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Elsevier

Books in Life sciences

  • Protides of the Biological Fluids

    Proceedings of the Twenty-Seventh Colloquium, 1979
    • 1st Edition
    • H. Peeters
    • English
    Protides of the Biological Fluids reviews trends in research concerning protides of the biological fluids, with emphasis on tumor-associated antigens (TAAs), lectins, and separation methods such as electrophoresis and isoelectric focusing. Examples of TAAs discussed in this book are carcinoembryonic antigens, mesenchyme-associate... antigens, and oncofetal pancreatic antigens. The mode of action of lectins as well as lectin-binding sites are also considered. This book is comprised of 195 chapters and begins with an overview of the strategy and monitoring of protein fractionation, followed by a discussion on the self-nonself concept of cancer and ""autoimmune"" diseases; presence of trophoblast antigens on the membranes of some human tumor and transformed cells; and non-specific cross-reacting antigens in human blood monocytes. Subsequent chapters explore the metabolism of carcinoembryonic antigen and alpha-fetoprotein during delivery; amino acid sequence identity of tissue polypeptide antigen fragments from different sources; isoferritins, glycoproteins, and viral antigens; and crossed immunoelectrophoresi... of yeast plasma membrane lectin receptors. The final section is devoted to separation techniques such as isotachophoresis, chromatography, electrophoresis, and isoelectric focusing. This monograph will be of value to biologists and researchers interested in protides of the biological fluids.

  • Mammalian Cell Membranes

    Volume 3, Surface Membranes of Specific Cell Types
    • 1st Edition
    • G. A. Jamieson + 1 more
    • English
    Mammalian Cell Membranes, Volume Three: Surface Membranes of Specific Cell Types reviews the knowledge on surface membranes of the various cell types which have been studied in detail. This volume contains 10 contributions that cover the review of mammalian cell membranes. The topics discussed in the book include epithelial membranes and vitamin A, the erythrocyte, the platelet, and lymphoid cells. The carbohydrate components of tumor cell periphery, the composition and structure of excitable nerve membrane, and the role of membranes in the fertilization process are covered as well. Cytologists, molecular biologists, biochemists, and anatomists will find the book very invaluable.

  • Immunopathology of Insulin

    Clinical and Experimental Studies
    • 1st Edition
    • K. Federlin
    • F. Gross + 2 more
    • English
    Monographs on Endocrinology, Volume 6: Immunopathology of Insulin provides information pertinent to the fundamental aspects of immunopathology of insulin. This book covers a variety of topics, including cell mediated immunity, biological effects of insulin, insulin allergy, insulin immunology, and humoral insulin antibodies. Organized into six chapters, this volume begins with an overview of the causal relationship between delayed hypersensitivity and antibody production. This text then explains the molecular localization of the most important immunologic components of the insulin molecule. Other chapters consider the clinical observation of allergic reactions of insulin antibodies in the tissue and the in vitro method of standard serology. This book discusses as well methods used for demonstration of insulin antibodies in humans and experimental animals. The final chapter deals with the investigations concerned with the various kinds of immune reactions, which follow the injection of insulin. This book is a valuable resource for endocrinologists, immunologists, and diabetologists.

  • A History of Medical Bacteriology and Immunology

    • 1st Edition
    • W. D. Foster
    • English
    A History of Medical Bacteriology and Immunology provides the account of the history of bacteriology from the year 1900 to 1938. This book presents details about the discovery of the important pathogenic bacteria of man, of how they were shown to be causally related to disease, and of the use of these discoveries in the diagnosis, treatment, and prevention of disease. Other topics discussed include the development of the germ theory of infectious diseases; contribution of Louis Pasteur and Robert Koch to medical bacteriology; and discovery of the more important human pathogenic bacteria. This text also discusses the scientific basis and practical application of immunology to medicine; main developments in bacteriology during the early 20th century; and chemotherapy of bacterial disease. This medically oriented text is beneficial for students and individuals conducting study on medical bacteriology and immunology.

  • Mammalian Cell Membranes

    Volume 2: The Diversity of Membranes
    • 1st Edition
    • G. A. Jamieson + 1 more
    • English
    Mammalian Cell Membranes, Volume Two: The Diversity of Membranes is a collection of reviews focusing on to specific types of intra- and extracellular membranes. The compendium contains 10 contributions devoted to the review of mammalian cell membranes. The topics covered in the book include the organization of the plasma membrane of mammalian cells, membranes of the endoplasmic reticulum and the secretory system and their role in plasma membrane regulation, and the structure of mitochondrial membranes. The nuclear envelope in mammalian cells, the myelin sheath, and the microvilli and cilia are also discussed. Cytologists, molecular biologists, biochemists, and anatomists will find the book very useful.

  • Immunological Aspects of Reproduction in Mammals

    • 1st Edition
    • D. B. Crighton
    • English
    Immunological Aspects of Reproduction in Mammals contains papers presented during a symposium at the University of Nottingham Easter School. The scholarly presentations provide a wealth of information on the field of reproductive immunology and indicate just how complex this field is and how many questions still remain to be answered. The book begins with reviews of the current status of the complexities and uncertainties of the cellular basis of the immune response and the structure and function of antibodies. This is followed by separate chapters on the assessment and interpretation of the phenomena surrounding autoimmune and isoimmune reactions to spermatozoa; advances in defining the distribution and degree of exposure of major histocompatibility antigens; the reproductive immunology of the mouse, horse, and sheep; and fetal and neonatal immunity. Subsequent chapters present studies of immunization of several species with either the hypothalamic hormone LH-RH, pituitary gonadotrophins, or ovarian steroids; and studies directed towards efforts to enhance animal production by either active or passive immunization of female farm animals against steroid hormones. This book will be a valuable reference text for those already involved in the field and a stimulus for others to enter this complex and fascinating area of research.

