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    • Overcoming Ovarian Cancer Chemoresistance

      • 1st Edition
      • Volume 11
      • November 6, 2020
      • Goli Samimi + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 1 9 8 4 0 7
      • eBook
        9 7 8 0 1 2 8 1 9 8 4 1 4
      Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer.

    • A Laboratory Guide to the Tight Junction

      • 1st Edition
      • April 24, 2020
      • Jianghui Hou
      • English
      • Paperback
        9 7 8 0 1 2 8 1 8 6 4 7 3
      • eBook
        9 7 8 0 1 2 8 2 2 6 4 3 8
      A Laboratory Guide to the Tight Junction offers broad coverage of the unique methods required to investigate its characteristics. The methods are described in detail, including its biochemical and biophysical principles, step-by-step process, data analysis, troubleshooting, and optimization. The coverage includes various cell, tissue, and animal models. Chapter 1 provides the foundations of cell biology of tight junction. Chapter 2 covers the Biochemical approaches for paracellular channels and is followed by chapter 3 providing the Biophysical approaches. Chapter 4 describes and discusses Histological approaches for tissue fixation and preparation. Chapter 5 discusses Light microscopy, while chapter 6 presents Electron microscopic approaches. Chapter 7 covers Transgenic manipulation in cell cultures, including DNA and siRNA, Mutagenesis, and viral infection. Chapter 8 covers transgenic manipulation in mice, including: Knockout, Knockin, siRNA knockdown, GFP/LacZ reporter, and overexpression. The final chapter discusses the future developments of new approaches for tight junction research. Researchers and advanced students in bioscience working on topics of cell junction, ion channel and membrane protein will benefit from the described methods. Clinicians and pathologists interested in tissue barrier diseases will also benefit from the biochemical and biophysical characterization of tight junctions in organ systems, and their connection to human diseases.

    • Genetically Modified Plants

      • 2nd Edition
      • September 21, 2020
      • Roger Hull + 2 more
      • English
      • Hardback
        9 7 8 0 1 2 8 1 8 5 6 4 3
      • eBook
        9 7 8 0 1 2 8 2 2 6 4 8 3
      Genetically Modified Plants, Second Edition, provides an updated roadmap and science-based methodology for assessing the safety of genetic modification technologies, as well as risk assessment approaches from regulators across different agroecosystems. This new edition also includes expanded coverage of technologies used in plant improvement, such as RNA-dependent DNA methylation, reverse breeding, agroinfiltration, and gene-editing technologies such as CRISPR and TALENS. This book is an essential resource for anyone interested in crop improvement, including students and researchers, practitioners in regulatory agencies, and policymakers involved in plant biotechnology risk assessment.

    • Food Safety and Quality Systems in Developing Countries

      • 1st Edition
      • April 15, 2020
      • André Gordon
      • English
      • Hardback
        9 7 8 0 1 2 8 1 4 2 7 2 1
      • eBook
        9 7 8 0 1 2 8 1 4 2 7 3 8
      Food Safety and Quality Systems in Developing Countries: Volume III: Technical and Market Considerations is a practical resource for companies seeking to supply food products from developing countries to developed country markets or to transnational business located in developing countries. It explores practical approaches to complying with food safety and quality systems requirements, backed by the science-based approaches used in the major markets applied in a developing country context. It explores the topic from the perspective of agribusiness value chains and includes deconstructions of regulatory and market channel-specific technical requirements in North America, Europe, and other major markets. Volume III builds on the platforms laid by the previous two volumes, providing guidance from industry-leading experts on addressing regulatory and market-specific microbiological, chemical, packaging and labelling, supply chain, and systems-related food safety and quality compliance requirements. This book addresses technical and market-determined standards that value chain participants in developing countries face supplying developed country markets or transnational firms, including hotels, major multiples, and quick serve restaurant brands.

