Systems of Nanovesicular Drug Delivery
- 1st Edition - July 16, 2022
- Imprint: Academic Press
- Editors: Amit Kumar Nayak, Md Saquib Hasnain, Tejraj M. Aminabhavi, Vladimir P. Torchilin
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 8 6 4 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 4 2 2 - 2
Systems of Nanovesicular Drug Delivery provides a thorough insight into the complete and up-to-date discussions about the preparation, properties and drug delivery applicati… Read more
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Request a sales quoteSystems of Nanovesicular Drug Delivery provides a thorough insight into the complete and up-to-date discussions about the preparation, properties and drug delivery applications of various nanovesicles. This volume discusses cubosomes, proniosomes and niosomes, dendrimerosomes and other new and effective approaches for drug delivery. It will be a valuable title and resource for academics and pharmaceutical scientists, including industrial pharmacists, analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical products and process development of tailor-made polysaccharides in drug delivery applications.
Recently, there have been a number of outstanding nanosystems in nanovesicular carrier-forms (such as nanoemulsions, self-nanoemulsifying systems, nanoliposomes, nanotransferosomes, etc.), that have been researched and developed for efficient drug delivery by many formulators, researchers and scientists. However, no previously published books have covered all these drug delivery nanovesicles collectively in a single resource.
- Provides thorough insights and up-to-date discussions about the various systems of nanovesicular drug delivery
- Covers advanced trigger-assisted systems (such as iontophoresis, ultra-sound triggering, etc.) and how they have been used for improved drug delivery by nanovesicles
- Presents recent advances in drug delivery fields by global leaders and experts from academia, research, industry and regulatory agencies
- Includes an updated literature review of relevant key topics, good quality illustrations, chemical structures, attractive flow charts and well-organized tables
Postgraduate students, doctoral and postdoctoral research fellows, academician, pharmaceutical scientists including industrial pharmacists and analytical scientists. Health care professionals and regulatory scientists actively involved in pharmaceutical product and process development of tailored-made polysaccharides in drug delivery applications
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Nanovesicular systems in drug delivery
- Abstract
- 1.1 Introduction
- 1.2 An overview of various nanovesicles currently available in the literature
- 1.3 Preparation of nanovesicles
- 1.4 Drug delivery applications of nanovesicles
- 1.5 Future challenges of nanovesicles
- 1.6 Conclusions and future prospects
- References
- Chapter 2. Nanoemulsions for drug delivery
- Abstract
- 2.1 Introduction
- 2.2 Preparation and characterization methods of nanoemulsions
- 2.3 Practical applications of nanoemulsions
- 2.4 Advantages, disadvantages and challenges of nanoemulsions
- 2.5 Conclusions
- References
- Chapter 3. Lipid-based nanocarriers for drug delivery: microemulsions versus nanoemulsions
- Abstract
- 3.1 Introduction
- 3.2 Drug delivery systems based on nano-sized emulsions
- 3.3 Nanoemulsions versus nicroemulsions: a big discussion
- 3.4 Conclusion
- Conflict of Interest
- Acknowledgements
- References
- Chapter 4. Self-nanoemulsifying systems for delivery of drugs
- Abstract
- 4.1 Introduction
- 4.2 General composition of the self-nanoemulsifying drug delivery systems
- 4.3 Method of preparation of self-nanoemulsifying drug delivery systems
- 4.4 Optimization of self-nanoemulsifying drug delivery system’s formulation
- 4.5 Characterization of self-nanoemulsifying drug delivery systems
- 4.6 Advancements in self-nanoemulsifying drug delivery systems