  • General Immunology

    • 1st Edition
    • Edwin L. Cooper
    • English
    General Immunology provides a general overview of the immune system. It presents topics in immunology from all living groups, treating cells, tissues, organs, and organismal levels of biological organization. The book contains 23 chapters organized into eight sections. Section I serves as an introduction to immunology—a science, a sketch of its history, some of its more recent contributors, something about gathering facts, immunology journals, and the entire biomedical enterprise of which immunology is just a part. Section II is devoted to antigens while Section III examines the immune system in chordates and the ontogeny of the immune system. Section IV on cells of the immune system covers monocytes, macrophages, the three granulocytic types, and mast cells. Section V deals with phagocytosis and the interaction of lymphocytes. Section VI is devoted to antigens in relation to antibody synthesis, antigen-antibody interactions, immunologlobulin structure, and immunologlobulin assembly. Section VII on organs of the immune system examines bone marrow, thymus, spleen, lymph nodes, and lymphoid aggregations. Section VIII discusses the evolution of the immune system. This text was written for advanced undergraduates. However, its comprehensiveness makes it useful to immunologists and biologists at all levels as well as medical students and clinicians.

  • Membrane Glycoproteins

    A Review of Structure and Function
    • 1st Edition
    • R. Colin Hughes
    • English
    Membrane Glycoproteins: A Review of Structure and Function deals with membrane glycoproteins found in biological systems. The book describes the structure and biosynthesis of the glycoproteins in relation to known or postulated functions in membranes. The text opens with an introduction and a topic on detection and distribution of membrane glycoproteins. The book then notes that the isolation of membrane glycoproteins brought by the progress in research and technology of membrane solubilization and purification of the soluble components is now possible. Discussion is also directed to glycoproteins as being integral components of intracellular membranes, and not just located on cell surfaces. Through the structural analysis of glycoproteins produced by the secretory glands, analysis of human blood group antigens is available. Likewise, discoveries are made, explaining that lectins are useful reagents in detecting the type and numbers of glycoproteins found on cellular members. Lectins are likewise being widely used in tests for carbohydrate-contain... substances in membrane-mediated processes. The metabolism, growth control, and cell surface reactions of membrane glycoproteins are also explained. The book can serve as a guide for biologists, chemists, biochemists, and academicians interested in the study of membranes or glycoproteins.

  • Fundamentals of Enzyme Kinetics

    • 1st Edition
    • Athel Cornish-Bowden
    • English
    Fundamentals of Enzyme Kinetics details the rate of reactions catalyzed by different enzymes and the effects of varying the conditions on them. The book includes the basic principles of chemical kinetics, especially the order of a reaction and its rate constraints. The text also gives an introduction to enzyme kinetics - the idea of an enzyme-substrate complex; the Michaelis-Menten equation; the steady state treatment; and the validity of its assumption. Practical considerations, the derivation of steady-state rate equations, inhibitors and activators, and two-substrate reactions are also explained. Problems after the end of each chapter have also been added, as well as their solutions at the end of the book, to test the readers' learning. The text is highly recommended for undergraduate students in biochemistry who wish to study about enzymes or focus completely on enzymology, as most of the mathematics used in this book, which have been explained in detail to remove most barriers of understanding, is elementary.

  • The Biochemistry of Parasites

    Proceedings of the Satellite Conference of the 13th Meeting of the Federation of European Biochemical Societies (FEBS) Held in Jerusalem, August 1980
    • 1st Edition
    • Gerald M. Slutzky
    • English
    The Biochemistry of Parasites documents the proceedings of the Satellite Conference of the 13th Meeting of the Federation of European Biochemical Societies (FEBS) held in Jerusalem, August 1980. The conference presented the opportunity to summarize work done by parasite biochemists and introduce this field to workers in classical biochemistry. The 45 papers in this volume are divided into two sections covering parasite biomembranes and parasite metabolism. The papers in the biomembranes section are further divided in two parts: the parasite membrane (Part I) and adherence of the parasite to host tissues (Part II). Part I is concerned with both classical and novel aspects of membrane structure and function. It includes studies on the membrane of the leishmania; the surface coat of trypanosomes; membrane function; and transport across the cell membrane. Part II covers topics such as the adherence of pathenogenic microorganisms and the importance of of carbohydrates in parasite-host adherence. The papers in the parasite metabolism section focus primarily on three groups of parasites: leishmania, malaria, and helminthes. Topics covered include the isolation and characterization of a proteolytic enzyme from Plasmodium lophurae (duck malaria); the selection and culture of malaria parasites resistant to aminopterin; and regulation of cyclic AMP metabolism in Leishmania promastigotes and amastigotes.

  • Experimental Biology with Micro-Organisms

    Students' Manual
    • 1st Edition
    • J. W. Garbutt + 1 more
    • English
    Experimental Biology with Micro-organisms: Students' Manual talks about micro-organisms and examines facts and different relevant studies. The first part of the book discusses handling, culturing, and observing a micro-organism; this part also explains the importance of such practices when dealing with the said subject. Also mentioned in this part are the nutrition of the micro-organisms and the explanations regarding autotrophs and heterotrophs and what complex food they manufacture or utilize. The book also presents a background on the life cycle of the organisms, such as bacteria, chlorella, slime molds, yeast, Mucor hiemalis, and Basidiomycetes. In Chapters 4 and 5, the book talks more about an organism's growth and genetics, along with some of its subtopics. The succeeding chapters focus more on the environment's effect on organisms. The book ends with an analysis of the different interactions. The book caters for people who are studying biology and acts as a great reference for bio research.

