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Advances in Clinical Chemistry
- 1st Edition, Volume 121 - May 29, 2024
- Editor: Gregory S. Makowski
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 9 7 0 2 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 9 7 0 3 - 8
Advances in Clinical Chemistry, Volume 121, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scient… Read more
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Request a sales quoteAdvances in Clinical Chemistry, Volume 121, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists.
- Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science
- Authored by world renowned clinical laboratory scientists, physicians, and research scientists
- Presents the international benchmark for novel analytical approaches in the clinical laboratory
Clinical Laboratory Professionals, Physicians and Research Scientists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Blood-brain barrier biomarkers
- Abstract
- 1 Introduction
- 2 Blood-brain barrier: overview
- 3 Blood-brain barrier in aging
- 4 Biomarkers: a brief introduction
- 5 Biomarkers for blood-brain barrier integrity
- 6 Cellular biomarkers of the BBB
- 7 Protein markers of the BBB
- 8 Imaging Markers of the BBB
- 9 Blood-brain barrier markers in neurodegenerative disease
- 10 Blood-brain barrier biomarkers for cerebrovascular diseases
- 11 Blood-brain barrier biomarkers for neuroinflammatory diseases
- 12 Blood-brain barrier biomarkers in neuropsychiatric conditions
- 13 Challenges in BBB biomarker research
- 14 Emerging trends in BBB biomarker research and future perspectives
- 15 Conclusions
- Acknowledgements
- References
- Chapter Two: suPAR in cardiovascular disease
- Abstract
- 1 Introduction
- 2 suPAR
- 3 suPAR measurement
- 4 suPAR and cardiovascular disease
- 5 Future perspectives
- 6 Conclusion
- References
- Chapter Three: Pleiotropic functions and clinical importance of circulating HDL-PON1 complex
- Abstract
- 1 Introduction
- 2 HDL: subclasses and constituents
- 3 Oxidative modifications of HDLs
- 4 PON1: a multifunctional enzyme with several physiological roles
- 5 Circulating HDL-associated PON1 as a worthy biomarker for CVD
- 6 Importance of PON1-HDL interaction: structural basis and functionality
- 7 Conclusions
- Conflicts of interest
- References
- Chapter Four: Adipokines in pregnancy
- Abstract
- Abbreviations
- 1 Introduction
- 2 Characteristics of adipokines and their receptors
- 3 Plasma levels and placental expression of adipokines during pregnancy
- 4 Effect of adipokines on placenta function
- 5 Levels of adipokines in plasma and placental in pregnancy pathologies
- 6 Summary and future perspectives
- References
- Chapter Five: Proteostasis in neurodegenerative diseases
- Abstract
- Abbreviations
- 1 Introduction
- 2 Translation and protein quality control
- 3 Major cytosolic chaperone systems in eukaryotes
- 4 Cellular protein misfolding, aggregation, and proteotoxicity
- 5 Protective roles of chaperones in neurodegeneration
- 6 Ubiquitin-proteasome system
- 7 Ubiquitin-proteasome system in neurodegeneration
- 8 Ubiquitin-proteasome system associated therapeutic interventions for neurodegenerative diseases
- 9 An overview of autophagy and related mechanisms
- 10 Forms of autophagy
- 11 Involvement of autophagy in life
- 12 Autophagy and neurodegeneration
- 13 Conclusion and outlook
- Acknowledgments
- References
- Chapter Six: Mitochondria: A source of potential biomarkers for non-communicable diseases
- Abstract
- 1 Introduction
- 2 Mitochondrial morphology and function
- 3 Mitochondrial homeostasis and heterogeneity
- 4 Mitochondrial dysfunction
- 5 Mitochondrial dysfunction in a non-communicable somatic disease
- 6 Cancer
- 7 Cancer and mitochondria
- 8 Diabetes
- 9 Diabetes and mitochondria
- 10 Diabetes and mitochondria-related pathophysiology
- 11 Neurodegenerative disease
- 12 Mitochondria in neurodegenerative disease
- 13 Cardiovascular disease
- 14 Cardiovascular disease and mitochondria
- 15 Mitochondrial dysfunction as a potential biomarker
- 16 Mitochondria as a therapeutic target
- 17 Conclusion
- References
- Index
- No. of pages: 394
- Language: English
- Edition: 1
- Volume: 121
- Published: May 29, 2024
- Imprint: Academic Press
- Hardback ISBN: 9780443297021
- eBook ISBN: 9780443297038
GM
Gregory S. Makowski
Dr Gregory S Makowski is a board-certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President Clinical Laboratory Services Hartford HealthCare in Connecticut.
Affiliations and expertise
Vice President and Chief Scientific Officer, Clinical Laboratory Partners, Newington, CT, USARead Advances in Clinical Chemistry on ScienceDirect