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Elsevier

Books in Clinical microbiology

  • Antimicrobial Resistance, Sepsis, and the Invisible Threats to Women’s Health

    • 1st Edition
    • Uzma Syed + 1 more
    • English
    Antimicrobial Resistance, Sepsis, and the Invisible Threats to Women’s Health focuses on the burden of antimicrobial resistance (AMR) and sepsis on women's health, providing the latest information to educate both global researchers and healthcare professionals. The book begins by introducing the fundamental concepts of antimicrobial resistance and sepsis, setting the stage for a deeper exploration of their impact on women's health. It examines the epidemiology of sepsis and antimicrobial resistance in women, highlighting key risk factors, research gaps, reproductive health, antimicrobial resistance, and sepsis in detail, and further emphasizing their disproportionate impact on women's health.Additional coverage includes strategies for recruiting women in clinical trials and research studies, exploring the One Health approach integrating women's health into the broader context of AMR and sepsis and the role of artificial intelligence and technology in combating AMR and sepsis. The book concludes with case studies of female patients and their families affected by AMR and sepsis.

  • Handbook of Immunoassay Technologies

    Approaches, Performances, and Applications
    • 2nd Edition
    • Sandeep K. Vashist + 1 more
    • English
    Handbook of Immunoassay Technologies: Approaches, Performances, and Applications, Second Edition unravels the role of immunoassays in the biochemical sciences. During the last four decades, a wide range of immunoassays has been developed, ranging from the conventional enzyme-linked immunosorbent assays to the smartphone-based point-of-care formats. The book discusses how advances in rapid biochemical procedures, novel biosensing schemes, fully integrated lab-on-a-chip platforms, prolonged biomolecular storage strategies, device miniaturization and interfacing, and emerging smart system technologies that have paved the way for next-generation immunoassays.Revised and updated, the second edition of Handbook of Immunoassay Technologies: Approaches, Performances, and Applications covers all the relevant, timely, and important developments in the field. This edition offers new content on topics such as antibody production for immunodiagnostics, multiplex immunoassays, chemiluminescent immunoassays, immunoassays for newborn screening, and immunoassays of viruses like SARS-CoV-2, HIV, Ebola, and Hepatitis C. The addition of these new topics as well as up-to-date content make the second edition a valuable and comprehensive resource on immunoassays.

  • Degradation of Antibiotics and Antibiotic-Resistant Bacteria From Various Sources

    • 1st Edition
    • Pardeep Singh + 1 more
    • English
    The excessive use of antibiotics has given rise to an increase in microbial resistance, threatening our ability to treat infectious diseases. The growth in resistance to antimicrobials and antibiotics threatens to reverse almost a century of medical progress. urgent action plans to tackle the crisis of Antimicrobial Resistance (AMR) and multi-resistant bacteria are needed. It is a major research task to find effective ways to reduce the release and degradation of antibiotics and ARBs to the environment. Degradations of Antibiotics and Antibiotic Resistance Bacteria from various sources addresses various issues related the generations and degradations, eliminations of antibiotics and antibiotics resistance bacteria. Degradations of Antibiotics and Antibiotic Resistance Bacteria from various sources contains both practical and theoretical latest and broad aspects of antibiotics and antibiotics resistance bacteria management through the various recent methods. Various factors which are responsible for the efficient degradations are highlighted in the Degradations of Antibiotics and Antibiotic Resistance Bacteria from various sources as separate chapters. Socioeconomic and policies on the ARBs are also discussed.

  • Encyclopedia of Infection and Immunity

    • 1st Edition
    • Nima Rezaei
    • English
    Encyclopedia of Infection and Immunity, Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their hosts. Specific areas of interest include host cellular and immune response to microbes, molecular mechanisms of action of beneficial microbes or host-associated microbial communities, microbial pathogenesis, virulence factors, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. Comprised of over 200 chapters written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases. More than 100 years after Robert Koch and Louis Pasteur established the microbial etiology of communicable diseases, the field of microbiology is experiencing a second period of rapid growth and expansion, driven by the realization that changes in host-associated microbial communities might be at the root of a broad spectrum of noncommunicable human diseases. These advances follow on the heels of recent progress in high-throughput sequencing technology, which has provided a wealth of information on the human microbiome and its physiological potential.

  • Fungi Bio-prospects in Sustainable Agriculture, Environment and Nano-technology

    Volume 3: Fungal Metabolites, Functional Genomics and Nano-technology
    • 1st Edition
    • Vijay Kumar Sharma + 3 more
    • English
    Fungi Bio-prospects in Sustainable Agriculture: Fungal metabolites and Nano-technology is a three-volume series that has been designed to explore the huge potential of the many diverse applications of fungi to human life. The series unveils the latest developments and scientific advances in the study of the biodiversity of fungi, extremophilic fungi, and fungal secondary metabolites and enzymes, while also presenting cutting-edge molecular tools used to study fungi. Readers will learn all about the recent progress and future potential applications of fungi in agriculture, environmental remediation, industry, food safety, medicine, and nanotechnology.Volum... 3 provides a comprehensive account of fungal metabolites, including bioactive and host origin compounds, along with other biomolecules, and mycotoxins. This book includes the applications, limitations, and prospects of working with fungal secondary metabolites. The authors explore fungi in the myco-mediated synthesis of nanoparticles along with their biotechnological, industrial, and agricultural uses. This book also discusses advancements in medical mycology for the diagnosis and treatment of fungal infections. Furthermore, this book provides up-to-date and in-depth knowledge about the adoption of advanced CRISPR-Cas9 technology in fungi for gene editing

  • Precision Medicine and Artificial Intelligence

    The Perfect Fit for Autoimmunity
    • 1st Edition
    • Michael Mahler
    • English
    Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options.

  • The Microbiome in Prenatal and Neonatal Life

    • 1st Edition
    • Josef Neu
    • English
    The Microbiome in Prenatal and Neonatal Life clarifies that the microbiome in the maternal fetal unit and immediate changes that occur as new microbes are acquired postnatally play major roles in subsequent health and disease. Rapidly developing technologies for multi-omic analyses and systems biology are shifting paradigms in both scientific knowledge and clinical care with regard to this topic. In essence, we are changing the idea that newborns emerge from sterile environments. As such, in-utero colonization may have impacts on the development of immunity and metabolism that, with epigenetic modifications, will lead to diseases in later life. In addition, the microbial profile that develops during and after birth depends on mode of delivery, type of feeding (human milk versus formula), and various other environmental factors to which the newborn is exposed.

  • Fungi Bio-prospects in Sustainable Agriculture, Environment and Nano-technology

    Volume 2: Extremophilic Fungi and Myco-mediated Environmental Management
    • 1st Edition
    • Vijay Kumar Sharma + 3 more
    • English
    Fungi Bio-prospects in Sustainable Agriculture, Environment and Nanotechnology, Volume Two: Extremophilic Fungi and Myco-mediated Environmental Management explores varied aspects of fungal biology and their relevance in microbiology and agriculture, thus allowing for better insights on basic and advanced biotechnological application in human welfare and sustainable agriculture. Chapters throw light on different sectors of fungi, including fungi in extreme circumstances, bioremediation, complex and toxic effluents, and mycoremediation. The book was designed to explore the possibility of huge fungal diversity for present and future generation in different sectors of human life. Volume Two focuses on extremophilic fungi and myco-mediated environmental management.

  • Fungi Bio-prospects in Sustainable Agriculture, Environment and Nano-technology

    Volume 1: Fungal Diversity of Sustainable Agriculture
    • 1st Edition
    • Vijay Kumar Sharma + 3 more
    • English
    Fungi bio-prospects in sustainable agriculture, environment and nanotechnology　is a three-volume series that has been designed to explore the huge potential of the many diverse applications of fungi to human life. The series unveils the latest developments and scientific advances in the study of the biodiversity of fungi, extremophilic fungi, and fungal secondary metabolites and enzymes, while also presenting cutting-edge molecular tools used to study fungi. Readers will learn all about the recent progress and future potential applications of fungi in agriculture, environmental remediation, industry, food safety, medicine, and nanotechnology. Volume 1 will cover the biodiversity of fungi and the associated biopotential applications. This volume offers insights into both basic and advanced biotechnological applications in human welfare and sustainable agriculture. The chapters shed light on the different roles of fungi as a bio-fertilizer, a bio-control agent, and a component of microbial inoculants. They also focus on the various applications of fungi in bio-fuel production, nano-technology, and in the management of abiotic stresses such as drought, salinity, and metal toxicity.　