  • Supramolecular Enzyme Organization

    Quaternary Structure and Beyond
    • 1st Edition
    • Peter Friedrich
    • English
    Supramolecular Enzyme Organization: Quaternary Structure and Beyond provides a comprehensive discussion of enzyme interactions. It attempts to place conceptually related phenomena in a common perspective by first scrutinizing enzyme interactions at the quaternary level and then moving on towards higher orders of organization. The book begins with a discussion of the hierarchy of enzymes, covering the structure of monomeric enzymes, enzyme structures beyond the monomeric stage, and protein-protein interactions. Separate chapters cover the chemistry of protein associations; the quaternary structure of enzymes; multienzyme systems; multienzyme complexes and conjugates; the association of enzymes with cellular structures; and metabolite compartmentation. The final chapters discuss trends in the study of enzyme systems and the dialectics of enzymology. This book is intended, not for the specialist, who knows much more about the individual questions than the text offers, but rather for the general biochemical reader interested in enzyme organization. There is practically no mathematics involved. Instead, quite elementary things are described, so that students and biologists with less background knowledge on enzymes will be able to join in.

  • The Shikimate Pathway

    Biosynthesis of Natural Products Series
    • 1st Edition
    • Edwin Haslam
    • Gordon Kirby
    • English
    The Shikimate Pathway gives a bird's eye view of the shikimate pathway and its implications for the life of a range of organisms. Topics covered in this book include the chemistry of intermediates in the shikimate pathway; biosynthesis of aromatic amino acids in this pathway; its metabolites; and its role in higher plants. This book is comprised of six chapters and begins by introducing the reader to shikimic acid, a natural product derived from the plant Illicium religiosum, along with the mechanistic and stereochemical aspects of the reactions of the shikimate pathway. The biosynthesis of aromatic amino acids from chorismate is also described, and then the discussion turns to the chemical properties and the detailed stereochemistry of intermediates and enzymes in the shikimate pathway. The next chapter examines the biosynthesis of isoprenoid quinones involved in electron transport and the folic acid group of co-enzymes in the shikimate pathway. The metabolism of the aromatic amino acids in microorganisms and higher organisms is considered, along with the biosynthesis and physiological functions of phenylpropanoid compounds and their derivatives in the shikimate pathway in higher plants. This book will be of general value to practitioners in the many and varied areas of biochemical research associated with metabolism.

  • Europe—Japan

    Futures in Science, Technology and Democracy
    • 1st Edition
    • Vincent J. McBrierty
    • English
    Europe-Japan: Futures in Science, Technology and Democracy presents the combined European and Japanese thinking on the implications of scientific and technological developments for society and democracy. This book addresses the challenges and the advantages that science and technology brings to Europe and Japan and explores how the process and application of scientific discovery can be beneficial to all people in the world. This monograph is comprised of six chapters and begins with a discussion on the impact of science on civilization and democracy, with emphasis on the challenges and opportunities afforded by technological innovations. The implications of advances in biology and medicine for human rights are the subject of the next chapter, paying particular attention to the themes of freedom, ethics, and the role of communication and dialogue in society. This book also explores cooperation and competition in science and advanced technology before concluding with a chapter that describes the scientific and technological linkages between Europe and Japan. This text will be a valuable resource for policymakers, parliamentarians, scientists, and others who are concerned with the increasingly complex arena of science and politics.

  • All Heal

    A Medical and Social Miscellany
    • 1st Edition
    • R M Shaw + 2 more
    • English
    All Heal contains a selection of the articles of more general interest that were published in The Proceedings of the Royal Society of Medicine since 1957. The editors have chosen no more than one paper from any individual author. This book features 17 medical and social miscellany articles. The topics covered by these papers include the evolution on teaching-hospital physicians in Great Britain, the relation between crime and the British penal system, the conflict between drug control and therapeutic freedom and the academic and economic freedom of British universities. This book will be of interest to persons dealing with studies on medical and social history of Great Britain since1957.

  • Immunology of the Liver

    Proceedings of an International Meeting Held at King's College Hospital Medical School London, on 6th and 7th July, 1970
    • 1st Edition
    • Martin Smith + 1 more
    • English
    Immunology of the Liver contains the proceedings of an International Meeting held at King's College Hospital Medical School in London on July 6-7, 1970. The meeting provided a forum for discussing progress made in understanding the immunology of the liver and tackled topics ranging from the pathology of chronic hepatitis to the occurrence and distribution of tissue antibodies in liver diseases. Cell-mediated responses and manifestations of immunological damage are also explored. Comprised of 33 chapters, this book begins with an introduction to the clinical, morphological, and virological aspects of liver disease. In particular, the clinical spectrum of autoimmune liver disease is considered, along with the pathology of chronic hepatitis. Morphological and immunological studies on chronic aggressive hepatitis and primary biliary cirrhosis are presented. Subsequent chapters focus on antibodies related to mitochondria; leukocyte migration in active chronic hepatitis and primary biliary cirrhosis; immunologic observations and electron microscopy of halothane-induced hepatic injury; and humoral and delayed hypersensitivity in chronic hepatitis. The final sections deal with results of immunosuppressive therapy and the immunology of liver transplantation. This monograph will be of interest to immunologists, pathologists, physiologists, clinicians, and research workers in the field of medicine.

  • DNA - Recombination Interactions and Repair

    Proceedings of the FEBS Symposium on DNA, Liblice, 1979
    • 1st Edition
    • S. Zadrazil + 1 more
    • English
    DNA: Recombination, Interactions and Repair presents the result of the proceedings of the FEBS Symposium on DNA, which focuses on DNA recombination in vivo and in vitro, DNA interactions, and DNA repair. This book presents problems involving topics on DNA that have been studied intensively using methodological approaches and developed techniques for cloning, physical mapping, and sequencing of DNA. This text also notes that this approach has provided a basis for further genetic studies at the molecular level. The problems related to the genetic complexity of higher organisms and the relationships between the structure of genetic material and the regulation of expression of genetic information, as well as genetic engineering of micro-organisms, which become amenable to experimental investigation, are also presented in this text. This book notes that these problems are closely associated with endeavors to understand the molecular foundations of living processes to create a rational basis for treating genetic and viral diseases. This text will be a valuable source of information for students studying in the field of genetics, especially those conducting extensive research on DNA.

