Applications of Nanovesicular Drug Delivery
- 1st Edition - July 22, 2022
- Imprint: Academic Press
- Editors: Amit Kumar Nayak, Md Saquib Hasnain, Tejraj M. Aminabhavi, Vladimir P. Torchilin
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 8 6 5 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 9 5 3 - 1
Applications of Nanovesicular Drug Delivery provides thorough insights and a complete and updated discussion on the preparation, properties and drug delivery applications of variou… Read more
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Request a sales quoteApplications of Nanovesicular Drug Delivery provides thorough insights and a complete and updated discussion on the preparation, properties and drug delivery applications of various nanovesicles. This volume will discuss target-specific drug application, such as ocular, transdermal, nasal, intravenous and oral delivery. This title is a valuable resource for academics, pharmaceutical scientists, including industrial pharmacists and analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical products and process development of tailored-made polysaccharides in drug delivery applications.
Recently, there have been a number of outstanding nanosystems in nanovesicular carrier-forms (such as nanoemulsions, self-nanoemulsifying systems, nanoliposomes, nanotransferosomes, etc.), that have been researched and developed for efficient drug delivery by many formulators, researchers and scientists. However, no previously published books have covered all these drug delivery nanovesicles collectively in a single resource.
- Provides thorough insights and up-to-date discussions about the various systems of nanovesicular drug delivery
- Covers advanced trigger-assisted systems (such as iontophoresis, ultra-sound triggering, etc.) and how they have been used for improved drug delivery by nanovesicles
- Presents recent advances in drug delivery fields by global leaders and experts from academia, research, industry and regulatory agencies
- Includes an updated literature review of relevant key topics, good quality illustrations, chemical structures, attractive flow charts and well-organized tables
Postgraduate students, doctoral and postdoctoral research fellows, academician, pharmaceutical scientists including industrial pharmacists & analytical scientists. Health care professionals and regulatory scientists actively involved in pharmaceutical product and process development of tailored-made polysaccharides in drug delivery applications
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Targeting cellular and molecular mechanisms of nanovesicular systems for the treatment of different diseases
- Abstract
- 1.1 Introduction
- 1.2 Lipid nanovesicular systems
- 1.3 Polymer nanovesicular systems
- 1.4 Conclusions
- References
- Chapter 2. Nanovesicles for drug codelivery
- Abstract
- 2.1 Introduction
- 2.2 Combination drug therapy
- 2.3 General overview of nanovesicles
- 2.4 Design and preparation techniques of codelivery nanovesicles
- 2.5 Nanodrug codelivery systems
- 2.6 Conclusion
- References
- Chapter 3. Theranostic nanovesicles
- Abstract
- 3.1 Introduction
- 3.2 Imaging strategies
- 3.3 Different nanovesicles used as theranostic system
- 3.4 Conclusion
- References
- Chapter 4. Nanovesicles for ocular drug delivery
- Abstract
- 4.1 Introduction
- 4.2 Physiology, routes of drug administration and ocular barriers for drug penetration
- 4.3 Ocular diseases
- 4.4 Nanovesicles for ocular drug delivery
- 4.5 Conclusions and future perspectives
- Acknowledgments and funding
- References
- Chapter 5. Nanovesicles for nasal drug delivery
- Abstract
- 5.1 Introduction
- 5.2 Intranasal drug delivery system
- 5.3 Dosage forms and absorption enhancers
- 5.4 Benefits of intranasal drug delivery
- 5.5 Barriers in nasal distribution
- 5.6 Need for intranasal drug delivery system
- 5.7 Anatomy and physiology of nasal route
- 5.8 Mechanism of absorption of drugs via nasal route
- 5.9 Nasal devices
- 5.10 Role of nanotechnology intranasal drug delivery
- 5.11 Nanovesicles for intranasal drug delivery
- 5.12 Applications of nanovesicular intranasal delivery system
- 5.13 Conclusion
- References
- Chapter 6. Nanovesicles for transdermal drug delivery
- Abstract
- 6.1 Introduction
- 6.2 Lipid-based vesicular nanostructures for transdermal drug delivery
- 6.3 Nanovesicles formed by nonlipid building blocks
- 6.4 Conclusion and future perspective
- References
- Chapter 7. Nanovesicles for intravenous drug delivery
- Abstract
- 7.1 Introduction
- 7.2 Intravenous drug administration
- 7.3 Nanovesicular systems
- 7.4 Intravenous nanovesicles for imaging
- 7.5 Intraveneous nanovesicles for therapy
