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Elsevier

Books in Pharmaceutical sciences

Elsevier's Pharmaceutical Sciences collection helps pharmaceutical scientists striving to optimize drug design and improve healthcare outcomes by offering comprehensive coverage of every aspect of drug development, integrating disciplines like organic chemistry, biology, and biotechnology. Focused on safety, efficacy, and formulation design, it includes specialized fields such as Clinical Pharmacology and Translational Research, providing valuable insights into the latest advancements in drug discovery.

  • Market-Driven Development of Inhaled Drug Products

    Translating Research into Marketable Drug Products
    • 1st Edition
    • Vivek Gupta
    • English
    Market-Driven Development of Inhaled Drug Products: Translating Research into Marketable Drug Products addresses the rapidly evolving field of pulmonary drug delivery, which has gained prominence for treating respiratory diseases and systemic therapies, including COVID-19. Despite its promise, inhaled drug development faces complex challenges such as respiratory physiology constraints, limited excipient approvals, and the necessity for drug-device combination products. This reference fills a critical gap by translating cutting-edge research into practical product development strategies. The content spans foundational topics including inhalation dosimetry, pulmonary pharmacokinetics, and safety studies, progressing to drug discovery, device influence, preclinical models, and regulatory frameworks. It further covers excipient selection, patient compliance, device engineering innovations including 3D printing, and packaging considerations. Contributions from leading experts worldwide provide a multidisciplinary perspective essential for navigating the complexities of inhaled drug development. Market-Driven Development of Inhaled Drug Products: Translating Research into Marketable Drug Products benefits pharmaceutical scientists and engineers by offering an integrated approach to inhaled therapy development. It supports improving product development cycles, regulatory submissions, and clinical trial designs while addressing patient adherence challenges. This reference is an indispensable resource for advancing inhaled therapeutics from concept to market.

  • Advances in Mitochondrial Drug Delivery

    From Molecular Mechanisms to Clinical Translation
    • 1st Edition
    • Prashant Kesharwani
    • English
    Advances in Mitochondrial Drug Delivery: From Molecular Mechanisms to Clinical Translation addresses the critical need for a comprehensive resource on mitochondrial-target... drug delivery systems. As recent advancements in drug delivery systems (DDS) have shown substantial promise in treating diseases linked to mitochondrial dysfunction, there is a pressing demand for a consolidated reference that covers both the foundational aspects and the latest innovations in this field. The book's Table of Contents encompasses a wide range of topics, beginning with the fundamentals of mitochondrial biology and drug delivery, followed by various mitochondrial-target... drug delivery strategies. It further explores advanced applications of these systems in treating cancer, neurodegenerative diseases, cardiovascular conditions, and more. Additionally, the book discusses future directions, clinical translation, and regulatory challenges, ensuring a holistic view of the subject matter. Advances in Mitochondrial Drug Delivery offers significant benefits to researchers, students, and professionals in pharmaceutical sciences and nanotechnology. By integrating diverse perspectives from leading experts, the book serves as an essential resource for understanding the complexities of mitochondrial-target... therapies, thereby fostering advancements in drug delivery systems and therapeutic strategies.

  • CRISPR Therapeutics Delivery Strategies

    • 1st Edition
    • Prashant Kesharwani
    • English
    CRISPR Therapeutics Delivery Strategies is a structured and comprehensive resource in the rapidly evolving field of CRISPR technology. As CRISPR-Cas systems translate to therapeutics, this reference provides critical insights into the challenges and advancements in effective delivery mechanisms. The book captures the essence of CRISPR's transformative potential in gene therapy, targeted cancer treatments, and personalized medicine, while also highlighting the importance of innovative delivery strategies to overcome existing barriers. The contents of the book offers a systematic exploration of CRISPR technology, beginning with foundational concepts and progressing to targeted drug delivery strategies. Each chapter explore specific applications, including CRISPR in cancer therapy, gene editing for rare diseases, and overcoming delivery barriers such as the blood-brain barrier. Additionally, ethical and regulatory considerations are addressed, providing a holistic view of the current landscape and future directions in CRISPR research. CRISPR Therapeutics Delivery Strategies serves as an essential resource for students, researchers, and professionals in the fields of pharmacology, biotechnology, and gene therapy. By compiling cutting-edge research and expert perspectives, this reference helps pharmaceutical scientists to navigate the complexities of CRISPR technology and its applications.

  • Pharmaceutical QbD with Design of Experiments

    Statistical Tools and Applications in Drug Delivery Systems
    • 1st Edition
    • Khushwant Yadav
    • English
    Pharmaceutical QbD with Design of Experiments: Statistical Tools and Applications in Drug Delivery Systems offers comprehensive coverage of best practices in pharmaceutical manufacturing. The first section discusses the principles and basics of Quality by Design (QbD). Part two covers the foundational statistical principles and tools for the Design of Experiments (DoE). Section three is dedicated to the applications of QbD for conventional formulations. The next section provides ample coverage of applications to Novel Drug Delivery Systems (NDDS), including micro and nano-particles. The final section discusses the application of QbD for the optimization of pharmaceutical processes and equipment.Researcher... in pharmaceutical manufacturing will benefit from this thorough statistical review, while students in this field will gain practical insights the experienced chapter authors provide in case studies. Industry professionals can find solutions to their particular problems within the insights and strategies shared in this book.

  • Biological Fluid–Mediated Transport Mechanisms for Targeted Drug Delivery in Next-Generation Cancer Immunotherapy

    • 1st Edition
    • Khemraj Deshmukh + 3 more
    • English
    Biological Fluid-Mediated Transport Mechanisms for Targeted Drug Delivery in Next-Generation Cancer Immunotherapy addresses the critical need for innovative therapeutic platforms that improve efficacy and reduce toxicity in cancer treatment. The volume explores how natural biofluids and derived carriers, like exosomes and extracellular vesicles, can serve as highly biocompatible vehicles for delivering immunotherapeutics. It emphasizes their roles in overcoming barriers such as immune evasion, rapid clearance, and systemic side effects, while also leveraging biofluid signatures for real-time diagnostics through liquid biopsies. The book encompasses topics from the composition and biomolecular content of biofluids to the engineering strategies for functionalization, targeting, and controlled release, integrating cutting-edge nanotechnologies and microfluidics.This reference book supports the advancement of next-generation precision cancer immunotherapies by providing insights into biofluid dynamics, bioresponsive carriers, and personalized approaches. It bridges basic science with translational potential, fostering innovation in nanomedicine, immunology, and biomedical engineering, and aims to accelerate the clinical impact of biofluid-inspired drug delivery systems.

  • Green Polymeric Materials in Drug Delivery

    Sustainable Solutions for Therapeutic Applications
    • 1st Edition
    • Parteek Prasher + 5 more
    • English
    Green Polymeric Materials in Drug Delivery: Sustainable Solutions for Therapeutic Applications addresses the critical intersection of polymer science, pharmaceutical technology, and environmental sustainability. This reference responds to the urgent need for eco-friendly drug delivery systems that improve therapeutic outcomes while minimizing ecological impact. It offers researchers and professionals a detailed exploration of green polymers derived from renewable sources and their transformative potential in healthcare. The comprehensive contents cover fundamental principles, synthesis, biocompatibility, formulation strategies, and innovative applications including nanomaterials, hydrogels, vesicular systems, and vaccine delivery. Chapters authored by leading experts examine targeted delivery routes such as mucosal, ocular, transdermal, and neural pathways. Regulatory frameworks and clinical trial insights further support translation from research to practice. Emerging technologies like AI-assisted formulation and 3D printing of implants are also discussed. This reference benefits polymer chemists, pharmaceutical scientists, regulatory experts, and clinicians by providing authoritative knowledge on sustainable materials for drug delivery. It equips readers with the scientific foundation and practical case studies necessary to advance green polymeric technologies in therapeutic development, fostering a sustainable future in pharmaceutical innovation and patient care.

  • Side Effects of Drugs Annual

    • 1st Edition
    • Volume 48
    • English
    Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 48, first published in 1977, presents clinicians and medical investigators with a critical survey of new data and trends in adverse drug reactions and interactions. Topics covered include ADRs, ADEs and SEDs: A Bird’s Eye View, Lithium, Drugs of abuse, Side effects of drugs used in the treatment of Alzheimer's disease, Sedatives and hypnotics, Antipsychotic agents, Anti-epileptic Medications, Side effects of opioid analgesics and narcotic antagonists, Anti-inflammatory and antipyretic analgesics and drugs used in gout, Side effects of local anesthetics and therapeutic gases, and more.Other sections covered include Antihistamines (H1 receptor antagonists), Drugs that act on the respiratory tract, Positive inotropic drugs and drugs used in dysrhythmias, Beta adrenergic antagonists and antianginal drugs, Drugs acting on the cerebral and peripheral circulations, Antihypertensive drugs, and much more.

  • Biopolymer Based Nano Drug Delivery for Cancer Wound Healing

    • 1st Edition
    • Vipan Kumar + 5 more
    • English
    Biopolymer Based Nano Drug Delivery for Cancer Wound Healing explores groundbreaking advancements in nanomedicine's role in treating cancer and promoting wound healing. The book delves into the pathophysiology of cancerous wounds, introduces biopolymer-based nanomedicine, and examines drug delivery systems using biopolymer-based nanoparticles. It concludes with future prospects of biopolymers in antitumor drug delivery systems. This resource is invaluable for researchers, advanced students, and R&D personnel across various fields, including cancer research, polymer science, biomaterials, biomedicine, pharmaceutics, biotechnology, and chemistry. Each chapter bridges theoretical concepts with practical applications, providing examples to illustrate key points.The book covers the pathophysiology of cancer and wounds, biopolymer-based nanomedicine for cancerous wounds, and drug delivery systems for healing. This is an essential reference for scientists and students focusing on pharmacy, drug delivery, and biomedicine.

  • Basic Principles of Drug Discovery and Development

    • 3rd Edition
    • Benjamin E. Blass
    • English
    **Selected for 2026 Doody's Core Titles in Pharmacy**Basic Principles of Drug Discovery and Development, Third Edition presents a unique overview of the drug discovery and development program not available elsewhere. Each chapter provides sufficient technical details on the topics covered so that non-experts will have the tools and information necessary to interact and exchange information with colleagues across the entire spectrum of the drug discovery and development process. The drug discovery and development process involves individuals and teams with a wide array of expertise ranging from basic sciences (medicinal chemistry, biology) to applied science (pharmacology, pharmacokinetics, clinical sciences) to business driven fields (regulatory affairs, intellectual property experts, marketing specialists).The success or failure of a program focused on bringing a new medication to market often depends on clear communication between individuals and teams with vastly different expertise. As a result, it is critical that experts in one aspect of drug discovery and development (e.g., medicinal chemists) have a working understanding of the wide range of disciplines that take part in the overall process.

  • Membrane Transporters and Drug Delivery

    A Comprehensive and Multidisciplinary Guide
    • 1st Edition
    • Elena Puris + 3 more
    • English
    Membrane Transporters and Drug Delivery: A comprehensive and multidisciplinary guide begins with a comprehensive introduction to membrane transporters, their function, structure, and regulation mechanisms. It then moves into the impact of diseases on transporters and how this may affect pharmacokinetics. The book also presents the latest advancements in transporter-mediated drug delivery. A unique feature of this book is its detailed exploration of the methodologies used in transporter research, providing readers with a comprehensive understanding of the strengths and limitations of each approach. It examines the roles of both efflux and influx transporters in drug pharmacokinetics and covers different strategies for utilizing membrane transporters for drug delivery and targeting to specific tissues and cell types. The book concludes with a discussion on regulatory and industrial aspects of transporter-related projects and explores the potential of artificial intelligence in transporter and drug delivery research.Membrane Transporters and Drug Delivery: A comprehensive and multidisciplinary guide begins with a comprehensive introduction to membrane transporters, their function, structure, and regulation mechanisms. It then moves into the impact of diseases on transporters and how this may affect pharmacokinetics. The book also presents the latest advancements in transporter-mediated drug delivery. A unique feature of this book is its detailed exploration of the methodologies used in transporter research, providing readers with a comprehensive understanding of the strengths and limitations of each approach. It examines the roles of both efflux and influx transporters in drug pharmacokinetics and covers different strategies for utilizing membrane transporters for drug delivery and targeting to specific tissues and cell types. The book concludes with a discussion on regulatory and industrial aspects of transporter-related projects and explores the potential of artificial intelligence in transporter and drug delivery research.

  • Targeting Intercellular Communication with Nanomedicine and Advanced Therapeutics

    • 1st Edition
    • Lara Scheherazade Milane + 1 more
    • English
    Targeting Intercellular Communication with Nanomedicine and Advanced Therapeutics delves into the complex world of intercellular communication biology and its implications on therapeutics. This book covers all areas of intercellular communication and therapeutics in development for different forms of communication, including their role in diseases such as cancer, neurological disorders, metabolic diseases, and inflammatory/immune diseases. Sections provide an introduction, biological targets, challenges, and approaches to overcoming biological barriers and the significance of contact points and mechanisms of internalization. Specifics of tunneling nanotubes, extracellular vesicles, and the immune and non-immune interface in various diseases are covered.Furthermore, the book explores the crosstalk of different forms of intercellular communication and the implications of mitochondrial exchange in the four primary pathological areas. This is an essential resource for researchers, students, and professionals in the field of drug development and delivery. By connecting the dots between extracellular vesicles, tunneling nanotubes, and cell-cell junctions, this book serves as a foundation for further advancements in the science of intercellular communication and it's applications to new drug discovery and delivery.

  • Snake Venom and Human Health

    Translating Nature’s Toxins into Therapeutics
    • 1st Edition
    • Subir Chandra Dasgupta + 2 more
    • English
    Snake Venom and Human Health: Translating Nature’s Toxins into Therapeutics offers a detailed exploration of the burgeoning field of venom-derived therapeutics. As biomedical research continues to uncover potential applications of snake venom, this book serves as an essential resource that bridges fundamental science and clinical application and examines how these potent biological substances are being transformed into innovative treatments for a wide array of health conditions, including cancer, infectious and parasitic diseases, cardiovascular issues, neurodegenerative disorders, diabetes, and autoimmune diseases. Starting with an overview of venom classification and structural insights, the book is organized into detailed chapters that cover the biochemical basis of snake venom, its therapeutic applications, and the emerging technologies supporting its development. Subsequent chapters explore specific medical applications—from anticancer and antimicrobial therapies to treatments for cardiovascular, neurological, dermatological, and metabolic disorders. It goes on to explore innovative topics as well as the regulatory and sustainability issues and ongoing challenges—such as safety concerns, ethical considerations, and scalability that surrounding venom research.Enriched by contributions from international experts in the field, Snake Venom and Human Health aims to provide researchers, clinicians, and industry professionals a thorough understanding of both the scientific foundations and the translational aspects of venom-based therapeutics.