  • Maximizing Gene Expression

    • 1st Edition
    • William Reznikoff + 1 more
    • English
    Maximizing Gene Expression focuses on prokaryotic and eukaryotic gene expression. The book first discusses E. coli promoters. Topics include structure analysis, steps in transcription initiation, structure-function correlation, and regulation of transcription initiation. The text also highlights yeast promoters, including elements that select initiation sites, transcription regulation, regulatory proteins, and upstream promoter elements. The text also describes protein coding genes of higher eukaryotes; instability of messenger RNA in bacteria; and replication control of the ColE1-type plasmids. The text then describes translation initiation, including the translation of prokaryotes and eukaryotes. The book puts emphasis on the selective degradation of abnormal proteins in bacteria. Topics include proteins rapidly hydrolyzed in E. coli; intracellular aggregates of abnormal polypeptides; energy requirement and pathway for proteins; proteolytic enzymes in E. coli; and regulation of ion expression. The text also highlights the detection of proteins produced by recombinant DNA techniques and mechanism and practice. The book is a good source of information for readers wanting to study gene expression.

  • Protides of the Biological Fluids

    Proceedings of the Twenty-Eighth Colloquium, 1980
    • 1st Edition
    • H. Peeters
    • English
    Protides of the Biological Fluids covers the proceedings of the 28th Meeting on Protides of the Biological Fluids held in 1980. This book mainly focuses on the evolution of proteins; the molecular biology of blood coagulation and fibrinolysis; and the hybridomas. In studying the evolution of proteins, this text looks into the evolutionary studies of immunoglobulin protein and nucleic acid sequences, fibrinogen, proteases, and other proteins. This book then explains molecular biology of blood coagulation and fibrinolysis by explaining the Hageman factor, kallikrein–kinin system, human high molecular weight, and other biological processes involved. The hybridomas and monoclonal antibodies are also tackled by specifically discussing the production of monoclonal antibodies; monoclonal antibody conformation; and monoclonal antibodies against molecules. This publication will be invaluable to students, practitioners, and researchers in the field of biology and physiology who are interested in studying protides.

  • Atlas of Chick Development

    • 3rd Edition
    • Ruth Bellairs + 1 more
    • English
    The Atlas of Chick Development, Third Edition, a classic work covering all major event of chick development, is extensively updated with new and more detailed photographs, enlargements showing regions of special-interest and complexity, and new illustrations. The revised text and expanded illustrative material describe the intricate changes that take place during development, together with accounts of recent experimental and molecular research that has transformed our understanding of morphogenesis. These wide-ranging updates make this book an essential resource for developmental biologists, geneticists, molecular biologists, poultry scientists, biochemists, immunologists, and other life scientists who use the chick embryo as their research model. Individuals joining this burgeoning area, ignited by the increased insight into events surrounding organ and tissue differentiation, will find this a valuable tool to help grow a basic knowledge of morphogenesis.

  • Fungi

    • 1st Edition
    • Volume 70
    • English
    Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 70th volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This thematic volume features reviews on fungi, including pathogenic fungi, symbiotic fungi, saprotrophic fungi and population genomics.

  • Current Issues in the Education of Students with Visual Impairments

    • 1st Edition
    • Volume 46
    • English
    International Review of Research in Developmental Disabilities is an ongoing scholarly look at research into the causes, effects, classification systems, and syndromes of developmental disabilities. Contributors come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences. The current volume, number 46, addresses current issues in the education of students with visual impairments. Topics covered include the expanded core curriculum for students with visual impairment; assistive technology; Braille reading comprehension; communication development; orientation and mobility issues, and more.

  • Learning and Memory

    A Biological View
    • 2nd Edition
    • Joe L. Martinez Jr. + 1 more
    • English
    This book presents a comprehensive, up-to-date overview of brain*b1behavior relations as they bear on learning and memory. The structure of memory is investigated from a diversity of approaches, including anatomical, pharmacological, electrophysiological and lesions, and through the use of different populations, such as invertebrate, vertebrate, and human.

  • A New Approach to Teaching and Learning Anatomy

    Objectives and Learning Activities
    • 1st Edition
    • Michael J. Blunt
    • English
    A New Approach to Teaching and Learning Anatomy: Objectives and Learning Activities presents sets of general instructional and specific behavioral objectives to define the framework of a course in human anatomy. The objectives are preceded by explanatory notes which deal with the principles and the techniques involved in their formulation so that their expansion or modification may be facilitated. Methods of using the objectives as guides to study are also suggested. This book is comprised of 13 chapters and begins with an introduction to the goals to be adopted for the course framework and the general objectives that will indicate course content as well as the sequence of learning. The discussion then turns to specific behavioral objectives and student-centered learning activities, followed by an outline of the anatomy course. The course is broken down into regions and systems and covers the anatomy of bones, joints, and muscles, along with peripheral nerves and vessels. The anatomy of the upper limb, head and neck, walls of thorax and abdomen, and the lower limb are considered. The viscera are ""fitted in"" to the musculo-skeletal framework on a systematic basis, and the course outline concludes with a section on neurological anatomy, that is, the cardiovascular system, respiratory system, gastrointestinal system, genito-urinary system, and neuroendocrine system. This monograph should be useful to those who are engaged in teaching-learning programs in anatomy whether as medical educators or as students.

