Hormones
- 1st Edition, Volume 142 - July 23, 2024
- Imprint: Academic Press
- Editor: Rossen Donev
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 3 4 6 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 3 4 7 - 7
Hormones, Volume 142, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Estrogen receptor binding mechan… Read more
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Request a sales quoteHormones, Volume 142, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Estrogen receptor binding mechanism with agonist and antagonist, Biomarker Identification of Medullary Thyroid Carcinoma from Gene Expression Profiles Considering without-treatment and with-treatment Studies – A Bioinformatics approach, Exploring the Role of Estrogen and Progestins in Breast Cancer: A Genomic Approach to Diagnosis, Structural insights on ER-alpha, ER-Beta, progesterone and their drug-targets interactions in Breast cancer, The predictive ability of myokines in patients with chronic heart failure, and much more.
Other chapters cover Endogenous and artificial regulators of pituitary glycoprotein hormone receptors, Insight into vitamin D3 action within the ovary - basic and clinical aspects, Hormonal basis of seasonal changes in metabolism, Viral mimicry and endocrine system: Divulging the importance in host-microbiome crosstalk, Recombinant hormones as biopharmaceuticals: past, present and future, Thyroid hormone biosynthesis and its role in brain development and maintenance, and much more.
Other chapters cover Endogenous and artificial regulators of pituitary glycoprotein hormone receptors, Insight into vitamin D3 action within the ovary - basic and clinical aspects, Hormonal basis of seasonal changes in metabolism, Viral mimicry and endocrine system: Divulging the importance in host-microbiome crosstalk, Recombinant hormones as biopharmaceuticals: past, present and future, Thyroid hormone biosynthesis and its role in brain development and maintenance, and much more.
- Highlights new advances in the field of hormones and hormone research
- Covers topics such as the Estrogen receptor binding mechanism with agonist and antagonist and Biomarker Identification of Medullary Thyroid Carcinoma from Gene Expression Profiles Considering without-treatment and with-treatment Studies
- Serves as an indispensable reference for researchers and students alike
Researchers, Government Agencies, Academics, Doctors
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: Unlocking estrogen receptor: Structural insights into agonists and antagonists for glioblastoma therapy
- Abstract
- 1 Introduction
- 2 Overview of estrogen receptor
- 3 Role of estrogen receptor in glioblastoma
- 4 Therapeutic interventions—aromatase inhibitors potential
- 5 Nanoparticle-based delivery systems
- 6 Conclusion
- Acknowledgment
- References
- Chapter Two: Exploring the role of estrogen and progestins in breast cancer: A genomic approach to diagnosis
- Abstract
- 1 Introduction
- 2 Methods and materials
- 3 Identifying genes with differential expression
- 4 Functional enrichment analysis
- 5 Result and discussion
- 6 Differentially expressed genes—DESeq2
- 7 Functional enrichment analysis—g: Profiler
- 8 Conclusion
- Acknowledgments
- References
- Chapter Three: Diagnostic and predictive abilities of myokines in patients with heart failure
- Abstract
- Abbreviations
- 1 Heart failure: current challenges in prevalence and burden
- 2 Myokines: definition and general biological function
- 3 Myokines in adverse cardiac remodeling and heart failure
- 4 Conclusion
- References
- Chapter Four: Insight into vitamin D3 action within the ovary—Basic and clinical aspects
- Abstract
- Abbreviations
- 1 Vitamin D3 production and metabolism
- 2 Mechanism of vitamin D3 action
- 3 Physiology of the ovary and vitamin D3
- 4 Vitamin D3 deficiency and ovarian disorders
- 5 Vitamin D3 and OC
- Website
- Acknowledgments
- References
- Chapter Five: Hormonal basis of seasonal metabolic changes in mammalian species
- Abstract
- Abbreviations
- 1 Introduction
- 2 Photoperiod
- 3 Air temperature and seasonal changes in metabolism
- 4 Diet, vitamins and seasonal changes in metabolism
- 5 Atmospheric pressure and seasonal changes in metabolism
- 6 Seasonal changes in metabolism and season-dependent exacerbation of chronic disease
- 7 Conclusions
- References
- Chapter Six: Overlapping action of melatonin and female reproductive hormones—Understand the impact in pregnancy and menopause
- Graphical abstract
- Abstract
- 1 Introduction
- 2 Biosynthesis of melatonin and female reproductive hormones
