Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary
- 1st Edition, Volume 95 - August 9, 2022
- Imprint: Academic Press
- Editor: Hiroshi Yamazaki
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 1 0 9 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 1 1 0 - 8
Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field ove… Read more
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Request a sales quotePharmacology and Toxicology of Cytochrome P450 - 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more.
Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more.
Research on many forms of P450s has been extended into different fields, from molecules to in vivo situations because pharmacologists and toxicologists appreciate and are attracted to the potential therapeutics. The purpose of this volume is to collect a comprehensive description of major progress to date, to discuss possible future directions, and to invite young researchers to join this important and exciting world of P450.
- Comprehensive coverage of major progress in the last 60 years on the P450 research in pharmacology and toxicology
- Discussion of possible future directions of the research on P450s, especially for improved pharmacotherapy in humans
- Encouragement to young scientists to join this important and exciting basic, translational, and advanced world of P450
A variety of pharmacologists and toxicologists
- Cover
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Reference
- In Memoriam—Tsuneo Omura
- Chapter One: Roles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future
- Abstract
- 1: Introduction
- 2: Where is the P450 field today and what do we know?
- 3: P450s and drug metabolism
- 4: P450s as drug targets
- 5: The future of P450 research
- 6: Conclusion
- References
- Chapter Two: Pharmacogenetics of the cytochromes P450: Selected pharmacological and toxicological aspects
- Abstract
- 1: Introduction
- 2: Relevance of cytochrome P450 polymorphisms to warfarin dosing and bleeding risk
- 3: Idiosyncratic adverse drug reactions and cytochrome P450 polymorphisms
- 4: Cytochrome P450 polymorphisms and disease susceptibility
- 5: Conclusion
- References
- Chapter Three: Cytochrome P450 enzymes and metabolism of drugs and neurotoxins within the mammalian brain
- Abstract
- 1: Introduction
- 2: CYP expression in the brain
- 3: Factors influencing CYPs in the brain
- 4: Functional impact of brain CYP metabolism
- 5: Conclusion
- References
- Chapter Four: Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences
- Abstract
- 1: Introduction
- 2: Results
- 3: Conclusion
- References
- Chapter Five: Atypical kinetics of cytochrome P450 enzymes in pharmacology and toxicology
- Abstract
- 1: Introduction
- 2: Atypical Michaelis-Menten kinetics and proposed mechanisms
- 3: Atypicalities in mechanism-based inactivation of cytochrome P450
- 4: Conclusion
- References
- Chapter Six: Biosynthesis using cytochrome P450 enzymes: Focus on synthesis of drug metabolites
- Abstract
- 1: Introduction
- 2: Utility of metabolite biosynthesis
- 3: Directed metabolite biosynthesis
- 4: Conclusion
- References
- Chapter Seven: Use of engineered cytochromes P450 for accelerating drug discovery and development
- Abstract
- 1: Introduction
- 2: Lead candidate synthesis and late-stage functionalization of pharmaceutical compounds
- 3: Production of drug metabolites
- 4: Limitations of P450s as biocatalysts for the pharmaceutical industry
- 5: Progress in changing properties of P450 systems
- 6: Engineering of substrate specificity
- 7: Engineering catalytic efficiency via the redox system
- 8: Engineering the ability to use oxygen surrogates
- 9: Progress in engineering thermostability
- 10: Novel chemistry
- 11: Conclusion
- References
- Chapter Eight: Assessing cytochrome P450 function using genetically engineered mouse models
- Abstract
- 1: Introduction
- 2: Available mouse models
- 3: Assessing CYP function in the in vivo metabolism and toxicity of therapeutic drugs