- 7.6 Intravenous nanovesicles for gene therapy
- 7.7 Intravenous nanovesicles for theranostic
- 7.8 Conclusion
- References
- Chapter 8. Nanovesicles for target specific drug delivery
- Abstract
- 8.1 Introduction
- 8.2 Liposomes as drug delivery vesicles
- 8.3 Polymeric micelles as drug delivery vehicles
- 8.4 Exosomes as drug delivery vesicles
- 8.5 Niosomes—drug delivery vesicles
- 8.6 New era of vesicular drug delivery systems
- 8.7 Conclusions
- References
- Chapter 9. Blood–brain barrier and nanovesicles for brain-targeting drug delivery
- Abstract
- 9.1 Introduction
- 9.2 Neurovascular unit
- 9.3 Issues with the targeted therapy of brain diseases
- 9.4 Nanoscale brain-targeting delivery systems
- 9.5 Nanovesicles
- 9.6 Concluding remarks
- References
- Chapter 10. Nanovesicles for hepatic-targeted drug delivery
- Abstract
- 10.1 Introduction
- 10.2 Nanovesicular systems for drug delivery to liver
- 10.3 Mechanism of nanovesicles-targeted delivery
- 10.4 Role in improving the drug distribution and pharmacokinetic parameters
- 10.5 Applications
- 10.6 Conclusion
- References
- Chapter 11. Nanovesicles for tumor-targeted drug delivery
- Abstract
- 11.1 Introduction
- 11.2 Nanovesicles
- 11.3 Targeting mechanisms of nanovesicles for tumor
- 11.4 Nanovesicles for tumor imaging
- 11.5 Nanovesicles for tumor treatment
- 11.6 Nanovesicles for theranostic approach
- 11.7 Conclusion
- References
- Chapter 12. Tumor microenvironment-responsive nanovesicular drug delivery systems
- Abstract
- 12.1 Introduction
- 12.2 Conclusion
- References
- Chapter 13. Nanovesicles for colon-targeted drug delivery
- Abstract
- 13.1 Introduction
- 13.2 Factors affecting colonic drug delivery
- 13.3 Advantages and limitations of colon-targeted drug delivery systems
- 13.4 Application of nanocarriers other than nanovesicles for colon-targeted drug delivery
- 13.5 Applications of nanovesicles for the treatment of colonic disease
- 13.6 Applications of nanovesicles in the detection of colonic disease
- 13.7 Conclusion and future prospects
- References
- Chapter 14. Nanovesicles for delivery of anticancer drugs
- Abstract
- 14.1 Introduction
- 14.2 Classification and development of the nanovesicles
- 14.3 Applications of the nanovesicles for the delivery of anticancer drugs
- 14.4 Conclusion and future prospects
- References
- Chapter 15. Nanovesicles for the treatment of skin disorders
- Abstract
- 15.1 Introduction
- 15.2 Types of nanovesicles
- 15.3 Skin disorders
- 15.4 Conclusion
- References
- Chapter 16. Nanovesicles for the delivery of nonsteroidal anti-inflammatory drugs
- Abstract
- 16.1 Introduction of nonsteroidal anti-inflammatory drug
- 16.2 Nonsteroidal anti-inflammatory agents
- 16.3 Nanotechnology and nonsteroidal anti-inflammatory drugs delivery
- 16.4 Liposomes
- 16.5 Nonliposomal lipid-based nanovesicles
- 16.6 Methods of preparation
- 16.7 Novel preparation methods
- 16.8 Conclusion
- References
- Chapter 17. Nanovesicles for delivery of central nervous system drugs
- Abstract
- 17.1 Introduction
- 17.2 Nanovesicles
- 17.3 Categories of nanovesicles
- 17.4 Nanovesicles for central nervous system disorders
- 17.5 Current challenges and future prospects
- 17.6 Conclusion
- Conflicts of interest
- References
- Chapter 18. Nanovesicles for the delivery of cardiovascular drugs
- Abstract
- 18.1 Introduction
- 18.2 A primer of cardiovascular diseases
- 18.3 Nanovesicles for the delivery of cardiovascular drugs
- 18.4 Future outlook
- Acknowledgments
- References
- Chapter 19. Nanovesicles for the delivery of antibiotics
- Abstract
- 19.1 Introduction
- 19.2 Nanovesicles as potential antibiotic drug delivery and/or targeting systems
- 19.3 Nanoparticle bacterial resistance
- 19.4 Antimicrobial resistance mechanisms
- 19.5 The impact of nanoparticles on microbial strength
- 19.6 Using numerous ways to combat microorganisms at the same time
- 19.7 Assisting in the transport of antibiotics
- 19.8 Negative side: as a drug resistance promoter
- 19.9 Nanoparticles antibacterial application
- 19.10 Dressings of wound
- 19.11 Bone fortification
- 19.12 Dental equipment
- 19.13 The mechanism for drug delivery
- 19.14 Types of nanovesicles used for the drug delivery
- 19.15 Efficiency of different nanovesicles for drug delivery system
- 19.16 Role of nanovesicles in the delivery of antibiotics
- 19.17 Summary and future perspectives
- Acknowledgment
- Disclosure statement
- References
- Chapter 20. Nanovesicles for delivery of antifungal drugs
- Abstract
- 20.1 Introduction
- 20.2 Vesicular delivery systems
- 20.3 Conclusion
- References
- Chapter 21. Nanovesicles in antiviral drug delivery
- Abstract
- 21.1 Introduction
- 21.2 What are nanovesicles?