- 4.7 Application of self-nanoemulsifying drug delivery systems and supersaturated self-nanoemulsifying drug delivery systems
- 4.8 Self-nanoemulsifying drug delivery system formulations in the market
- References
- Chapter 5. Liposomes as efficient lipid nanovesicular systems for drug delivery
- Abstract
- 5.1 Introduction
- 5.2 Liposomes and their classifications
- 5.3 Preparation of liposomes
- 5.4 Drug delivery applications of liposomes
- 5.5 Marketed liposomes
- 5.6 Conclusion
- References
- Chapter 6. Functionalized liposomes: a nanovesicular system
- Abstract
- 6.1 Introduction
- 6.2 PEGylated liposomes (stealth liposomes)
- 6.3 Peptide-functionalized liposomes
- 6.4 Liposomes functionalized with antibody
- 6.5 Liposomes functionalized with small molecules
- 6.6 Nucleic acid-ligand or aptamers functionalized liposomes (aptamosomes)
- 6.7 Vitamin-functionalized liposomes
- 6.8 Protein-functionalized liposomes
- 6.9 Theranostic liposomes
- 6.10 Enzyme-functionalized liposomes (enzymosomes)
- 6.11 Conclusion
- References
- Chapter 7. Transferosomes: a novel nanovesicular approach for drug delivery
- Abstract
- 7.1 Introduction
- 7.2 Transfersomes as drug delivery carriers
- 7.3 Mechanism of skin permeation by transferosomes
- 7.4 Formulation additives of transfersomes
- 7.5 Factors affecting properties of transfersomes
- 7.6 Methods of transfersomes’ preparations
- 7.7 Transfersomes under clinical trials
- 7.8 Marketed transferosomes
- 7.9 Conclusion
- References
- Chapter 8. Proniosomes and niosomes for enhanced drug delivery
- Abstract
- 8.1 Introduction
- 8.2 Methods of preparation and considerations
- 8.3 Characterization of niosomes and proniosomes
- 8.4 Application and administration routes of niosomes and proniosomes
- 8.5 Sensitive and stealthy niosomes
- 8.6 Niosomes and proniosomes: a comparative scheme
- 8.7 Conclusion
- Conflict of interest
- Acknowledgements
- References
- Chapter 9. Cubosomes: a promising vesicular system for drug delivery
- Abstract
- 9.1 Introduction
- 9.2 Cubosomes as versatile nanovesicle carriers for therapeutics
- 9.3 At the frontier of cubosomal delivery systems
- 9.4 Conclusions and future prospects
- Acknowledgments
- References
- Chapter 10. Exosomes: a novel vesicular drug delivery platform
- Abstract
- 10.1 Introduction
- 10.2 Exosomes
- 10.3 Biological functions of exosomes
- 10.4 Use of exosomes as drug delivery systems via transfer of cargoes
- 10.5 Therapeutic applications of exosomes as drug delivery systems
- 10.6 Conclusion
- References
- Chapter 11. Polymersomes as versatile drug delivery vesicular carriers
- Abstract
- 11.1 Introduction
- 11.2 Synthesis of block copolymers and techniques for self-assembly of synthetic amphiphiles in polymersomes
- 11.3 Analytical techniques for the assessment of block copolymers and polymersomes
- 11.4 Modeling techniques for phenomena of molecular organization in micelles and vesicles
- 11.5 Case studies for drug delivery with polymersomes
- Notation and abbreviations
- Acknowledgements
- References
- Chapter 12. Aquasomes: a novel platform for drug delivery
- Abstract
- 12.1 Introduction
- 12.2 Composition of aquasomes
- 12.3 Preparation of aquasomes
- 12.4 Characterization of aquasomes
- 12.5 Stability of aquasomes
- 12.6 Administration and application of aquasomes
- 12.7 Advantages of aquasomes
- 12.8 Limitations of aquasomes
- 12.9 Future perspectives
- 12.10 Conclusion
- References
- Chapter 13. Aquasomes: a nanoparticulate approach for therapeutic applications
- Abstract
- 13.1 Introduction
- 13.2 Composition of aquasomes and role of each component
- 13.3 Role of self-assembly in aquasomes
- 13.4 Preparation technique of aquasomes
- 13.5 Characterization of aquasome
- 13.6 Applications of aquasomes
- 13.7 Challenges
- 13.8 Future possibilities and regulatory considerations
- 13.9 Conclusion
- References
- Chapter 14. Ethosomes: a potential vesicular carrier for drug delivery
