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Books in Medicinal chemistry

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41-50 of 110 results in All results

Progress in Medicinal Chemistry

  • 1st Edition
  • Volume 55
  • February 1, 2016
  • G. Lawton + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 6 3 7 1 5 - 4
  • eBook
    9 7 8 - 0 - 4 4 4 - 6 3 7 4 2 - 0
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development.

Drug-Like Properties

  • 2nd Edition
  • December 17, 2015
  • Li Di + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 1 0 7 6 - 1
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 1 3 2 2 - 9
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

Advances in Clinical Chemistry

  • 1st Edition
  • Volume 72
  • October 12, 2015
  • Gregory S. Makowski
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 3 3 1 4 - 2
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 3 3 1 5 - 9
Advances in Clinical Chemistry, Volume 72, the latest installment in this internationally acclaimed series contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Advances in Clinical Chemistry

  • 1st Edition
  • Volume 71
  • September 24, 2015
  • Gregory S. Makowski
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 2 2 5 6 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 2 5 2 2 - 2
Advances in Clinical Chemistry, Volume 71, is the latest installment in this internationally acclaimed series. This latest volume contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

The Practice of Medicinal Chemistry

  • 4th Edition
  • July 1, 2015
  • Camille Georges Wermuth + 3 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 4 1 7 2 0 5 - 0
  • eBook
    9 7 8 - 0 - 1 2 - 4 1 7 2 1 3 - 5
The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery.With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development.

Recent Advances in Medicinal Chemistry, Volume 1

  • 1st Edition
  • June 2, 2015
  • Atta-ur Rahman + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 3 9 6 1 - 8
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 3 9 6 2 - 5
Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more.

Medicinal Chemistry of Anticancer Drugs

  • 2nd Edition
  • April 28, 2015
  • Carmen Avendaño + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 4 - 6 2 6 4 9 - 3
  • eBook
    9 7 8 - 0 - 4 4 4 - 6 2 6 6 7 - 7
Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design.

Progress in Medicinal Chemistry

  • 1st Edition
  • Volume 54
  • January 30, 2015
  • G. Lawton + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 6 3 4 8 0 - 1
  • eBook
    9 7 8 - 0 - 4 4 4 - 6 3 4 8 5 - 6
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a new era for Chagas Disease drug discovery? and imaging in drug development.

Annual Reports in Medicinal Chemistry

  • 1st Edition
  • Volume 49
  • September 24, 2014
  • Manoj C Desai
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 0 1 6 7 - 7
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 0 3 7 2 - 5
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry with an emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies.

Organic Chemistry Concepts and Applications for Medicinal Chemistry

  • 1st Edition
  • April 14, 2014
  • Joseph E. Rice
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 0 7 3 9 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 0 8 3 2 - 4
Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams.