Books in Life sciences

Managing the Drug Discovery Process

2nd Edition
March 9, 2023
Susan Miller + 5 more
English
Paperback
9 7 8 0 1 2 8 2 4 3 0 4 6
eBook
9 7 8 0 1 2 8 2 4 3 0 5 3

Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharma... industry.

Medicinal Chemistry of Chemotherapeutic Agents

1st Edition
March 9, 2023
Pratap Chandra Acharya + 1 more
English
Paperback
9 7 8 0 3 2 3 9 0 5 7 5 6
eBook
9 7 8 0 3 2 3 9 0 7 0 1 9

Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-infective and Anti-cancer Drugs focuses on the basics and fundamentals of chemistry involved in chemotherapeutic agents. Each chapter comprises distinct chemical classifications that include structure and IUPAC nomenclature, synthetic schemes and routes for each drug, mechanism of the drug action, metabolic pathway and structure–activity relationship (SAR) studies. The book covers current research focused on drug resistance and methods to overcome it, the development of newer drugs belonging to each category of the chemotherapeutic agents, molecules currently under clinical trials, and newly approved drugs, if any. This book will be a valuable resource for academics and researchers, helping them to understand the fundamentals of the medicinal chemistry of the chemotherapeutic agents.

Green Products in Food Safety

1st Edition
March 9, 2023
Bhanu Prakash + 1 more
English
Paperback
9 7 8 0 3 2 3 9 5 5 9 0 4
eBook
9 7 8 0 3 2 3 9 5 5 9 1 1

Green Products in Food Safety explores the potential of green chemicals in the sustainable management of food biodeterioration agents and addresses the current existing limitations of green products for their sustainable application. The book summarizes food loss by biodeterioration agents (bacteria, fungi, mycotoxin, and insect pest); novel detection methods for hazardous food contaminants; different sources of green chemicals, their origin, extraction, and characterization methods; and bioactivity of green products against biodeterioration agents with their molecular sites of action. Also included are discussions of pharmacological properties of green chemicals, metabolic engineering of green chemical biosynthesis, natural therapy for bovine mastitis, the role of molecular modeling and dynamics in food science, nanocarriers for application in the food system, elucidation of novel site of action, toxicity prediction, ecological perception, Intellectual Property Right (IPR), regulations, and perspectives on the commercial application of green products. This book covers basic and translational aspects that prove to be beneficial for food scientists, researchers, students, and young professionals.

Intellectually Impaired People

1st Edition
March 9, 2023
Klaus Rose
English
Paperback
9 7 8 0 4 4 3 1 8 8 1 3 8
eBook
9 7 8 0 4 4 3 1 8 8 1 2 1

Intellectually Impaired People: The Ongoing Battle addresses challenges against the background of history, changing societal environments, and current intellectual approaches and attitudes toward persons with disabilities. The book discusses national and international conventions, societal attitudes, sheltered workshops, the right of intellectually impaired persons for self-responsibility and its limitations, and the place of mentally impaired persons in the public image. Additionally, the book attempts to capture the forces that drive the changes of our conceptual frameworks. The US Tuskegee study which withheld antibiotics from black men with syphilis was not ended by scientific criticism but by a courageous man, press reports, and a changed social perception. The non-hiding of handicapped children is not the result of government orders, there are many non-resolvable dilemmas and tension between supporting, understanding, and patronizing a complex situation with many potential future avenues.

Chitosan

1st Edition
March 8, 2023
Ioannis Savvaidis
English
Paperback
9 7 8 0 1 2 8 2 1 6 6 3 7
eBook
9 7 8 0 1 2 8 2 3 2 3 5 4

Chitosan: Novel Applications in Food Systems is a practical resource for those looking to understand new applications of chitosan in the food industry. The content presented is written by experts in the field who have worked on the latest application of chitosan-based research to help researchers and scientists understand how recent applications combined with traditional food preservation hurdles, or novel hurdles such as active packaging, irradiation and essential oils can improve methods of controlling microorganisms in foods. With an emphasis of potential of chitosan in food safety this reference briefly summarizes what chitosan-based research has already done for the industry, including potential applications.

Conceptual Development of Industrial Biotechnology for Commercial Production of Vaccines and Biopharmaceuticals

1st Edition
March 7, 2023
Basanta Kumara Behera
English
Paperback
9 7 8 0 4 4 3 1 8 7 4 8 3
eBook
9 7 8 0 4 4 3 1 8 7 4 9 0

Conceptual Development of Industrial Biotechnology for Commercial Production of Biopharmaceuticals and Vaccines provides insights on how to bring sustainability into biologic drug production. The cumulative facts and figures within in the book are helpful to promoters in monitoring value chain transfer process of super quality biologics for better return in profits. In addition, this is a useful reference for students, researchers and scientists in biotechnology, pharmaceutical science, medical sciences, and the R&D division of biotechnology-based industries. Conceptual development of biotechnology has taken new avenues with the integration of medical sciences, physical science, and engineering, hence this is a timely source. The current global market for vaccines, especially COVID-19, is tremendous. Bivalent oral polio vaccine, diphtheria, tetanus-containing, and measles-containing vaccines have a high demand internationally and recombinant DNA technology and protein engineering are helpful in the production of quality bio-products.

Smart Nanomaterials to Combat the Spread of Viral Infections

1st Edition
March 4, 2023
Raju Khan + 1 more
English
Paperback
9 7 8 0 3 2 3 9 9 1 4 8 3
eBook
9 7 8 0 3 2 3 9 9 3 7 9 1

Smart Nanomaterials to Combat the Spread of Viral Infections comprises nanotechnology-based approaches with detailed preventive and treatment methodology for enabling their application in antiviral systems. This book discusses the role of metal nanoparticles in the treatment of and prevention of viral infections and nanotechnology advancements in antiviral coatings to combat affected surfaces. It also covers the use of nanomaterials for the efficient intracellular delivery of antiviral agents to disinfect and treat viral infections. This is a timely coverage of how nanotechnologies and materials as well as the utilization of artificial intelligence and Internet of things–based smart nano-systems are used to control and manage viral infections during the COVID-19 pandemic. Advances in smart research and future antimicrobial applications round out the book. This book provides a comprehensive overview of smart nanomaterials and advanced nano-system applications to researchers and academics in virology, microbiology, chemistry, material science, nanotechnology, and biotechnology as well as those in industries interested in their virucidal properties to prevent viral infections.

MRI/DTI Atlas of the Human Brainstem in Transverse and Sagittal Planes

1st Edition
March 2, 2023
George Paxinos + 5 more
English
Hardback
9 7 8 0 3 2 3 9 1 5 8 3 0
eBook
9 7 8 0 4 4 3 1 3 6 3 9 9
eBook
9 7 8 0 3 2 3 9 1 5 8 4 7

**Selected for Doody’s Core Titles® 2024 in Neuroscience**MRI/DT... Atlas of the Human Brainstem in Transverse and Sagittal Planes presents a detailed view of the human brainstem in DTI/MRI. It is the first ever MRI or histological atlas to present detailed diagrams of sagittal views of the brainstem. Presenting data of unprecedented quality, images are juxtaposed with detailed diagrams in the transverse and sagittal planes. The atlas features a 50 micron resolution for the GRE and 200 microns for the FAC and DWI, 8000 times higher than that seen in a clinical MRI and 1000 times higher than that seen in a clinical DTI scan, all based on one brain.This atlas is important for neuroscientists, neurosurgeons, pathologists, anatomists, neurophysiologists, radiologists, radiotherapists (e.g., for cyberknife guidance), and graduate students in neuroscience.

Natural Products in Vector-Borne Disease Management

1st Edition
March 2, 2023
Nagendra Singh Chauhan + 1 more
English
Paperback
9 7 8 0 3 2 3 9 1 9 4 2 5
eBook
9 7 8 0 3 2 3 9 1 2 9 0 7

Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the global impact of specific vector-borne diseases, gaps in management, and natural products in specific stages of development - discovery, optimization, validation, and preclinical/clinical development. Toxic effects and mechanisms of action are also discussed. This book also explores how therapeutic plant derivatives can be used to combat the vectors of infection and how natural products can be used to manage and treat vector-borne diseases like malaria, leishmaniasis, dengue, and trypanosomiasis. With the inclusion of case studies on field and clinical applications and the contributions from experts in the field, Natural Products in Vector-Borne Disease Management is an essential resource to researchers, academics, and clinicians in parasitology, virology, microbiology, biotechnology, pharmacology, and pharmacognosy working in the field of vector-borne diseases.

Regulation of Downstream Targets

1st Edition
Volume 134
March 2, 2023
Rossen Donev
English
Hardback
9 7 8 0 4 4 3 1 3 1 8 1 3
eBook
9 7 8 0 4 4 3 1 3 1 8 2 0

Regulation of Downstream Targets, Volume 134 in the Advances in Protein Chemistry and Structural Biology series, presents interesting chapters on topics such as Transcriptional regulatory mechanisms and signaling networks in Viral Infections, Identification of potential key genes associated with pathogenesis and prognosis of endometrial cancer based on Integrated Bioinformatics Approaches, Differential regulation of genes in stage IB pancreatic cancer associated with increased risk of metastasis, AMPK-related LKB1-downstream targets, A compilation of bioinformatic approaches to identify novel downstream targets for the detection and prophylaxis of cancer, Protein phosphatases and their targets: Critical determinants of signaling pathway in plants, and more. Other sections cover Calcium decoders and their targets: The holy alliance that regulate cellular responses, Importin alpha family NAAT/IBB domain: functions of a multi-faceted long chameleon sequence, Aurora Kinase A and related downstream molecules: A Potential Network for Cancer Therapy, Emerging Role of Heat Shock Proteins in Cardiovascular Diseases, Function, Structure, Evolution, Regulation and Drug Target Relevance of Arylalkylamine N-acetyltransferase, and Analysis of signaling cascades from myeloma cells treated with pristimerin.

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