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Elsevier

Books in Pharmacology

Elsevier's Pharmacology collection studies how drugs interact with biological systems to improve health and treat disease. It covers pharmacodynamics, exploring drug effects on biology, and pharmacokinetics, studying how the body affects drugs. Branches like Pharmacogenetics. Essential for pharmacologists, this collection offers invaluable insights into drug interactions, efficacy, and safety, crucial for advancing drug development and improving patient outcomes.

  • Pharmaceutical Manufacturers

    An International Directory
    • 1st Edition
    • David D. Braun
    • English
    This international directory of pharmaceutical manufacturers includes 1,046 firms in 50 countries. They are arranged alphabetically by country and company name. In addition to name and address, other information such as telephone and fax number, and key personnel are also listed, where available.Completing the directory, is a listing of 124 Contract Manufacturers in 19 countries of ethical and/or non-prescription pharmaceuticals. These are arranged alphabetically by country and company name.

  • Biochemistry, Molecular Biology, and Therapeutic Implications

    Nitric Oxide: Biochemistry, Molecular Biology, And Therapeutic Implications
    • 1st Edition
    • Volume 34
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume contains chapters that address diverse but interrelated areas pertaining to the chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. The contents form a comprehensive treatise of factors influencing the control of nitric oxide production in various cell types.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 64
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Every fifth volume ofAdvances in Heterocyclic Chemistry contains a cumulative subject index.

  • Immunopharmacology of Respiratory System

    • 1st Edition
    • Stephen T. Holgate
    • English
    Immunopharmacology represents the boundary between the immune system and chemical mediators of the inflammatory and neuroendocrine responses. The subject as applied to the respiratory system embraces most of the common non-malignant lung diseases of which asthma and allied disorders are the most prevalent. An understanding of the underlying mechanisms of the disorders provides rationale for prevention and drug treatment as well as creating opportunities for novel drug development. Immunopharmacology of Respiratory System embraces all of these principles and should enable the reader to become rapidly updated in an area of medical importance.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 33
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 30
    • James A. Bristol
    • English
    Praise for the Series:"This series is one of the very few annual publications which justify the title of an absolute must for the pharmacologist, chemist, or physician who is interested in the chemistry of drug development."--Enzym... book is strongly recommended for researchers, teachers, students, administrators - in short, anyone whose interests impinge on medicinal chemistry. In view of the work's documented reference value, it is a must for inlusion in the scientist's personal library."--Journal of Medicinal Chemistry"All topics are covered in sufficient depth, with extensive references, to allow either the specialist or the novice to be informed of the latest developments in a particular area of medicinal chemistry."--Norman Gilman, Hoffmann-La Roche, Inc, in the JOURNAL OF PHARMACEUTICAL SCIENCESAdvances in Medicinal Chemistry continues to provide timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

  • Advances in Pharmaceutical Sciences

    • 1st Edition
    • Volume 7
    • English
    The seventh volume of Advances in Pharmaceutical Sciences heralds a welcome continuation of this well-respected series. Acknowledged experts provide comprehensive statements of current research and development in selected fields of pharmaceutical technology. This book will be of great value to those working in academia and the pharmaceutical industry.

  • Advances in Drug Research

    • 1st Edition
    • Volume 26
    • English
    Volume 26 continues the trend of shorter, more frequent volumes. With Volume 25, the series gained a new co-editor, Urs Meyer. While retaining the commitment to publish chapters on therapeutic or chemical classes and on general topics or concepts, the series' coverage has expanded to include methodological chapters, and new areas of recognized or potential significance to drug research, especially in molecular pharmacology.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 32
    • English

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 63
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area-one of great importance to organic chemists, polymer chemists, and many biological scientists. Every fifth volume ofAdvances in Heterocyclic Chemistry contains a cumulative subject index.

