar, New Rajinder Nagar, New Delhi, Delhi, IndiaRead Advances in Cancer Biomarkers Research on ScienceDirect