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    • The 50th Anniversary Issue of Fish Physiology

      • 1st Edition
      • Volume 40A
      • October 31, 2023
      • English
      • Hardback
        9 7 8 0 4 4 3 1 3 7 3 3 4
      • eBook
        9 7 8 0 4 4 3 1 3 7 3 4 1
      The series "Fish Physiology" recently celebrated its 50th Anniversary. In total, the editors of the series have produced a total of 47 books (several volumes have two books) that contain almost 500 chapters since the inaugural volume published in 1969. The content of the "Fish Physiology" volumes has evolved over time. The initial volumes were devoted to understanding the basic mechanisms and principles of fish physiology, with a focus on a few model species and some application to natural environmental conditions. Then, as the field better understood mechanisms, the approach was broadened to not only delve deeper into system physiology (e.g., chapters in early volumes were expanded to become books), but interspecific differences in physiology were explored, permitting a more evolutionary framework. Finally, as interspecific physiological mechanisms were further resolved, it became possible to discuss physiology in light of a changing world. Thus, physiology can now inform on conservation, sustainability and management, as exemplified with the most recent volumes. This anniversary issue celebrates the series by highlighting some of the very important early work in the field that was published in the Series. In particular, we wished to (re)introduce new researchers to this research that has stood the test of time and that shaped the field. Each re-published chapter is preceded by a short review written by experts in the field to provide an overview/introductio... of each selected chapter, discuss what is particularly noteworthy or important in the particular chapter, and discuss why in their opinion this chapter has become a classic in its own right and how it has inspired the field of fish physiology today?

    • Epigenetic Regulation of Cancer - Part A

      • 1st Edition
      • Volume 380
      • August 31, 2023
      • English
      • Hardback
        9 7 8 0 4 4 3 2 2 1 7 8 1
      • eBook
        9 7 8 0 4 4 3 2 2 1 7 9 8
      Epigenetic Regulation of Cancer - Part A, Volume 380 in the International Review of Cell and Molecular Biology series, presents content from various experts in epigenetics who cover multiple facets of cancer-associated epigenetic alterations, including the impact of epigenetic deregulation in all steps of oncogenesis as well as promising strategies to therapeutically target cancer-associated epigenetic deregulation. Specific chapters cover Epigenetic regulation of epithelial-mesenchym... transition during cancer development, Novel insights into DNA methylation-based epigenetic regulation of breast tumor angiogenesis, Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sites, Non-coding RNAs in the epigenetic landscape of Cutaneous T-cell lymphoma, and much more.

    • Integrated Methods in Protein Biochemistry: Part B

      • 1st Edition
      • Volume 679
      • January 18, 2023
      • English
      Integrated Methods in Protein Biochemistry: Part B, Volume 678 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Precise modification of native proteins, purification, and analysis of bioconjugates, NanoBiT-based methods to monitor the activation and modulation of RTKs, The interplay of G-protein βγ subunit and PLC-β enzyme in PIP2 hydrolysis and downstream signaling, Structure and function of bacterial secretion system, Tools and protocols for probing protein sumoylation, Spectroscopic analysis of cysteine dioxygenase: a mammalian thiol-dioxygenase, DeGlyPHER: MS-based analysis of viral spike N-glycoforms, and more. Additional sections cover Covalent protein painting: MS-based protein footprinting, Characterization of GPCR signaling complexes using negative-staining electron microscopy, Probing protein misfolding and dissociation with free electron laser, Optimized protocol for the characterization of Cas12a activities, Proximity proteomics for the identification and characterization of extracellular vesicles, Structural and Functional characterization of lytic polysaccharide monooxygenases, and much more.