  • Side Effects of Drugs Annual

    A Worldwide Yearly Survey of New Data and Trends
    • 1st Edition
    • Volume 18
    • English
    Under the supervision of the series editors, an international team of expert authors have gathered together the latest information on adverse drug effects from the international literature. In addition to describing new reports of adverse drug effects, the authors have subjected those reports to critical analysis, setting them into context in terms of clinical relevance and importance, and cross-referring to previous reports where necessary. New adverse effects are reported and evaluated and previously reported adverse effects are re-evaluated in the light of the most recent information. A special feature is the reviews, in which selected adverse effects are discussed in depth. The use of the book is enhanced by three separate indexes, allowing the reader to enter the text by drug name, adverse effect name, or drug interaction.

  • Chemistry and Pharmacology

    • 1st Edition
    • Volume 46
    • English
    Internationally acclaimed for more than forty years, this serial, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structureelucidation... synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Pharmacology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

  • The Chemistry and Pharmacology of Taxol® and its Derivatives

    • 1st Edition
    • Volume 22
    • H. Timmerman
    • V. Farina
    • English
    Taxol®, a naturally occurring diterpenoid is one of the most exciting antitumor drugs available today. Its current indications (refractory ovarian and metastatic breast cancer) may soon be expanded since the drug is showing activity against lung and head-and-neck cancers.The book opens with a review of the naturally occurring taxoids, a chapter which is not a comprehensive list of all taxoids isolated to date, but attempts a systematic approact to describing the different classes of taxoids, with particular reference to all skeletal types and the various functionality patterns. Biosynthetic studies are also discussed, as well as some of the basic chemistry and common functionalities of taxoidic skeleton. Structural identification of taxoids, mostly by spectroscopic means; the formulation of taxanes; the metabolism and pharmacokinetics of Taxol® are also discussed, as are the chemistry of taxanes in relation to SAR studies; SAR aspects of the phenylisoserine side chain; and the mode of action of the taxanes and the mechanisms of resistance.The book is therefore written for medical chemists, in order to stimulate further research in this area and to provide the reader with the necessary background information to start a research program in the area.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 62
    • English
    Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Every fifth volume ofAdvances in Heterocyclic Chemistry contains a cumulative subject index.

  • Immunopharmacology of Free Radical Species

    • 1st Edition
    • English
    Free radicals have been implicated in a entire host of different human disease states, which suggests that although they may not have a pivotal causal role, they are involved in the perpetuation of disease. In recentyears, it has become evident that although free radicals most certainly do have this role in perpetuating inflammatory reactions, they have perhaps a far more important role in acting as second messenger systems to maintain normal cell function. It is theperturbations of these reactions which pose the most intriguing therapeutic challenges. This volume deals with various basic mechanisms of free radical processes and injury. The emphasis in each case is on potential therapeutic strategies developing fromthis new knowledge.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 32
    • English
    Volume 32 contains issues of interest to scientists working in pharmacology, biochemistry, and physiology, particularly to those in HIV, cancer, neurology, and cardio-vascular research and medicine. The chapters on new approaches to cancer therapy and schizophrenia will be of special interest to pharmacologists. Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Anesthesia and Cardiovascular Disease

    • 1st Edition
    • Volume 31
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Volume 31 deals with the mechanisms of anesthetic actions under normal conditions as well as pathophysiologic states.

  • DNA Topoisomerases: Topoisomerase-Targeting Drugs

    • 1st Edition
    • Volume 29B
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

  • Anesthesia and Cardiovascular Disease

    • 1st Edition
    • Volume 31
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Volume 31 deals with the mechanisms of anesthetic actions under normal conditions as well as pathophysiologic states.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 36
    • English
    Published since 1959, this serial presents in-depth reviews on key topics in neuroscience, from molecules to behavior. The serial stays keenly attuned to recent developments in the field through the contributions offirst-class experts. Neuroscientists as well as clinicians, psychologists, physiologists, and pharmacologists will find this serial an indispensable addition to their library.