- Abstract
- 14.1 Introduction
- 14.2 Advantages and disadvantages of ethosomes
- 14.3 Mechanism of skin permeation by ethosomes
- 14.4 Method of preparation
- 14.5 Characterization of ethosomes
- 14.6 Application of ethosomes
- References
- Chapter 15. Nanophytosomes: a novel approach for the delivery of herbal drugs
- Abstract
- 15.1 Introduction
- 15.2 Plant bioactive compounds and factors affecting their absorption and bioavailability
- 15.3 Delivery systems as strategies to improve natural products bioavailability
- 15.4 Phytosomes as delivery systems for phytochemicals
- 15.5 Conclusions
- Acknowledgments
- References
- Chapter 16. Hyalurosomes: a newer approach for drug delivery
- Abstract
- 16.1 Introduction
- 16.2 Obtaining hyalurosomes and liposomes
- 16.3 Hyaluronic acid-CD44 interactions
- 16.4 Hyalurosomes as dermal and topical drug delivery systems
- 16.5 Hyalurosomes as anti-inflammatory drug delivery systems
- 16.6 Hyalurosomes in cancer treatment
- 16.7 Dual mechanisms of hyaluronic acid-modified liposomes in cancer treatment
- 16.8 Concluding remarks
- References
- Chapter 17. Glycerosomes: a new tool for effective drug delivery
- Abstract
- 17.1 Introduction
- 17.2 Effect of excipients on critical quality attributes
- 17.3 Effect on morphology
- 17.4 Glycerosomes as carrier for drug delivery
- 17.5 Conclusion
- References
- Chapter 18. Bilosomes: a novel platform for drug delivery
- Abstract
- 18.1 Introduction
- 18.2 Material used for the preparation of bilosomes
- 18.3 Procedures for preparation of bilosomes
- 18.4 Characterization of bilosomes
- 18.5 Mechanisms of drug absorption enhancement
- 18.6 Factors affecting performance of bilosomes
- 18.7 Surface engineering of bilosomes
- 18.8 Features of bilosomes
- 18.9 Deficiencies of bilosomes
- 18.10 Applications of bilosomes
- 18.11 Concluding remarks
- References
- Chapter 19. Dendrimers and dendrimersomes as a novel tool for effective drug delivery applications
- Abstract
- 19.1 Introduction
- 19.2 Synthesis of dendrimers and metallodendrimers
- 19.3 Synthesis of dendrimersomes
- 19.4 Drug delivery applications of dendrimers and dendrimersomes
- 19.5 Dendrimers and dendrimersomes: advantages, limitations, and future prospects
- 19.6 Conclusions
- References
- Chapter 20. Nanobubbles to aid drug delivery
- Abstract
- 20.1 Introduction
- 20.2 Composition of nanobubbles
- 20.3 Stability and factors affecting the stability of nanobubbles
- 20.4 Preparation of nanobubbles
- 20.5 Applications of nanobubbles
- 20.6 Summary
- References
- Chapter 21. Nanospanlastic as a promising nanovesicle for drug delivery
- Abstract
- 21.1 Introduction to the nanospanlastics
- 21.2 Composition and characteristics of nanospanlastics
- 21.3 Applications of nanospanlastic as a promising nanovesicle for drug delivery system
- 21.4 The therapeutic efficacy of nanospanlastics
- 21.5 Role of nanospanlastics for improving the bioavailability of natural plants
- 21.6 Role of nanospanlastics in drug repurposing treatment of animal diseases
- 21.7 Role of nanospanlastics for improving the topical delivery of inhibitor
- 21.8 Future of nanomedicine and drug delivery system
- 21.9 Conclusion
- References
- Further reading
- Chapter 22. Stimuli-responsive nanovesicles for smart drug delivery
- Abstract
- 22.1 Introduction
- 22.2 Challenges associated with conventional nanovesicles
- 22.3 Design considerations of various stimuli-responsive nanovesicles
- 22.4 Applications of stimuli-responsive nanovesicles
- 22.5 Conclusion
- Conflict of interest
- Acknowledgments
- References
- Chapter 23. Smart nanovesicles for drug delivery
- Abstract
- 23.1 Introduction
- 23.2 Different types of nanovesicles
- 23.3 Synthetic nanovesicles
- 23.4 Methods of preparation of niosomes
- 23.5 Other types of nanovesicles
- References
- Chapter 24. Iontophoretic drug delivery systems
- Abstract
- 24.1 Introduction
- 24.2 Historical background and development of iontophoresis
- 24.3 Iontophoresis drug delivery system components and mechanisms
- 24.4 Drug transport pathways
- 24.5 Factors affecting iontophoretic drug delivery
- 24.6 Pharmaceutical application of iontophoresis
- 24.7 Future formulation strategies using iontophoresis
- 24.8 Conclusion
- References
- Chapter 25. Ultrasound triggered nanovescicular drug delivery systems
- Abstract
- 25.1 Introduction
- 25.2 Responsive drug delivery systems
- 25.3 Ultrasound triggered drug delivery carriers
- 25.4 Mechanism of drug delivery
- 25.5 Factors affecting drug delivery
- 25.6 Some recent studies
- 25.7 Underlying challenges and future prospects
- 25.8 Conclusions
- References
- Chapter 26. Nanovesicles for image-guided drug delivery
- Abstract
- 26.1 Nanovesicles for photoacoustic image-guided drug delivery
- 26.2 Nanovesicles for ultrasound image-guided drug delivery
- 26.3 Nanovesicles for magnetic resonance image-guided drug delivery
- 26.4 Nanovesicles for positron emission tomography image-guided drug delivery
- 26.5 Nanovesicles for single-photon emission computed tomography image-guided drug delivery
- 26.6 Nanovesicles for multimodal image-guided drug delivery
- References
- Index
- Edition: 1
- Published: July 16, 2022
- No. of pages (Paperback): 468
- No. of pages (eBook): 468
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323918640
- eBook ISBN: 9780323914222
AN
Amit Kumar Nayak
Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.
Affiliations and expertise
Professor, Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IndiaMH
Md Saquib Hasnain
Prof. (Dr.) Md Saquib Hasnain has over 13 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 100 publications in various high impact peer-reviewed journals, more than 100 book chapters and 30 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record. He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.
Affiliations and expertise
Department of Pharmacy, Marwadi University, Rajkot, Gujarat, IndiaTA
Tejraj M. Aminabhavi
Tejraj M. Aminabhavi is the Director of Research at the Center for Energy and Environment , School of Advanced Sciences, KLE Technological University, Hubballi, India. He works in the area of membrane transport processes, molecular modeling of polymer surfaces, wastewater treatment technologies, drug delivery polymers and sustainable environmental engineering.
Affiliations and expertise
Director of Research, Center for Energy and Environment, School of Advanced Sciences, KLE Technological University, Hubballi, Karnataka, IndiaVT
Vladimir P. Torchilin
Dr Vladimir P. Torchilin is a University Distinguished Professor of Pharmaceutical Sciences and Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Mass. He graduated from the Moscow University with MS in Chemistry, and also obtained there his Ph.D. and D.Sc. in Polymer Chemistry, Chemical Kinetics and Catalysis, and Chemistry of Physiologically Active Compounds in 1971 and 1980, respectively. In 1991 Dr. Torchilin joined Massachusetts General Hospital and Harvard Medical School as the Head of Chemistry Program, Center for Imaging and Pharmaceutical Research, and Associate Professor of Radiology. Since 1998 Dr. Torchilin is with Northeastern University. He was there the Chair of the Department of Pharmaceutical Sciences in 1998-2008. His main interests include drug delivery and targeting, nanomedicine, multifunctional and stimuli-sensitive pharmaceutical nanocarriers, biomedical polymers, experimental cancer therapy, cancer immunology, novel imaging agents. He has published more than 500 original papers, more than 250 reviews and book chapters, wrote and edited 13 books, and hold more than 40 patents.
Affiliations and expertise
University Distinguished Professor of Pharmaceutical Sciences and Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, USARead Systems of Nanovesicular Drug Delivery on ScienceDirect