  • Cellular Therapies for Cancer Treatment

    Advancements in Drug Delivery Strategies
    • 1st Edition
    • Arun Kumar Singh + 3 more
    • English
    Cellular Therapies for Cancer Treatment: Advancements in Drug Delivery Strategies explores the innovative use of cellular therapy to combat cancer, placing an emphasis on state-of-the-art delivery approaches. By covering a variety of cellular therapies for cancer, such as stem cells, immune cells, and others, this book provides a comprehensive introduction to the field. It describes ways to deliver drugs that target cancer cells more efficiently, decrease off-target effects, and enhance therapy outcomes. Sections provide a brief overview of cancer cell biology, describe the need for advance drug delivery systems, and address challenges and future directions.The book also goes into the ideas behind cellular therapies and how they may overcome drug resistance and make existing cancer treatments more effective. By elaborating on the value of diversity and inclusion in cancer research and treatment, the book also emphasizes the importance of all patients having equal access to innovative therapies. All things considered, this book is a great tool for researchers, doctors, and students in the cancer treatment sector.

  • Nonthermal Extraction Technologies of Polysaccharides

    Principles, Techniques, Characterization, and Applications
    • 1st Edition
    • Seyed Mohammad Taghi Gharibzahedi
    • English
    Nonthermal Extraction Technologies of Polysaccharides: Principles, Techniques, Characterization, and Applications explores cutting-edge nonthermal extraction technologies, including ultrasound, microwave, high-pressure, pulsed electric field, enzymatic extraction methods, and cold plasma technology and their effects on polysaccharide biofunctionalities, such as antioxidant and antimicrobial properties and potential applications. With an examination of the therapeutic benefits associated with these compounds, including anti-cancer, antioxidant, antimicrobial, anti-inflammatory, and anti-obesity properties, this book aspires to highlight advanced techniques to significantly enhance polysaccharide yield, bioactivity, and purity when compared to traditional approaches.The initial chapters introduce the fundamental structures, sources, and importance of polysaccharides, thus setting the stage for a deeper understanding of their functionality and chemical characterization. By offering both theoretical frameworks and practical guidance, this book equips professionals with the knowledge required to effectively incorporate polysaccharides into health-promoting products for advancing research and applications in the evolving landscape of functional foods and biomedical innovation.

  • Medicines Safety and Pharmacovigilance

    Introduction, Concepts, and Applications
    • 1st Edition
    • Rabia Hussain
    • English
    Medicines Safety and Pharmacovigilance: Introduction, Concepts, and Applications provides a comprehensive guide for pharmaceutical professionals navigating the complex landscape of medicine safety and vigilance. Designed to support strategic decision-making, this reference draws on industry expertise to uphold the highest standards of patient care. The book addresses essential regulatory requirements, reporting obligations, and ethical considerations, offering practical guidance for implementing effective pharmacovigilance systems. Covering the latest technological advancements, it ensures readers are equipped to meet the modern challenges faced by healthcare and pharmaceutical sectors in monitoring the safety and efficacy of medicines for diverse populations worldwide.Beyond the foundational concepts, the book presents detailed insights into signal detection, risk management plans, and the real-world application of pharmacovigilance through case studies from both high- and low-middle-income countries. It examines the pivotal role of pharmacists and the importance of tailored approaches for special populations, while emphasizing effective communication of medicines safety.

  • Topical Dermal Drug Delivery

    Concepts and Advances
    • 1st Edition
    • Jitender Madan + 4 more
    • English
    Topical Dermal Drug Delivery: Concepts and Advances compiles, in a single volume, the most recent advances in topical and dermal formulations for the treatment of skin disorders.The book covers three major concepts. The skin anatomy and physiology part includes chapters focused on relevant information for drug delivery. The second part of the book deals with several recent topical dermal drug delivery systems, including computational methods, permeation enhancers, bio precursors, hydrogels, emugels, exosomes and several nanotechnology enabled systems. The third and final part covers scaling up, toxicity, clinical trials, and regulatory considerations.This is a complete reference for academic and corporate pharma researchers investigating targeted drug delivery to the skin. Medical & Health Sciences researchers would also benefit from understanding the delivery systems covered in this book.

  • Advanced Cancer Therapeutics

    Strategies and Technologies for Targeted Drug Delivery
    • 1st Edition
    • Manish Kumar + 2 more
    • English
    Advanced Cancer Therapeutics: Strategies and Technologies for Targeted Drug Delivery explores the heterogeneity of tumors and microenvironmental factors that influence cancer treatment and contribute to drug resistance. The book discusses critical elements such as tumor stroma, vasculature, pH, hypoxia, and enzymatic activity that impact therapeutic efficacy. Sections cover advanced drug formulations, including supramolecular systems, metal-organic frameworks, and nanomedicine, focusing on their roles in selective drug delivery for early detection, diagnosis, and treatment of various cancers. In addition, it reviews the current status and future perspectives of these formulations, highlighting their potential to enhance therapeutic outcomes while minimizing side effects.Readers will also find discussions on the limitations of nanocarriers, along with regulatory and ethical considerations related to anticancer formulations. This resource is invaluable for researchers, clinicians, and students, offering insights into the latest advancements in drug delivery systems.

  • The Future of Pharma Across All Sectors in the Artificial Intelligence Era

    • 1st Edition
    • Miltiadis Lytras + 5 more
    • English
    The Future of Pharma Across All Sectors in the Artificial Intelligence Era offers a thorough examination of the pharmaceutical industry's current landscape, highlighting the myriad challenges, opportunities, and trends that are poised to shape its future. Edited by experts, this book delves into transformative technological advancements, including artificial intelligence, machine learning, big data analytics, and blockchain. These technologies are redefining pharmaceutical research, development, and commercialization, making precision medicine and personalized therapies a reality, while integrating genomic medicine into the pharmaceutical value chain.Additionally, the book addresses educational implications for academic curricula, emphasizing the need for digital transformation in healthcare delivery models. It scrutinizes regulatory trends and compliance, offering insights into navigating complex landscapes to ensure product quality and safety. The book emphasizes the pharmaceutical industry's role in tackling infectious diseases and health disparities, promoting health equity through innovative drug development and access initiatives. Future trends and predictions are speculated upon, considering demographic shifts and evolving healthcare needs, while market dynamics and commercial strategies are analyzed to equip pharmaceutical companies with practical recommendations for navigating competitive landscapes.

