SUSTAINABLE DEVELOPMENT
Innovate. Sustain. Transform.
Save up to 30% on top Physical Sciences & Engineering titles!
Obesity Hypoventilation Syndrome
From Physiologic Principles to Clinical Practice
- 1st Edition - July 22, 2020
- Editor: Aiman Tulaimat
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 5 2 9 0 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 5 2 9 1 - 1
Obesity Hypoventilation Syndrome: From Physiologic Principles to Clinical Practice summarizes the current state of knowledge regarding the epidemiology, physiology and treatment… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteObesity Hypoventilation Syndrome: From Physiologic Principles to Clinical Practice summarizes the current state of knowledge regarding the epidemiology, physiology and treatment of obesity hypoventilation syndrome (OHS). Currently, the identification and management of OHS is suboptimal, especially in the acute setting, hence the misdiagnosis or mislabeling of the problem has a significant impact on patient outcomes. This volume brings together all aspects of assessment and management into a main resource for understanding the complex physiological and clinical consequences of this condition.
- Provides one page chapter summaries that cover epidemiology, physiology and treatment options
- Presents an easy to use reference on obesity hypoventilation syndrome, including symptoms
- Contains chapters with detailed discussions of topics, including color images, graphs and tables that summarize current research
Research scientists as well as respiratory and sleep medicine specialists
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Part I: Historical and social introduction
- Chapter 1: Obesity: A social and public policy perspective
- Abstract
- The obesity epidemic
- Disparities in obesity and related conditions
- Overview of social ecological model
- Individual-level influences on obesity
- Interpersonal-level influences
- Organizational-level influences
- Community-level influences
- Society-level influences
- Chapter 2: History of obesity hypoventilation
- Abstract
- Respiration and the ancient Greeks
- Ancient Greek accounts of hypoventilation
- Chemists and clinicians: Ne’er the two shall meet
- Partial pressures, polio, and polysomnography
- Part II: The burden of obesity on respiratory
- Chapter 3: Effect of obesity on the respiratory system
- Abstract
- Introduction
- Respiratory patterns
- Respiratory system compliance
- Oxygenation, ventilation, perfusion, and gas exchange
- Chapter 4: The burden of obesity hypoventilation syndrome
- Abstract
- Prevalence and risk factors
- Prevalence of OHS among patients on home mechanical ventilation
- Prevalence of OHS among patients with acute hypercapnic respiratory failure
- Social and health care consequences of OHS
- Effect of OHS on the quality of life and health status
- Mortality
- Part III: Pathophysiology of obesity hypoventilation syndrome
- Chapter 5: Neural control of breathing in sleep
- Abstract
- Introduction
- Mechanisms controlling breathing
- Changes in breathing during sleep
- Mechanism of central apnea generation
- Clinical relevance
- Chapter 6: Pathogenesis of sleep apnea
- Abstract
- Conflict of interest
- Introduction
- Importance of sleep apnea phenotypes to understand sleep apnea pathophysiology
- Physiologic determinants in obese and nonobese patients with OSA
- Phenotypic traits in patients with severe OSA
- Chapter 7: The pathophysiology of obesity hypoventilation syndrome
- Abstract
- Introduction
- The origins
- Mechanics and work of breathing
- Respiratory muscles
- Gas exchange and control of ventilation
- Fat distribution
- Renal response
- Polycythemia
- Leptin
- Orexin
- Effect of treatment
- Chapter 8: Evolution of obesity hypoventilation syndrome
- Abstract
- Introduction
- Respiratory adaptation
- Acute hypercapnia during sleep
- Respiratory-renal interactions
- Evolution to chronic hypercapnia during wakefulness
- Impact of obesity and coexisting respiratory disease
- Goals of therapy
- Hazards of medical therapy
- Chapter 9: Cardiovascular, neurological, and inflammatory complications of obesity hypoventilation syndrome
- Abstract
- Introduction
- Cardiovascular consequences of OHS
- Neurological complications of OHS
- Inflammatory complications of OHS
- Part IV: Clinical assessment of a patient with obesity hypoventilation
- Chapter 10: Assessment of patients with obesity hypoventilation syndrome
- Abstract
- A historical example
- Diagnosing OHS
- Evaluation of respiratory function
- Polysomnography
- Comorbidities in patients with OHS
- Central nervous system manifestation
- Hepatic manifestation
- Chapter 11: Detection of hypoventilation
- Abstract
- Phenotypes of sleep-disordered breathing in obese patients
- Symptoms
- Carbon dioxide
- Bicarbonate levels
- Pulse oximetry
- Parameters measured by positive airway pressure devices
- Measuring response to treatment
- Chapter 12: Diagnosis of sleep-disordered breathing
- Abstract
- Polysomnography and sleep stage scoring: A brief historical introduction
- Definitions
- Assessment of a patient suspected of having SDB
- Diagnosing SDB during hospitalization
- Part V: Management of obesity hypoventilation
- Chapter 13: Positive airway pressure I: Equipment
- Abstract
- Introduction
- What are the key technical components of PAP equipment?