  • Footprinting of Nucleic Acid-Protein Complexes

    • 1st Edition
    • English
    Footprinting of Nucleic Acid-Protein Complexes provides protocols for studying the stoichiometry, binding site size and location, and structural changes in nucleic acids caused by their interaction with proteins. The methods are central to studying key biological processes, such as transcription and translation. The techniques are important to experiments in vivoand in vitro, in eukaryotes and in prokaryotes, at qualitative and quantitative levels,and across many disciplines.This book is a laboratory manual of footprinting techniques for studying nucleic acid-protein interactions. It contains clear and concise descriptions of the most important methodologies, and includes in vivo as well as in vitro applications. It is aimed at bench scientists from graduate students on, and should be of value in industrial labs as well as in academic settings. Use of different footprinting approaches can provide unique insights into DNA-protein systems. The protocols containedin this handbook are written to be"user-friendly,"an... thus should be conducive to extending the use of footprinting to new systems. The section on quantitative analysis of DNAse I footprints should prove especially useful for in depth evaluation of cooperative interactions.

  • Organization and Practice in Tuberculosis Bacteriology

    • 1st Edition
    • C. H. Collins + 2 more
    • English
    Organization and Practice in Tuberculosis Bacteriology focuses on the organization and technical methods of tuberculosis bacteriology. This book discusses the mycobacteria and mycobacterial disease and role and scope of the tuberculosis laboratory in human and veterinary medicine and epidemiology. The organization of tuberculosis laboratory services; collection, preservation and transport of specimens; and examination of direct smears are also elaborated. This text likewise covers the decontamination of specimens, inoculation of culture media, and identification of species and variants of tubercle bacilli. Other topics include the drug sensitivity tests, animal inoculation and assay tests; problems faced in the therapy of tuberculosis, and lipid chromatography. This publication is suitable for biologists, medical practitioners, and clinicians concerned with tuberculosis bacteriology.

  • Biochemical Disorders of the Skeleton

    Postgraduate Orthopaedics Series
    • 1st Edition
    • Roger K. W. Smith
    • English
    Biochemical Disorders of the Skeleton explores the biochemical and clinical aspects of skeletal disorders, including osteoporosis, osteomalacia, Paget's disease of bone, osteogenesis imperfecta, and Marfan's syndrome. Homocystinuria, Ehlers-Danlos syndrome, mucopolysaccharidose... hyperphosphatasia and hypophosphatasia, and fibrous dysplasia are also considered. Comprised of 12 chapters, this book begins with an overview of the physiology of bone, with emphasis on the structures produced by bone cells and the different hormones that influence them. The symptoms, signs, and investigation of metabolic bone disease are then described and compared. The following chapters focus on the biochemistry and clinical aspects of disorders affecting the skeleton, from osteoporosis and osteomalacia to Ehlers-Danlos syndrome, fibrous dysplasia, osteopetroses and hyperostoses, and fibrogenesis imperfecta ossium. The final chapter offers a short description of advances that have been made in understanding these biochemical disorders, including the significance of low-plasma calcitonin in women; the role of mithramycin in Paget's disease; and the identification of the different types of osteogenesis imperfecta. This monograph will be a valuable resource for physicians, pediatricians, and orthopedic surgeons.

  • Virology

    A Laboratory Manual
    • 1st Edition
    • Florence G. Burleson + 2 more
    • English
    Virology: A Laboratory Manual is designed for a one-semester virology laboratory course, although more than one semester of exercises are included. Choices of experiments allow for flexibility within a sequentially organized framework. The text features detailed experimental protocols with comprehensive sections on materials and preparations for all exercises, plus introductory material, discussion questions, and further reading. the use of few viruses and cell lines provides continuity and simplifies preparation of the laboratory exercises. An Instructor's Manual is available to give alternative and assistance in laboratory set-up.

  • Introduction to Biostatistics

    A Guide to Design, Analysis and Discovery.
    • 1st Edition
    • Ronald N. Forthofer + 1 more
    • English
    The Biostatistics course is often found in the schools of public Health, medical schools, and, occasionally, in statistics and biology departments. The population of students in these courses is a diverse one, with varying preparedness. The book assumes the reader has at least two years of high school algebra, but no previous exposure to statistics is required.Written for individuals who might be fearful of mathematics, this book minimizes the technical difficulties and emphasizes the importance of statistics in scientific investigation. An understanding of underlying design and analysis is stressed. The limitations of the research, design and analytical techniques are discussed, allowing the reader to accurately interpret results. Real data, both processed and raw, are used extensively in examples and exercises. Statistical computing packages - MINITAB, SAS and Stata - are integrated. The use of the computer and software allows a sharper focus on the concepts, letting the computer do the necessary number-crunching.

  • Enzyme Nomenclature 1992

    Recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology and the Nomenclature and Classification of Enzymes
    • 1st Edition
    • NC-IUBMB + 1 more
    • English
    Recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the Nomenclature and Classification of Enzymes.

  • Nasals, Nasalization, and the Velum

    • 1st Edition
    • Volume 5
    • English
    Although nasalization has been discussed in the context of more general aspects of linguistics in other books, this text is the first and primary resource focusing solely on nasalization. This volume features articles discussing all aspects of nasalization, including physiology, perception, aerodynamics, acoustics, phonetic and phonological representations, research methodology, and instrumentation. Each chapter examines important research advances achieved within the last ten years and closes with a detailed discussion of the current research.

  • Single Neuron Computation

    • 1st Edition
    • Thomas M. McKenna + 2 more
    • English
    This book contains twenty-two original contributions that provide a comprehensive overview of computational approaches to understanding a single neuron structure. The focus on cellular-level processes is twofold. From a computational neuroscience perspective, a thorough understanding of the information processing performed by single neurons leads to an understanding of circuit- and systems-level activity. From the standpoint of artificial neural networks (ANNs), a single real neuron is as complex an operational unit as an entire ANN, and formalizing the complex computations performed by real neurons is essential to the design of enhanced processor elements for use in the next generation of ANNs.The book covers computation in dendrites and spines, computational aspects of ion channels, synapses, patterned discharge and multistate neurons, and stochastic models of neuron dynamics. It is the most up-to-date presentation of biophysical and computational methods.