  • Nanoengineered Therapeutics for Lung Cancer

    Advanced Drug Delivery Strategies
    • 1st Edition
    • Arun Kumar Singh + 4 more
    • English
    Nanoengineered Therapeutics for Lung Cancer: Advanced Drug Delivery Strategies explores contemporary methods for diagnosing and treating lung cancer using cutting-edge nanotechnology. The book provides a foundational understanding of lung cancer biology, detailing innovative nanodrug delivery strategies and their practical applications in treatment. The content is strategically structured, covering the design, synthesis, and application of nanodrug delivery systems. Chapters delve into specific technologies such as gold nanoparticles, exosome-mediated therapies, and siRNA-based gene silencing. The book also addresses challenges like drug resistance and toxicity, offering insights into future research directions and advancements in the field. This book benefits graduate students, researchers, and healthcare professionals by seamlessly integrating theoretical concepts with practical applications. It serves as an essential educational resource, equipping readers with the knowledge and skills needed to tackle complex challenges in lung cancer treatment using nanomedicine. This comprehensive guide ensures that readers stay at the forefront of the rapidly evolving landscape of cancer therapeutics.

  • CDK4/6 inhibitors in Breast Cancer Therapy

    • 1st Edition
    • Pankaj Kumar Singh + 3 more
    • English
    CDK4/6 inhibitors in Breast Cancer Therapy examines the pivotal role of CDK4/6 inhibition in treating hormone receptor-positive (HR+)/HER2-negative advanced breast cancer. The book highlights FDA-approved applications of these inhibitors alongside endocrine therapy and explores ongoing research into their potential as neoadjuvant treatments. It provides insights into the drug discovery and development of CDK4/6 inhibitors, covering their molecular mechanisms, pharmacology, and clinical applications. Chapters address their use in mono and adjuvant therapies, as well as challenges in targeting, while also discussing market potential and post-marketing safety issues.This book is a valuable resource for researchers and academics, enhancing understanding of CDK4/6 inhibitors' chemistry and therapeutic implications. By presenting detailed information on clinical trials and market formulations, it equips the audience with essential knowledge to navigate the complexities of targeted breast cancer therapies and contributes to advancing research in this critical area.

  • Contemporary Research Methods in Pharmacy and Health Services - Volume 2

    • 1st Edition
    • Aleda M. H. Chen + 5 more
    • English
    Contemporary Research Methods in Pharmacy and Health Services, Volume Two is an essential resource for researchers and practitioners in the field of pharmaceutical science. Building on the groundbreaking work published in the esteemed journals Research in Social and Administrative Pharmacy (RSAP) and Exploratory Research in Clinical and Social Pharmacy (ERCSP), this volume addresses the critical need for comprehensive and structured methodologies in evaluating and implementing pharmacy services. By transforming selected articles into fully developed chapters, the book enriches the discourse surrounding contemporary research methods, making it an invaluable tool for advancing knowledge and practice.The volume features a diverse array of chapters that cover a wide range of topics, including the use of the Consolidated Framework for Implementation Research (CFIR) to evaluate telepharmacy services for outpatient cancer patients, the translation and validation of adherence measurement tools, and the application of network analysis in health code systems. Other notable contributions explore innovative strategies for improving clinical pharmacy services, conducting scoping reviews in pharmacy education, and employing mixed-methods approaches to enhance medication counseling.

  • Innovative Strategies Against Blood Parasites

    Advancing Control Through Natural Products and Next-Generation Technologies
    • 1st Edition
    • Mohamed Dkhil
    • English
    Innovative Strategies Against Blood Parasites: Advancing Control Through Natural Products and Next-Generation Technologies explores innovative strategies for controlling blood parasitic diseases by combining natural products with next-generation technologies like nanotechnology and AI. The book provides a multidisciplinary approach to developing sustainable, effective, and accessible therapies to combat drug resistance and improve patient outcomes. Bridging traditional pharmacognosy with modern biomedical advances, the volume covers natural antiparasitic compounds, nanomedicine-based delivery systems, and computational tools such as genomics and machine learning.It features case studies, practical applications, and future perspectives, serving as an essential resource for researchers, clinicians, policymakers, and students involved in parasitology, tropical medicine, and drug discovery.

  • Cell Free Synthesis of Biologics

    A Comprehensive Guide
    • 1st Edition
    • Sarfaraz Niazi
    • English
    Cell Free Synthesis of Biologics: A Comprehensive Guide addresses the need for efficient production methods in biopharmaceutical manufacturing. As the demand for biologics continues to rise, traditional cell-based production systems often fall short due to high costs and complexity. This book offers a detailed exploration of cell-free protein synthesis (CFPS), providing researchers and professionals with the latest methodologies, best practices, and troubleshooting strategies necessary for successful implementation. The content is structured into comprehensive chapters that cover the historical development, technical foundations, optimization strategies, advanced technologies, and the regulatory landscape surrounding CFPS.Each section is designed to guide users through the complexities of establishing and scaling up cell-free systems, ensuring a clear understanding of the processes involved and the potential applications in therapeutic development, diagnostics, and industrial biotechnology. This book provides pharmaceutical scientists and pharma manufacturing professionals with practical insights and innovative strategies to enhance efficiency and reduce costs in biopharmaceutical production.

  • Innovative Nanocarriers for Stimulated Drug Delivery

    A Comprehensive Guide to Stimuli-responsive Nanoparticles
    • 1st Edition
    • Prashant Kesharwani
    • English
    Innovative Nanocarriers for Stimulated Drug Delivery: A Comprehensive Guide to Stimuli-responsive Nanoparticles summarizes recent advances and achievements in nanocarriers responsive to external or internal stimuli. The book presents different stimuli-sensitive strategies and their applications in drug delivery, therapy, and theranostics. Sections provide fundamental knowledge on the experiential and experimental aspects of stimuli-responsive nanocarriers, discuss external-responsive nanocarriers for biomedical applications, such as ultrasound, thermal, magnetic, light, and electric field-response systems, and describe internal stimuli-responsive nanocarriers for biomedical applications, including pH, hypoxia, redox potential, enzyme, glucose, and microRNA-responsive nanocarriers. Additionally, the book covers dual and multimodal-responsiv... nanocarriers and the therapeutic aspects of stimuli-responsive nanocarriers, such as metallic and non-metallic stimuli-responsive nanocarriers in the treatment of various cancer and noncancerous diseases. Finally, recent advances and regulatory aspects of stimuli-responsive nanocarriers, including clinical translation, challenges, biological toxicity, safety issues, clinical trials, and future perspectives are covered.

  • Gene and Cell Therapies

    Principles of Pharmaceutical Development
    • 1st Edition
    • Chris Van Der Walle
    • English
    Gene and Cell Therapies: Principles of Pharmaceutical Development explores increasing interest in gene and cell therapies following powerful demonstrations of their capability to treat rare genetic disorders, advanced cancers, and regenerate or repair tissues. Sections cover the design of viral vectors, oncolytic viruses, ribonucleic acid cancer vaccines, and autologous and allogeneic cell therapies, along with impacts on their pharmaceutical development. Advances in molecular and cell biology that have led to efficacious and safe gene and cell therapies are also covered, including their relationship to the process and analytical developments that ensure quality.Gene and Cell Therapies: Principles of Pharmaceutical Development scope and style, along with included case studies, learning points, and lecture slides will allow non-specialists to develop a foundational understanding, while new concepts urge further advancements. Although these new, advanced medicines are continually being improved upon, their complex manufacture remains a key obstacle to increasing patient access.