  • The Human Microbiome in Early Life

    Implications to Health and Disease
    • 1st Edition
    • Omry Koren + 1 more
    • English
    The Human Microbiome in Early Life: Implications to Health and Disease presents recent research advances that have highlighted the significance of early life, possibly beginning before birth, in the establishment of both the microbiome and its role in health and disease. The book reviews current knowledge on the origins of the human microbiota in early life, presents exposures which may disturb normal microbial colonization, and covers their implications to the risk of disease. Finally, emerging means to modify the early human microbiome to improve health are discussed.

  • Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease

    • 1st Edition
    • Shyamasree Ghosh
    • English
    Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease enables the reader to understand the role of sialylation as a post translational modification. The book provides insights on the latest knowledge in the field of sialoglycobiology. Sialic acids as terminal residues of oligosaccharide chains play crucial roles in several cellular recognition events. Synthesized post translationally, they play an important role in recognition, signaling, immunological response and cell-cell interaction. Improper sialylations have been associated with several diseases including cancer. In the post genomics and proteomics era, sialoglybiology has become more and more important in deciphering health and disease conditions.

  • Taxonomic Guide to Infectious Diseases

    Understanding the Biologic Classes of Pathogenic Organisms
    • 2nd Edition
    • Jules J. Berman
    • English
    Taxonomic Guide to Infectious Diseases: Understanding the Biologic Classes of Pathogenic Organisms, Second Edition tackles the complexity of clinical microbiology by assigning every infectious organism to one of 40+ taxonomic classes and providing a description of the defining traits that apply to all the organisms within each class. This edition is an updated, revised and greatly expanded guide to the classes of organisms that infect humans. This book will provide students and clinicians alike with a simplified way to understand the complex fields of clinical microbiology and parasitology.

  • Functionalized Nanomaterials for the Management of Microbial Infection

    A Strategy to Address Microbial Drug Resistance
    • 1st Edition
    • Rabah Boukherroub + 2 more
    • English
    Functionalized Nanomaterials for the Management of Microbial Infection: A Strategy to Address Microbial Drug Resistance introduces the reader to the newly developing use of nanotechnology to combat microbial drug resistance. Excessive use of antibiotics and antimicrobial agents has produced an inexorable rise in antibiotic resistance in bacterial pathogens. The use of nanotechnology is currently the most promising strategy to overcome microbial drug resistance. This book shows how, due to their small size, nanoparticles can surmount existing drug resistance mechanisms, including decreased uptake and increased efflux of the drug from the microbial cell, biofilm formation, and intracellular bacteria. In particular, chapters cover the use of nanoparticles to raise intracellular antimicrobial levels, thus directly targeting sites of infection and packaging multiple antimicrobial agents onto a single nanoparticle.

  • Current and Emerging Technologies for the Diagnosis of Microbial Infections

    • 1st Edition
    • Volume 42
    • English
    Current and Emerging Technologies in Microbial Diagnostics, the latest volume in the Methods in Microbiology series, provides comprehensive, cutting-edge reviews of current and emerging technologies in the field of clinical microbiology. The book features a wide variety of state-of-the art methods and techniques for the diagnosis and management of microbial infections, with chapters authored by internationally renowned experts. This volume focuses on current techniques, such as MALDI-TOF mass spectroscopy and molecular diagnostics, along with newly emerging technologies such as host-based diagnostics and next generation sequencing.

  • Vascular Responses to Pathogens

    • 1st Edition
    • Felicity N.E. Gavins + 1 more
    • English
    Vascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature. It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease. Formatted to discuss the topic of the interaction of pathogens with the vascular rather than individual diseases described separately, this reference demonstrates that common mechanisms are at play in many different diseases because they have a similar context, their vasculature. This all-inclusive reference book is a must-have tool for researchers and practicing clinicians in the areas of vascular biology, microvasculature, cardiology, and infectious disease.

  • Research in Medical and Biological Sciences

    From Planning and Preparation to Grant Application and Publication
    • 1st Edition
    • Petter Laake + 2 more
    • English
    Research in Medical and Biological Sciences covers the wide range of topics that a researcher must be familiar with in order to become a successful biomedical scientist. Perfect for aspiring as well as practicing professionals in the medical and biological sciences, this publication discusses a broad range of topics that are common yet not traditionally considered part of formal curricula, including philosophy of science, ethics, statistics, and grant applications. The information presented in this book also facilitates communication across conventional disciplinary boundaries, in line with the increasingly multidisciplinary nature of modern research projects.

