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Nanotherapeutics in Cancer Vaccination and Challenges

1st Edition - March 3, 2022

Editors: Mahfoozur Rahman, Sarwar Beg, Waleed H Almalki, Nabil A. Alhakamy, Hani Choudhry

Paperback ISBN:

9 7 8 - 0 - 1 2 - 8 2 3 6 8 6 - 4

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 2 3 6 8 7 - 1

Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and… Read more

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Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects.

Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
Preface
Acknowledgments
Chapter 1. Cancer vaccines: past, present, and future
1. Introduction
2. Cancer vaccines and their applications
3. Smart carriers in cancer vaccine delivery
4. Key challenges: formulation challenges and regulatory hurdles
5. Conclusion and future perspectives
Chapter 2. Inorganic nanoparticulate carriers in management of cancer: theranostics and toxicity apprehension
1. Introduction
2. Inorganic nanoparticles
3. Advantages of inorganic nanoparticle
4. Application of inorganic nanoparticles in cancer treatment
5. Conclusion
Chapter 3. Recent developments in cancer vaccines: where are we?
1. Introduction
2. Vaccines and their mechanism of action
3. Classification of cancer vaccine
4. The fundamental mechanism of antitumor immunity
5. Cancer and its types
6. Present cancer treatments
7. Significance of the development of cancer vaccine
8. Known or possible targets for the development of cancer vaccines
9. Current status on the development of cancer vaccines
10. Future perspectives of cancer vaccines
11. Conclusion
12. Conflict of interest
Chapter 4. Application of nanotechnology assisted devices in cancer treatment
1. Introduction
2. Nanotechnology in cancer
3. Devices based on nanotechnology
4. Nanotechnology and medical devices
5. Emerging medical devices using nanotechnology for cancer therapy
6. Challenges and regulations
7. Advantages and disadvantages of nanotechnology in cancer
8. Conclusion
9. Conflict of interest
Chapter 5. Advancement in protein-based nanocarriers in targeted anticancer therapy
1. Introduction
2. Protein-based nanocarriers in targeted drug delivery
Chapter 6. Elastic liposomes as transcutaneous DNA vaccine vectors
List of abbreviations
1. Introduction: brief history of vaccinology and focus on DNA vaccines
2. Need for targeted DNA vaccines
3. Liposomes as DNA vaccine vectors
4. The skin as an immunization route
5. Topical application of DNA vaccines and optimization of material delivery through colloidal vectors
6. Conclusions
Chapter 7. Nanotechnology-based manipulation of dendritic cells for enhanced immunotherapy strategies
1. Introduction
2. Mechanism of action conciliated by the interaction between nanoparticles (NPs) and dendritic cells (DCs)
3. Potential change in pharmacological effects
4. Potential effects of NPs on DCs
5. Conclusion
Chapter 8. Peptide-based anticancer targeted therapeutics: state of the art
1. Introduction
2. Peptide-based anticancer targeted therapeutics
3. Future perspectives and conclusion
Chapter 9. Polyplexes-based delivery systems for cancer vaccine delivery
1. Introduction
2. Cancer vaccines
3. Nanotechnology based carrier system for cancer vaccine delivery
4. Polyplexes
5. Characterization of polyplexes
6. Applications of lipoplexes and polyplexes
7. Conclusion
Chapter 10. Lipopolyplex-based delivery system for cancer vaccine delivery
1. Introduction
2. Lipopolyplex structure and physicochemical properties
3. Types of cancer vaccine
4. Therapeutic cancer vaccine targeted delivery
5. Advantages of lipopolyplex based delivery
6. Limitations
7. Conclusion
Chapter 11. Inorganic nanoparticulate carriers in cancer vaccination
1. Introduction
2. Cancer immunotherapy
3. Nanomedicine: unmet need in cancer immunotherapy
Chapter 12. Functional nanomaterials and nanocomposite in cancer vaccines
1. Generally employed vaccines and antigens for anticancer therapy
2. Identified tumor-associated antigens
3. Whole tumor cells or tumor lysates
4. DNA vaccines
5. Subunit peptide vaccine
6. mRNA vaccine
7. Personalized vaccine and neoantigen
8. Functional nanomaterials
9. Liposomal nanovaccine
10. PLGA nanovaccine
11. Dendrimers nano vaccine
12. Approved cancer vaccines: for treatment and prevention
13. Cancer vaccines approved for chemoprevention [68]
14. Conclusion
Chapter 13. DNA vaccines for cancer treatment: challenges and promises
1. Introduction
2. Nano-carriers for transfer of DNA vaccines
3. Conclusion
Chapter 14. mRNA-based nanovaccines as newer treatment modalities in cancer
1. Introduction
2. mRNA nanovaccines in cancer: stability manifestations
3. mRNA-based nanoparticulate systems
4. Conclusion and future perspectives
Chapter 15. Cancer immunotherapy: moving forward with peptide T-cell vaccines
1. The concept: immunotherapy in cancer
2. Peptide-based cancer vaccines: types and examples
3. Selection of delivery systems for peptide T-cell vaccines
4. Challenges in optimization of peptide vaccines
5. Peptide-based vaccines in clinical trials
6. Future of peptide-based cancer vaccines
Chapter 16. Product development and scale-up challenges in cancer vaccine development
1. Introduction
2. Vaccine for cancer therapy
3. Mode of action of therapeutic vaccines
4. Vaccine vectors
5. Development pathway of cancer vaccines
6. Clinical trials of cancer vaccines
7. Approved therapeutic cancer vaccines
8. Adjuvant therapy
9. Regulatory framework for development of cancer vaccines
10. Scale-up and challenges of cancer vaccine
11. Conclusion
Chapter 17. Regulatory landscape in the approval of cancer vaccine
1. Introduction
2. Background in the approval of cancer vaccine
3. Regulatory considerations
4. Quality considerations
5. Nonclinical considerations
6. Clinical considerations
7. General vaccine approval process by regulatory body
8. FDA requirements on cancer
9. Regulatory guidance of FDA to admit the approval of cancer vaccine
10. Regulatory guidance of European regulatory system to admit the approval of cancer vaccine
11. Regulatory guidance of PMDA (The Pharmaceuticals and Medical Devices Agency by Govt. of Japan) admit the approval of cancer vaccine in Japan
12. Various guidelines for cancer vaccine in remaking world
Chapter 18. Cross-presentation-based nanovaccine for cancer immunotherapy
1. Introduction
2. Understanding the concept of antigen cross-presentation
3. Targeting DC subsets for enhancing cross-presentation
4. C-type lectin receptors (CLRs) for targeted delivery
5. TLRs and their adjuvant activity
6. Plant lectins as a new player in targeted nanovaccine development
7. Liposomes as nanocarrier for antigen delivery
8. Advancing cancer immunotherapy using next generation glyco-nanovaccine
9. Advancing next generation anticancer nanovaccine development
10. Conclusion and future perspectives
Chapter 19. Immunotherapy-based cancer vaccines: state of the art
1. Introduction
2. T cell-based cancer immunotherapy
3. Types of T-cell vaccines
4. Conclusion
Chapter 20. Therapeutic peptides in anticancer therapy
1. Introduction
2. Cell-penetrating and tumor-targeting peptides
3. Nanomedicine-peptide complexes for cancer therapy
4. Conclusion and future perspectives
Chapter 21. Inorganic nanoconjugates for cancer theragnosis
1. Introduction
2. Inorganic nanoparticles in cancer therapy and vaccination
3. Conclusion and future perspectives
Index

Mahfoozur Rahman

Mahfoozur Rahman is an Assistant Professor at the Department of Pharmaceutical Sciences, Faculty of Health Science, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Allahabad, India. He has authored more than 130 publications in peer-reviewed journals, 30 book chapters, seven books, and four articles in international magazines with various publishers. He has a Google Scholar h-index of 27 and over 1700 citations to his credit. He also serves on the editorial boards and as guest editor for several journals. He has received travel grants from various international congresses, such as IAPRD, MDS, Nano Today, KSN and WCN, on the basis of his research work and contribution in the field.

Affiliations and expertise

Assistant Professor, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, India

Sarwar Beg

Sarwar Beg, PhD is currently serving as AMS-DBT Newton International Fellow at University of Central Lancashire, UK, and working in the area of glioblastoma research using targeted nanomedicines. He is also serving as the Assistant Professor at Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi. He has over a decade of teaching and research experience in the field of pharmaceutics and biopharmaceutics, especially in the development of novel and nanostructured drug delivery systems using Quality-by-Design paradigms with core expertise in computational pharmaceutics, experimental designs and multivariate statistical techniques. He has authored over 200 publications, 60 book chapters, 15 books, 03 Indian patent applications and H-Index of 40 with over 5400 citations to his credit.

Affiliations and expertise

Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi, India

Waleed H Almalki

Dr. Waleed Hassan Almalki is an associate professor of pharmacology at the college of pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia. He earned his doctoral degree from the University of Glasgow, United Kingdom having a dissertation on ocular pharmacology. His current research is focused on the broad areas of host-virus networks in hepacivirus C disease progression as well as host-virus genes expression during oxidative stress, hepatic steatosis, fibrosis, and hepatocellular carcinoma. He is also enthusiastically involved in the studies of tyrosine kinase inhibitors for the treatment of breast and colon cancer, in the Saudi population. Dr. Waleed has published many research and review articles in peer-reviewed international journals on HCV pathogenesis, treatment and drug designing as well as edited various book chapters about pathological angiogenesis, pharmacological assays and infectious disease epidemiology.

Affiliations and expertise

Associate Professor, Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia

Nabil A. Alhakamy

Affiliations and expertise

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Mohamed Saeed Tamer Chair for Pharmaceutical Industries, King Abdulaziz University, Jeddah 21589, Saudi Arabia

Hani Choudhry

Dr. Hani Choudhry is an Associate Professor of Genomics and the Head of Cancer and Mutagenesis Unit at the King Fahd Center for Medical Research in King Abdulaziz University (KAU), Saudi Arabia. Dr. Choudhry completed his DPhil in Clinical Medicine in Prof. Sir Peter Ratcliffe (Nobel Laureate 2019)’s lab at the Wellcome Trust Center for Human Genetics, University of Oxford, UK. Dr. Choudhry has received a number of international and prestigious awards including two AACR Scholar-in-Training Award, the Susan G. Komen for the Cure Award, the ASHG/Charles J. Epstein Trainee Award for Excellence in Human Genetics Research (SF), the Professional Achievement Award and the National Cancer Research Institute (NCRI) Prize Award. He was awarded by the British Embassy and the UAE International Genetic Disorders Prevention Award- Scientific Excellence Award in GCC. Dr. Choudhry’s current scientific interests focus on developing genomic technologies, and the integration of both clinical and pathological information with data generated from high-throughput molecular techniques. His work addresses the impact of genome and epigenome heterogeneity on the biology and clinical behaviour of diseases. In addition, he is leading a number of initiatives on artificial intelligence (AI) powered genome and drug discovery.

Affiliations and expertise

King Fahd Center for Medical Research in King Abdulaziz University (KAU), Saudi Arabia