  • Immunogenetics

    • 1st Edition
    • Gabriel S Panayi + 1 more
    • English
    Immunogenetics is a 12-chapter book that begins with the elucidation of the major histocompatibility complex genes and their role in autoimmune and infectious diseases. Subsequent chapters explore the human major histocompatibility complex, including implications of their complement genes for linkage disequilibrium and disease associations. This book also describes the genetics of human immunoglobulins; T-cell clones; genes of the major histocompatibility complex of the mouse; and the generation, characterization, and use of monoclonal antibodies of murine and human origin. Specific diseases are also discussed; these include spondoarthritides, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and autoimmune thyroid disease. This book will be of beneficial value to specialists in infectious diseases, endocrinology, connective tissue diseases, and neurology, as well as to medical scientists in immunology and molecular biology.

  • Recombinant DNA Methodology

    • 1st Edition
    • English
    Recombinant DNA methods are powerful, revolutionary techniques that allow the isolation of single genes in large amounts from a pool of thousands or millions of genes and the modification of these isolated genes or their regulatory regions for reintroduction into cells for expression at the RNA or protein levels. These attributes lead to the solution of complex biological problems and the production of new and better products in the areas of medicine, agriculture, and industry.Recombinant DNA Methodology, a volume in the Selected Methods in Enzymology series produced in benchtop format, contains a selection of key articles from Volumes 68, 100, 101, 153, 154, and 155 of Methods in Enzymology. The essential and widely used procedures provided at an affordable price will be an invaluable aid to the graduate student and the researcher.

  • Immunology

    • 1st Edition
    • Lars Ã…. Hanson + 1 more
    • English
    Immunology focuses on the study of immunology. The first half of this book provides a treatise of basic immunology, while the rest is more clinically orientated and illustrates the importance of immune mechanisms for health and disease. This text emphasizes the three good reasons why immunology should be studied. First is that man cannot survive without immunological defense against foreign material. Second is that these same immunological defense mechanisms can cause various forms of tissue damage that result in different diseases. Finally, some immunological reactions can be used as sensitive and highly specific methods for analytical and diagnostically useful determinations of low molecular substances. This publication is primarily intended for students of medicine and natural sciences, as well as clinicians concerned with the field of immunology.

  • Antimetabolites in Biochemistry, Biology and Medicine

    Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10-12, 1978
    • 1st Edition
    • J. Skoda + 1 more
    • English
    FEBS: Federation of European Biochemical Societies, Volume 57: Antimetabolites in Biochemistry, Biology, and Medicine is a collection of papers that presents that advancement in the field of antimetabolites research. The title first covers the use of antimetabolites in enzymology, and then proceeds to tackling the consequences of analog incorporation into nucleic acids. Next, the selection discusses the rational approach to the use of antimetabolite in commination cancer chemotherapy an in immunosuppression. The text also covers the aspects of selective antiviral action. In the last part, the selection details various compounds, along with their synthesis and mechanisms of action. The book will be of great use to researchers and practitioners of biochemistry, biology, and medicine.

  • Cellular Pathology Technique

    • 4th Edition
    • C. F. A. Culling + 2 more
    • English
    Cellular Pathology Technique aims to maintain the twin objectives of producing a comprehensive bench book and a text for students that will take the Special Examination in Cellular Pathology of the Institute of Medical Laboratory Sciences. The organization of this fourth edition has been reshaped. Some sections were expanded such as those about the theory of staining, and new chapters were added dealing with immunolocalization, the endocrine system, and quantification. This book is organized into 10 parts. The introductory part provides basic information on cells and tissues and outlines the methodology in cellular pathology techniques. This is followed by chapters that deal with various aspects of cellular pathology including tissues, cells and cell products of special interests, electron microscopy, and immunocytochemistry. This book will be of interest to students of cellular pathology and those in the medical profession.

  • Bone Tumours in Man and Animals

    • 1st Edition
    • L. N. Owen
    • English
    Bone Tumours in Man and Animals covers advances in the understanding of the pathogenesis of bone neoplasia in humans and animals as well as their diagnosis and treatment. In the case of animals, particular emphasis is placed on dogs. This book is comprised of 15 chapters and begins by introducing the reader to the principles of diagnosis, including biopsy and bone scanning, and methods of treatment employed for bone tumors in human and animal patients, including surgery, radiotherapy, and chemotherapy. The following chapters focus on bone cysts and benign tumors of osseous origin; osteosarcoma in humans and animals such as dogs, cats, and mice; and tumors of cartilaginous origin such as solitary enchondroma, enchondromatosis, chondroblastoma, and chondromyxoid fibroma. Tumors arising from fibrous, fatty, neurological, or undifferentiated connective tissue are also considered, along with those arising from bone marrow or lymphoid tissue. This book concludes by offering suggestions for future research. This text is intended for clinicians, radiologists, and pathologists, both medical and veterinary, as well as for biologists, biochemists, and radiation physicists.

  • Lipid Metabolism in Ruminant Animals

    • 1st Edition
    • William W. Christie
    • English
    Lipid Metabolism in Ruminant Animals is a nine-chapter book that first discusses the anatomy, physiology, and microbiology of the ruminant digestive tract. Subsequent chapters center on lipid metabolism in the rumen; digestion, absorption and transport of lipids in ruminant animals; the composition, structure and function of lipids in the tissues of ruminant animals; and the effects of diet and other factors on the lipid composition of ruminant tissues and milk. Other chapters focus on lipid metabolism in the mammary gland, adipose tissue, liver, and other selected tissues of ruminant animals.

