Advances in Immunology

Chapter One: Macrophages and Mitochondria: A Critical Interplay Between Metabolism, Signaling, and the Functional Activity

• Abstract
• 1 Introduction
• 2 Mitochondrial Metabolism Governs Macrophage Activation State
• 3 Mitochondrial ROS in Innate Immune Responses
• 4 Mitochondrial-Mediated Antiviral Immunity
• 5 Inflammasome Activation and Mitochondria
• 6 Concluding Remarks
• Acknowledgments

Chapter Two: Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination

• Abstract
• 1 Antibody Diversification During the Humoral Response
• 2 Molecular Mechanisms of SHM and CSR
• 3 DNA Deamination at the Igs
• 4 AID Initiates a DNA Repair Cascade
• 5 Postdeamination Roles of AID?
• 6 Perspectives
• Acknowledgments

Chapter Three: Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5

• Abstract
• 1 Background
• 2 Lessons From CIITA
• 3 NLRC5 and Its Role in Regulating MHC Class I Levels
• 4 NLRC5 and Its Emerging Roles in Health and Disease
• 5 Concluding Remarks
• Acknowledgments

Chapter Four: Nucleic Acid Immunity

• Abstract
• 1 Introduction
• 2 Principles of Nucleic Acid Immunity in Different Species
• 3 Historic Overview of Different Fields Merging Into Nucleic Acid Immunity
• 4 Functional Components of Nucleic Acid Immunity
• 5 Innate and Adaptive Components in Nucleic Acid Immunity
• 6 Innate and Adaptive Nucleic Acid Immunity in Prokaryotes
• 7 Receptors and Nucleases Not Involving Classical Immune Functions
• 8 RNA Interference
• 9 Immune-Sensing Receptors
• 10 Conclusions
• Acknowledgments

Chapter Five: About Training and Memory: NK-Cell Adaptation to Viral Infections

• Abstract
• 1 Introduction
• 2 NK-Cell Adaptations to Viral Infections
• 3 Functional Imprinting of Adaptive NK Cells
• 4 Epigenetic Remodeling as Hallmark of Immune Training and Memory
• 5 Training and Cross-Reactive Memory: Consequences for Heterologous Immunity
• 6 Outlook and Outstanding Questions
• Acknowledgments