  • Protein-Based Nanoparticles in Drug Delivery

    • 1st Edition
    • Prashant Kesharwani
    • English
    Protein-based Nanoparticles in Drug Delivery is a comprehensive book aimed at pharmaceutical scientists and researchers both in academia and corporate environments focused on nanotechnology drug delivery and pharmaceutical-relat... disciplines. The book covers the design and characterization of various protein nanoparticles, sheds light on the power of an endogenous substance as a drug delivery system, and highlights the possible future trends in the use of protein-based drug delivery. It covers in-depth novel applications of protein-based drug delivery from fundamental to most current use cases. The book comprises three parts. Part one is devoted to the foundations of protein-based drug delivery, including nanocarriers development, drug encapsulation, targetability, and in vivo properties. Part two explores the applications of protein-based nanoparticles in drug delivery, covering topics such as protein nanoparticles in cancer therapy, genetic material delivery, and nanocarriers based on milk protein, silk, and gliadin. Part three addresses recent advances and regulatory aspects of protein-based nanoparticles in drug delivery, including clinical translation, challenges, biological toxicity, and environmental hazards associated with protein-based nanoparticles. Protein-based Nanoparticles in Drug Delivery provides a complete journey of protein-based drug delivery, offers an in-depth understanding of the design and characterization of various protein nanoparticles, and highlights possible future trends in this field. Pharmaceutical scientists will benefit from the novel applications of protein-based nanoparticles drug delivery approaches in the biological field. Nanotechnologists, biologists, chemists, physicists, engineers, and clinicians will also benefit from the foundational content provided as a basis to support communication and tackle the multidisciplinary challenges associated with research in this exciting field.

  • Drug Targeting Complexity

    Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy
    • 1st Edition
    • Lalit Kumar + 2 more
    • English
    Drug Targeting Complexity: Tissue-Specific Regulation and Molecular Paradigms in Cancer Therapy presents a rigorous examination of advanced strategies for the selective targeting of neoplastic cells and their distinct microenvironments. This comprehensive volume elucidates both tissue-specific and tumor-specific molecular targets, clarifying how these methodologies can significantly enhance therapeutic precision while mitigating off-target effects. The initial section of the text provides an in-depth analysis of tissue-specific regulatory targets across various organs, including the liver, lungs, brain, skin, and bones. It delineates the critical mediators and mechanisms that govern tumor immunity, thereby identifying novel therapeutic avenues.Each chapter meticulously evaluates key regulatory molecules such as TGF-β, CTLA-4, and IL-10, exploring their roles in tumorigenesis and the potential for targeted interventions across a spectrum of malignancies. Subsequent sections focus on tumor tissue-specific molecular targets, encompassing immunological checkpoints, growth factors, and signaling pathways pertinent to cancers of the liver, stomach, ovary, prostate, and colon. The text provides insights into the application of monoclonal antibodies and molecular inhibitors as strategies to impede cancer progression and address therapeutic resistance. Concluding chapters address emerging therapeutic paradigms, including precision medicine and nanotechnology.

  • Advancing Integrative Medicine Through Medical Intelligence

    Introduction to Medical Intelligence with Integrative Medicine
    • 1st Edition
    • Sumbul Mehdi + 1 more
    • English
    Advancing Integrative Medicine Through Medical Intelligence: Introduction to Medical Intelligence with Integrative Medicine" explores the synergy between advanced technologies like AI and data analytics, and traditional medicine. This comprehensive book examines how these fields converge to enhance healthcare outcomes.The book covers key topics such as the role of AI in modern medicine, integration of traditional practices like Ayurveda and Unani with AI, and holistic approaches for patient care. It also includes AI-assisted mental health interventions, disease prevention through traditional methods, and AI in diagnosing chronic diseases and managing pain.Academics, researchers, and healthcare professionals will find this book invaluable for understanding how to combine AI and integrative medicine to improve health outcomes. It offers practical case studies and explores emerging trends that will shape the future of healthcare, making it a crucial resource for those interested in the evolving landscape of medical practices.

  • Advances in Tablet Manufacturing Technologies

    • 1st Edition
    • Honey Goel + 2 more
    • English
    Advances in Tablet Manufacturing Technologies consolidates cutting-edge information on the latest technologies in tablet design and manufacturing, addressing the pressing need for innovation in an increasingly complex global market. The book is structured to provide a thorough understanding of tablet technology, beginning with foundational concepts and progressing through specialized topics. Key sections explore the historical context of tablet development, the significance of pharmaceutical excipients, preformulation aspects, and the physics of tablet compression. Subsequent chapters explore advanced topics, including coated tablets, modified-release formulations, organ-specific tablets, and state-of-the-art innovations like 3D printed tablets.Each chapter is enriched with practical examples and case studies, ensuring that readers can apply theoretical knowledge to real-world scenarios. With contributions from a diverse group of national and international experts, this book is an invaluable asset for scientists in academia and industry alike. It elucidates preformulation parameters, outlines regulatory frameworks, and discusses recent advances in excipient technology and in-process testing equipment.

  • Multifunctional Nano pharmaceuticals for Biomedical Applications

    • 1st Edition
    • Sushil K. Kashaw + 3 more
    • English
    Multifunctional Nanopharmaceuticals for Biomedical Applications covers the latest advancements in multifunctional nanopharmaceuticals while also addressing the pressing need for innovative solutions for unmet medical challenges. Each chapter explores key topics such as the fundamentals of nanotechnology and drug delivery, PEGylated lipid carriers for cancer theranostics, and the latest in biomimetic nanomicells and nanorobots. With detailed discussions on design strategies, formulation techniques, and regulatory aspects, readers will gain a thorough understanding of the complexities and innovations in this dynamic field. The exploration of clinical applications and future trends also equips readers with the knowledge to navigate the evolving landscape of nanomedicine.This is an essential resource for researchers interested in the transformative potential of nanotechnology in drug delivery and disease treatment. It empowers readers to harness cutting-edge technologies for effective therapies, paving the way for a new era of personalized, precise, and potent medicine. With the rapid evolution of nanomedicine, this book serves as a crucial tool for researchers, students, healthcare professionals, and industry experts alike, bridging the gap between fundamental concepts and their real-world applications.

  • Developing Solid Oral Dosage Forms

    Pharmaceutical Theory and Practice
    • 3rd Edition
    • Yihong Qiu + 4 more
    • English
    Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Third Edition is a comprehensive and up-to-date guide for professionals and academics engaged in all aspects of oral dosage form development, from discovery support through commercial manufacturing. This new edition features 13 new or rewritten chapters, along with significant updates to existing content, reflecting the latest advancements in the field, including new theories, scientific findings, approaches, techniques, modeling, and the emerging opportunities offered by AI.This book consists of 44 chapters covering in-depth principles of physical pharmacy, biopharmaceutics, and industrial pharmacy, and their applications throughout the R&D process and commercial production of oral dosage forms. New chapters address topics such as absorption evaluation of oral dosage forms, formulation principles, and applications based on supersaturation, patient-centric product design, product design through the 505(b)(2) NDA pathway, design of experiments (DoE), process modeling, 3D printing, and machine learning applications in commercial manufacturing. Existing chapters have been updated or completely rewritten to provide advanced information and include practical case studies. Important topics such as amorphous solid dispersions, modified-release delivery, manufacturing technologies, modeling and simulation, fundamentals of dissolution and bioequivalence, IVIVC, biowaivers, regulatory frameworks, and many others are covered.The new edition of this book is an indispensable resource for industry professionals, academic institutions, and regulatory bodies seeking to stay current with advances in solid dosage form development and manufacturing. It offers a thorough understanding of fundamental principles and techniques, along with practical guidance on applying these concepts to real-world challenges.