- 3 Regulation of female reproductive hormones by melatonin
- 4 Melatonin in pregnancy and menopause: impact on clinical outcomes
- 5 Concluding remarks
- References
- Chapter Seven: Evolution of biosynthetic human insulin and its analogues for diabetes management
- Abstract
- 1 Introduction
- 2 The structural chemistry of insulin
- 3 Role of insulin in diabetes management
- 4 Conclusions
- References
- Chapter Eight: Hormonal regulation in diabetes: Special emphasis on sex hormones and metabolic traits
- Abstract
- 1 Introduction
- 2 Imbalance in sex hormones and its impact on diabetes
- 3 The impact of sex hormones on glucose metabolism in diabetes
- 4 Sex hormones and insulin: molecular pathway
- 5 Metabolic trait of diabetes: maternal or paternal
- 6 The clinical dilemma of diabetes among transgenders
- 7 Influence of metabolic traits on diabetic progression
- 8 The mechanism linking obesity and diabetes to oxidative stress and inflammation
- 9 The other way around: diabetes, a factor for reproductive disorders
- 10 Stress in modern life: a key factor for hormonal imbalance and diabetes
- 11 Diabetes management by hormonal therapy
- 12 Current research on sex hormones in diabetes
- 13 Future perspective
- 14 Conclusion
- Acknowledgments
- References
- Chapter Nine: Therapeutic potentials of glucose-dependent insulinotropic polypeptide (GIP) in T2DM: Past, present, and future
- Abstract
- 1 Introduction
- 2 Evolving patterns in incretin-based therapeutic approaches and medications
- 3 Past research on GIP in T2DM
- 4 Insulinotropic effects of GIP and GLP-1
- 5 Non-insulinotropic effects of GIP and GLP-1
- 6 Bifunctional role of GIP as a receptor activator and inhibitor
- 7 Role of GIP in lipidosis in white adipose tissue
- 8 Exploring the potential implications of GIP in other diseases
- 9 Cardiovascular disease
- 10 Non-alcoholic fatty liver disease
- 11 Neurodegenerative diseases
- 12 Renal diseases
- 13 GIPR: a promising therapeutic target for managing T2DM
- 14 Therapeutic potential of GIP in T2DM
- 15 Leveraging drug repurposing and target reutilization in T2DM management
- 16 Unlocking the potential of structurally modified GIP: a novel therapeutic avenue for T2DM
- 17 Overcoming the labyrinth: navigating obstacles in bringing incretin hormone-based therapies to the clinic
- 18 The future of GIP in T2DM
- 19 Conclusion
- References
- Chapter Ten: Thyroid hormone biosynthesis and its role in brain development and maintenance
- Abstract
- 1 Introduction
- 2 Historical perspective on thyroid hormone research
- 3 Thyroid gland anatomy
- 4 Steps in thyroid hormone biosynthesis
- 5 Deiodinases
- 6 Thyroid hormone receptors
- 7 Thyroid hormone transporters
- 8 Regulation of thyroid hormone biosynthesis
- 9 Effect of thyroid hormone on the brain
- 10 The hypothyroid brain
- 11 The hyperthyroid brain
- 12 Early neurogenesis and proliferation
- 13 Brain maintenance
- 14 Thyroid hormone and brain diseases
- 15 Impact of environmental disruptors on thyroid hormone-mediated neural function
- 16 Discussion
- Acknowledgments
- References
- Chapter Eleven: Biomarker identification of medullary thyroid carcinoma from gene expression profiles considering without-treatment and with-treatment studies—A bioinformatics approach
- Abstract
- Abbreviations
- 1 Introduction
- 2 Materials and methods
- 3 Results
- 4 Discussion
- 5 Conclusion
- Acknowledgments
- References
- Chapter Twelve: A crosstalk between ‘osteocyte lacunal-canalicular system’ and metabolism
- Abstract
- 1 Introduction
- 2 Materials and method for animal study
- 3 Structural and morphological analyses of femur bone
- 4 Statistical analysis of metabolic (serum) parameters
- 5 Strategy about the potential roles of metabolic relation
- 6 Limitation of current study
- 7 Conclusion
- 8 Funds
- Acknowledgment
- References
- Chapter Thirteen: Viral mimicry and endocrine system: Divulging the importance in host-microbial crosstalk
- Abstract
- 1 Introduction
- 2 Viral hormone mimics and their functions
- 3 Regulatory proteins and human hormones with homologous sequences in viral genomes
- 4 Viral molecular mimics implicated in cancer and autoimmune diseases
- 5 Concluding remarks
- References
- Edition: 1
- Volume: 142
- Published: July 23, 2024
- No. of pages (Hardback): 456
- No. of pages (eBook): 488
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443193460
- eBook ISBN: 9780443193477
RD
Rossen Donev
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.
Affiliations and expertise
Head of Research, MicroPharm Limited, UKRead Hormones on ScienceDirect