  • DNA Topoisomearases: Biochemistry and Molecular Biology

    • 1st Edition
    • Volume 29A
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

  • Side Effects of Drugs Annual

    A Worldwide Yearly Critical Survey of New Data and Trends
    • 1st Edition
    • Volume 17
    • English
    Under the supervision of the series editors, an international team of expert authors have gathered together the latest information on adverse drug effects from the international literature. In addition to describing new reports of adverse drug effects, the authors have subjected those reports to critical analysis, setting them into context in terms of clinical relevance and importance, and cross-referring to previous reports where necessary. New adverse effects are reported and evaluated and previously reported adverse effects are re-evaluated in the light of the most recent information. A special feature is the reviews, in which selected adverse effects are discussed in depth. The use of the book is enhanced by three separate indexes, allowing the reader to enter the text by drug name, adverse effect name, or drug interaction.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 28
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 25
    • English

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 31
    • English
    This book contains six chapters, each of which is a self-contained, thorough review by an expert in the field of a particular topic in medicinal chemistry, bacteriology or pharmacology. Each topic is a currently active subject of research in either the quest for new drugs or a better understanding of the role of known biochemical phenomena. In addition, all of the chapters contain an extensive list of relevant reference books, papers and other publications. The book will be of great interest to medicinal and pharmaceutical chemists, and will serve as a valuable source of reference.

  • Cyclic GMP: Synthesis, Metabolism, and Function

    • 1st Edition
    • Volume 26
    • English
    This volume is dedicated to the topic of cyclic GMP. Chapters include discussions on the guanylyl cyclase and phosphodiesterase isoenzyme families for cyclic GMP synthesis and hydrolysis, cyclic GMP-dependent protein kinases, and various hormones and ligands that regulate cyclic GMP formation and/or metabolism. Several chapters also deal with some of the effects of cyclic GMP on other second messengers such as calcium ion transport and smooth muscle relaxation. Some clinical studies with cyclic GMP and atrial natriuretic peptide are also discussed. The last chapter raises many important questions in the field that remain to be addressed.

  • Sigma Receptors

    • 1st Edition
    • Volume 12
    • English
    This is the 12th in the Neuroscience Perspectives Series. The existence of sigma receptors in the central nervous system has only relatively recently been established. In line with the aims of Neuroscience Perspectives, this volume will cover the historical background of the subject, together with the physiological, molecular biological and pharmacological aspects, with a discussion on the concept of sigma receptors subtypes and their postulated relevance for CNS disorders.

  • Immunopharmacology of Neutrophils

    • 1st Edition
    • English
    About the Series:The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid arthritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their prevention and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for the many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects of immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have a distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory mediators ("cells and mediators"). The second covers each of the major organ systems and the diseases involving the immune and inflammatory responses that can affect them ("systems"). The third covers different classes of drugs currently used to treat these diseases as well as those under development ("drugs"). About the Book:This book addresses the key issues that face neutrophils during their very short but extremely important lives. The discovery that neutrophils have the capacity to phagocytose and kill foreign organisms set the stage for a fascinating research field that continues to stimulate exciting new findings throughout the world. Neutrophils target the sites of infection or injury, and are thus equipped with sensors for soluble signals ("chemoattractants") generated in the tissue in response to tissue infection or injury, and sensors for molecules on surfaces. These receptors are important so that the cell can distinguish, for example, activated endothelium to stimulate adherence and emigration, or alternatively the bacterial surface to stimulate phagocytosis and killing. A deficiency in any of these mechanisms can result in life-threatening infection. An over-reaction can result in damage to the tissues that the neutrophil should be programmed to protect.