  • An Atlas of the Commoner Skin Diseases

    With 120 Plates Reproduced by Direct Colour Photography from the Living Subject
    • 2nd Edition
    • Henry C. G. Semon
    • English
    An Atlas of the Commoner Diseases focuses on dermatoses most frequently observed in the routine outpatient practice. The book provides abbreviated clinical descriptions, as well as outline of treatment. The book first offers information on the differential diagnosis and treatment of acne, alopecia areata, chilblains, and dermatitis artefacta. The diagnosis and treatment of dermatitis herpetiformis, lichenified dermatitis, dermatitis medicamentosa, and other variations of dermatitis are also presented. The text also presents the prognosis and treatment of the different variations of eczema and epidermophytosis. The manuscript offers information on the localization, clinical manifestations, and treatment of epithelioma and its variants, erysipeloid, erythema induratum, erythema iris, erythema nodusum, and glossitis. The text ponders on the etiology and treatment of herpes zoster, impetigo, kerion, lichen planus, lupus vulgaris, and psoriasis. The manuscript is a dependable reference for readers interested in the commoner disease.

  • An Atlas of the Commoner Skin Diseases

    With 147 Plates Reproduced by Direct Colour Photography from the Living Subject
    • 4th Edition
    • Henry C. G. Semon
    • English
    An Atlas of the Commoner Skin Diseases, Fourth Edition presents a collection of the dermatoses most commonly seen in the routine of out-patient practice. This book includes in each plate abbreviated clinical descriptions, the important differential diagnoses, and outlines of treatment. Organized into 148 chapters, this edition begins with an overview of the prevailing form of acne vulgaris in its papulo-pustular stage. This text then illustrates the main characteristics of a developed and progressive patch of alopecia areata. Other chapters consider the case of acute seborrhoeic dermatitis of the scalp and face, which is the commonest of all skin diseases. This book discusses as well the cutaneous complications of varicose veins and the case of occupational or trade eczema. The final chapter deals with the rare condition of tylosis, which is a bilateral and symmetrical congenital horny thickening of the skin of the palms and soles. This book is a valuable resource for dermatologists.

  • An Atlas of the Commoner Skin Diseases

    With 153 Plates Reproduced by Direct Colour Photography from the Living Subject
    • 5th Edition
    • Henry C. G. Semon
    • English
    An Atlas of the Commoner Skin Diseases focuses on dermatoses most frequently observed in the routine outpatient practice. The book provides abbreviated clinical descriptions, diagnosis, and prognosis, as well as outline of treatment. The book first offers information on the differential diagnosis and treatment of acne and its variants, alopecia areata, cellulitis, cheiropompholyx, and chilblains. The text also ponders on the diagnosis, treatment, and prophylaxis of dermatitis and its variants. The publication also takes a look at the treatment, antihistaminic agents, and psychotherapy of eczema and its variants, differential diagnosis, prognosis, and treatment of epithelioma and its variants, and the diagnosis and treatment of erythema induratum and its variants. The manuscript also takes a look at the prognosis and treatment of granuloma and its variants, herpes zoster, impetigo, lichen planus, neurodermatitis and its variants, and psoriasis. The manuscript is a dependable reference for readers interested in the commoner disease.

  • Toxoplasma Gondii

    The Model Apicomplexan - Perspectives and Methods
    • 2nd Edition
    • Louis M. Weiss
    • English
    This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists. Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.

  • Molecular Action of Toxins and Viruses

    • 1st Edition
    • Volume 2
    • P. Cohen + 1 more
    • English
    Molecular Action of Toxins and Viruses investigates the molecular action of bacterial toxins and viruses and its striking similarity to the mechanisms by which many neural and hormonal stimuli control normal cell functions. Topics covered include the biological activity of diphteria toxin; the role of cholera toxin in the regulation of hormone-sensitive adenylate cyclase; toxic lectins and related proteins; and bacterial cytolysins (membrane-damaging toxins). Comprised of nine chapters, this volume begins with a discussion on the biosynthesis and biological activity of diphtheria toxin, toxin-resistant mutant cells, and the entry of toxin into cells and fragment A in the cytoplasm of living cells. The reader is then systematically introduced to the use of cholera toxin as a probe to study the regulation and interaction of adenylate cyclase components; the toxic action of lectins and related proteins such as abrin, ricin, and modeccin; and the ability of bacterial cytolysins to damage cell membranes. The remaining chapters focus on the mechanism of action of colicin E2, colicin E3, and cloacin DF13; similarities in the action of different bacterial toxins; the role of cell membranes in infection with bacterial viruses and colicins; and the life cycle and infection mechanisms of bacteriophage T4. The book concludes with an analysis of the involvement of protein kinases in viral transformation. This monograph will be of interest to students, practitioners, and researchers in fields ranging from molecular biology and biochemistry to cell biology, bacteriology, and physiology.

