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Books in Pharmacology general

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21-30 of 317 results in All results

Clinical Trials and Tribulations

  • 1st Edition
  • March 1, 2023
  • Gayathri De Lanerolle + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 1 7 8 7 - 0
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 1 7 8 8 - 7
Clinical Trials and Tribulations evaluates the multiple layers of complexities around research management, also exploring current practices, challenges and future directions. The book provides answers to readers questions and problems through extensive use of real-world examples, case studies and lessons learned. Following an approach to provide pragmatic viewpoints as well as concepts and methodologies and its alignment with specific practices, the book explores paradigms between planning and conducting research in academia vs. healthcare vs. industry in the UK vs. Europe vs. America. It highlights practical solutions to real-world complex issues that have been documented by independent regulators. This will be an indispensable book for all staff working in clinical research within healthcare, academia and industry, as well as students intending to work in clinical trials.

DNA Interactions with Drugs and Other Small Ligands

  • 1st Edition
  • March 1, 2023
  • Marcio Santos Rocha
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 9 1 3 9 - 1
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 3 8 5 - 2
DNA Interactions With Drugs and Other Small Ligands: Single Molecule Approaches and Techniques provides the reader with all the main information, a "state-of-the-art" of sorts and an overall review of the field. There is no other book currently available that covers all these subjects together. On the contrary, the different subjects that are developed in this book are currently scattered in journal articles and other books.

Environmental Carcinogenesis

  • 1st Edition
  • Volume 96
  • February 24, 2023
  • Max Costa
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 9 7 7 5 - 1
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 7 7 6 - 8
Environmental Carcinogenesis, Volume 96 in the Advances in Pharmacology series, reports on work done with carcinogenic metals and the mechanisms of their carcinogenicity, including Arsenic and Chromate. Chapters in this release include Breast cancer carcinogenesis by organophosphate pesticides, Polyadenylation of Canonical histone H3.1 in Carcinogenesis, Epigenomic reprogramming in iAs-mediated carcinogenesis, MicroRNAs and epigenetic regulation in metal-induced angiogenesis and carcinogenesis, Environmental epigenetics and new mechanistic markers of chemical exposure, Arsenic carcinogenesis by inhibition of DNA repair, Genetic and environmental reprogramming of the sarcoma epigenome, Mechanism of chromate carcinogenesis by chromatin alterations, and more. Other chapters cover Arsenic carcinogenesis and microRNAs, Epigenetic mechanism of Cr(VI)-induced cell malignant transformation and tumorigenesis, The dark side of NRF2 in arsenic carcinogenesis, and Chemical mechanisms of DNA damage by carcinogenic chromium(VI).

Elemene Antitumor Drugs

  • 1st Edition
  • December 2, 2022
  • Tian Xie
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 2 1 4 4 3 - 1
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 3 2 4 8 - 3
Elemene Antitumor Drugs: Molecular Compatibility Theory and its Applications in New Drug Development and Clinical Practice introduces natural anti-tumor drug elemene and systematic basic and clinical research. Basic principles of the compatibility theory of traditional Chinese medicine and the research and development process of the natural anti-tumor drug elemene under the guidance of this principle are introduced. In addition, the traditional extraction and separation of elemene and the new biosynthesis technology developed by the author's team are described. Then, the systematic anti-tumor mechanism research of elemene are introduced, including unique multi-target and comprehensive anti-tumor mechanisms and detailed mechanisms for treating specific tumors. Under the guidance of compatibility theory, clinical research on the combined application of elemene and different chemotherapeutic drugs has been further carried out, achieving positive results in clinical practice. Finally, the book also introduces the research and exploration of new drug delivery systems of elemene, as well as the structural modification and drug discovery progress taking elemene structure as the lead compound.

Advances in Extraction and Applications of Bioactive Phytochemicals

  • 1st Edition
  • November 30, 2022
  • Mihir Kumar Purkait + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 8 5 3 5 - 9
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 8 5 3 6 - 6
Advances in Extraction and Applications of Bioactive Phytochemicals presents comprehensive and systematic coverage of extraction techniques for bioactive phytochemical compounds and their delivery and therapeutic effectiveness. Sections focus on the pharmaceutical industry’s perspective, aiming at compiling recent advances of natural products in the field of drug delivery, including a brief overview of plant-based bioactive molecules, utilization of different plant elements for the extraction of phytochemicals, a compilation of conventional extraction approaches, advanced extraction methods, including Supercritical carbon-dioxide extraction, computational methods to improve production, drug delivery aspects of bioactive phytochemicals, their therapeutic effectiveness, and more. This book is a complete reference targeted at pharma researchers in academic and corporate environments and those willing to apply the most current extraction methods and health applications. Researchers in medicinal chemistry and chemical engineering will also benefit from this comprehensive resource.

