Elemene Antitumor Drugs
Molecular Compatibility Theory and its Applications in New Drug Development and Clinical Practice
- 1st Edition - December 2, 2022
- Imprint: Elsevier
- Author: Tian Xie
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 1 4 4 3 - 1
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 2 4 8 - 3
Elemene Antitumor Drugs: Molecular Compatibility Theory and its Applications in New Drug Development and Clinical Practice introduces natural anti-tumor drug elemene and systemati… Read more
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Request a sales quoteElemene Antitumor Drugs: Molecular Compatibility Theory and its Applications in New Drug Development and Clinical Practice introduces natural anti-tumor drug elemene and systematic basic and clinical research. Basic principles of the compatibility theory of traditional Chinese medicine and the research and development process of the natural anti-tumor drug elemene under the guidance of this principle are introduced. In addition, the traditional extraction and separation of elemene and the new biosynthesis technology developed by the author's team are described. Then, the systematic anti-tumor mechanism research of elemene are introduced, including unique multi-target and comprehensive anti-tumor mechanisms and detailed mechanisms for treating specific tumors.
Under the guidance of compatibility theory, clinical research on the combined application of elemene and different chemotherapeutic drugs has been further carried out, achieving positive results in clinical practice. Finally, the book also introduces the research and exploration of new drug delivery systems of elemene, as well as the structural modification and drug discovery progress taking elemene structure as the lead compound.
- Systematically introduces the principles of molecular compatibility theory and its application in new drug development and clinical practice
- Provides comprehensive information on drug development, drug preparation, mechanism study and clinical research of the natural antitumor drug elemene
- Includes valuable experience in drug development and related industry chain construction based on natural products
- Introduces clinical research ideas and experiences for expanding clinical indications
- Presents the practical methods and research experience of the secondary development of traditional Chinese medicine
College and university researchers, teachers and students, clinicians, pharmacists, drug R&D researchers, Undergraduate and graduate students majoring in Chinese medicine
- Cover image
- Title page
- Table of Contents
- Copyright
- Forward I
- Forward II
- Part 1. Development of Elemene Antitumor Drug Based on Molecular Compatibility
- Chapter 1. Molecular Compatibility Theory and Its Applications in Tumor Treatment
- 1.1. Developmental history of Chinese medicine compatibility
- 1.2. Theoretical basis and characteristics of molecular compatibility theory
- 1.3. Applications of molecular compatibility
- 1.4. Significance of developing the molecular compatibility theory
- 1.5. Development of research methods of modern Chinese medicines by molecular compatibility theory
- 1.6. Innovative strategies for clinical treatment of systematic and complicated diseases provided by molecular compatibility theory
- 1.7. Conclusions
- Chapter 2. Research and Development of The Antitumor Drug Elemene Liposome
- 2.1. Research and development history of elemene liposome
- 2.2. Market application of elemene liposome
- 2.3. Conclusions
- Part 2. Drug Sources of Elemene
- Chapter 3. Traditional Extraction and Separation, Manufacturing Process, and Quality Standards of Elemene
- 3.1. Introduction
- 3.2. Extraction and separation techniques for elemene
- 3.3. GMP flow chart
- 3.4. Specification standards of elemene-related products
- 3.5. Conclusions
- Chapter 4. Advances in The Biosynthesis of β-elemene
- 4.1. Key enzyme of sesquiterpene synthesis in mevalonate and methylerythritol 4-phosphate pathways
- 4.2. Transcriptome analysis of Curcuma wenyujin
- 4.3. Biosynthesis of elemene in microbial cells
- 4.4. Conclusions