  • Germfree Research

    Biological Effect of Gnotobiotic Environments
    • 1st Edition
    • James Heneghan
    • English
    Germfree Research: Biological Effect of Gnotobiotic Environments is an account of the Proceedings of the Fourth International Symposium on Germfree Research. The volume comprises of 12 sections and 97 chapters. The first two sections serve as introduction to the status of germfree research as an approach to micro-ecology and gnotobiotic technology in clinical medicine. Another aspect discussed in the book deals with nutrition, metabolism, and microbiology. The last section provides a thorough and detailed discussion on gnotobiotic technology. Large part of the book focuses on gnotobiotic environments and its different aspects. Topics discussed include gnotobiotic environment on isolated patients and in dentistry and parasitology, as well as carcinogenesis in and physiological effects of gnotobiotic environments. The book is a very valuable source of information for many students and professionals in the fields of clinical medicine, biology, microbiology, nutritional science, and biochemistry.

  • Aerobiology

    • 1st Edition
    • I Silver
    • English
    Aerobiology documents the proceedings of the Third International Symposium held at the University of Sussex, England, in September 1969. The book is organized into three chapters that correspond to the three sessions held during the symposium. These three sessions dealt with themes of airborne infections in closed and segregated environments; the value and use of germ-free environments; and physiological and genetic factors in host resistance. Examples of the contributions during these sessions included studies on the transmission of meningococci among Army recruits; the transfer and acquisition of micro-organisms between and by patients nursed in a uni-directionally ventilated environment and those in an open ward; and the association between blood group status and susceptibility to certain virus infections. The symposium also included seminars that focused on the following themes: intramural spread of infection; laboratory safety; the immunological aspects of pathogenesis; vaccines and vaccination methods; microbial survival in air; rapid diagnosis; techniques in aerobiology; and the ways in which airborne particles cause infection.

  • Taxonomic Guide to Infectious Diseases

    Understanding the Biologic Classes of Pathogenic Organisms
    • 1st Edition
    • Jules J. Berman
    • English
    In the past few decades, there have been great advances in the phylogenetic classification of infectious diseases of man. Taxonomic Guide to Infectious Diseases organizes this information into a standard biological classification and provides a short, clinically-oriented description of every genus (class) of infectious organism. It covers an overview of modern taxonomy, including a description of the kingdoms of life and the evolutionary principles underlying the class hierarchy, and each following chapter will describe one phylum and the genera that contain infectious species. Taxonomic Guide to Infectious Diseases is written in an engaging, narrative style, providing the reader with an easy to digest yet clinically-oriented story of the pathogenic features of each genus. Designed for researchers, clinicians and students of infectious diseases, medical microbiology and pathology.

  • Staphylococcus Aureus

    Molecular and Clinical Aspects
    • 1st Edition
    • D A Aldeen + 1 more
    • English
    Staphylococcus aureus is resident in skin and nasal membranes with a formidable pathogenic potential to cause a variety of community and hospital acquired infections. This authoritative survey covers the impact of genome sequences into our understanding of MRSA and MSSA pathogenesis. World specialists from America, Germany, Japan, Sweden and the UK contribute knowledge and experience which will be welcome to researchers, practitioners and postgraduate students of immunology, microbiology, bacteriology and pharmacology worldwide.