  • Fundamentals of Biologicals Regulation

    Vaccines and Biotechnology Medicines
    • 2nd Edition
    • Rebecca Sheets + 6 more
    • English
    This second edition of Fundamentals of Biologicals Regulation: Vaccines and Biotechnology Medicines serves as an introduction to the international regulatory arena in which biologicals are developed and offers an overview of the processes and insight into the scientific concepts underpinning global regulations. In this new edition the book provides more in-depth coverage of Quality by Design, Combination Products, Quality Target Product Profiles, Risk Management Plans and REMS, and switching from reliance on in vivo to in vitro analytical methods. This new edition also reflects the new developments and processes accelerated by the COVID-19 vaccine experience, including emergency use authorizations and conditional marking authorizations. New pedagogic elements and case studies have been added to improve learning outcomes for students. This book provides multiple levels of readership with guidance on basic concepts, a detailed look at regulatory challenges, and practical insight into how regulators consider regulatory science and regulatory process issues across various regions with emphasis on the European Medicines Agency and the U.S. Food and Drug Administration. Graduate students will benefit from the new pedagogic features. Regulatory professionals will have in Fundamentals of Biologicals Regulation: Vaccines and Biotechnology Medicines a complete guide to navigate through the approval process.

  • AI Powered Drug delivery to Neuro and Cardiovascular Systems

    Perspectives and Future Challenges
    • 1st Edition
    • Chandra P. Sharma + 2 more
    • English
    AI-Powered Drug Delivery to Neuro and Cardiovascular Systems: Perspectives and Future Challenges is a definitive reference exploring the transformative influence of Artificial Intelligence (AI) in neuro and cardiovascular drug delivery. This book integrates cutting-edge research to explain how AI is poised to reshape clinical protocols, therapeutic strategies, and regulatory standards. By examining advancements in robotics and intelligent systems, it demonstrates how AI enhances precision, personalization, and efficiency in drug delivery for heart and neurological conditions, providing readers with a thorough understanding of these innovations and their potential to revolutionize healthcare practices.The book delves into AI-driven drug design and testing for cardiovascular diseases and explores the application of AI in cardiac drug delivery vehicles. It discusses bioengineered heart and vessel therapeutics, redox homeostasis, and targeted drug replenishment in cardiac matrix remodeling. Additionally, it addresses mitochondrial drug retention, AI-assisted gene therapy for neurodegenerative disorders, and the role of AI in optimizing heart health. The text highlights smart systems for managing cerebrovascular accidents and neuromodulation with pharmacotherapy. Finally, it covers translational challenges, future directions, and the significance of AI-driven prediction models and robotic delivery mechanisms.

  • Artificial Intelligence in Precision Drug Design, Volume 2

    Advanced Applications
    • 1st Edition
    • Khalid Raza
    • English
    Artificial Intelligence in Precision Drug Design, Volume 2: Advanced Applications explores the transformative role of AI in modern drug discovery and development, presenting cutting-edge research and methodologies that integrate machine learning, network pharmacology, and computational modeling to accelerate therapeutic innovation. It covers a wide range of applications, including AI-driven drug repurposing, combination therapies, cancer immunotherapy, neuroscience, vaccine development, and molecular dynamics, but also delves into emerging technologies such as quantum computing, large language models, and graph neural networks. Designed for academics, this volume provides researchers, clinicians, and graduate students with a resource on the latest AI methodologies in precision medicine.Users will find this to be a great resource that supports evidence-based innovation, fosters interdisciplinary collaboration, and equips them with insights to advance personalized healthcare solutions.

  • Artificial Intelligence in Precision Drug Design, Volume 1

    Foundations and Core Techniques
    • 1st Edition
    • Khalid Raza
    • English
    Artificial Intelligence in Precision Drug Design: Advanced Applications showcases how artificial intelligence (AI) is revolutionizing modern drug discovery and development. Building upon the foundational principles established in Volume 1, this book dives into real-world applications where AI accelerates innovation, enhances predictive accuracy, and enables breakthrough therapeutics. Featuring contributions from leading global researchers and practitioners, the book explores machine learning, deep learning, and network-based approaches applied to complex biomedical challenges. Key areas include AI driven drug repurposing, combination therapies, immunotherapy, vaccine design, quantum computing, and the integration of large language models in drug discovery. Additional chapters highlight predictive modeling using electronic health records, AI-powered medical imaging, and explainable AI for structure-based drug design. What sets this volume apart is its emphasis on practical impact, demonstrating how data, computation, and interdisciplinary collaboration converge to advance precision medicine. Designed for scientists, clinicians, educators, and students, it serves as both a comprehensive reference and a source of inspiration for leveraging AI to transform healthcare.

  • Lipid Nanoparticles-Based mRNA Delivery System

    • 1st Edition
    • Raj Kumar
    • English
    Lipid Nanoparticles-Based mRNA Delivery System offers a comprehensive exploration of lipid nanoparticles (LNPs), the most promising delivery vehicles for mRNA. The book consolidates current knowledge, identifies research gaps, and provides insights into the latest developments in LNP technologies, making it an essential resource for researchers, pharmaceutical developers, and clinicians at the forefront of mRNA therapeutics. Exploring the intricacies of LNP formulation, the book covers a wide range of topics, including the fundamental principles of lipid nanoparticles, design strategies for effective mRNA encapsulation, and the unique challenges associated with various routes of administration—such as intravenous, oral, transdermal, and intranasal delivery.The book also examines the therapeutic applications of lipid-based systems, particularly in vaccines and cancer immunotherapy, while addressing critical challenges like immunogenicity and regulatory considerations. Final sections provide a forward-looking perspective on future trends and innovations in lipid-based mRNA delivery systems, ensuring that readers are well-equipped to navigate this rapidly evolving field.

  • Nanotechnology-Based Innovations in Chronic Obstructive Pulmonary Disease (COPD) Treatment and Management

    • 1st Edition
    • Harish Dureja + 5 more
    • English
    Nanotechnology-Based Innovations in Chronic Obstructive Pulmonary Disease (COPD) Treatment and Management explores innovative drug delivery systems utilizing nanotechnology to revolutionize the treatment and management of COPD. By presenting the latest advancements in nanotechnologies—inc... polymeric nanoparticles, liposomes, and theranostic nanoparticles—this volume aims to enhance patient outcomes, alleviate symptoms, and improve lung function, thereby addressing the urgent need for more effective therapies. Structured to cater to a diverse audience, from beginners to advanced researchers, this comprehensive text begins with an overview of COPD, its epidemiology, and current limitations in treatment. The core chapters explore a wide range of nanotechnological applications for diagnosis and disease management, including cutting-edge topics such as nano-immunotherapy and green nanotechnology. Each chapter was developed by a multidisciplinary team of experts from academia and industry, ensuring a comprehensive approach that integrates insights from pharmaceutical sciences, respiratory health, and bioinformatics. Nanotechnology-based Innovations in Chronic Obstructive Pulmonary Disease (COPD) Treatment and Management not only fills a critical gap in COPD literature but also serves as an invaluable resource for researchers, clinicians, and students alike. It promises to be a definitive guide on how innovative drug delivery systems can transform COPD care, paving the way for future advancements in respiratory health management.

