Redox Signaling in Wound Healing in Elderly Populations: Theoretical Basis, Part 1
- 1st Edition, Volume 2 - July 24, 2024
- Imprint: Academic Press
- Editors: Ufuk Cakatay, Richard Faragher, Mehmet Can Atayik
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 9 4 5 6 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 9 4 5 7 - 0
Redox Signaling in Wound Healing in Elderly Populations: Theoretical Basis, Part 1 deals with wounds in different types and locations (diabetic, ischemic, post-operational) in sub… Read more
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Request a sales quoteRedox Signaling in Wound Healing in Elderly Populations: Theoretical Basis, Part 1 deals with wounds in different types and locations (diabetic, ischemic, post-operational) in subcellular and macro dimensions, examine their relationship with aging aim to target deteriorating redox signaling cascades, and will also focus on promising therapeutic approaches. Understanding the indication for the use of new therapeutics targeting the illuminated pathways in wound healing will help adjust treatment regimens befitting modern medicine. Ineffective redox adaptation and disseminated oxidative injury are the hallmarks of continuing oxidative stress. However, oxidative stress cannot be simply described as the imbalance between ROS formation and antioxidant defense capacity; it also covers impairment in redox sensing and signaling pathways. The term oxidative stress is an expression that is losing its use in modern redox biology. It is now an accepted fact that ROS cannot be described as an apparent enemy or friend. Its optimum level modulates signal transduction and stress responses by acting as a second messenger for redox-sensitive cascades. Redox-dependent second messengers are generated in subcellular locations according to specific rules and regulations. Their appearance depends on cellular needs in response to external and internal stimuli variations. A good understanding of the wound healing cascades, which deteriorate especially in advancing ages, is critical in developing the most appropriate approach. To understand the redox signaling mechanisms and healing cascades in wound healing, to pioneer new pharmacoactive drugs that can be developed based on these mechanisms, to reveal the deteriorating dynamics in the elderly patient group, and to propose new treatment methods suitable for the advanced age group.
- The only source where all intracellular and intercellular redox homeostasis, cascades, and mechanisms of wound healing in elderly people
- Deals with wounds in different types and locations (diabetic, ischemic, post-operational) in subcellular and macro dimensions, examine their relationship with aging, and aim to target deteriorating cascades
- It will help adjust redox-based treatment regimens befitting modern medicine
Well-established academicians students and researchers in gerontology, geriatrics, surgery, oncology, biochemistry, pharmacology, and pathology
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Chapter One Redox signaling in regenerative medicine: Regulatory mechanisms and therapeutic implications
- Abstract
- 1 Introduction
- 2 The role of redox signaling in regulating stem cell function
- 3 Signaling mechanism regulating cellular function by redox
- 4 Role of redox signaling in wound healing
- 5 Therapeutic role of redox signaling in regenerative medicine
- 6 Challenges and future directions
- References
- Chapter Two Age-related aspects of redox signaling cascades of wound healing
- Abstract
- 1 Introduction
- 2 Aging and wound healing
- 3 Mechanism of wound healing
- 4 Redox signaling in the wound healing
- 5 Therapy against wound healing
- 6 Future directions
- 7 Conclusion
- References
- Chapter Three Nrf2 as a potential target for improving wound healing in the elderly
- Abstract
- 1 Wound healing process: Age-related changes and contact point with Nrf2
- 2 Nrf2 structure and its activation
- 3 Role of Nrf2 signaling pathway in wound healing
- 4 Nrf2 as a potential therapeutic target for wound healing in the elderly
- 5 Conclusions and perspectives
- References
- Chapter Four Impact of senescence in impaired wound healing
- Abstract
- 1 Introduction
- 2 Aging processes and cell senescence
- 3 Mechanisms involved in senescence wound healing
- 4 Factors affecting wound healing
- 5 Therapeutic approaches
- 6 Conclusion
- References
- Chapter Five Role of immunosenescence in impaired wound healing with age
- Abstract
- 1 Overview of wound healing and aging
- 2 Stages of wound healing and effects of age and immunosenescence
- 3 The hematopoietic system and wound healing
- 4 Factors and pathologies contributing to delayed wound healing: Clinical examples and underlying mechanisms
- 5 Interventions targeting immunosenescence to improve wound healing
- 6 Conclusion
- Acknowledgments
- References
- Chapter Six Targeting redox signaling pathway through integration of caloric restriction and wound healing process for enhanced repair
- Abstract
- 1 Introduction
- 2 Understanding caloric restriction as an intervention
- 3 Cellular and molecular mechanisms of caloric restriction
- 4 Implications for health and longevity
- 5 Redox signaling and it's role in wound healing process
- 6 Molecular insights into improved wound healing under caloric restriction