- 21.3 Composition of nanovesicles
- 21.4 Development of nanovesicles
- 21.5 Nanovesicles characterization
- 21.6 Application of nanovesicles
- 21.7 Antiviral drugs
- 21.8 Medical applications of antiviral drugs
- 21.9 Designing of antiviral drugs
- 21.10 Approved antiviral drugs
- 21.11 Nanovesicles in antiviral drug delivery
- 21.12 Conclusion
- References
- Further reading
- Chapter 22. Nanovesicles for targeting autoimmune diseases
- Abstract
- 22.1 Introduction
- 22.2 Sources of extracellular nanovesicles
- 22.3 Biological functions
- 22.4 Immune system response to generic nanovesicles
- 22.5 Nanovesicle production, cellular communication, and autoimmunity
- 22.6 Nanovesicles and autoimmune diseases
- 22.7 Nanovesicle-facilitated autoimmune disease treatment therapies
- 22.8 Modifications for the targeted delivery of extracellular nanovesicles
- 22.9 Utilization of nanovesicles in autoimmune clinical trials
- 22.10 Conclusion and future outlook
- References
- Chapter 23. Nanovesicular systems for protein and peptide delivery
- Abstract
- 23.1 Introduction
- 23.2 Liposomes
- 23.3 Polymersomes
- 23.4 Exosomes
- 23.5 Nonionic vesicles (niosomes)
- 23.6 Organic–inorganic hybrid nanovesicles
- 23.7 Conclusions
- References
- Chapter 24. Nanovesicles for the delivery of siRNA
- Abstract
- 24.1 Introduction
- 24.2 Preparation of nanovesicles and small interfering RNA-loaded nanovesicles
- 24.3 Some applications of nanovesicles for the delivery of small interfering RNA in target cells/drug delivery
- 24.4 Conclusion
- References
- Chapter 25. Clinical trials of nanovesicles for drug delivery applications
- Abstract
- 25.1 Introduction
- 25.2 The legal framework for clinical trials
- 25.3 Regulatory challenges in clinical trials in the field of nanovesicles
- 25.4 Liposomes
- 25.5 Peptide-based nanovesicles
- 25.6 Exosomes
- 25.7 Phytosomes
- 25.8 Niosomes
- 25.9 Conclusions
- References
- Index
- Edition: 1
- Published: July 22, 2022
- No. of pages (Paperback): 524
- No. of pages (eBook): 524
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323918657
- eBook ISBN: 9780323919531
AN
Amit Kumar Nayak
Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.
Affiliations and expertise
Professor, Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, IndiaMH
Md Saquib Hasnain
Prof. (Dr.) Md Saquib Hasnain has over 13 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 100 publications in various high impact peer-reviewed journals, more than 100 book chapters and 30 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record. He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.
Affiliations and expertise
Department of Pharmacy, Marwadi University, Rajkot, Gujarat, IndiaTA
Tejraj M. Aminabhavi
Tejraj M. Aminabhavi is the Director of Research at the Center for Energy and Environment , School of Advanced Sciences, KLE Technological University, Hubballi, India. He works in the area of membrane transport processes, molecular modeling of polymer surfaces, wastewater treatment technologies, drug delivery polymers and sustainable environmental engineering.
Affiliations and expertise
Director of Research, Center for Energy and Environment, School of Advanced Sciences, KLE Technological University, Hubballi, Karnataka, IndiaVT
Vladimir P. Torchilin
Dr Vladimir P. Torchilin is a University Distinguished Professor of Pharmaceutical Sciences and Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Mass. He graduated from the Moscow University with MS in Chemistry, and also obtained there his Ph.D. and D.Sc. in Polymer Chemistry, Chemical Kinetics and Catalysis, and Chemistry of Physiologically Active Compounds in 1971 and 1980, respectively. In 1991 Dr. Torchilin joined Massachusetts General Hospital and Harvard Medical School as the Head of Chemistry Program, Center for Imaging and Pharmaceutical Research, and Associate Professor of Radiology. Since 1998 Dr. Torchilin is with Northeastern University. He was there the Chair of the Department of Pharmaceutical Sciences in 1998-2008. His main interests include drug delivery and targeting, nanomedicine, multifunctional and stimuli-sensitive pharmaceutical nanocarriers, biomedical polymers, experimental cancer therapy, cancer immunology, novel imaging agents. He has published more than 500 original papers, more than 250 reviews and book chapters, wrote and edited 13 books, and hold more than 40 patents.
Affiliations and expertise
University Distinguished Professor of Pharmaceutical Sciences and Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, USARead Applications of Nanovesicular Drug Delivery on ScienceDirect