  • Virgin Lands

    Two Years in Kazakhstan, 1954-5
    • 1st Edition
    • L. I. Brezhnev
    • English
    Virgin Lands: Two Years in Kazakhstan, 1954-5 focuses on the life, career, and experiences of L. I. Brezhnev when he stayed in Kazakhstan to push for the improvement of the agriculture sector of the country. The book first offers information on the experiences of L. I. Brezhnev as a farmer, land-use surveyor, metallurgist, factory worker, and politician. Brezhnev underscores how he pushed for the organization of collective farms. The text also highlights the poor state of agriculture in the country, including the farming methodologies that Brezhnev and his countrymen have adopted to overcome the extreme conditions of farming lands. The manuscript details the improvement of state farms, particularly noting the increase in harvest and the number of farms to be set up. Brezhnev narrates how the state farms are affected by drought and extreme weather conditions, and how they have doubled the crop areas through the use of farm implements. The book also underscores the role of farm machineries in the increase of production of grain, meat, and vegetables. The text is a dependable source of data for readers interested in the life and career of L. I. Brezhnev, particularly his dedication to develop agriculture in Kazakhstan.

  • High Technology Aids for the Disabled

    • 1st Edition
    • W.J. Perkins
    • English
    High Technology Aids for the Disabled presents some technical aids and microcomputers for the disabled. This technology could herald a major advance in improving the quality of life of many disabled people. Organized into four parts, this book begins with an assessment of disability. This book then presents a very wide variety of bioengineering approaches to replacement of function. Subsequent chapters explore the reduction of handicap using computer technology, following three main themes: microcomputer systems, user input controls, and speech training and recognition. The last part discusses the collaboration with user organizations in the development of technological aids. This book will be useful for disabled people in coping with their respective difficulties and for those people involved in helping disabled people maximize their human potential.

  • Cellular Immunology LabFax

    • 1st Edition
    • English
    LABFAX volumes are purpose-designed data reference books for practicing scientists. Each book presents the key information for a major subject in one place and so saves hours of searching. The authors and editors of each LABFAX volume have searched the original literature for the accurate data they know the subject specialist needs.Cellular Immunology Labfax is a detailed compendium of information on the tissues and cells of the immune system, cell lines and hybridomas, antigens and receptors, the major histocompatibility complex, soluble immunoregulatory molecules, in vivo procedures, important features of species used in immunological research, and much more.The contents of Cellular Immunology Labfax have been carefully chosen to complement the data presented in Immunochemistry Labfax. It is therefore the companion volume to this text.

  • Lipids: Structure and Function

    The Biochemistry of Plants
    • 1st Edition
    • Volume 9
    • P. Michael Conn
    • English
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 9: Lipids: Structure and Function focuses on the advancements in the methodologies, principles, techniques, and technologies involved in plant lipid research. The selection first elaborates on the analysis and structure determination of acyl lipids, oxidative systems for modification of fatty acids, and lipases. Topics include lipid acyl hydrolases, properties of the lipoxygenase reaction, metabolism of the hydroperoxide products of lipoxygenase, physical and chemical methods of structure determination, and chromatographic methods of separation. The manuscript then examines the biosynthesis of saturated fatty acids, biochemistry of plant acyl carrier proteins, and biosynthesis of monoenoic and polyenoic fatty acids. Discussions focus on polyunsaturated fatty acid biosynthesis and regulation, molecular biology, and immunological characterization of acyl carrier proteins. The publication ponders on lipids of blue-green algae, lipid-derived defensive polymers and waxes and their role in plant-microbe interaction, sulfolipids, and galactolipid synthesis. The selection is a vital source of information for researchers interested in the structure and functions of lipids.

  • Enzyme Regulation and Mechanism of Action

    Proceedings of the FEBS Special Meeting on Enzymes, Cavtat, Dubrovnik, 1979
    • 1st Edition
    • P. Mildner + 1 more
    • English
    Enzyme Regulation and Mechanism of Action contains the proceedings of the Federation of European Biochemical Societies' Special Meeting on Enzymes held in Dubrovnik, Croatia in 1979. The meeting provided a forum for reviewing advances in understanding the regulation and mechanism of action of enzymes. The discussions are organized around three themes: regulation of enzyme activity; the role of enzymes in the synthesis of nucleic acids and proteins; and proteolytic enzymes. Comprised of 33 chapters, this volume begins with an analysis of partial amino acid sequence of rabbit liver fructose 1,6-bisphophatase and sites of cleavage by proteinases. The reader is then introduced to physiological inactivation of enzymes in yeasts; structure and functions of protein kinases; and control points in the citric acid cycle. Subsequent chapters focus on ligand binding properties and subunit interactions in yeast alcohol dehydrogenase; the role of water in the acceleration of an enzymatic reaction; DNA polymerases of human normal and leukemic cells; and the phylogenetic and developmental aspects of gastric proteinases and their zymogens. This book is intended for enzymologists.

  • Reflections on Biochemistry

    In Honour of Severo Ochoa
    • 1st Edition
    • A. Kornberg + 2 more
    • English
    Reflections on Biochemistry: In Honour of Severo Ochoa offers reflections on a wide range of topics relating to biochemistry, including energy metabolism, lipids and saccharides, regulation, nucleic acids and the genetic code, protein biosynthesis, and cell biology. The essays celebrate Severo Ochoa's outstanding contributions to biochemistry spanning nearly half a century. This book is comprised of 47 chapters and begins with a biography of Ochoa and his scientific work in the field of biochemistry, particularly his research on intermediary metabolism, RNA synthesis, and the genetic code. The discussion then turns to energy metabolism, photosynthesis, and fermentation, touching on topics such as the role of lactic acid in the development of biochemistry and the biosynthesis of cell components from acetate. The next section is devoted to lipids, saccharides, and cell walls and includes chapters that deal with biotin, sulfur biochemistry, and dipicolinic acid. Subsequent chapters explore hormonal regulation of adipose tissue lipolysis; the structural relationship between genes and enzymes; bacteriophages, colicins, and ribosomes; and cell biology and neurobiology. This monograph will be of interest to biochemists and students of biochemistry.