    • The Immunological Synapse - Part B

      • 1st Edition
      • Volume 178
      • July 11, 2023
      • English
      • Hardback
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      • eBook
        9 7 8 0 4 4 3 1 9 1 6 4 0
      The Immunological Synapse - Part B, Volume 178 in the Methods in Cell Biology series provides state-of-the-art methods for the study of the immunological synapse. This first volume covers various aspects on T cell and natural killer (NK) cell synapses, including imaging polarized granule release using TIRF microscopy, analysis of actin reorganization and centrosome polarization, redirected degranulation, live cell-imaging to quantify cytotoxic and chemotactic dynamics, quantification of interactions between APCs and T cells, assessment of membrane lipid state at the immunological synapse, proteomic analysis and imaging of NK-tumor cell interaction, evaluating natural killer cell effector functions against breast cancer cells derived from human tumor tissue, evaluation of chimeric antigen receptor (CAR)-modified cell immunological synapse quality using the glass-supported planar lipid bilayer, and monitoring potency of therapeutic CAR T cells. It also includes one chapter on quantification of lymphocytic choriomeningitis virus specific T cells and LCMV viral titers, and one chapter on the murine antibody-dependent cellular phagocytosis assay.

    • ZIP Metal Ion Transporters

      • 1st Edition
      • Volume 687
      • August 31, 2023
      • English
      • Hardback
        9 7 8 0 3 2 3 9 5 7 7 6 2
      • eBook
        9 7 8 0 3 2 3 9 5 7 7 7 9
      ZIP Metal Ion Transporters, Volume 684 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Biochemistry, Biophysics and Structural Biology, Structure determination of a bacterial ZIP in lipidic cubic phase, Cell-based metal transport assay for animal and plant ZIPs, Measurement of metal binding affinity and transport activity in ZIP transporters using spectroscopic methods, Considerations in production of the (prokaryotic) ZIP family transporters for structural and functional studies, Metal-protein interactions investigated using model systems: thermodynamic, spectroscopic and computational methods, and more. Additional chapters cover Getting Zinc Into and Out of Cells, In-silico modeling of ZIP9 (TBD), Cellular Function and Regulation, Methods to visualize zinc transporter proteins of the SLC39A family in cells, Assessing metal ion transporting activity of ZIPs: intracellular zinc and iron detection, In vitro studies for studying manganese transport and homeostasis, and much more.

    • Secretory Proteins

      • 1st Edition
      • Volume 133
      • January 17, 2023
      • Rossen Donev
      • English
      • Hardback
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      • eBook
        9 7 8 0 4 4 3 1 5 8 2 1 6
      Secretory Proteins, Volume 133 in the Advances in Protein Chemistry and Structural Biology series highlights new advances in the field, including chapters on Proprotein Convertases regulate trafficking and maturation of key proteins within the secretory pathway, Secretory Proteins in Cancer Diagnosis, Senescent Cells and SASP in Cancer Microenvironment: new approaches in cancer therapy, Autophagy for secretory protein: Therapeutic targets in cancer, Secretory proteins and pathways of secretion of osteosarcoma, Monocyte secretory proteins as drug targets for arresting progression of atherosclerosis, The secretory phenotypes of envenomed cells: insights into venom cytotoxicity, Macromolecules for secretory pathway in SARS-CoV-2 infection, and much more. Other sections cover Exploring the role of secretory proteins in the human infectious diseases diagnosis and therapeutics, Secretory proteins in orchestration of microbial pathogenesis- the curious case of Staphylococcus aureus, Influence of pathological mutations in Aspartylglucosylamin... Deaspartylase causing Aspartylglucosaminur... an in silico approach, and Change in conformational dynamics of Lipase A secretory protein upon mutation causing Wolman disease.

    • Temas selectos en enfermedad vascular cerebral

      • 2nd Edition
      • July 15, 2023
      • Fernando Barinagarrementeria Aldatz + 1 more
      • Spanish
      • Paperback
        9 7 8 8 4 1 3 8 2 3 9 9 7
      • eBook
        9 7 8 8 4 1 3 8 2 5 8 3 0
      En un panorama en que no abundan los textos sobre la especialidad en lengua española, esta nueva edición de Temas selectos en enfermedad vascular cerebral se distingue por recoger, de forma rigurosa y exhaustiva, los enormes avances alcanzados en este campo durante los últimos diez años. Entre ellos, se incluyen las nuevas técnicas de neuroimagen, el papel de la medicina prehospitalaria en la cadena de supervivencia del ictus, la evaluación del paciente con sospecha de ictus en la sala de emergencias y, sobre todo, el tratamiento agudo del ictus isquémico, cuya enorme evolución ha cambiado drásticamente el pronóstico de esta devastadora enfermedad.