    • Preparation of Phytopharmaceuticals for the Management of Disorders

      • 1st Edition
      • November 3, 2020
      • Chukwuebuka Egbuna + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 0 2 8 4 5
      • eBook
        9 7 8 0 1 2 8 2 0 2 8 5 2
      Preparation of Phytopharmaceuticals for the Management of Disorders: The Development of Nutraceuticals and Traditional Medicine presents comprehensive coverage and recent advances surrounding phytopharmaceuticals... nutraceuticals and traditional and alternative systems of medicines. Sections cover the concepts of phytopharmaceuticals... their history, and current highlights in phytomedicine. Also included are classifications of crude drugs, herbal remedies and toxicity, traditional and alternative systems of medicine, nanotechnology applications, and herbal cosmeticology. Final sections cover applications of microbiology and biotechnology in drug discovery. This book provides key information for everyone interested in drug discovery, including medicinal chemists, nutritionists, biochemists, toxicologists, drug developers and health care professionals. Students, professors and researchers working in the area of pharmaceutical sciences and beyond will also find the book useful.

    • Vertebrate Endocrinology

      • 6th Edition
      • October 10, 2020
      • David O. Norris + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 2 0 0 9 3 3
      • eBook
        9 7 8 0 1 2 8 2 0 0 9 4 0
      Vertebrate Endocrinology, Sixth Edition, provides a comprehensive, up-to-date treatment of the endocrine system for college and university students as well as researchers. This book is logically arranged, easily comprehended, and well-illustrated. It covers traditional hormone-based systems and introduces all forms of chemical communication, their implications for the health of humans, domesticated, and wild vertebrates. Written by two experts who have completed extensive research in comparative vertebrate endocrinology with an emphasis on natural and anthropogenic environmental factors influencing endocrine systems. Collectively, the authors have taught courses in endocrinology at the undergraduate and graduate level for more than 60 years. After first publishing in 1985, Vertebrate Endocrinology, Sixth Edition, continues to serve as an important resource for graduate students and advanced undergraduates in the biological sciences, animal sciences, and veterinary sciences. Endocrine researchers will also benefit from the book’s relevance in the areas of comparative, veterinary, and mammalian endocrinology.

    • Salt, Fat and Sugar Reduction

      • 1st Edition
      • March 10, 2020
      • Maurice O'Sullivan
      • English
      • Paperback
        9 7 8 0 1 2 8 1 9 7 4 1 7
      • eBook
        9 7 8 0 1 2 8 2 2 6 1 2 4
      Salt, Fat and Sugar Reduction: Sensory Approaches for Nutritional Reformulation of Foods and Beverages explores salt, sugar, fat and the current scientific findings that link them to diseases. The sensory techniques that can be used for developing consumer appealing nutritional optimized products are also discussed, as are other aspects of shelf life and physicochemical analysis, consumer awareness of the negative nutritional impact of these ingredients, and taxes and other factors that are drivers for nutritional optimization. This book is ideal for undergraduate and postgraduate students and academics, food scientists, food and nutrition researchers, and those in the food and beverage industries.

    • Neuronal Chloride Transporters in Health and Disease

      • 1st Edition
      • June 19, 2020
      • Xin Tang
      • English
      • Paperback
        9 7 8 0 1 2 8 1 5 3 1 8 5
      • eBook
        9 7 8 0 1 2 8 1 5 3 1 9 2
      In the past several years, there has been an exciting body of new research that links impairments in the expression or function of neuronal chloride transporters to a growing number of diseases spanning from autism to brain aging. This book introduces the core concepts and highlights the recent advances in understanding the physiology and pathophysiology of the KCC and NKCC families of neuronal chloride transporters. Neuronal chloride transporter biology is reviewed, including roles in setting the transmembrane chloride gradient and the chloride transport-independen... functions, such as regulating excitatory neurotransmission. Chapters are also dedicated to addressing the structure, post-translational modification, membrane trafficking, and protein interaction partners of neuronal chloride transporters, as well as the genetic and environmental factors that regulate their expression in neurons and the novel therapeutic approaches that target neuronal chloride transporters to treat neurological diseases. This new volume will provide readers with an up-to-date summary of the recent advances in neuronal chloride transporter research, with particular emphasis on some of the key emerging topics in the field.

