Advances in Immunology
- 1st Edition, Volume 133 - February 15, 2017
- Editor: Frederick Alt
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 1 2 4 0 9 - 3
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 2 4 1 0 - 9
Advances in Immunology, Volume 133, the latest release in this long-established and highly respected publication, presents current developments and comprehensive reviews in immun… Read more
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Request a sales quoteAdvances in Immunology, Volume 133, the latest release in this long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.
- Contains contributions from leading authorities
- Informs and updates on all the latest developments in the field of immunology
- Addresses molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities
Chapter One: Macrophages and Mitochondria: A Critical Interplay Between Metabolism, Signaling, and the Functional Activity
- Abstract
- 1 Introduction
- 2 Mitochondrial Metabolism Governs Macrophage Activation State
- 3 Mitochondrial ROS in Innate Immune Responses
- 4 Mitochondrial-Mediated Antiviral Immunity
- 5 Inflammasome Activation and Mitochondria
- 6 Concluding Remarks
- Acknowledgments
Chapter Two: Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination
- Abstract
- 1 Antibody Diversification During the Humoral Response
- 2 Molecular Mechanisms of SHM and CSR
- 3 DNA Deamination at the Igs
- 4 AID Initiates a DNA Repair Cascade
- 5 Postdeamination Roles of AID?
- 6 Perspectives
- Acknowledgments
Chapter Three: Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5
- Abstract
- 1 Background
- 2 Lessons From CIITA
- 3 NLRC5 and Its Role in Regulating MHC Class I Levels
- 4 NLRC5 and Its Emerging Roles in Health and Disease
- 5 Concluding Remarks
- Acknowledgments
Chapter Four: Nucleic Acid Immunity
- Abstract
- 1 Introduction
- 2 Principles of Nucleic Acid Immunity in Different Species
- 3 Historic Overview of Different Fields Merging Into Nucleic Acid Immunity
- 4 Functional Components of Nucleic Acid Immunity
- 5 Innate and Adaptive Components in Nucleic Acid Immunity
- 6 Innate and Adaptive Nucleic Acid Immunity in Prokaryotes
- 7 Receptors and Nucleases Not Involving Classical Immune Functions
- 8 RNA Interference
- 9 Immune-Sensing Receptors
- 10 Conclusions
- Acknowledgments
Chapter Five: About Training and Memory: NK-Cell Adaptation to Viral Infections
- Abstract
- 1 Introduction
- 2 NK-Cell Adaptations to Viral Infections
- 3 Functional Imprinting of Adaptive NK Cells
- 4 Epigenetic Remodeling as Hallmark of Immune Training and Memory
- 5 Training and Cross-Reactive Memory: Consequences for Heterologous Immunity
- 6 Outlook and Outstanding Questions
- Acknowledgments
- No. of pages: 242
- Language: English
- Edition: 1
- Volume: 133
- Published: February 15, 2017
- Imprint: Academic Press
- Hardback ISBN: 9780128124093
- eBook ISBN: 9780128124109
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