  • Immunopharmacology of Epithelial Barriers

    • 1st Edition
    • English
    The realisation that epithelial tissues are not simply passive barriers to the adsorption of materials into internal environments has brought about an enormous growth of investigation of mucosal functions and their active and passive protective roles. Epithelia are highly organized but complex structures, subserving numerous functions, including immunological defence. The use of pharmacological tools in these systems is increasing, which is improving our understanding of epithelial immunobiology. This volume adopts a step-by-step approach, whereby each chapter builds upon the previous one, progressively adding important foundation information, culminating in a series of chapters concerning particular epithelia, including respiratory, gastrointestinal, renal and ocular. The result is a comprehensive but integrated treatise of epithelial function and its immunopharmacology, which aims to serve as an appropriate starting point at which the clinical pulmonologist and the research scientist can obtain an appreciation of some aspects of epithelial immunopharmacology as they are currently understood.

  • The G-Protein Linked Receptor Facts Book

    • 1st Edition
    • Steve Arkinstall
    • English
    How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact?The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common , easy–to-follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for.

  • Immunopharmacology of Joints and Connective Tissues

    • 1st Edition
    • English
    The consequences for diseases involving the immune system such as AIDS, and chronic inflammatory diseases such as bronchial asthma, rheumatoid athritis, and atherosclerosis, now account for a considerable economic burden to governments worldwide. In response there has been an enormous research effort investigating the basic mechanisms underlying such diseases, and a tremendous drive to identify novel therapeutic applications for their preventions and treatment. Though a plethora of immunological studies have been published in recent years, little has been written about the implications of such research for drug development. As a consequence, this area has not gained the prominence of other new fields such as molecular pharmacology or neuropharmacology, and a focal information source for many pharmacologists interested in diseases of the immune system remains unpublished. The Handbook of Immunopharmacology series provides such a source through the commissioning of a comprehensive collection of volumes on all aspects immunopharmacology. Editors have been sought after for each volume who are not only active in their respective areas of expertise, but who also have distinctly pharmacological bias to their research. The series follows three main themes, each represented by volumes on individual component topics. The first covers each of the major cell types and classes of inflammatory responses that can affect them ("Systems"). The third covers different classes of diseases as well as those under development ("Drugs").

  • Analytical Profiles of Drug Substances and Excipients

    • 1st Edition
    • Volume 22
    • English
    Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Analytical Profiles of Drug Substances and Excipients brings this information together into one source. The series has recently been expanded to include profiles of excipient materials.

  • Immunopharmacology of Mast Cells and Basophils

    • 1st Edition
    • English
    There has been a steady and continued research effort directed to understanding both the function and the role of mast cells and basophils ever since these cells were first described at the end of the nineteenth century. One of the most significant advances has perhaps been the appreciation of the fact that mast cells do not represent a single homogenous population of cells: they display heterogeneity at the morphological, biochemical and functional levels. The one characteristic that unites all types of mast cells and basophils appears to be the possession of the high affinity membrane receptor for immunoglobulin E, through which the cells may be stimulated. This volume begins with a review of the origin and development of mast cells and basophils. It continues by reviewing our knowledge of the stimuli to mast cells and basophils and the biochemical mechanisms which link the signal generated by stimulus to the response machinery of the cell. Further chapters deal with the drug control of mast cell and basophil responses, the heterogeneity of the cells' functions and the mediators' release by the cells, along with the morphological aspects of the cells' function. This book is completed by a selection of examples which examine the role of the mast cells or basophils in lung, skin and gastrointestinal tract. However, the role of the mast cell with regard to normal physiology, remains an open question. This book aims to provide an up-to-date account of mast cell and basophil biology, together with an insight into the functional relevance of these cells in some tissue types.

  • Immunopharmacology of the Heart

    • 1st Edition
    • English
    This volume sets out to consider a range of cardiac diseases for which drugs may play a therapeutic role by virtue of their effects on aspects of the immune system. The book reviews diseases of the heart which may involve an immunopharmacologica... component, and methods and techniques for the study of physiological and biochemical functions in the heart. An important focus is the immunopharmacology of the coronary vascular endothelium and the role of cellular and biochemical components of the immune system in the pathogenesis of atherosclerosis. The content also includes a review of the use of immunologically relevant agents in the setting of cardiac transplantation from aclinical perspective. Immunotherapy has a definite role to play in cardiology to a greater or lesser extent than other forms of intervention, depending on the type of cardiac disease. Immunopharmacology of the Heart aims to identify and clarify this role and points to potential developments of the future. Immunopharmacology of the Heart is a volume for the SYSTEMS theme of The Handbook of Pharmacology. In common with all other volumes it contains standardized illustrations and terms/abbreviations (glossaries of illustrations and terms published at the back of the volume). Other topics covered include: Leukocytes and their role in ischaemic heart disease. Complement activation. Sudden cardiac death. The stunned myocardium and reperfusion injury.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 46
    • English