    • Celiac Disease

      • 1st Edition
      • Volume 179
      • August 21, 2023
      • English
      • Hardback
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      • eBook
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      Celiac Disease, Volume 179 in the Methods in Cell Biology series is composed of extensive protocols about novel and widely used techniques for celiac disease research. Topics covered in this volume include Pepsin trypsin digested gliadin treatment of intestinal cells in vitro, Ex vivo Gliadin Stimulation of Intestinal Cells, Measuring intestinal permeability in celiac disease ex vivo using Ussing chambers, Intestinal permeability assessment using lactulose and mannitol, In vivo sensitization to gliadin by oral administration, Separation of epithelial and immune cells from intestinal biopsy samples, Isolation and study of dendritic cells and macrophages from human intestinal samples, Gnobiotic mouse models to study gluten sensitivity, and more. Other sections in this new release include In vitro differentiation of macrophages from peripheral blood cells of celiac patients, Assessment of activated gut-homing CD8+ T cells in blood by flow cytometry during a three-day gluten challenge, Isolation, cryopreservation and thawing of peripheral blood mononuclear cells for downstream applications, and more.

    • Enzymes in RNA Science and Biotechnology Part B

      • 1st Edition
      • Volume 692
      • November 2, 2023
      • English
      • Hardback
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      • eBook
        9 7 8 0 4 4 3 2 3 9 7 7 9
      Enzymes in RNA Science and Biotechnology, Part B, Volume 692 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as Quantitative base-resolution sequencing technology for mapping pseudouridines in mammalian mRNA, Quantitative base-resolution DAMM-seq for mapping RNA methylations in tRNA and mitochondrial dsRNA, Discovering RNA modification enzymes using a comparative genomics approach, Functional analysis of tRNA modification enzymes using mutational profiling, and Fluorescent labeling of tRNA for rapid kinetic interaction studies with tRNA-binding proteins.Other chapters cover Enzymatic Synthesis of RNA Standards for Mapping and Quantifying RNA Modifications in Sequencing Analysis, Characterizing RNase L-mediated mRNA decay in single cells, Characterization of RNase J, Pri-miRNA cleavage assays for the Microprocessor complex, The pre-miRNA cleavage assays for DICE, Methods for study of ribonuclease targeting chimeras, and Profiling the in vivo RNA interactome associated with the endoribonuclease RNase III in Staphylococcus aureus.

    • Cilia: From Mechanisms to Disease–Part B

      • 1st Edition
      • Volume 176
      • April 21, 2023
      • English
      • Hardback
        9 7 8 0 4 4 3 1 8 5 8 8 5
      • eBook
        9 7 8 0 4 4 3 1 8 5 8 9 2
      Cilia: From Mechanisms to Disease Part B, Volume 176 of the Methods in Cell Biology series, presents interesting chapters on topics such as The challenge of dissecting gene function in model organisms: tools to characterize genetic mutants and assess transcriptional adaptation in zebrafish, Human LUHMES and NES cells as models for studying primary cilia in neurons, Fixation methods and immunolabeling for cilia proteins in ciliary and extraciliary locations, Single-molecule imaging in the primary cilium, Methods to analyze primary cilia in mouse cardiac lesion model, Methods to study motile ciliated cell types in a zebrafish brain mode, and more. Other sections cover Clinical and Molecular diagnosis in BBS (Bardet-Biedl syndrome), Modeling ciliopathies in patient-derived primary cells, Analysis of motility and mucociliary function of tracheal epithelial cilia, High-speed Super-resolution SPEED Microscopy to study Live Primary Cilium, Methods for siRNA delivery in retina explants, Methods to study primary cilia and autophagy in the brain, and more.

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