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Books in Life sciences

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    • Nanotherapeutics in Cancer Vaccination and Challenges

      • 1st Edition
      • March 3, 2022
      • Mahfoozur Rahman + 4 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 3 6 8 6 4
      • eBook
        9 7 8 0 1 2 8 2 3 6 8 7 1
      Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy.

    • Inflammation and Obesity

      • 1st Edition
      • September 24, 2022
      • Raman Mehrzad
      • English
      • Paperback
        9 7 8 0 3 2 3 9 0 9 6 0 0
      • eBook
        9 7 8 0 3 2 3 9 0 9 6 1 7
      Inflammation and Obesity: A New and Novel Approach to Manage Obesity and its Consequences is a comprehensive and up-to-date exploration of the correlation between obesity and inflammation. From the pathophysiology of obesity and inflammation, to the molecular mechanisms of obesity induced chronic inflammation, the book discusses how obesity and inflammation interact with other diseases. It highlights the hidden risk factors of obesity induced chronic inflammation, provides specific patient management guidelines regarding the higher inflammatory response in patients, and concludes with new therapeutic strategies to address inflammation in obese patients.

    • Phenotyping of Human iPSC-derived Neurons

      • 1st Edition
      • September 9, 2022
      • Elizabeth D. Buttermore
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 2 7 7 5
      • eBook
        9 7 8 0 1 2 8 2 2 2 7 8 2
      Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline. In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification.

    • Movement Disorders in Childhood

      • 3rd Edition
      • July 12, 2022
      • Harvey S. Singer + 3 more
      • English
      • Hardback
        9 7 8 0 1 2 8 2 0 5 5 2 5
      • eBook
        9 7 8 0 3 2 3 9 0 0 0 7 2
      Movement Disorders in Childhood, Third Edition provides the most up-to-date information on the diseases and disorders that affect motor control, an important area of specialization within child neurology. In this new edition, each chapter has been fully revised to include all of the latest scientific and therapeutic advances. Updates include new insights in motor development, control, goal-directed and habitual behaviors, classifications of movements and their complex and integrated circuitry. The authors also discuss developments in pathophysiologic mechanisms, immunology and metabolic disorders. New chapters include coverage of genetics of movement disorders and movement disorders in psychiatric conditions.Appendice... include an updated and revised drug index and genetic search strategy. An updated Companion website hosts selected educational videos to help diagnose movement disorders.

    • Novel Concepts in iPSC Disease Modeling

      • 1st Edition
      • Volume 15
      • January 8, 2022
      • Alexander Birbrair
      • English
      • Paperback
        9 7 8 0 1 2 8 2 3 8 8 2 0
      • eBook
        9 7 8 0 1 2 8 2 3 8 8 3 7
      The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs - Novel Concepts, Volume 15 addresses how important induced pluripotent stems cells are and how can they can help treat certain diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different disorders, such as liver disease, type-1 diabetes, Parkinson’s disease, macular degeneration of the retina and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.

    • Citrus Fruit

      • 2nd Edition
      • August 24, 2022
      • Milind Ladaniya
      • English
      • Hardback
        9 7 8 0 3 2 3 9 9 3 0 6 7
      • eBook
        9 7 8 0 3 2 3 9 9 3 0 7 4
      Citrus Fruit: Biology, Technology and Evaluation, Second Edition presents a comprehensive view of these globally important crops, from cultivars to consumer acceptability. Now fully revised and updated to address the latest technologies and advancements, along with an exploration of highly current topics, including the impacts of climate and COVID-19, the book presents fresh fruit scenarios from around the globe. Sections explore the challenge of losses, background on fresh citrus cultivars production, factors that impact fruit quality, morphology, anatomy, physiology and biochemistry of fruit, fruit maturity, grades, and physico-chemical characteristics before moving into aspects of post-harvest technology. From irradiation and quality control to the nutritive, medicinal and safety aspects, the book presents the wide range of factors that can impact successful citrus crop production, delivery and consumption. Intended as a resource for researchers and scientists dealing with the growth, development and distribution of citrus fruit, the book provides up-to-date coverage on global citrus fruit production and practices.

