Epigenetic Regulation of Cancer - Part A
- 1st Edition, Volume 380 - August 31, 2023
- Imprint: Academic Press
- Editors: Sheila Spada, Lorenzo Galluzzi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 2 1 7 8 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 2 1 7 9 - 8
Epigenetic Regulation of Cancer - Part A, Volume 380 in the International Review of Cell and Molecular Biology series, presents content from various experts in epigenetics who… Read more
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Request a sales quoteEpigenetic Regulation of Cancer - Part A, Volume 380 in the International Review of Cell and Molecular Biology series, presents content from various experts in epigenetics who cover multiple facets of cancer-associated epigenetic alterations, including the impact of epigenetic deregulation in all steps of oncogenesis as well as promising strategies to therapeutically target cancer-associated epigenetic deregulation. Specific chapters cover Epigenetic regulation of epithelial-mesenchymal transition during cancer development, Novel insights into DNA methylation-based epigenetic regulation of breast tumor angiogenesis, Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sites, Non-coding RNAs in the epigenetic landscape of Cutaneous T-cell lymphoma, and much more.
- Provides accurate and critical review articles from invited experts on each selected topic
- Presents the newest insights and remarks on multiple subjects
- Offers a broad range of perspectives on detailed features
Undergraduate and graduated students to establish and active scientists in the specific field linked to cell and molecular biology
- Cover image
- Title page
- Table of Contents
- International Review of Cell Andmolecular Biology
- Copyright
- Contributors
- Epigenetic regulation of cancer
- Acknowledgments
- References
- Chapter One: Epigenetic regulation of epithelial–mesenchymal transition during cancer development
- Abstract
- 1 Introduction
- 2 Epigenetic modifications and human cancers
- 3 EMT and human cancers
- 4 Epigenetic regulation of EMT in human cancers
- 5 Epigenetic therapy targeting EMT for management of human cancers
- 6 Conclusions and future perspectives
- References
- Chapter Two: Novel insights into DNA methylation-based epigenetic regulation of breast tumor angiogenesis
- Abstract
- 1 Introduction
- 2 Conclusion
- 3 Future perspectives
- Acknowledgements
- References
- Chapter Three: Super-enhancer landscape rewiring in cancer: The epigenetic control at distal sites
- Abstract
- 1 Introduction
- 2 Promoters and typical enhancers
- 3 Super-enhancers (SEs)
- 4 Super-enhancers identification
- 5 eRNAs
- 6 The Mediator complex
- 7 Chromatin remodelers
- 8 TADs, chromatin organization and distal CREs
- 9 Super-enhancer, phase separation and membraneless organells
- 10 SEs in cancer an introduction
- 11 SEs expansion or contraction in cancer
- 12 Subversion of hierarchically organization of SEs in cancer
- 13 SEs and ncRNAs, dangerous liaisons in cancer progression
- 14 SEs and ncRNAs, altered circuits in resistance to therapy
- 15 SEs for classification of tumors subtypes or cancer ethnicity, predicts subclonal evolution and identify new druggable targets
- 16 Conclusions
- Acknowledgments
- References
- Chapter Four: Non-coding RNAs in the epigenetic landscape of cutaneous T-cell lymphoma
- Abstract
- 1 Introduction
- 2 miRNAs in CTCL
- 3 Long non-coding RNAs in CTCL
- 4 Non-coding RNAs in CTCL patients
- 5 Conclusion and future perspectives
- References
- Chapter Five: Epigenetic mechanism of therapeutic resistance and potential of epigenetic therapeutics in chemorefractory prostate cancer
- Abstract
- 1 Introduction
- 2 Epigenetic reprogramming-dependent aberrant regulation of genes during therapeutic resistance development in prostate cancers
- 3 Aberrant expression of epigenetic regulatory genes during therapeutic resistance in prostate cancer
- 4 Epigenetic regulation of DNA repair genes in prostate cancer chemoresistance
- 5 Epigenetic regulation of androgen-dependent growth in ADT in prostate cancer
- 6 Epigenetic regulation of genes associated with cellular plasticity during chemoresistance in prostate cancer
- 7 Potential of epigenetics-based therapeutics in prostate cancer treatment
- 8 Summary
- References
- Chapter Six: Epigenetic inhibitors and their role in cancer therapy
- Abstract
- Abbreviations
- 1 Introduction
- 2 Epigenetic modifications
- 3 The role of epigenetics in cancer development
- 4 Epigenetics as a target for cancer therapies
- 5 Epi-drugs
- 6 Small non-coding RNAs
- 7 Conclusion and future perspectives
- Acknowledgments
- References
- Edition: 1
- Volume: 380
- Published: August 31, 2023
- No. of pages (Hardback): 270
- No. of pages (eBook): 277
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443221781
- eBook ISBN: 9780443221798
SS
Sheila Spada
Sheila Spada is at Weill Cornell Medical College, NY, USA
Affiliations and expertise
Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USALG
Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology.
Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals:
OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.
Affiliations and expertise
Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USARead Epigenetic Regulation of Cancer - Part A on ScienceDirect