  • Antibiotic Resistance and Nanotherapy

    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Antibiotic Resistance and Nanotherapy is a comprehensive guide that explores an interdisciplinary approach to address the pressing issue of antibiotic resistance and explores the possibility of nanotherapy as a cutting-edge strategy to treat illnesses that are resistant to antibiotics, employing nanoparticles to target and kill bacteria selectively without damaging healthy cells. It details the underlying mechanisms of drug resistance in intracellular and extracellular pathogens and explores the latest advancements in nanotechnology, including the development of innovative nanomaterials and delivery systems that can be utilized to combat antibiotic-resistant infections. This book also discusses the ethical and practical challenges associated with implementing nanotherapy for bacterial resistance. Featuring contributions from experts in the field, this book is an essential resource for researchers, medical professionals, and policymakers seeking to understand and tackle the immediate threat posed by antibiotic resistance.

  • How to Develop Robust Scale-up Strategies for Complex Injectable Dosage Forms

    From Bench to the Clinics
    • 1st Edition
    • Neelam Poonia + 2 more
    • English
    How to Develop Robust Scale-up Strategies for Complex Injectable Dosage Forms: From Bench to the Clinics provides a comprehensive roadmap for transitioning complex injectable formulations from the laboratory to clinical applications. Offering an exploration of various complex injectables, including liposomal dosage forms, nanoparticles, and microspheres, this book delves into dosage form design, excipient selection, stability studies, and optimization techniques. The book examines manufacturing technologies such as aseptic processing, sterile filtration, and lyophilization, and their applications in producing complex injectables. Discussions on quality control measures, analytical techniques, and quality assurance practices are provided to ensure consistent quality and purity throughout the manufacturing process.Readers will benefit from the expert knowledge and practical insights shared by industry professionals and leading researchers, including successful examples of marketed complex injectables. Highlighting best practices and regulatory requirements, this book offers a comprehensive overview of the guidelines for the development, manufacturing, and commercialization of complex injectables. Ideal for pharmaceutical scientists, formulation developers, and regulatory professionals, this book is a valuable resource for anyone involved in the scale-up and commercialization of complex injectable dosage forms.

  • Math Calculations for Pharmacy Technicians

    A Worktext
    • 5th Edition
    • Elaine Beale
    • English
    Master the math skills needed to calculate drug dosages safely and accurately! Math Calculations for Pharmacy Technicians, 5th Edition, covers the competencies required by the American Society of Health-System Pharmacists (ASHP). Designed specifically for pharmacy technicians, the book includes a review of basic math, conversions between measurement systems, interpretation of drug labels and physicians' orders, and calculation of medications based on a patient's age, body weight, or body surface area. Two basic methods of calculating drug dosages are described: ratio/proportion and dimensional analysis. Simplifying calculation concepts, Elaine Beale’s worktext breaks down calculations, provides examples, and contains hundreds of practice problems to help you develop calculation confidence and prepare for a successful career as a pharmacy technician.

  • Harnessing Endogenous Mechanisms for Targeted Drug Delivery

    • 1st Edition
    • Anisha A. D’Souza + 2 more
    • English
    Harnessing Endogenous Mechanisms for Targeted Drug Delivery presents a comprehensive exploration of the evolving landscape of targeted drug delivery, emphasizing the strategic utilization of the body's intrinsic biological pathways. This authoritative two-volume reference addresses the critical need for precision in therapeutic delivery, overcoming physiological, anatomical, and immunological barriers through innovative endogenous mechanisms. By integrating foundational concepts with advanced methodologies, the work underscores the transition from traditional passive and active targeting to sophisticated endogenous strategies that enhance drug specificity and efficacy.The text systematically examines the multifaceted challenges inherent in drug delivery, including detailed analyses of in vivo barriers such as the blood-tumor barrier, blood-brain barrier, ocular, pulmonary, and gastrointestinal obstacles, as well as cellular and intracellular impediments. It further elucidates endogenous stimuli-responsive systems, nutrient transporter exploitation, glyco-targeting, and stealth peptide modifications. Comprehensive coverage extends to drug conjugates, protein corona phenomena, and cell-based delivery platforms encompassing stem cells, leukocytes, erythrocytes, and platelets. The series also addresses extracellular vesicles, viral vectors, and plant virus-based carriers, culminating in critical discussions on manufacturing complexities, regulatory considerations, and clinical translation challenges.This definitive resource is indispensable for graduate students, postdoctoral researchers, and professionals in academia and industry engaged in targeted drug delivery research and development. By providing an in-depth understanding of endogenous targeting mechanisms and their translational potential, the book fosters innovation and supports the advancement of precision therapeutics with the goal of improving patient outcomes.

  • Handbook of Pharmaceutical Wet Granulation

    Theory and Practice in a Quality by Design Paradigm
    • 2nd Edition
    • Ajit S. Narang + 1 more
    • English
    Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm, Second Edition offers a single and comprehensive reference dedicated to all aspects of pharmaceutical wet granulation, taking a holistic approach by combining introductory principles with practical solutions. Chapters are written by international experts across industry, academic and regulatory settings, and cover a wide spectrum of relevant and contemporary wet granulation topics, techniques and processes. This completely revised and updated edition features five new chapters covering new AI tools applied to scaling up granulation processes, model drive design, machine learning models for granule property prediction, design and scale up of fluid bed granulation, and process analytical methods. This book is the prefect reference for pharmaceutical manufacturing professionals. Academic researchers will benefit from the practical advice provided by the editors and chapter authors.

  • Side Effects of Drugs Annual

    • 1st Edition
    • Volume 47
    • English
    Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 47, first published in 1977, presents clinicians and medical investigators with a critical survey of new data and trends in adverse drug reactions and interactions. Topics covered include ADRs, ADEs and SEDs: A Bird’s Eye View, Lithium, Drugs of abuse, Side effects of drugs used in the treatment of Alzheimer's disease, Sedatives and hypnotics, Antipsychotic agents, Anti-epileptic Medications, Side effects of opioid analgesics and narcotic antagonists, Anti-inflammatory and antipyretic analgesics and drugs used in gout, Side effects of local anesthetics and therapeutic gases, and more.Other sections covered include Antihistamines (H1 receptor antagonists), Drugs that act on the respiratory tract, Positive inotropic drugs and drugs used in dysrhythmias, Beta adrenergic antagonists and antianginal drugs, Drugs acting on the cerebral and peripheral circulations, Antihypertensive drugs, and much much more.

