
Recent Advances in Medicinal Chemistry, Volume 1
- 1st Edition - June 2, 2015
- Imprint: Bentham Science Publishers
- Editors: Atta-ur Rahman, Muhammad Iqbal Choudhary, George Perry
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 0 3 9 6 1 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 3 9 6 2 - 5
Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in… Read more

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Request a sales quoteOriginally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more.
- Edited and written by leading experts in medicinal chemistry research
- Reviews recent advances in the field, including the characterization of inorganic nanomaterials as therapeutic vehicles
- Covers a variety of topical areas, such as HPLC and in the analysis of tricyclic antidepressants in biological samples, and tannins and their influence on health
Medicinal Chemistry and Pharma researchers
- Foreword
- Preface
- List of Contributors
- Chapter 1: New Functions of Old Drugs: Aureolic Acid Group of Anti-Cancer Antibiotics and Non-Steroidal Anti-Inflammatory Drugs
- Abstract
- 1 Introduction
- 2 Principal Functions of NSAIDs and Aureolic Acid Anticancer Antibiotics and their Mechanism of Action
- 3 Other Functions of these Drugs and Mechanism of Actions
- 4 Chemical Dissection of the Drugs to Understand Alternate Functions
- 5 Conclusion
- Acknowledgements
- Conflict of Interest
- Disclosure
- Chapter 2: Updated Report on a Novel Mercaptopyruvate Sulfurtransferase Thioredoxin-Dependent Redox-Sensing Molecular Switch: A Mechanism for the Maintenance of Cellular Redox Equilibrium
- Abstract
- Introduction
- A Redox-Sensing Molecular Switch Formed via an Intermolecular Disulfide Bond
- Low Redox Potential Sulfenate Formation At A Catalytic Site Cysteine: Another Mechanism By Which Mst Serves As An Anti-Oxidant Protein
- Conclusions
- Acknowledgements
- Conflict Of Interest
- Disclosure
- Chapter 3: Characterization of Inorganic Nanomaterials as Therapeutic Vehicles
- Abstract
- Introduction
- Concluding Remarks
- Acknowledgements
- Conflict of Interest
- Disclosure
- Chapter 4: Aromatase Inhibitors: A New Reality for the Adjuvant Endocrine Treatment of Early-Stage Breast Cancer in Postmenopausal Women
- Abstract
- Introduction
- Conclusions
- Acknowledgements
- Conflict of Interest
- Disclosure
- Chapter 5: Bacterial FabH: Towards the Discovery of New Broad-Spectrum Antibiotics
- Abstract
- Introduction
- Bacterial Type II FAS the Biological Process
- FabH as a Drug Target Differences and Advantages
- Three Dimensional Structure of FabH
- Substrate Binding and Specificity
- Catalytic Mechanism and Substrate Binding
- Molecular Modeling Studies of FabH
- Concluding Remarks
- Acknowledgements
- Conflict of Interest
- Disclosure
- Chapter 6: Tannins and their Influence on Health
- Abstract
- 1 Introduction
- 2 Classification of Tannins
- 3 Absorption and Metabolism of Tannins
- 4 Biological Activity
- 5 Human Intervention Studies
- 6 Adverse and Undesirable Effects
- 7 Conclusions
- Acknowledgements
- Conflict of Interest
- Disclosure
- Abbreviations
- Chapter 7: Rho-GTPases and Statins: A Potential Target and a Potential Therapeutic Tool Against Tumors?
- Abstract
- Introduction
- Role of RhoA in Normal and Tumor Cells
- Statins Inhibit RhoA Activity
- Statins and Tumor Growth/Apoptosis
- Statins and Angiogenesis
- Statins and Metastasis
- Statins, Chemotherapy Efficacy and Multidrug Resistance
- Statins and Chemoprevention of Tumors
- Statins in Cancer Treatment
- Acknowledgements
- Conflict of Interest
- Disclosure
- Chapter 8: Carotenoids that are Involved in Prostate Cancer Risk
- Abstract
- Introduction
- Types of Carotenoids and their Distribution in Diets
- Conclusions
- Acknowledgements
- Conflict of Interest
- Disclosure
- Chapter 9: Preclinical Studies of Saponins for Tumor Therapy
- Abstract
- Diverse Structures and Functions of Saponins
- Saponins as Anti-Cancer Agents
- Dioscins
- Saikosaponins
- Julibrosides
- Soy Saponins
- Ginseng Saponins
- Avicins
- Knowledge, Gaps and Future
- Combinations of Saponins and Other Anti-Cancer Agents
- Conclusions
- Acknowledgements
- Conflict of Interest
- Disclosure
- Abbreviations
- Chapter 10: Pharmacological Neuroprotection for Acute Spinal Cord Injury
- Abstract
- 1 Introduction
- 2 Epidemiology
- 3 Pathophysiology
- 4 Search Criteria
- 5 Current Treatment of Acute Spinal Cord Injuries
- 6 Promising Future Pharmacological Therapies
- Conclusions
- Acknowledgements
- Conflict of Interest
- Disclosure
- Chapter 11: HPLC and its Essential Role in the Analysis of Tricyclic Antidepressants in Biological Samples
- Abstract
- 1 Introduction
- 2 Chemistry and Activity
- 3 Analytical Methods
- 4 Conclusions
- Acknowledgements
- Conflict of Interest
- Disclosure
- Abbreviations
- Chapter 12: Gene Expression Profiles in Breast Cancer to Identify Estrogen Receptor Target Genes
- Abstract
- Introduction
- Estrogen Receptors
- Mechanisms of ER Action
- Global Gene Expression Profiling of ER Action
- Future Considerations
- Acknowledgements
- Conflict of Interest
- Disclosure
- Chapter 13: Trans-Plasma Membrane Electron Transport in Human Blood Platelets: An Update
- Abstract
- Plasma Membrane Redox System
- Medicinal Effects on Platelet PMR System
- Acknowledgements
- Conflict of Interest
- Abbreviations
- Chapter 14: Role of Intermediate States in Protein Folding and Misfolding
- Abstract
- Introduction
- Acknowledgements
- Conflict of Interest
- Disclosure
- Index
- Edition: 1
- Published: June 2, 2015
- Imprint: Bentham Science Publishers
- No. of pages: 486
- Language: English
- Paperback ISBN: 9780128039618
- eBook ISBN: 9780128039625
AR
Atta-ur Rahman
MC
Muhammad Iqbal Choudhary
GP