Autism
- 1st Edition, Volume 173 - July 23, 2020
- Imprint: Academic Press
- Editors: Mirolyuba Ilieva, Wai Lau
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 2 4 2 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 2 4 3 - 1
Autism, Volume 173 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide vari… Read more
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Request a sales quoteAutism, Volume 173 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. Chapters in this new release include updates on atypical brain development in autism spectrum disorder, predicting early diagnosis of autism spectrum disorder using neural and behavioral measures, the roles of the endocannabinoid system in autism spectrum disorder, the neurobiology of sensory processing in autism spectrum disorder, the effects of oxytocin administration on individuals with ASD, resting-state abnormalities of posterior cingulate in autism spectrum disorder, and more.
- Includes comprehensive coverage of molecular biology
- Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided
- Contains contributions from renowned experts in the field
Scientists working actively in a field, including those at levels ranging from graduate student to senior investigator. New investigators to a field who wish to familiarize themselves with the latest work
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: The putative etiology and prevention of autism
- Abstract
- 1: Background
- 2: Glia
- 3: Astrocytes and microglia (CNS)
- 4: Oligodendrocytes (CNS)
- 5: Schwann cells (PNS)
- 6: Myelination and IGF-1
- 7: Autism etiology
- 8: Connectivity
- 9: Polymorphism and biomarkers
- 10: Autism prevention
- 11: Challenge
- Acknowledgments
- Chapter Two: Role of environmental factors and epigenetics in autism spectrum disorders
- Abstract
- 1: Context: Genetics yes, but not only
- 2: Environmental factors
- 3: Environmental animal models for ASD
- 4: Epigenetics mechanisms: The examples of valproate and folate
- 5: Conclusion
- Chapter Three: Genomics, transcriptomics, proteomics and big data analysis in the discovery of new diagnostic markers and targets for therapy development
- Abstract
- 1: Introduction
- 2: Omics and big data studies of autism spectrum disorder
- 3: Conclusions and future directions in the biomarker and therapy discovery based on -omics and big data analysis
- Chapter Four: Autism spectrum disorder risk prediction: A systematic review of behavioral and neural investigations
- Abstract
- 1: Introduction
- 2: Methods
- 3: Results
- 4: Discussion
- Chapter Five: Resting-state abnormalities of posterior cingulate in autism spectrum disorder
- Abstract
- 1: Anatomy of the PCC
- 2: Structural connectivity of the PCC
- 3: Resting state fMRI: Intrinsic connectivity networks
- 4: The PCC as the central hub in DMN
- 5: ASD
- 6: Local resting state abnormality of the PCC in ASD
- 7: Long-range resting state abnormality of the PCC in ASD
- 8: Importance of local underconnectivity of the dorsal PCC in ASD
- 9: Importance of the PCC-MPFC hypoconnectivity in ASD
- 10: Future directions
- Chapter Six: Neurobiology of sensory processing in autism spectrum disorder
- Abstract
- 1: Introduction
- 2: Atypical sensory processing in ASD
- 3: Vestibular system
- 4: Somatosensory system
- 5: Visual system
- 6: Auditory system
- 7: Olfactory and gustatory systems
- 8: Neuroplasticity and sensory integration
- 9: Conclusion
- Acknowledgment
- Chapter Seven: The role of the endocannabinoid system in autism spectrum disorders: Evidence from mouse studies
- Abstract
- 1: Animal models of autism spectrum disorder (ASD)
- 2: Understanding the etiopathology of ASD: The role of the endocannabinoid system
- 3: Alterations of ECS in animal models of ASD: Toward novel therapeutic approaches
- 4: ASD-like phenotypes induced by manipulations of the ECS: Relevance for designing animal models of ASD
- 5: Conclusions and perspectives
- Chapter Eight: The effects of oxytocin administration on individuals with ASD: Neuroimaging and behavioral evidence
- Abstract
- 1: Introduction
- 2: Oxytocin
- 3: Oxytocin and ASD
- 4: Oxytocin administration in individuals with ASD
- 5: Discussion
- 6: Conclusions
- Chapter Nine: Microglia in animal models of autism spectrum disorders
- Abstract
- 1: Introduction
- 2: Animal models of ASDs
- 3: Animal models of ASD exhibiting possible microglia involvement
- 4: Treatment of ASDs by controlling microglial functions
- 5: Conclusion
- Chapter Ten: The early overgrowth theory of autism spectrum disorder: Insight into convergent mechanisms from valproic acid exposure and translational models
- Abstract
- 1: Introduction
- 2: The early overgrowth theory of ASD
- 3: Valproic acid and ASD
- 4: VPA and the cellular and molecular mechanisms of early overgrowth
- 5: Concluding remarks and future directions
- Acknowledgments
- Chapter Eleven: The role of neuroglia in autism spectrum disorders
- Abstract
- 1: Autism spectrum disorders
- 2: Etiology of autism spectrum disorders
- 3: Molecular aspects of autism spectrum disorders
- 4: Neuroglia in autism spectrum disorders
- 5: Conclusions
- Chapter Twelve: Oxidative stress, metabolic and mitochondrial abnormalities associated with autism spectrum disorder
- Abstract
- 1: Etiology of autism spectrum disorder
- 2: Oxidative stress and ASD
- 3: Metabolic abnormalities and ASD
- 4: Mitochondrial abnormalities and ASD
- 5: A unified framework
- 6: Comorbidity
- 7: Future treatment options
- Chapter Thirteen: In vitro models for ASD-patient-derived iPSCs and cerebral organoids
- Abstract
- 1: Modeling human neurodevelopment in vitro
- 2: CRISPR/Cas9 and iPSC technologies
- 3: Limitations and future directions
- Index
- Edition: 1
- Volume: 173
- Published: July 23, 2020
- No. of pages (Hardback): 400
- No. of pages (eBook): 400
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780128212424
- eBook ISBN: 9780128212431
MI
Mirolyuba Ilieva
Mirolyuba Ilieva obtained her Master degree in Cell biology and Pathology at Sofia University in 2006. In August 2013 she got a PhD in Nanotechnology from Danish Technical University (DTU). She has been researcher at Copenhagen University and currently she is a scientist in the Department of Psychiatry, Odense, University of Southern Denmark. Her research is focused on induced pluripotent stem cells and brain organoids as a model for neurodevelopmental psychiatric disorders, e. g. Autism Spectrum Disoeders; neurotrophic factors mimetic peptides as therapeutic agents, nanosensors for monitoring gene expression during cell reprograming and neuronal differentiation. EU expert for reviewing projects for Marie Skłodowska-Curie Individual Fellowships.
Affiliations and expertise
Department of Psychiatry, Odense, University of Southern DenmarkWL
Wai Lau
Way Lau is an Assistant Professor in Department of Special Education and Counselling at the Education University of Hong Kong. He completed his Ph.D. in biomedical sciences in Department of Medicine and did his postdoctoral trainings in Departments of Psychiatry and Psychology at the University of Hong Kong. One of his key research interests is on identifying biomarkers of Autism Spectrum Disorder, using molecular and system neurosciences techniques, and psychobiological approach. He is also keen on studying mechanisms of psychological resilience in non-clinical samples and students with special educational needs for prevention of stress-induced mental illness, and cultivation of resilience and strength in counteracting adversity.
Affiliations and expertise
Assistant Professor in Department of Special Education and Counselling at the Education University of Hong KongRead Autism on ScienceDirect