  • Functionalized Drug Delivery Systems

    • 1st Edition
    • Umesh Gupta + 1 more
    • English
    Functionalized Drug Delivery Systems delves into the potential of various functionalized drug delivery systems, such as polymeric micelles, dendrimers, metallic nanoparticles, and SMEDDS. It offers a comprehensive guide from basic concepts to advanced surface engineering techniques. The book covers liposomes, dendrimers, metal nanoparticles, polymeric micelles, niosomes, and ethosomes, concluding with a chapter on the regulatory framework. This invaluable resource is perfect for pharmaceutical researchers and graduate students keen on advancing their understanding and application of these innovative drug delivery methods. The book also provides consolidated literature reviews, making it a foundational text for new researchers.Its chapters are dedicated to specific techniques, offering detailed insights into each method. Readers will gain knowledge on improving drug absorption and targeted delivery, supported by practical examples and case studies. The final chapter on regulatory frameworks ensures compliance and best practices in developing functionalized drug delivery systems. This book is an essential read for anyone in the field of pharmaceutical research.

  • Fundamentals and Design of Drug Delivery Systems

    A Textbook with Lab Activities
    • 1st Edition
    • Wujie Zhang
    • English
    Fundamentals and Design of Drug Delivery Systems: A Textbook with Lab Activities is an essential resource for pharmaceutical sciences and engineering students. Covering all key concepts related to drug delivery courses, it introduces basic pharmacology, barriers to drug delivery, drug targeting, and novel drug delivery systems. Design considerations and approaches are thoroughly illustrated. The textbook reflects nanotechnology in various chapters and includes practical lab activities, providing a comprehensive understanding of drug delivery systems, experimental design, and data analysis. It is ideally suited for upper-undergraduate and graduate courses.In addition to the foundational material, the textbook delves into cutting-edge topics such as biomimetic drug delivery systems, targeted delivery systems, stimuli-responsive systems, and micro/nano-robots-ba... drug delivery systems. Emerging fields like cell therapy, artificial intelligence (AI) in drug delivery, and 3D printing-based systems are also explored. Professionals in the Pharma industry will benefit from the innovative concepts and platforms presented, making it a valuable addition to their resources.

  • Dissipative Particle Dynamics

    Fundamentals and Applications in Soft Matter Science and Engineering
    • 1st Edition
    • Alexander V. Neimark + 1 more
    • English
    Dissipative Particle Dynamics: Fundamentals and Applications in Soft Matter Science and Engineering comprehensively presents the fundamentals of dissipative particle dynamics (DPD) theoretical formulations and computational strategies, providing practical guidance on the application of DPD models to various colloidal and interfacial phenomena involving phase separations, self-assembly and transport in complex fluids, polymeric, surfactant, nanoparticle, and biological systems. In addition, the book contains instructive advice on efficient implementation of the DPD models in open-source computational packages. Since the introduction of the principles of DPD methodology, multiple efforts have been made to improve the computational basis of DPD, and to devise advanced versions and modifications. There are numerous research papers on this topic, but no books until now. Readers will find this to be a comprehensive reference source of multifaceted, interdisciplinary applications that provides practical guidance for efficient computational implementation.

  • Inorganic Biomaterials for Drug Delivery

    • 1st Edition
    • Amit Kumar Nayak + 2 more
    • English
    Inorganic Biomaterials for Drug Delivery covers a wide range of inorganic biomaterial types and their properties, from traditional materials like ceramics, metallics, and bioglasses to novel composites and nano-engineered inorganic biomaterials. Biocompatibility, toxicity, and regulatory considerations are also thoroughly discussed, ensuring the reader is fully equipped for efficient biomaterials selection and utilization in drug delivery applications. This is a must-have reference for those working in the fields of materials science, biomedical engineering, pharmaceutical science, pharmacology, chemical engineering, and clinical science.

  • NanoPDT

    Nanomaterials-Enhanced Photodynamic Therapy
    • 1st Edition
    • Saeid Moghassemi + 2 more
    • English
    NanoPDT: Nanomaterials-Enhanc... Photodynamic Therapy covers extensively the therapeutic potential of multifunctional nanosystems that has made so much progress within the biomedical and pharmaceutical research communities over recent decades. Traditional photodynamic therapy (PDT), however, faces several limitations, primarily due to the hydrophobic nature of photosensitizers (PS), which tend to aggregate in aqueous environments, resulting in inadequate biodistribution and limited bioavailability. These constraints significantly reduce the efficacy of photodynamic therapy. The book also explores the most relevant combination therapies available. Four chapters are dedicated to the combination of NanoPDT with other approaches like Immunotherapy, Radiotherapy, chemotherapy, and photothermal therapy. NanoPDT: Nanomaterials-Enhanc... Photodynamic Therapy is an essential resource for pharmaceutical researchers, clinicians, and students in the fields of nanomedicine, oncology, and photodynamic therapy. It offers a thorough exploration of the latest advancements and future directions, providing valuable insights for those looking to enhance the efficacy and specificity of PDT through nanotechnology and its combined applications. The book's comprehensive coverage of both oncological and non-oncological applications makes it a crucial addition to the literature, bridging the gap between fundamental research and clinical practice.

  • Nanotechnology in Cosmeceuticals

    Advances, Challenges and Future Perspectives
    • 1st Edition
    • Chin Wei Lai + 1 more
    • English
    Nanotechnology in Cosmeceuticals: Advances, Challenges and Future Perspectives explores the fundamental principles of nanotechnology in cosmetics required to understand chemistry related formulation and the dermatological effects of these products. This book by provides an in-depth analysis of nanotechnology in cosmeceuticals, covering pharmaceutical, chemical, and toxicological aspects. The contents of this book are divided in seven parts. The first lays the foundations of cosmetics, and nanotechnology applications. The second part focuses no nano-metaloxides, including titanium, zinc, gold, silver and others. The third part covers carbon-based products in cosmeceuticals with chapters on graphene, nano-hydroxyapatite, and general carbon-based products. The next part focuses on nano-organics, nanocellulose and biodegradable materials. Part five is dedicated to formulations of liposomes, lipids in drug delivery. Part six covers recent trends, advances, applications and progress of nanotechnology and nano products in cosmeceuticals. The final part focuses on safety and toxicity aspects of nano-cosmeceuticals. Nanotechnology in Cosmeceuticals: Advances, Challenges and Future Perspectives is an ideal reference for pharmacologists, cosmetic scientists, and chemists in academic research and corporate settings looking into leveraging nanoscience to improve the performance of cosmetics. Dermatologists and food scientists may also benefit from the foundational content present in the first part of the book.

  • Ophthalmic Drug Delivery

    Advancement, Industrialization Prospect and Applications
    • 1st Edition
    • Neelesh Kumar Mehra
    • English
    Ophthalmic Drug Delivery: Advancement, Industrialization Prospect and Applications delves into the complexities and potential of scaling up and commercializing pharmaceutical innovations within ophthalmology. This book serves as a complete guide through research findings, industry insights, and regulatory guidelines, offering a thorough roadmap for the future of drug delivery systems targeting the eye. The importance of understanding the eye's physiology and anatomy is emphasized, laying the foundational knowledge necessary for developing effective treatments. The book continues by exploring various aspects such as novel formulations, fixed-dose combinations, and microbiological considerations.It also discusses cutting-edge research in reverse engineering approaches, the significance of Quality by Design (QbD), and the treatment of eye-related diseases like glaucoma, age-related macular degeneration, uveal melanoma, cataracts, and fungal keratitis. Corporate researchers will find the manufacturing insights particularly beneficial, making this an essential resource for professionals in the field of ophthalmic drug delivery.

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