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    • Redox Signaling in Wound Healing in Elderly Populations: Theoretical Basis, Part 1

      • 1st Edition
      • Volume 2
      • July 24, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 9 4 5 6 3
      • eBook
        9 7 8 0 4 4 3 2 9 4 5 7 0
      Redox Signaling in Wound Healing in Elderly Populations: Theoretical Basis, Part 1 deals with wounds in different types and locations (diabetic, ischemic, post-operational) in subcellular and macro dimensions, examine their relationship with aging aim to target deteriorating redox signaling cascades, and will also focus on promising therapeutic approaches. Understanding the indication for the use of new therapeutics targeting the illuminated pathways in wound healing will help adjust treatment regimens befitting modern medicine. Ineffective redox adaptation and disseminated oxidative injury are the hallmarks of continuing oxidative stress. However, oxidative stress cannot be simply described as the imbalance between ROS formation and antioxidant defense capacity; it also covers impairment in redox sensing and signaling pathways. The term oxidative stress is an expression that is losing its use in modern redox biology. It is now an accepted fact that ROS cannot be described as an apparent enemy or friend. Its optimum level modulates signal transduction and stress responses by acting as a second messenger for redox-sensitive cascades. Redox-dependent second messengers are generated in subcellular locations according to specific rules and regulations. Their appearance depends on cellular needs in response to external and internal stimuli variations. A good understanding of the wound healing cascades, which deteriorate especially in advancing ages, is critical in developing the most appropriate approach. To understand the redox signaling mechanisms and healing cascades in wound healing, to pioneer new pharmacoactive drugs that can be developed based on these mechanisms, to reveal the deteriorating dynamics in the elderly patient group, and to propose new treatment methods suitable for the advanced age group.

    • Case-Based Practical Training of Colposcopy and Cervical Pathology

      • 1st Edition
      • July 23, 2024
      • Nadereh Behtash + 5 more
      • English
      • Hardback
        9 7 8 0 4 4 3 2 4 7 9 4 1
      • eBook
        9 7 8 0 4 4 3 2 4 7 9 5 8
      Case-Based Practical Training in Colposcopy and Cervical pathology: With Diagrams and Images is an illustrated reference to improve theoretical and practical knowledge to understand and perform colposcopy. Cervical cancer screening has advanced a great deal over the last century, and the medical field has come far in detect early pre-cancer and invasive cancer of the cervix though colposcopy and pathology. Anyone in the field of gynecology, pathology, and oncology will find this book useful to better understand the different levels of prevention, including vaccinations and screening and for students to correctly understand colposcopy and cervical pathology through real illustrated case studies. The book’s aim is for for prevention and treatment of anogenital and HPV related -diseases and supports the goal of the World Health Organization to cure cervical cancer by 2030.

    • Hormones

      • 1st Edition
      • Volume 142
      • July 23, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 1 9 3 4 6 0
      • eBook
        9 7 8 0 4 4 3 1 9 3 4 7 7
      Hormones, Volume 142, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Estrogen receptor binding mechanism with agonist and antagonist, Biomarker Identification of Medullary Thyroid Carcinoma from Gene Expression Profiles Considering without-treatment and with-treatment Studies – A Bioinformatics approach, Exploring the Role of Estrogen and Progestins in Breast Cancer: A Genomic Approach to Diagnosis, Structural insights on ER-alpha, ER-Beta, progesterone and their drug-targets interactions in Breast cancer, The predictive ability of myokines in patients with chronic heart failure, and much more.Other chapters cover Endogenous and artificial regulators of pituitary glycoprotein hormone receptors, Insight into vitamin D3 action within the ovary - basic and clinical aspects, Hormonal basis of seasonal changes in metabolism, Viral mimicry and endocrine system: Divulging the importance in host-microbiome crosstalk, Recombinant hormones as biopharmaceuticals: past, present and future, Thyroid hormone biosynthesis and its role in brain development and maintenance, and much more.

    • Bio-organic Amendments for Heavy Metal Remediation

      • 1st Edition
      • July 23, 2024
      • Allah Ditta + 3 more
      • English
      • Paperback
        9 7 8 0 4 4 3 2 1 6 1 0 7
      • eBook
        9 7 8 0 4 4 3 2 1 6 1 1 4
      Bio-organic Amendments for Heavy Metal Remediation: Water, Soil and Plant Approaches and Technologies focuses on these core continuum media to explore remediation options using microbial, organic, and combined approaches. This volume in the Plant Biology, Sustainability and Climate Change series offers a comprehensive view of techniques and approaches for addressing contamination by heavy metals. It provides a comprehensive view of the challenge, with a focus on the bioremediation of heavy metals contamination using ecotechnological approaches for protecting the soil, water, and plant continuum.As anthropogenic activities increasingly negatively impact natural resources, there has been significant disturbance of the water, soil, and plant continuum due to the accumulation of heavy metals. The bioaccumulation of heavy metals in the food chain could pose life-threatening effects on plants as well as humans, and there is need to find effective and sustainable remediation options. The application of bio-organic amendments could serve as a sustainable solution to this problem.

    • Essentials of Translational Pediatric Drug Development

      • 1st Edition
      • July 22, 2024
      • Elke Gasthuys + 3 more
      • English
      • Paperback
        9 7 8 0 3 2 3 8 8 4 5 9 4
      • eBook
        9 7 8 0 3 2 3 9 0 4 2 9 2
      Essentials of Translational Pediatric Drug Development: From Past Needs to Future Opportunities provides integrated and up-to-date insights relevant for both translational researchers and clinicians active in the field of pediatric drug development. The book covers all key aspects from different stakeholder perspectives, providing a literature overview and careful reflection on state-of-the-art approaches. It will be an ideal guide for researchers in the field who are designing and performing high quality, innovative pediatric-adapted drug development by helping them define needs/challenges and possible solutions that advance and harmonize pediatric drug development.Despite the broad consensus that children merit the same quality of drug treatment as any other age group, children remain frequently neglected during drug research and development. Even with the adoption of multiple legislations addressing this problem, the lack of efficacy and safety data of marketed as well as newly developed drugs still remain in the pediatric population.

