Tailor-Made Polysaccharides in Drug Delivery

1st Edition - September 1, 2022
Editors: Amit Kumar Nayak, Md Saquib Hasnain
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 2 8 6 - 8
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 2 8 7 - 5

Tailor-Made Polysaccharides in Drug Delivery provides extensive details on all the vital precepts, basics and fundamental aspects of tailored polysaccharides in the pharma… Read more

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Tailor-Made Polysaccharides in Drug Delivery provides extensive details on all the vital precepts, basics and fundamental aspects of tailored polysaccharides in the pharmaceutical and biotechnological industry for understanding and developing high quality products. The book offers a comprehensive resource to understand the potential of the materials in forming new drug delivery methods. It will be useful to pharmaceutical scientists, chemical engineers, and regulatory scientists and students actively involved in pharmaceutical product and process development of tailored-made polysaccharides in drug delivery applications.

The utilization of natural polymeric excipients in numerous healthcare applications demand the replacement of the synthetic polymers with the natural ones due to their biocompatibility, biodegradability, economic extraction and readily availability. The reality behind the rise in importance of these natural materials is that these sources are renewable if grown in a sustainable means and they can tender incessant supply of raw materials. Amongst these natural polymers, polysaccharides are considered as excellent excipients because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of polysaccharides in drug delivery.

Cover image
Title page
Table of Contents
Copyright
Contributors
About the editors
Preface
Chapter 1: Synthesis of tailor-made polysaccharides: An overview
Abstract
Chapter 1: Introduction
2: Syntheses of tailor-made polysaccharides
3: Conclusion
References
Chapter 2: Drug delivery dosage forms made of tailor-made natural polysaccharides
Abstract
1: Introduction
2: Tablets made of tailor-made natural polysaccharides
3: Nanoparticles made of tailor-made natural polysaccharides
4: Microparticles made of tailor-made natural polysaccharides
5: Beads made of tailor-made natural polysaccharides
6: Hydrogels made of tailor-made natural polysaccharides
7: Miscellaneous
8: Conclusion
References
Further reading
Chapter 3: Carboxymethylated polysaccharides in drug delivery
Abstract
1: Introduction
2: Carboxymethylation process
3: Carboxymethyl polysaccharides in drug delivery
4: Conclusion
References
Chapter 4: Thiolated polysaccharides in drug delivery
Abstract
1: Introduction
2: Various thiolated polysaccharides used in drug delivery formulations
3: Conclusion
References
Chapter 5: Cross-linked polysaccharides in drug delivery
Abstract
1: Introduction
2: Cross-linking of and the cross-linked polysaccharides
3: Cross-linked polysaccharides applied in DDSs
4: Smart cross-linking strategies
5: Conclusion
References
Chapter 6: Graft copolymers of polysaccharides: Synthesis techniques and pharmaceutical applications
Abstract
1: Introduction
2: Polysaccharides
3: Graft copolymers and different techniques of polymer grafting
4: Properties of graft copolymers
5: Pharmaceutical applications of polysaccharide graft copolymers
6: Conclusion
References
Chapter 7: Grafted polysaccharides in drug delivery
Abstract
1: Introduction
2: Polysaccharide-based graft copolymers
3: Grafted polysaccharides in DDSs
4: Conclusion
References
Chapter 8: Polysaccharide-based polyelectrolyte complex systems in drug delivery
Abstract
1: Introduction
2: What is a polyelectrolyte complex?
3: Advantages of PECs
4: Factors affecting the formation and stability of PECs
5: Polysaccharides used to fabricate polyelectrolyte complexes (PECs)
6: Various dosage forms fabricated by polyelectrolyte complexation
7: Conclusion
References
Chapter 9: Polysaccharide-based interpenetrating polymeric network systems in drug delivery
Abstract
1: Introduction
2: IPNs: Definition, properties, and classifications
3: Chitosan-based IPN systems in drug delivery
4: Alginate-based IPN systems in drug delivery
5: Pectin-based IPN systems in drug delivery
6: Gellan gum-based IPN systems in drug delivery
7: Locust bean gum-based IPN systems in drug delivery
8: Xanthan gum-based IPN systems in drug delivery
9: Carrageenan-based IPN systems in drug delivery
10: Conclusion
References
Chapter 10: Polysaccharide nanoconjugates in drug delivery
Abstract
1: Introduction
2: Polysaccharide nanoconjugates
3: Advantages of polysaccharide nanoconjugates in drug delivery
4: Polysaccharide used for nanoconjugation
5: Recent progress
6: Conclusion
References
Chapter 11: Functionalized chitosan in drug delivery
Abstract
Acknowledgments
1: Introduction
2: Functionalized chitosan derivatives as drug delivery systems
3: Conclusion
References
Chapter 12: Modified alginates in drug delivery
Abstract
1: Introduction
2: Alginate biopolymer
3: Physicochemical heterogeneity toward drug delivery
4: Biological synergistic attributes toward drug delivery
5: Modification of alginate
6: Application of modified alginate in drug delivery
7: Concluding remarks
8: Future directions
References
Chapter 13: Uses of tailor-made plant starches in drug delivery
Abstract
1: Introduction
2: Starch: Basic chemistry and properties
3: Plant-derived starches as pharmaceutical excipients in drug delivery
4: Synthesis of tailor-made plant starches and their uses in drug delivery
5: Clinical potential of tailor-made starches
6: Conclusion
References
Chapter 14: Cancer targeting by tailor-made polysaccharides
Abstract
1: Introduction
2: Polysaccharides and their importance
3: Tailor-made chitosan-based systems for cancer-targeting applications
4: Tailor-made hyaluronic acid-based systems for cancer-targeting applications
5: Tailor-made pectin-based systems for cancer-targeting applications
6: Tailor-made heparin-based systems for cancer-targeting applications
7: Tailor-made dextran-based systems for cancer-targeting applications
8: Tailor-made chondroitin sulfate-based systems for cancer-targeting applications
9: Tailor-made cyclodextrin-based systems for cancer-targeting applications
10: Tailor-made pullulan-based systems for cancer-targeting applications
11: Tailor-made alginate-based systems for cancer-targeting applications
12: Tailor-made amylose-based systems for cancer-targeting applications
13: Conclusion
References
Chapter 15: Delivery of genes and growth factors using tailor-made polysaccharides
Abstract
1: Introduction
2: Polysaccharides
3: Gene therapy and applications of tailor-made polysaccharides for gene delivery
4: Growth factors and applications of tailor-made polysaccharides for growth delivery
5: Conclusion
References
Index

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 10 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 70 publications in various high impact peer-reviewed journals, more than 100 book chapters and 16 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record in Google Scholar (h-index: 32). He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and expertise

Department of Pharmacy, Palamau Institute of Pharmacy, Daltonganj, Jharkhand, India