- Part 3. Studies on The Antitumor Mechanism of Elemene
- Chapter 5. An Overview of The Anticancer Mechanism of Elemene
- 5.1. Introduction
- 5.2. Apoptosis
- 5.3. Nonapoptotic cell death
- 5.4. Antimetastasis
- 5.5. Immune system
- 5.6. Cell cycle arrest
- 5.7. Regulation of differentiation
- 5.8. Conclusions
- Chapter 6. Antitumor Mechanisms of Elemene in Specific Cancers
- 6.1. Antitumor mechanisms of elemene in primary liver cancer
- 6.2. Antitumor mechanisms of elemene in lung cancer
- 6.3. Antitumor mechanisms of elemene in gastric cancer
- 6.4. Antitumor mechanisms of elemene in glioma
- 6.5. Antitumor mechanisms of elemene in other cancers
- 6.6. Conclusions
- Part 4. Clinical Research on Molecular Compatibility of Elemene
- Chapter 7. Clinical Applications of Elemene
- 7.1. Introduction
- 7.2. Lung cancer
- 7.3. Gastric cancer
- 7.4. Esophageal cancer
- 7.5. Liver cancer
- 7.6. Colorectal cancer
- 7.7. Pancreatic cancer
- 7.8. Breast cancer
- 7.9. Cervical cancer
- 7.10. Nasopharyngeal carcinoma
- 7.11. Leukemia
- 7.12. Malignant lymphoma
- 7.13. Intracranial tumors
- 7.14. Osseous metastasis of the malignant tumors
- 7.15. Malignant pleural effusion
- 7.16. Cancer-related fatigue
- 7.17. Cancer pain
- 7.18. Bladder cancer
- 7.19. Malignant tumors
- 7.20. Conclusions
- Chapter 8. Clinical Research on Drug Combination Based on Elemene
- 8.1. Introduction
- 8.2. Elemene increases chemotherapy efficacy
- 8.3. Reversal of drug resistance by elemene
- 8.4. Clinical study of elemene combined with chemotherapy
- 8.5. Conclusions
- Part 5. Research on Elemene Molecular Compatibility Therapy and Drug Delivery System
- Chapter 9. Developing a Novel Drug Delivery System for Elemene to Synergize Therapeutic Strategies
- 9.1. Introduction
- 9.2. Novel drug delivery system of elemene
- 9.3. Hydrogel delivery system platform for elemene
- 9.4. Novel combination therapy strategies for elemene-based drugs
- 9.5. Novel combination therapy using elemene and mRNA drugs
- 9.6. Conclusions
- Part 6. Structural Optimization and Modification of Elemene
- Chapter 10. Structural Optimization and Modification Based on β-elemene
- 10.1. Introduction
- 10.2. 13/14-Halogenated derivatives of β-elemene
- 10.3. 13/14-Alcohol, aldehyde, ether, and ester derivatives of β-elemene
- 10.4. 13/14-Amine derivatives of β-elemene
- 10.5. 13-Aromatic heterocyclic derivatives of β-elemene
- 10.6. 13-Radioactive derivatives of β-elemene
- 10.7. 13-Vinyl substituted derivatives of β-elemene
- 10.8. 13-NO donor β-elemene hybrids
- 10.9. 13,14-Macrocycles of β-elemene
- 10.10. Structure–activity relationships
- 10.11. Conclusions
- Index
- Edition: 1
- Published: December 2, 2022
- No. of pages (Hardback): 310
- No. of pages (eBook): 310
- Imprint: Elsevier
- Language: English
- Hardback ISBN: 9780443214431
- eBook ISBN: 9780443132483
TX
Tian Xie
Professor Tian Xie holds an M.D. degree and is currently a Professor at Hangzhou Normal University School of Pharmacy. He is the director of the Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province and head of the Engineering Laboratory of Development and Application of Traditional Chinese Medicine in Zhejiang Province. Dr. Xie has been engaged in research, teaching and industrialization of Chinese and Western Medicine, natural medicine research and development, targeted liposomes development, pharmaceutical engineering, and green chemistry for more than 40 years.
Professor Tian Xie is also the inventor of the elemene oral emulsion and elemene injection antitumor drugs. The successful development of elemene antitumor drugs has achieved extensive clinical and social benefits. The drug has been used in China for nearly 20 years, benefiting hundreds of thousands of cancer patients. The development of elemene series drugs has also increased the demand for the source of elemene, "Wenyujin", and tens of thousands of farmers in Zhejiang Province have significantly increased their income by planting Wenyujin.
Affiliations and expertise
Professor, Hangzhou Normal University School of Pharmacy, Hangzhou Normal University National University Science Park, ChinaRead Elemene Antitumor Drugs on ScienceDirect