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The Pharmacological Potential of Cyanobacteria explores the bioactive compounds isolated from cyanobacteria and their relationship to human health and biotechnological applications. The book presents an overview of the chemistry and ecology of cyanobacteria, focusing on culture needs and techniques of biomass production. It is organized according to the different biological activities and biotechnological applications of compounds discovered in recent years. Besides biological activity, the mechanism of action of compounds is explained, along with molecular structure. Finally, compounds already used in therapeutics and biotechnology, as well as those in phases of approval or clinical trials are explored.
Each chapter is written by a different research group with expertise in the field and publications in peer reviewed journals. Researchers and students in pharmaceutical academic research, pharmaceutical industrial sector personnel, health professionals, and nutritionists will find this book to be very useful.
Covers all the bioactive compounds of cyanobacteria discovered thus far
Includes chapters by experts in the field, covering the chemistry and mechanisms of action of cyanobacteria-bioactive compounds
Provides a general overview of organisms, from biomass production to compound isolation and evaluation of bioactivities in different cell and cell-free systems
Scientists developing their research in the field of cyanobacteria, especially in the structure elucidation of new compounds with interest for human health, and in the biotechnological applications of these organisms. Advanced students and academic researchers in the disciplines of Biology, Biochemistry and Phytochemistry
Cover image
Title page
Table of Contents
Copyright
List of Contributors
Preface
Chapter 1. Trends in Cyanobacteria: a contribution to systematics and biodiversity studies
Abstract
1.1 General aspects of Cyanobacteria
1.2 Cyanobacteria biodiversity
1.3 Classification systems and future challenges for Cyanobacteria taxonomy
References
Chapter 2. Specialized metabolites from cyanobacteria and their biological activities
Abstract
2.1 Introduction
2.2 Secondary metabolites isolated from cyanobacteria
Acknowledgments
References
Chapter 3. Cyanobacterial anticancer compounds in clinical use: Lessons from the dolastatins and cryptophycins
Abstract
3.1 Introduction
3.2 Cyanobacterial compounds in clinical trials
3.3 Discussion
3.4 Concluding remarks
Acknowledgments
References
Chapter 4. Anti-inflammatory compounds from cyanobacteria
Abstract
4.1 Introduction
4.2 Inflammatory process—general overview
4.3 Cyanobacteria as source of anti-inflammatory compounds
4.4 Applicability of cyanobacterial compounds as anti-inflammatory agents
4.5 Final remarks
Acknowledgments
References
Chapter 5. UV-protective secondary metabolites from cyanobacteria
Abstract
5.1 Introduction
5.2 Scytonemins
5.3 Mycosporine-like amino acids of cyanobacteria
5.4 Future perspectives on scytonemins and mycosporine-like amino acids
5.5 Other potentially UV-protective compounds
References
Chapter 6. Antimicrobial activity of Cyanobacteria-derived compounds
Abstract
6.1 Introduction
6.2 Antibiotic resistance crisis and impact
6.3 Cyanobacteria as a promising source for antibiotic discovery
6.4 Recent studies in antimicrobial activity of Cyanobacteria
6.5 Perspectives and novel technologies for antimicrobial study in Cyanobacteria
6.6 Conclusions
Acknowledgments
References
Chapter 7. The role of toxins: impact on human health and aquatic environments
Abstract
7.1 Bloom definition and toxin biologic role
7.2 Cyanotoxins
7.3 Cyanotoxin impacts
Acknowledgments
References
Chapter 8. Cyanobacterial pigments: photosynthetic function and biotechnological purposes
Abstract
8.1 Introduction
8.2 Biotechnological uses of cyanobacterial pigments
8.3 Cyanobacterial pigment production—approaches and biotechnological perspectives
8.4 Conclusions
Acknowledgments
References
Chapter 9. Cyanobacteria in cosmetics: a natural alternative for anti-aging ingredients
Abstract
9.1 General introduction
9.2 Cyanobacteria in cosmetics
9.3 Conclusions
Acknowledgments
References
Chapter 10. The nutraceutical potential of cyanobacteria
Abstract
10.1 Introduction
10.2 Cyanobacteria production methods
10.3 Cyanobacteria as food supplements
10.4 Spirulina
10.5 Klamath
10.6 Nostoc
10.7 Cyanobacteria and micropathogens out of control
10.8 Microalgae as food supplements
10.9 Conclusions
References
Index
No. of pages: 356
Language: English
Published: January 19, 2022
Imprint: Academic Press
Paperback ISBN: 9780128214916
eBook ISBN: 9780128214923
GL
Graciliana Lopes
Graciliana Lopes is a pharmacist, with specialization in Phytochemistry and Pharmacognosy, and with a strong background in biological assays in cell and cell-free systems, and mechanisms of action of drugs. Her research has been most devoted to the fields of inflammation, microbiology, oxidative stress and chromatography.
Affiliations and expertise
CIIMAR – Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Novo Edifício do Terminal de Cruzeiros de Leixões, Avenida General Norton de Matos, s/n, 4450-208 Matosinhos, Portugal
MS
Marisa Silva
Marisa Silva is a Biologist has a strong background in marine toxins and in chromatographic techniques, with emphasis on LC-MS/MS. Her research contributed to the update of EFSA’s recommendations regarding emergent marine toxins monitoring and public health risk hazard.
Affiliations and expertise
MARE - Marine and Environmental Sciences Centre, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016, Lisbon, Portugal
VV
Vitor Vasconcelos
Department of Biology the Faculty of Sciences , Porto University and the head of the Laboratory of Ecotoxicology, Genomics and Evolution (LEGE) at the Marine and Environmental Research Center (CIIMAR) of Porto University, Portugal
Affiliations and expertise
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208, Matosinhos, Portugal
Departamento de Biologia, Faculdade de Ciências, Universidade do Porto, Rua Campo Alegre s/n, 4169-007, Porto, Portugal