    • Comprehensive Foodomics

      • 1st Edition
      • November 8, 2020
      • Alejandro Cifuentes
      • English
      • Hardback
        9 7 8 0 1 2 8 1 6 3 9 6 2
      • Hardback
        9 7 8 0 1 2 8 1 6 3 9 5 5
      Comprehensive Foodomics, Three Volume Set offers a definitive collection of over 150 articles that provide researchers with innovative answers to crucial questions relating to food quality, safety and its vital and complex links to our health. Topics covered include transcriptomics, proteomics, metabolomics, genomics, green foodomics, epigenetics and noncoding RNA, food safety, food bioactivity and health, food quality and traceability, data treatment and systems biology. Logically structured into 10 focused sections, each article is authored by world leading scientists who cover the whole breadth of Omics and related technologies, including the latest advances and applications. By bringing all this information together in an easily navigable reference, food scientists and nutritionists in both academia and industry will find it the perfect, modern day compendium for frequent reference. List of sections and Section Editors: Genomics - Olivia McAuliffe, Dept of Food Biosciences, Moorepark, Fermoy, Co. Cork, Ireland Epigenetics & Noncoding RNA - Juan Cui, Department of Computer Science & Engineering, University of Nebraska-Lincoln, Lincoln, NE Transcriptomics - Robert Henry, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St Lucia, Australia Proteomics - Jens Brockmeyer, Institute of Biochemistry and Technical Biochemistry, University Stuttgart, Germany Metabolomics - Philippe Schmitt-Kopplin, Research Unit Analytical BioGeoChemistry, Neuherberg, Germany Omics data treatment, System Biology and Foodomics - Carlos Leon Canseco, Visiting Professor, Biomedical Engineering, Universidad Carlos III de Madrid Green Foodomics - Elena Ibanez, Foodomics Lab, CIAL, CSIC, Madrid, Spain Food safety and Foodomics - Djuro Josić, Professor Medicine (Research) Warren Alpert Medical School, Brown University, Providence, RI, USA & Sandra Kraljević Pavelić, University of Rijeka, Department of Biotechnology, Rijeka, Croatia Food Quality, Traceability and Foodomics - Daniel Cozzolino, Centre for Nutrition and Food Sciences, The University of Queensland, Queensland, Australia Food Bioactivity, Health and Foodomics - Miguel Herrero, Department of Bioactivity and Food Analysis, Foodomics Lab, CIAL, CSIC, Madrid, Spain

    • Neurophysiology in Neurosurgery

      • 2nd Edition
      • March 20, 2020
      • Vedran Deletis + 3 more
      • English
      • Hardback
        9 7 8 0 1 2 8 1 5 0 0 0 9
      • eBook
        9 7 8 0 1 2 8 1 5 0 0 1 6
      Over the last 18 years, there have been many advances in the field of intraoperative monitoring. This new edition of Neurophysiology in Neurosurgery: A Modern Approach provides updates on the original techniques, as well as other more recent methodologies that may either prove beneficial or are commonly used in neuromonitoring. The purpose of this book is to describe the integration of neuromonitoring with surgical procedures. Each methodology is discussed in detail as well as chapters describing how those methodologies are applied to multiple surgical procedures and the evidence used to support those uses. The second edition features a surgical procedure section, which focuses on specific surgical procedures and the type of monitoring used during these procedures. The original chapters have been updated, expanded, and the structure modified to ensure the book is beneficial to both physiologists and surgeons. This book is written for neurosurgeons, neurophysiologists, neurologists, anesthesiologists, interventional neuroradiologists, orthopedic surgeons, and plastic surgeons.

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