How Synthetic Drugs Work

  • 1st Edition
  • September 6, 2022
  • Imran Kazmi + 4 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 9 8 5 5 - 0
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 1 3 6 8 - 3
How Synthetic Drugs Work: Insights into Molecular Pharmacology of Classic and New Pharmaceuticals provides comprehensive, structured access to robust information on molecular pharmacology for clinicians, research scientists and advanced health care students. The book covers the foundations of molecular pharmacology and the main drug classes, including detailed information on their mechanisms of action and the application of molecular pharmacology in drug development. This book is an ideal reference for graduate students and researchers in pharmacology, however, researchers in corporate settings will also benefit from the book's structured and detailed coverage of mechanisms of action of synthetic drugs.

Tailor-Made Polysaccharides in Drug Delivery

  • 1st Edition
  • September 2, 2022
  • Amit Kumar Nayak + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 1 2 8 6 - 8
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 1 2 8 7 - 5
Tailor-Made Polysaccharides in Drug Delivery provides extensive details on all the vital precepts, basics and fundamental aspects of tailored polysaccharides in the pharmaceutical and biotechnological industry for understanding and developing high quality products. The book offers a comprehensive resource to understand the potential of the materials in forming new drug delivery methods. It will be useful to pharmaceutical scientists, chemical engineers, and regulatory scientists and students actively involved in pharmaceutical product and process development of tailored-made polysaccharides in drug delivery applications.The utilization of natural polymeric excipients in numerous healthcare applications demand the replacement of the synthetic polymers with the natural ones due to their biocompatibility, biodegradability, economic extraction and readily availability. The reality behind the rise in importance of these natural materials is that these sources are renewable if grown in a sustainable means and they can tender incessant supply of raw materials. Amongst these natural polymers, polysaccharides are considered as excellent excipients because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of polysaccharides in drug delivery.

Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary

  • 1st Edition
  • Volume 95
  • August 9, 2022
  • Hiroshi Yamazaki
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 1 1 0 9 - 2
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 1 1 1 0 - 8
Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more. Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more. Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume is to collect a comprehensive description of major progress to date, to discuss possible future directions, and to invite young researchers to join this important and exciting world of P450.

Applications of Nanovesicular Drug Delivery

  • 1st Edition
  • July 22, 2022
  • Amit Kumar Nayak + 3 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 1 8 6 5 - 7
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 1 9 5 3 - 1
Applications of Nanovesicular Drug Delivery provides thorough insights and a complete and updated discussion on the preparation, properties and drug delivery applications of various nanovesicles. This volume will discuss target-specific drug application, such as ocular, transdermal, nasal, intravenous and oral delivery. This title is a valuable resource for academics, pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical products and process development of tailored-made polysaccharides in drug delivery applications. Recently, there have been a number of outstanding nanosystems in nanovesicular carrier-forms (such as nanoemulsions, self-nanoemulsifying systems, nanoliposomes, nanotransferosomes, etc.), that have been researched and developed for efficient drug delivery by many formulators, researchers and scientists. However, no previously published books have covered all these drug delivery nanovesicles collectively in a single resource.

Systems of Nanovesicular Drug Delivery

  • 1st Edition
  • July 16, 2022
  • Amit Kumar Nayak + 3 more
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 1 8 6 4 - 0
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 1 4 2 2 - 2
Systems of Nanovesicular Drug Delivery provides a thorough insight into the complete and up-to-date discussions about the preparation, properties and drug delivery applications of various nanovesicles. This volume discusses cubosomes, proniosomes and niosomes, dendrimerosomes and other new and effective approaches for drug delivery. It will be a valuable title and resource for academics and pharmaceutical scientists, including industrial pharmacists, analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical products and process development of tailor-made polysaccharides in drug delivery applications. Recently, there have been a number of outstanding nanosystems in nanovesicular carrier-forms (such as nanoemulsions, self-nanoemulsifying systems, nanoliposomes, nanotransferosomes, etc.), that have been researched and developed for efficient drug delivery by many formulators, researchers and scientists. However, no previously published books have covered all these drug delivery nanovesicles collectively in a single resource.

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Pharmacology