    • Sensory Analysis for the Development of Meat Products

      • 1st Edition
      • January 25, 2022
      • José Manuel Lorenzo + 3 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 8 3 2 6
      • eBook
        9 7 8 0 3 2 3 9 0 3 1 8 9
      Sensory Analysis for the Development of Meat Products: Methodological Aspects and Practical Applications highlights the application of sensory analysis in the development of meat products. It presents the background and historical aspects of sensory evaluation on the characterization and development of meat products. Divided into two sections, the book discusses fundamental concepts, methodological approaches, statistical analysis, innovative methods, and presents case studies using these approaches. Chapter include definitions, applications, literature reviews, recent developments, methods and end of chapter glossaries. Researchers in sensory analysis and meat processing, as well as new product developers, will benefit from this comprehensive resource on the topics discussed.

    • Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-oncology

      • 1st Edition
      • May 26, 2022
      • Imteyaz Qamar + 1 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 0 4 6 1 2
      • eBook
        9 7 8 0 3 2 3 9 0 4 6 2 9
      Cardiovascular Toxicity and Therapeutic Modalities Targeting Cardio-Oncology: From Basic Research to Advanced Study analyzes the emerging the field of cardio-oncology, reviewing recent advancements in the field, discussing how to monitor and treat cancer survivors for cardiotoxicity, and identifying potential cardiac side effects in novel cancer therapies. By adopting a translational approach, the book first comprehensively covers the basic science, mechanisms and concepts, which is followed by advanced state-of-art of cardio-oncology. Other sections cover tyrosine kinase inhibitors, Anthracyclines, and biomarkers in cardiotoxicity induced by chemotherapeutic drugs, noninvasive cardiovascular imaging techniques, radiotherapy induced cardiovascular, and more. Anti-cancer treatment is associated with serious cardiovascular adverse events, including arterial and pulmonary hypertension, supraventricular and ventricular arrhythmias, systolic and diastolic cardiac dysfunction and coronary artery disease. Progress in cancer therapy over the past decades improved long-term survival but increased cancer therapy-related cardiotoxicity. Both traditional chemotherapeutic agents and newer therapies have demonstrated profound cardiovascular toxicities. It is important to understand the mechanisms of these toxicities to establish strategies for the prevention and management of complications—arrhyt... heart failure, and even death.

    • Vaccinology and Methods in Vaccine Research

      • 1st Edition
      • March 10, 2022
      • Rebecca Ashfield + 3 more
      • English
      • Paperback
        9 7 8 0 3 2 3 9 1 1 4 6 7
      • eBook
        9 7 8 0 3 2 3 9 1 4 3 8 3
      Vaccinology and Methods in Vaccine Research is a combination of cutting-edge methodologies, experimental approaches and literature reviews. The book covers all aspects of vaccine development, including basic immunology (focusing on the stimulation of adaptive immunity, which is required for vaccine efficacy), approaches to vaccine design and target validation, vaccine biomanufacturer and clinical development. Existing vaccinology resources are theoretical reference books, whereas this book provides a practical handbook for use in the research lab and classroom by those working in vaccinology and training others in the field. It is authored and edited by scientists actively engaged in vaccine research and development for day-to-day teaching/methodologi... advice.

    • Visceral and Ectopic Fat

      • 1st Edition
      • October 28, 2022
      • Hildo J. Lamb
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 1 8 6 0
      • eBook
        9 7 8 0 1 2 8 2 3 0 1 2 1
      While the health consequences and mechanisms by which visceral fat causes disease are well-studied, relatively less is known about ectopic fat, its patterns of deposition and its effects on the pathoetiology of type 2 diabetes, atherosclerosis, and cardiovascular disease. Visceral and Ectopic Fat: Risk Factors for Type 2 Diabetes, Atherosclerosis, and Cardiovascular Disease covers the wealth of literature that has been amassed over the past decade on this topic. This reference brings all the research and clinical data together in one volume and helps clinicians and academic researchers understand more thoroughly the underlying mechanisms and interrelation between fat depots and ectopic fat stores in relation to health and disease. It showcases some of the recent developments in adipose tissue biology, particularly on the impact of interventional strategies - bariatric surgery, liposuction, physical and dietary intervention - of which information is desired among health specialists and policy makers.

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