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 28
    • English

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 30
    • English
    In this volume, the medicinal chemistry of the rapidly expanding family of retinoids, of promising semi-synthetic erythromycins and of the multifaceted amidines is reviewed. Another chapter continues the coverage of inorganic elements which have a medical role; recent studies on the various biological roles of manganese are also examined. Inhibition of enkephalin-degrading enzymes is reviewed, as are studies of the digitalis recognition site which are expected to lead to the development of more highly selective inotropic drugs. This work should be of value to medicinal chemists, pharmacists and pharmacologists. It should also be appreciated by all newcomers, as well as those who wish to be kept up to date with recent work on these topics.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 45
    • English

  • Advances in Pharmacology

    • 1st Edition
    • Volume 24
    • English

  • Carotenoids, Part B: Metabolism, Genetics, and Biosynthesis

    • 1st Edition
    • Volume 214
    • John N. Abelson + 1 more
    • English
    The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 44
    • English

  • Platelets: Receptors, Adhesion, Secretion, Part B

    • 1st Edition
    • Volume 215
    • John N. Abelson + 1 more
    • English
    This volume contains a comprehensive collection of methods for the isolation of platelet membranes, subcellular organelles, the cytoskeleton, and for the assay and purification of platelet receptors.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 43
    • English

  • Carotenoids, Part A, Chemistry, Separation, Quantitation, and Antioxidation

    • 1st Edition
    • Volume 213
    • John N. Abelson + 1 more
    • English
    This volume and its companion, volume 214 of Methods in Enzymology, present a comprehensive, state-of-the-art compilation of the molecular and cellular methodology needed for pursuing research with carotenoids.

  • Annual Reports in Medicinal Chemistry

    • 1st Edition
    • Volume 27
    • English

  • Advances in DNA Sequence-specific Agents

    • 1st Edition
    • Volume 1
    • L.H. Hurley
    • English
    This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.

  • Progress in Nucleic Acid Research and Molecular Biology

    • 1st Edition
    • Volume 42
    • English

  • International Review of Neurobiology

    • 1st Edition
    • Volume 33
    • English
    Published since 1959, this serial presents in-depth reviews of key topics in neuroscience, from molecules to behavior. The serial stays keenly atuned to recent developments through the contributions of first-class experts in the many fields of neuroscience. Neuroscientists as well as clinicians, psychologists, physiologists and pharmacoloists will find this serial an indispensable addition to their library.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 29
    • English
    The 29th volume of the series presents yet again, an exemplary survey of a wide range of current topics in medicinal chemistry and pharmacology. Eight expert reviews emphasize the relationships between chemical structure and pharmacological activity. These detailed discussions of some of the most exciting developments in the field today, will prove of great value to future research. The book begins with a study of anti-inflammatory activities of 5-lipoxygenase inhibitors, followed by an overview of the antiarrhythmic therapeutic possibilities offered by Class III electrophysiological agents. Structures and activities of some opioid ligands are surveyed, and the investigation into pharmacologically active pyridazine derivatives is continued. Dopamine D2 receptor agonists offer exciting therapeutic potential, as do ondansetron and related 5-HT 3 antagonists. The herbal origin of many modern drugs is yet again reflected in a survey of the herb feverfew. The volume concludes, as it began, with enzyme inhibition - in this case concerning synthetic inhibitors of interstitial collagenases.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 23
    • English

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