    • Metabolomics for Personalized Vaccinology

      • 1st Edition
      • July 22, 2024
      • Mahbuba Rahman
      • English
      • Paperback
        9 7 8 0 4 4 3 1 5 5 2 6 0
      • eBook
        9 7 8 0 4 4 3 1 5 5 2 7 7
      Metabolomics for Personalized Vaccinology provides insight into the importance of personalized vaccines in the clinical and research environments. It explores the development of personalized vaccines, which requires in-depth knowledge of the patient’s health status, particularly the immune system, and on metabolomics, the closest indicator of the disease phenotype. Specifically, the book provides an understanding of how metabolomics might be employed in personalized vaccinology and how the metabolic pathway of the host’s system is altered by vaccine administration.Over the past few years, researchers have published articles on personalized vaccines, but these are sparse. Therefore, compiling information on this topic gives the reader an overview of the progress of the field, despite being at its infancy.Metabolomics for Personalized Vaccinology is ideally suited for researchers and postgraduate students who are interested in clinical and nonclinical studies where metabolites are used for the identification of disease and therapeutic targets.

    • Learning Deep Brain Stimulation Management through Clinical Cases

      • 1st Edition
      • July 20, 2024
      • Martijn Beudel
      • English
      • Paperback
        9 7 8 0 4 4 3 1 8 9 1 0 4
      • eBook
        9 7 8 0 4 4 3 1 8 9 1 1 1
      Learning Deep Brain Stimulation Management through Clinical Cases reviews the clinical practice of applying deep brain stimulation (DBS) to patients with movement disorders. The book explores the cardinal aspects of applying DBS in diverse movement disorders based on patient’s needs. Every case answers all questions, providing case descriptions and step-by-step procedures for optimal replication. Every chapter includes a clinical decision support system (CDSS) depicted in flowcharts that can be used for reference. Deep Brain Stimulation (DBS) uses electrical stimulation to regulate electrical signals in neural circuits to and from identified areas in the brain to improve movement symptoms.The management of DBS in a movement disorders can be challenging, optimizing patient journeys and grasping all clinical aspects of the highly technological therapy. Hence, this book provides the informaiton necessary to embrace new breakthroughs.

    • Quality Assurance Management

      • 1st Edition
      • July 20, 2024
      • Gayathri De Lanerolle + 3 more
      • English
      • Paperback
        9 7 8 0 1 2 8 2 2 7 3 2 9
      • eBook
        9 7 8 0 1 2 8 2 2 7 3 3 6
      Quality Assurance Management: A Comprehensive Overview of Real-World Applications for High Risk Specialties demonstrates how to best design and implement standard operating procedures (SOPs) to ensure protocol and regulation adherence. The book showcases similarities and differences between healthcare and academic quality assurance systems, resulting in counter-productivity and performance issues, in addition to regulatory inspection preparedness. It uses the processes and standards of the UK to demonstrate how to combine QA and research building into ‘building blocks’ that share a common pathway for effective project design, analysis and unbiased interpretation of collated data.This book fills a gap, providing original research in QA that especially focuses on specialist areas. It will be of use to research and clinical staff working in clinical research within healthcare, academia and industry.

    • Current Status of Prostate Cancer: Diagnosis, Biomarkers and Therapies

      • 1st Edition
      • Volume 161
      • July 20, 2024
      • English
      • Hardback
        9 7 8 0 4 4 3 2 9 6 2 8 4
      • eBook
        9 7 8 0 4 4 3 2 9 6 2 9 1
      • eBook
        9 7 8 0 4 4 3 3 5 0 5 2 8
      Current Status of Prostate Cancer: Diagnosis, Biomarkers and Therapies, Volume 161 in the Advances in Cancer Research series, covers timely topics such as The Prostate Cancer Tissue N-glycome as a Source of Biomarkers, a Progression from Normal to Metastatic Disease, Multiplexed Targeted Proteomics for Prostate Cancer Biomarker Verification, MRI for the Detection of Clinically Significant Prostate Cancer: Update and Future Directions, Genetic and epigenetic factors for prostate cancer progression, Epigenetic regulation of androgen dependent and independent prostate cancer, Molecular Landscape of Prostate Cancer Bone Metastasis, Future of radioligand Therapy in PC, and more.Additional chapters of note include Advancements in Computer Vision and Pathology: Unraveling the Potential of Artificial Intelligence for Precision Diagnosis and Beyond and Extracellular Vesicles in Prostate Cancer.

    • Circuits, Signals, and Systems for Bioengineers

      • 4th Edition
      • July 19, 2024
      • John Semmlow
      • English
      • Paperback
        9 7 8 0 4 4 3 1 5 8 8 6 5
      • eBook
        9 7 8 0 4 4 3 1 5 8 8 7 2
      Circuits, Signals, and Systems for Bioengineers: A MATLAB-Based Introduction, Fourth Edition, guides the reader through the electrical engineering principles that can be applied to biological systems. It details the basic engineering concepts that underlie biomedical systems, medical devices, biocontrol, and biomedical signal analysis, providing a solid foundation for students in important bioengineering concepts. Fully revised and updated to better meet the needs of instructors and students, the fourth edition expands on concepts introduced in the previous edition through computational methods that allow students to explore operations, such as correlations, convolution, the Fourier transform, and the transfer function. New medical examples and applications are included throughout the text.

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