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Biochemistry of Drug Metabolizing Enzymes

Trends and Challenges

  • 1st Edition - May 28, 2022
  • Latest edition
  • Editors: Muhammad Sajid Hamid Akash, Kanwal Rehman
  • Language: English

Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsib… Read more

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Description

Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsible for their deactivation, and their malfunction. Chapters explain the biochemistry of DMEs, including biochemical activation, functions, computational approaches, different contaminants on the action and function of DMEs, and describe the importance of DMEs in the drug development process. Conditions covered include metabolic diseases, cardiovascular diseases, neurological diseases, physiological diseases, xenobiotics and inflammatory responses, and their contribution in the malfunctioning of drug metabolizing enzymes.

This book is the perfect resource for pharmacology and biochemistry researchers to understand the principles of DMEs. Researchers in the corporate environment will also benefit from the comprehensive list of diseases associated with malfunction of DMEs.

Key features

  • Includes extensive classification of DMEs, their mechanism of action and computational analysis
  • Covers the biotransformation of drug by DMEs and the possible impact of environmental contaminants
  • Discusses the activity of DMEs in different clinical conditions such as cardiovascular disease, metabolic disorders, inflammation and neurotoxicity
  • Includes modern and novel bioanalytical techniques to predict the effect of DMEs

Readership

Researchers and scientists in Pharmaceutical Sciences, Biochemistry and biotechnology. Drug development corporate researchers

Table of contents

1. Biochemical activation of drug metabolizing enzymes: From mechanism of action to functions

2. Computational approaches and drug metabolizing enzymes: Concepts and challenges

3. Biotransformation of drugs by drug metabolizing enzymes: Concepts and challenges

4. Emerging environmental contaminants and drug metabolizing enzymes: Retrospective analysis and prospects

5. Impact of prodrugs on drug metabolizing enzymes: From function to regulation

6. Impact of hormones on drug metabolizing enzymes: From function to regulation

7. Impact of receptors on drug metabolizing enzymes: From function to regulation

8. Biochemistry of cathepsin enzymes and metabolic functions in lysosome

9. Fate of drug metabolizing enzymes in metabolic diseases: Challenges and strategies

10. Fate of drug metabolizing enzymes in cardiovascular diseases: Challenges and strategies

11. Fate of drug metabolizing enzymes in neurological diseases: Challenges and strategies

12. Impact of physiological factors on drug metabolizing enzymes: Challenges and strategies

13. Xenobiotics and drug metabolizing enzymes: Challenges and strategies

14. Drug metabolizing enzymes and inflammatory responses: Mechanism of induction and treatment strategies

15. Polymorphism and drug metabolizing enzymes: Challenges and strategies

16. Modulation of human microbiome and drug metabolism: Current trends and future prospects

17. Bioanalytical techniques for prediction of metabolic activity of drug metabolizing enzymes: Challenges

18. Role of pharmacogenomics for prediction of personalized medicines: Concepts and challenges

19. Dietary sources of drug metabolizing enzymes: From production to regulation

20. Vitamin deficiencies and drug metabolizing enzymes: Challenges and strategies

21. Malnutrition and Drug metabolizing enzymes: Challenges and strategies

22. Drug metabolizing enzymes and oxidative stress: Mechanism of induction and treatment strategies

Product details

  • Edition: 1
  • Latest edition
  • Published: May 28, 2022
  • Language: English

About the editors

MA

Muhammad Sajid Hamid Akash

Dr. Akash is currently working as an Associate Professor at the Department of Pharmaceutical Chemistry, Government College University Faisalabad, Pakistan. He got his PhD degree in Pharmaceutical Analysis from Zhejiang University, China. Currently, he is focusing on investigating the effect of endocrine disrupting chemicals on various molecular and metabolic pathways that are involved in metabolic disorders and their treatment strategies. His research work is cutting-edge and worthy of extension in developing countries, like Pakistan, where it can be most beneficial and cost-effective, especially for diabetic patients. Based on his significant scientific contributions in the field of Pharmaceutical Sciences, he has been awarded “Research Productivity Awards” from the Pakistan Council for Science and Technology, the PAS Gold Medal from the Pakistan Academy of Sciences, and the A.R. Shakoori Gold Medal from the Zoological Society of Pakistan.
Affiliations and expertise
Associate Professor and Chairman at Department of Pharmaceutical Chemistry, Government College University Faisalabad (GCUF), Pakistan

KR

Kanwal Rehman

Dr. Kanwal Rehman is working as an Associate Professor at the Department of Pharmacy in The Women University, Multan, Pakistan. Dr. Rehman received her PhD in Pharmacology from Zhejiang University, China. She nurtures a keen interest in the pathogenesis of metabolic disorders and new therapeutic modalities for its treatment. Currently, she is focusing on the investigation of the role of pharmacogenomics based upon gene polymorphism on various molecular and metabolic pathways that are involved in mitogenic disorders and treatment strategies, like natural biogenic compounds against different risk factors of metabolic disorders, including pancreatitis, cardiometabolic disorders, and hormonal imbalance. Dr. Rehman has also been awarded the Research Productivity Award by the Pakistan Council for Science and Technology, Pakistan; the PAS Gold Medal from the Pakistan Academy of Sciences; and the A.R. Shakoori Gold Medal from the Zoological Society of Pakistan.
Affiliations and expertise
Associate Professor, Department of Pharmacy in The Women University, Multan, Pakistan

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