- OHS phenotypes and therapy choices
- What treatment options are best for OHS patients?
- Practical considerations for equipment reimbursement in the United States
- Chapter 14: Positive airway pressure II: Settings and outcomes
- Abstract
- Introduction
- Matching mechanism to therapy
- PAP therapy for OHS—What choice do we have?
- Managing chronic stable OHS
- Bilevel positive airway pressure therapy
- CPAP vs BPAP therapy—Are two pressures better than one?
- Oxygen therapy
- Obesity hypoventilation without obstructive sleep apnea
- Managing acute presentations of OHS with PAP therapy
- Conclusions
- Chapter 15: The effects of weight loss, tracheostomy, and medication on obesity hypoventilation syndrome
- Abstract
- The effects of weight loss on breathing, sleep-disordered breathing, and OHS
- Tracheostomy in sleep apnea and OHS
- Medications and OHS
- Chapter 16: Weight loss: Lifestyle interventions and pharmacotherapy
- Abstract
- Introduction
- Clinical assessment of the patient
- Motivating patients to adopt weight loss behaviors
- How to achieve weight loss through lifestyle intervention
- Pharmacotherapy
- Medications that cause weight gain
- Weight maintenance
- Chapter 17: Surgical weight loss
- Abstract
- Patient selection
- Procedure selection
- Weight loss effects
- Postoperative complications
- Early postoperative management
- Chapter 18: Tracheostomy in morbidly obese patients
- Abstract
- Patient selection
- Effect of OHS on surgical management
- Perioperative management
- Upper airway surgery for patients with severe OSA and OHS
- Surgical technique
- Chapter 19: Obesity hypoventilation in the intensive care unit
- Abstract
- Introduction
- Pathophysiology of ventilatory failure
- The characteristics of patients with OHS in acute hypercapnic respiratory failure
- Differential diagnosis and comorbidities
- Treatment with noninvasive ventilation
- Treatment with invasive mechanical ventilation
- Other issues in intensive care related to the morbidly obese
- Long-term outcomes
- Conclusions
- Chapter 20: Perioperative considerations and management in patients with obesity hypoventilation syndrome
- Abstract
- Introduction
- Pathophysiology
- Preoperative assessment
- Intraoperative considerations
- Postoperative considerations
- Index
- No. of pages: 298
- Language: English
- Edition: 1
- Published: July 22, 2020
- Imprint: Academic Press
- Paperback ISBN: 9780128152904
- eBook ISBN: 9780128152911
AT
Aiman Tulaimat
Dr. Tulaimat has 18 years of experience specializing in Sleep Medicine and Internal Medicine. He is affiliated with John H Stroger Jr Hospital of Cook County where he is the Director of Sleep Medicine and serves on the Executive Medical Staff and Stroke Committee.
He has over 20 articles, 3 book chapters, 3 letters and 34 abstracts published in the field of respiratory medicine/pulmonary.
Affiliations and expertise
Director of Sleep Medicine Services and Director of Research, John H. Stroger, Jr, Hospital of Cook County and Assistant Professor of Medicine, Rush College of Medicine, Chicago, USARead Obesity Hypoventilation Syndrome on ScienceDirect