- 4: Assessing the function of CYPs in the in vivo metabolism, bioactivation, and toxicity of known or suspected chemical carcinogens
- 5: Conclusion
- References
- Chapter Nine: Expression and functional activity of cytochrome P450 enzymes in human hepatocytes with sustainable reproducibility for in vitro phenotyping studies
- Abstract
- 1: Introduction
- 2: Preparation of hepatocytes (from chimeric mice)
- 3: Expression and activity of human P450 enzymes
- 4: P450 enzyme-dependent drug metabolism
- 5: Human hepatocytes during 1- to 4-weeks of culture
- 6: Conclusion
- References
- Chapter Ten: Cytochrome P450s in chimeric mice with humanized liver
- Abstract
- 1: Introduction
- 2: Characterization of humanized liver from chimeric mice
- 3: In vivo drug metabolism by humanized liver mouse
- 4: Pharmacokinetic study using humanized liver mouse
- 5: Drug interaction study using humanized liver mouse
- 6: Human P450-inactivated chimeric mouse model using mechanism-based inhibitor
- 7: Conclusion
- References
- Chapter Eleven: Polymorphic cytochromes P450 in non-human primates
- Abstract
- 1: Introduction
- 2: Molecular characteristics of P450s
- 3: Genetic polymorphisms
- 4: Conclusion
- References
- Chapter Twelve: Cytochrome P450 enzymes in the pediatric population: Connecting knowledge on P450 expression with pediatric pharmacokinetics
- Abstract
- 1: Introduction
- 2: Developmental changes in cytochrome P450 enzyme expression
- 3: Utilization of P450 ontogeny for predicting pharmacokinetics of drugs in the pediatric population: Physiologically-based pharmacokinetic (PBPK) modeling and simulations
- 4: Future challenges
- 5: Conclusion
- References
- Chapter Thirteen: Cytochrome P450 polymorphism: From evolution to clinical use
- Abstract
- 1: Introduction
- 2: Selection of CYP gene variants in relation to environmental and dietary factors
- 3: Genetic selection in humans
- 4: Genetic variants of CYP genes
- 5: Examples of Functionality of CYP polymorphism
- 6: Missing heritability
- 7: Pharmacogenomic labels
- 8: Looking into the future
- 9: Conclusion
- References
- Further reading
- Edition: 1
- Volume: 95
- Published: August 9, 2022
- Imprint: Academic Press
- No. of pages: 434
- Language: English
- Hardback ISBN: 9780323911092
- eBook ISBN: 9780323911108
HY
Hiroshi Yamazaki
Hiroshi Yamazaki has been Professor of the Laboratory of Drug Metabolism and Pharmacokinetics at Showa Pharmaceutical University, Tokyo, Japan since 2005. After receiving his BS and MS degrees from Gifu Pharmaceutical University and a PhD in Pharmaceutical Sciences from Osaka University in Japan, he trained as a post-doctoral fellow at Vanderbilt University School of Medicine, Nashville, TN, USA in 1994. He was recruited as an Associate Professor at Kanazawa University from Osaka Prefectural Institute of Public Health in 1998 and then an Associate Professor at Hokkaido University Graduate School of Pharmaceutical Sciences in 2001.
Professor Yamazaki’s research has focused on cytochromes P450, flavin-containing monooxygenases, and simple pharmacokinetic modeling. His P450 papers cover a broad range of topics. He has authored over 500 original publications (http://orcid.org/0000-0002-1068-4261) with an h-index of 66 in Scopus (Author ID: 557193405959) . Professor Yamazaki is a member of several professional societies and editorial committees and was designated as one of the experts of Chemical Substance Assessment Groups (of the Food and Safety Commission of Japan, 2006-15). He is a recipient of the Japanese Society for the Study of Xenobiotics (JSSX) Award and Fellowship and was ex-JSSX President (2017-19) and Editor-in-Chief of Drug Metabolism and Pharmacokinetics (2014-17). Professor Yamazaki was the leading organizer of 19th International Conference on Cytochrome P450, in Tokyo, Japan in 2015.
Affiliations and expertise
Showa Pharmaceutical University, Tokyo, JapanRead Pharmacology and Toxicology of Cytochrome P450 - 60th Anniversary on ScienceDirect