  • Regulatory Proteolytic Enzymes and Their Inhibitors

    11th Meeting Copenhagen 1977
    • 1st Edition
    • Staffan Magnusson + 2 more
    • English
    Regulatory Proteolytic Enzymes and Their Inhibitors consists of contributed papers from the 11th Meeting of the Federation of European Biochemical Societies in Copenhagen in 1977. This collection describes the role of proteases in the physiological regulation, a matter of the activation and de-activation of enzymes. The text also discusses the activation mechanism of pepsinogen and other acid protease zymogens. One paper reviews a discovery — that of a separate and distinct class of precursors, the pre-secretary proteins, and then discusses other studies on preproinsulin. The text then discusses the primary structures and presumed functions of immunoglobulin precursors. Another paper continues with the work of Reich and co-workers who found that transformation of cultured fibroblasts from different species by oncogenic viruses is related to the production and release of proteases that are responsible in activating the proenzyme plasminogen into plasmin. Another paper discusses plasminogen activation as having some relationship with pathological processes. The book also reviews the plasminogen activator secretion by normal and neoplastic human tissues. The text discusses the results when primary cultures established from biopsies of normal kidneys secreted plasminogen activators in amounts over those secreted by actual malignant tissues. The book then notes the role of neutral and acid proteinases in male reproduction and the role of plasminogen activators in female ovulation. This collection can be useful for micro-biologists, research biologists, molecular scientists, and students of molecular biology.

  • Protides of the Biological Fluids

    Proceedings of the Twenty-Sixth Colloquim, 1978
    • 1st Edition
    • H. Peeters
    • English
    Protides of the Biological Fluids contains the proceedings of the 26th Colloquium in 1978. Two topics are highlighted, the first one being the immune complexes and the second one being the cytoskeletal proteins. This book is organized into three sections, namely, Immune Complexes, Cytoskeletal Proteins, and Techniques. The Immune Complexes section states the biochemical problems and answers some intriguing clinical problems in this field. This section details the theory of the antigen/antibody reaction, the isolation of complexes, and the nature of the antigen. The Cytoskeletal Proteins section discusses the theoretical aspect of cell structure. The last section describes the assay methods and individual protein assays.

  • Regulatory Mechanisms of Carbohydrate Metabolism

    11th Meeting Copenhagen 1977
    • 1st Edition
    • Viggo Esmann
    • English
    Regulatory Mechanisms of Carbohydrate Metabolism contains the proceedings of the 11th meeting of the Federation of European Biochemical Societies, held at Copenhagen in 1977. The symposium is attended by thousands of biochemists and their associates to present and discuss the regulatory mechanisms of carbohydrate metabolism. The compendium records the nine sessions of the symposium encompassing 30 chapters of various discussions on the regulatory mechanisms of carbohydrate metabolism. Topics on metabolism of pyruvate in animals; mechanism of insulin secretion; the role of pyruvate in the regulation of carbohydrate metabolism; and control of muscle glycogen metabolism by protein kinases and phosphates are covered. Ketogenesis and carbohydrate metabolism; factors controlling glucagon secretion; and energy homeostasis and the regulation of carbohydrate metabolism are discussed as well. Biochemists, chemists, physicians, pharmacologists, and students of medicine will find this book a good source on insight.

  • Protides of the Biological Fluids

    Proceedings of the Twenty-Third Colloquium, Brugge, 1975
    • 1st Edition
    • H. Peeters
    • English
    Protides of the Biological Fluids contains the proceedings of the 23rd Colloquium on "Protides of the Biological Fluids" held in Brugge, Belgium in 1975. The discussions were organized around three themes: proteinase inhibitors, clinical evaluation of plasma protein patterns, and affinity chromatography. Comprised of 117 chapters, this volume begins with an overview of carcinofetal proteins, followed by an analysis of proteinase inhibition. The reader is then introduced to the mechanism and structure of human alpha-1-proteinase inhibitor; some properties of a complex between ?2-macroglobulin and brinase; and the interaction of proteinase inhibitors with blastocyst proteinases involved in implantation. Subsequent chapters deal with the thermodynamics and kinetics of the interaction of trypsin with trypsin inhibitors; purification and characterization of acid-stable proteinase inhibitors from human seminal plasma; and the possible role of protease inhibitors in cartilage metabolism. The book also explores the structure and function of animal proteinase inhibitors as well as techniques and methods used in clinical evaluation of plasma protein patterns. This monograph will be of interest to biologists and research workers in biology.

  • Gene Expression

    Protein Synthesis and Control RNA Synthesis and Control Chromatin Structure and Function
    • 1st Edition
    • Brian F. C. Clark + 2 more
    • English
    Gene Expression provides research papers on selected topics in gene expression, presented at the 11th meeting of the Federation of European Biochemical Societies, held at Copenhagen in August 1977. The book presents research knowledge provided by eminent researchers in the field of biochemistry. Each chapter contains material that is important to other researchers, such as on initiation mechanism of protein synthesis in prokaryotes; translocation mechanism of the ribosome; and analysis of ribosomal translocation by drugs. Mechanisms for the intracellular compartmentation of newly synthesized proteins; RNA synthesis and control; the sub-structure of nucleosome core particles; and future prospects on chromosome structure and function are detailed as well. The text will be of use to researchers and workers in the field of medicine, pharmacology, gene therapy, and biochemistry.

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