  • Cryptosporidium: From Molecules to Disease

    • 1st Edition
    • R.C.A. Thompson + 2 more
    • English
    In the relatively short period since Cryptosporidium was recognised as a human pathogen, and that it could be transmitted in water as well as directly between animals and people, it has been the subject of intense investigations. Its status as an opportunistic pathogen, especially in AIDS patients, and the lack of effective anti-cryptosporidial drugs have served to emphasise the public health importance of this organism. This has to some extent overshadowed the fact that Cryptosporidium is also an important pathogen of domestic animals and wildlife. In recent years, the application of molecular biology and culture techniques have had an enormous impact on our understanding of the aetiological agents of cryptosporidial infections and our ability to study the causative agents in the laboratory. As a consequence, a wealth of information and novel data has been produced during the last 3-4 years, particularly in the areas of taxonomy, biology, pathogenesis, epidemiology - particularly zoonotic and water borne transmission, and treatment.It is thus very timely to bring together in this book the international research community involved to review the major advances in research and identify the important research priorities for the future, thus enabling as wide an audience as possible to benefit from and share in this comprehensive look at Cryptosporidium and cryptosporidiosis.

  • Phagocytosis: Microbial Invasion

    • 1st Edition
    • Volume 6
    • S. Gordon
    • English
    The present volume focuses on microbial invasion strategies of pathogen uptake. An accompanying volume (Vol. 5) in the series presents the phagocytic process from the viewpiont of the host cell. This field of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research and brings together cell biologists, microbiologists, and immunologists wiht disthemes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular parasitism and medically important organisms. The neutrophil is far more than a supporting player to the macrophage and some attempt is made to remind the reader of some of its unique skills. To retain a manageable size, the emphasis is on relatively early events such as mutual recognition, cell entry, and response, rather than on longterm changes in gene expression by either host cell or pahtogen. Viruses are excluded not because of lack of importance but because of somewhat different research approaches, although it is becoming increasingly clear that large viruses (e.g. Vaccinia) and Listeria monocytogenes, share common strategies in invasion and intercellular spread.

  • Handbook of Animal Models of Infection

    Experimental Models in Antimicrobial Chemotherapy
    • 1st Edition
    • Merle A. Sande
    • Oto Zak
    • English
    Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for in vivo efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections.

  • Automation: Genomic and Functional Analyses

    • 1st Edition
    • Volume 28
    • English
    Automation is the major future trend for many areas in microbiology, molecular biology, and biochemistry, among other disciplines. It is an enormously exciting area, where techniques and assays that were once repetitive, tedious, and time consuming can be performed robotically, liberating the time of researchers and hospital laboratory workers for more interesting work. Many techniques have now been automated and often miniaturized, including PCR analysis, DNA/RNA preparation, diagnostic test (e.g., Pap tests), compound screening, and of course, sequencing. Some major advances, notably in Professor Leroy Hood's group, have resulted in the ability to perform thousands of assays simultaneously on a normal microscope slide. Automation, edited by two of the leading experts in the field, presents the very latest experimental techniques explained in detail. This book has succeeded in bringing together researchers at the forefront of clone library construction, genome analysis, sequencing, computational data evaluation and functional analysis, to provide insight into this "new age" of research based on genomic and chemical screening.

  • Antibiotic-Producing Stetomyces

    • 1st Edition
    • Stephen W. Queener
    • English
    The Bacteria: Volume IX: Antibiotic-Producing Streptomyces explores how Streptomyces, including actinomycetes, produce a variety of antibiotics such as aminocyclitols, ansamycins, macrolides, and tetracyclines. Topics covered range from physiology and fermentation to genetic recombination and chromosome mapping in Streptomyces, biomodification of antibiotics by Streptomyces, and biosynthesis of tylosin and erythromycin. The genome structure and evolution of Streptomyces are also discussed. This volume is comprised of 10 chapters and begins with a discussion on the taxonomy of Streptomyces based on morphology, physiological characteristics, the composition of cell constituents such as cell walls, and the presence of characteristic lipids, sugars, and quinones. The discussion then turns to the intraspecific and interspecific recombination in Streptomyces; pathways of DNA repair and mutagenesis in Streptomyces fradiae; strategies for isolation of improved Streptomyces mutants for antibiotic production; and derivation of DNA cloning vectors from Streptomyces phages. The biology and use of Streptomyces plasmids as cloning vectors are also described. The final chapter is devoted to major structural classes of antibiotics produced by Streptomyces, including anthracyclines and other quinones, β-lactams, macrolides, nucleosides, peptides, polyenes, polyether antibiotics, and tetracyclines. This book will be of value to microbiologists, bacteriologists, biochemists, and biologists.