The Hidden World of Protein Aggregation
- 1st Edition, Volume 206 - May 30, 2024
- Latest edition
- Editors: David B. Teplow, Bahareh Dabirmanesh, Vladimir N. Uversky
- Language: English
The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggreg… Read more
Description
Description
Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation.
Key features
Key features
- Provides an introduction to the folding of protein and associated conditions leading to aggregation and linked pathology
- Discusses structural biology and computational methodologies for analysis of protein (mis)folding and aggregation
- Describes functional amyloids and their biotechnological applications
Readership
Readership
Table of contents
Table of contents
Bahareh Dabirmanesh and Vladimir N. Uversky
1. Protein Aggregation: An Overview
Vladimir N. Uversky
2. Pathways of Amyloid Fibril Formation and Aggregation
Bahareh Dabirmanesh and Fatemeh Aziziyan
3. Factors Influencing Amyloid Fibril Formation
Khosro Khajeh and Fatemeh Aziziyan
4. Morphological Features and Types of Aggregated Structures
Vladimir N. Uversky
5. Each big journey starts with a first step: Importance of Oligomerization
Vladimir N. Uversky
6. Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation
Vladimir N. Uversky
7. Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils
Bahareh Dabirmanesh and Farnoosh Farzam
8. Prediction of Protein Aggregation
Khosro Khajeh
9. Amyloid Fibril Cytotoxicity and Associated Disorders
Khosro Khajeh
10. Inhibitors of Amyloid Fibril Formation
Khosro Khajeh and Fatemeh Aziziyan
11. Therapeutic Approaches in Proteinopathies
Vladimir N. Uversky
12. Functional Amyloids
Bahareh Dabirmanesh
13. Biotechnological Applications of Amyloid Fibrils
Bahareh Dabirmanesh
14. The Hidden World of Protein Aggregation
Bahareh Dabirmanesh and Vladimir N. Uversky
Product details
Product details
- Edition: 1
- Latest edition
- Volume: 206
- Published: June 6, 2024
- Language: English
About the editors
About the editors
DT
David B. Teplow
David B. Teplow, Ph.D., is a Professor of Neurology, Emeritus, at UCLA and an internationally recognized leader in efforts to understand and treat Alzheimer's disease. Dr. Teplow's group has used a multi-disciplinary approach to determine how neurotoxic peptides, such as the amyloid β-protein (Alzheimer's disease) and α-synuclein (Parkinson’s disease), form neurotoxic structures that kill neurons and to develop the means to block these processes. Dr. Teplow received undergraduate training at UC Berkeley; a Ph.D. from the University of Washington; and was a postdoctoral scholar at Caltech. Before coming to UCLA, Dr. Teplow was a faculty member in the Department of Neurology, Harvard Medical School. Dr. Teplow has published >250 peer-reviewed articles, books and book chapters, and commentaries, in addition to serving on numerous national and international scientific advisory boards. Dr. Teplow was a founding editor of the Journal of Molecular Neuroscience and Current Chemical Biology, He is Editor-in-Chief of the Elsevier serial Progress in Molecular Biology and Translational Science and is Associate Editor-in-Chief of the American Journal of Neurodegenerative Disease.
BD
Bahareh Dabirmanesh
VU
Vladimir N. Uversky
Vladimir N. Uversky is Professor in the Department of Molecular Medicine at the Morsani College of Medicine, University of South Florida. His research centers on protein folding, misfolding, and intrinsic disorder. He began his career at the Institute of Protein Research and the Institute for Biological Instrumentation in Russia, before moving to the University of California, Santa Cruz in 1998 and Indiana University–Purdue University Indianapolis in 2004, where he served as Senior Research Professor. He has been at USF since 2010 and is a Fellow of the Royal Society of Biology, the Royal Society of Chemistry, the American Institute for Medical and Biological Engineering, and the American Association for the Advancement of Science. Professor Uversky has authored numerous research papers and reviews and edited several books and book series on protein structure, folding, and misfolding. He serves as an editor for several scientific journals.