- 7 Future perspectives
- 8 Conclusion
- References
- Chapter Seven CoQ10, more than an antioxidant in skin health and wound healing promotion
- Abstract
- 1 Introduction: The essential role of CoQ10 in cell physiology
- 2 CoQ10 is the main antioxidant in cell membranes
- 3 Clinical evidence of the effect of CoQ10 on wound healing
- 4 Chronic wound healing in aging
- 5 CoQ10-dependent induction of extracellular matrix components
- 6 CoQ10-dependent modulation of metalloproteinases
- 7 Improvement of CoQ10 delivery
- 8 Conclusions
- References
- Edition: 1
- Volume: 2
- Published: July 24, 2024
- No. of pages (Hardback): 232
- No. of pages (eBook): 277
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443294563
- eBook ISBN: 9780443294570
UC
Ufuk Cakatay
Ufuk Çakatay (May 09, 1965 –) is a Turkish biochemist and biogerontologist. He is a full professor of medical biochemistry at Istanbul-University Cerrahpaşa in Istanbul, Turkey. He has a long-standing interest in oxidative protein damage, redox signaling, and biomarkers of proteostasis. Much less is known about the relationship between redox signaling events and senescent cells. However, it has been shown that the number of senescent cells in many tissues increases with age and that senescent cells are found in various age-related diseases. The development of experimental animal models for age-related disorders and the optimization of various bioanalytical techniques for the assessment of redox status in aging tissue are among his major research interests. Professor Çakatay has authored more than 100 publications in several leading journals, including research papers, book chapters, editorials, and invited reviews on free radical biology, aging, diabetes, redox signaling, and senotherapeutics. He has been a guest editor, reviewer, and editorial board member for more than 50 journals. In addition, Professor Çakatay has a keen interest in mentoring medical students and promoting their research careers. He has received several prestigious awards, including the Top Reviewer Award from Elsevier Science Publishing, and was a former member of the Animal Research and Ethics Committee of Istanbul University.
Affiliations and expertise
Cerrahpasa Faculty of Medicine, Department of Medical Biochemistry, Istanbul University-Cerrahpasa, Istanbul, TurkeyRF
Richard Faragher
Richard Faragher is Professor of Biological Gerontology at the University of Brighton and is past Chair of the British Society for Research on Ageing, the International Association of Biomedical Gerontology and the American Aging Association. He read Biochemistry at Imperial College, London and undertook doctoral studies on human premature ageing at the University of Sussex. His primary research interest is the relationship between cellular senescence and organismal ageing. He has published widely on the phenotype of senescent cells and on compounds that reverse the process.
He holds the Royal Pharmaceutical Society Conference Science Medal for his work on the mechanisms of Werner’s syndrome, the Help the Aged ‘Living Legend’ award for his championship of older people, the Paul F Glenn Award for research into the mechanisms of ageing and the British Society for Research on Ageing’s highest honour, the Lord Cohen of Birkenhead Medal.
Professor Faragher is a Fellow of the American Aging Association and has served as a member of the Research Advisory Council of the Charity Research into Ageing and on strategy and funding panels for the BBSRC, the US National Institutes on Ageing and the European Union. From 2005-2008 he was Co-director of the BBSRC-EPSRC SPARC programme, a research network designed to build national capacity to conduct inter-disciplinary ageing research. He is currently a Director of the American Federation for Aging Research, serves on the Scientific Advisory Board of the Longevity Vision Fund and co-directs the BBSRC-MRC funded Building Links in Ageing Science and Translation (BLAST) research network.
Affiliations and expertise
Professor of Biological Gerontology at the University of Brighton and is past Chair of the British Society for Research on Ageing, the International Association of Biomedical Gerontology and the American Aging Association.MC
Mehmet Can Atayik
Dr. Atayik is currently working in the Department of General Surgery at Hacettepe University Faculty of Medicine. He has been working as a scientist and researcher with Prof. Ufuk Çakatay since 2017. His research interests are in the fields of aging, age-related disorders, redox biology, oncogenetics, melatonin, mitochondria, surgical advances, and developing novel techniques for modern surgery. Dr. Atayik has conducted clinical research and experimental studies. He has published many scientific papers, such as research papers, narrative reviews, and book chapters, and has worked as an author, referee, editorial assistant, and guest editor, and editor in many prominent publishing houses. He was awarded the Young Investigator Presentation Prize at the VIII. International Congress of Molecular Medicine, which was held in Istanbul, Turkey, in November 2021.
Affiliations and expertise
Scientist and Researcher, Department of General Surgery, Hacettepe University Faculty of Medicine, TurkeyRead Redox Signaling in Wound Healing in Elderly Populations: Theoretical Basis, Part 1 on ScienceDirect