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    • Advances in Immunology

      • 1st Edition
      • Volume 133
      • February 15, 2017
      • English
      • Hardback
        9 7 8 0 1 2 8 1 2 4 0 9 3
      • eBook
        9 7 8 0 1 2 8 1 2 4 1 0 9
      Advances in Immunology, Volume 133, the latest release in this long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

    • Arthropod Vector: Controller of Disease Transmission, Volume 1

      • 1st Edition
      • April 25, 2017
      • Stephen K. Wikel + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 0 5 3 5 0 8
      • eBook
        9 7 8 0 1 2 8 0 9 2 3 7 8
      Arthropod Vector: Controller of Disease Transmission, Volume 1: Vector Microbiome and Innate Immunity of Arthropods is built on topics initially raised at a related Keystone Symposium on Arthropod Vectors. Together with the separate, related Volume 2: Vector Saliva-Host Pathogen Interactions, this work presents a logical sequence of topic development that leads to regulatory considerations for advancing these and related concepts for developing novel control measures. The three themes of symbionts, vector immune defenses and arthropod saliva modulation of the host environment are central to the concept of determinants of vector competence that involves all aspects of vector-borne pathogen development within the arthropod that culminates in the successful transmission to the vertebrate host. These three areas are characterized at the present time by rapid achievement of significant, incremental insights, which advances our understanding for a wide variety of arthropod vector species, and this work is the first to extensively integrate these themes.

    • Morphological Mouse Phenotyping

      • 1st Edition
      • January 26, 2017
      • Jesus Ruberte + 2 more
      • English
      • Hardback
        9 7 8 0 1 2 8 1 2 9 7 2 2
      • Paperback
        9 7 8 0 1 2 8 1 2 8 0 5 3
      • eBook
        9 7 8 0 1 2 8 1 2 8 7 7 0
      Morphological Mouse Phenotyping: Anatomy, Histology and Imaging is an atlas of explanatory diagrams and text that guides the reader through normal mouse anatomy, histology, and imaging. The book is targeted for mouse researchers and veterinarian and human pathologists, and presents a complete, integrative description of normal mouse morphology. Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypotheses has encouraged the development of massive global projects, making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans; however, a mouse is not a man.

    • Mycotoxins in Foodstuffs — 3

      • 1st Edition
      • April 7, 2017
      • M. Jemmali
      • English
      • Hardback
        9 7 8 0 0 8 0 2 1 1 9 4 7
      • Paperback
        9 7 8 1 4 8 3 1 2 5 3 8 1
      • eBook
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      Mycotoxins in Foodstuffs—3 is a collection of invited lectures presented at the International Union of Pure and Applied Chemistry's Third International Symposium on Mycotoxins in Foodstuffs, held in Paris, France, on September 16-18, 1976. The papers explore the health hazards posed by mycotoxins found in foodstuffs, including aflatoxins and trichothecenes, as well as ways of addressing the problem. This book is comprised of 11 chapters and begins with a discussion on how to design a program for monitoring problem foods and surveying potential problem foods for a number of mycotoxins. The next chapter describes a methodology for the design and evaluation of testing programs to estimate aflatoxin concentrations in granular foodstuffs. The action taken by various countries regarding mycotoxins in foodstuffs (food and feed), under legislative provision or code of practice, is then examined. Subsequent chapters deal with the metabolism of aflatoxin and other mycotoxins in relation to their toxicity and the accumulation of residues in animal tissues; mode of action of trichothecenes; and mode of action and human health aspects of aflatoxin carcinogenesis. The human health hazards associated with mycotoxins are also considered, along with prevention, elimination, and detoxification of aflatoxins. This monograph will be a useful resource for chemists, nutritionists, food scientists, and toxicologists.

    • Carcinogenesis

      • 1st Edition
      • March 31, 2017
      • William Montagna + 1 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 3 3 4 7 5
      • Hardback
        9 7 8 0 0 8 0 1 1 5 7 6 4
      • eBook
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      Advances in Biology of Skin, Volume VII: Carcinogenesis covers proceedings of the 15th Symposium on the Biology of Skin, held at the Oregon Regional Primate Research Center on April 9-11, 1965, under the auspices of the University of Oregon Medical School. This book is composed of nineteen chapters, and begins with the mechanism of tissue homeostasis in adult mammals and the kinetics of epidermal reaction to carcinogenic agents and other skin irritants. The succeeding chapters deal with the growth promoting effects of tumors on tissues, the reaction pattern distinctions between normal and neoplastic epithelium, and some biological implications of chemical carcinogenesis. Considerable chapters are devoted to various carcinogens, including hydrocarbons, viruses, androgens, and estrogens. Other chapters consider the physicochemical mechanisms of acceleration of skin carcinogenesis and experimental observations of environmental carcinogenesis. The mechanisms of skin cancer induction due to ultraviolet radiation, as well as arsenic induced tumors are examined. The concluding chapters describe some forms of skin tumors, such as adnexal tumors and basal cell epithelioma. This book will prove useful to oncologists and researchers in the field of carcinogenesis.

    • Nutrition in the Prevention and Treatment of Disease

      • 4th Edition
      • April 28, 2017
      • Ann M. Coulston + 3 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 9 2 8 2
      • eBook
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      Nutrition in the Prevention and Treatment of Disease, Fourth Edition, is a compilation of current knowledge in clinical nutrition and an overview of the rationale and science base of its application to practice in the prevention and treatment of disease. In its fourth edition, this text continues the tradition of incorporating new discoveries and methods related to this important area of research Generating and analyzing data that summarize dietary intake and its association with disease are valuable tasks in treating disease and developing disease prevention strategies. Well-founded medical nutrition therapies can minimize disease development and related complications. Providing scientifically sound, creative, and effective nutrition interventions is both challenging and rewarding.

    • Functional Neural Transplantation IV

      • 1st Edition
      • Volume 230
      • May 25, 2017
      • English
      • Hardback
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      • eBook
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      Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.

    • Nutrients in Dairy and Their Implications for Health and Disease

      • 1st Edition
      • June 19, 2017
      • Ronald Ross Watson + 2 more
      • English
      • Hardback
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      • eBook
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      Nutrients in Dairy and Their Implications for Health and Disease addresses various dairy products and their impact on health. This comprehensive book is divided into three sections and presents a balanced overview of the health benefits of milk and milk products. Summaries capture the most salient points of each chapter, and the importance of milk and its products as functional foods is addressed throughout.

    • Neurochemical Aspects of Alzheimer's Disease

      • 1st Edition
      • May 25, 2017
      • Akhlaq A. Farooqui
      • English
      • Paperback
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      • eBook
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      Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists... and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders.

    • The Heart in Rheumatic, Autoimmune and Inflammatory Diseases

      • 1st Edition
      • February 10, 2017
      • Udi Nussinovitch
      • English
      • Hardback
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      • eBook
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      The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe.

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