Caspases as Molecular Targets for Cancer Therapy
- 1st Edition - August 10, 2024
- Imprint: Academic Press
- Editor: Ankur Vaidya
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 6 4 4 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 6 4 5 - 8
Caspases as Molecular Targets for Cancer Therapy discusses the recent developments on targeted therapies for cancer using caspases. It describes the selection of specific caspases… Read more
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Request a sales quoteCaspases as Molecular Targets for Cancer Therapy discusses the recent developments on targeted therapies for cancer using caspases. It describes the selection of specific caspases for cancer therapy with the current standard of care and highlights numerous assay techniques for caspase activities.
This book discusses topics such as mutations within apoptosis gene, inflammatory caspases, tumor suppression, and the different caspase types and their role in anticancer activity. In addition, it discusses caspase activity assay procedure and future perspectives.
It is a valuable resource for researchers, students, and members of biomedical and medical fields who want to learn more about novel anticancer targeted therapies.
- Discusses thoroughly caspases, their mechanism of action, and mutations responsible for the development of cancer.
- Presents updated literature of synthetic compounds for the development of caspase-mediated new anticancer drugs.
- Encompasses comprehensive compilation of recently introduced anticancer drugs in the market, the health outcomes, and pharmacoeconomics.
Graduate students and researchers in cancer research, oncologists, clinicians
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- About the editor
- Preface
- Chapter 1. Introduction to caspases, its function, mechanism, and classification
- 1. Introduction
- 2. Caspases
- 3. Conclusions
- Chapter 2. Mutations within apoptosis gene and caspases
- 1. Introduction
- 2. Understanding apoptosis genes
- 3. Caspases: The executioners of apoptosis
- 4. Diseases associated with apoptosis gene and caspase mutations
- 5. Clinical implications and therapeutic opportunities
- 6. Conclusion and future perspectives
- Chapter 3. Inflammatory caspase-1, -4, and -5 and their role in anticancer activity
- 1. Introduction
- 2. Synthetic caspase inhibitors
- Chapter 4. Caspase-2 and tumor suppression
- 1. Introduction
- 2. Anticancer connection of caspase-2
- 3. Structural features of caspase-2 regarding its activation and processing
- 4. RAIDD- and RIP1-mediated initiation of caspase-2 independently of PIDD
- 5. PIDD-mediated initiation of caspase-2
- 6. Roles of caspase-2 in DNA damage and cellular stress
- 7. Synthetic caspase inhibitors
- 8. Peptide-based inhibitors
- 9. Nonpeptidic compounds
- 10. Summary and conclusion
- Chapter 5. Caspase-3: A promising target for anticancer agents
- 1. Introduction
- 2. Caspase-3 and apoptotic pathway
- 3. The impact of caspase-3 on apoptosis
- 4. Activators of caspase-3
- 5. Conclusion
- Chapter 6. Caspase 7 mutations and their activators
- 1. Introduction
- 2. Functional consequences of caspase-7 mutation
- 3. Activators of caspase-7
- 4. Clinical relevance and potential therapeutic strategies
- 5. Conclusion
- Chapter 7. Reinstating the expression and activation of caspase-8 and caspase-10 in cancer therapy
- 1. Introduction
- 2. Pharmacology of caspase-8
- 3. Caspase-8 overexpression induces cell death
- 4. Overview of apoptosis and its dysregulation in cancer
- 5. Dysregulation in diseases
- 6. Significance of caspase-8 and caspase-10 dysregulation in cancer progression
- 7. Molecular mechanisms of caspase-8 and caspase-10 dysregulation in cancer
- 8. Therapeutic strategies to restore caspase-8 and caspase-10 function
- 9. Small molecule activators of caspase-8 and caspase-10
- 10. Conclusion
- Chapter 8. Caspase-9 gene mutation and its activators
- 1. Introduction
- 2. Molecular basis of caspase-9
- 3. Genetic mutations in caspase-9
- 4. Diseases associated with caspase-9 mutations
- 5. Activators of caspase-9
- 6. Therapeutic implications and future directions
- 7. Conclusion
- Chapter 9. Caspases activity assay procedures
- 1. Introduction
- 2. Caspase activation pathways
- 3. Types of caspase activity assay
- 4. Selection of caspase substrates
- 5. Experimental setup
- 6. Protocols for caspase activity assays
- 7. Data analysis and interpretation
- 8. Applications
- 9. Conclusion
- Chapter 10. Current and future prospective of caspases targeting in cancer therapy
- 1. Introduction
- 2. Exploring caspase targeting in cancer therapy as a therapeutic approach
- 3. Current caspase targeting modalities: From bench to the clinic
- 4. Conclusion and prospects
- Index
- Edition: 1
- Published: August 10, 2024
- No. of pages (Paperback): 264
- No. of pages (eBook): 300
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443156441
- eBook ISBN: 9780443156458
AV
Ankur Vaidya
Dr. Ankur Vaidya obtained his PhD from Dr. H.S. Gour University, when he researched design, synthesis, and screening of a few quinoline and oxadiazole derivatives for anticancer activities. He has 12 years of experience in teaching and research, and already supervised 18 PhD students. He wrote 5 book chapters and co-authored 2 books, including Nanotechnology Applications for Cancer Chemotherapy (Elsevier, 2020).
Affiliations and expertise
Assistant Professor, Pharmacy College, Uttar Pradesh University of Medical Sciences, IndiaRead Caspases as Molecular Targets for Cancer Therapy on ScienceDirect