Books in Immunology

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Advances in Immunology

1st Edition
Volume 157
April 11, 2023
Frederick W. Alt + 1 more
English
Hardback
9 7 8 - 0 - 4 4 3 - 1 9 3 2 8 - 6
eBook
9 7 8 - 0 - 4 4 3 - 1 9 3 2 9 - 3

Advances in Immunology, Volume 157, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Chapters in this new release include Antigen receptor structure and signaling, T cells in the brain inflammation, The molecular mechanism of RIG-I/MDA5 activation and signaling, GSDMD biology, cGAS-STING pathway, The CARD8 inflammasome in HIV infection, and much more.

Epigenetic Regulation of Cancer in Response to Chemotherapy

1st Edition
Volume 158
March 27, 2023
Joseph Landry + 2 more
English
Hardback
9 7 8 - 0 - 4 4 3 - 1 9 4 1 8 - 4
eBook
9 7 8 - 0 - 4 4 3 - 1 9 4 1 9 - 1

Epigenetic Regulation of Cancer in Response to Chemotherapy, Volume 158 of the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting chapters on timely topics, including Epigenetically Programmed Resistance to Chemotherapy and Promotion of Immune Evasion in Cancer, A Role for the Epigenome in Cancer Cell Drug Tolerance, Histone Methylation and X Chromosomal Genes in Metastasis of Breast Cancer, Targeting Epigenetic Regulation Using Small Molecule Inhibitors, Histone Deacetylase Inhibitors as Sanguine Epigenetic Therapeutics against Pugnacious Lung Cancer, From ecology to oncology: To understand cancer stem cell dormancy, ask a Brine shrimp (Artemia), and more. Additional chapters cover Predictive Models of Chemoresistance Generated by Crunching the Public Drug Screen, Epigenomic and Genomic Profiling Datasets via Regression-, Machine Learning, and Knowledge-Based Methods, Probing on the Mechanisms of lncRNAs on Cancer Drug Resistance, Drug Tolerant Persister Cells in Cancer: Current Knowledge and Therapeutic Perspectives, and much more.

In Silico Approach Towards Magnetic Fluid Hyperthermia of Cancer Treatment

1st Edition
February 28, 2023
Muhammad Suleman
English
Paperback
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eBook
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In Silico Approach Towards Magnetic Fluid Hyperthermia in Cancer Treatment: Modeling and Simulation presents mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies. Finite element method-based models of all hyperthermia processes of liver, brain and breast tumors are simulated on COMSOL Multiphysics software. Problems of constant versus variable heat sources, the backflow problem, the enhanced permeation and retention effect, the flow around Happel’s sphere in cells model structure, the deformation effect in poroelastic brain tumor, 3D flow through porous tissue, the reacting nanofluid flows, and optimization of parameters have been simulated for quantitative analysis. This important reference aids in hyperthermia treatment planning in clinical applications and provides an important compendium for practitioners as well as non-medical practicing scientists and engineers and is resource for both research and medical practice in hyperthermia treatment planning in clinical applications.

Translational Autoimmunity, Volume 6

1st Edition
February 20, 2023
Nima Rezaei
English
Paperback
9 7 8 - 0 - 3 2 3 - 8 5 8 3 1 - 1
eBook
9 7 8 - 0 - 3 2 3 - 9 8 4 5 4 - 6

Translational Autoimmunity: Advances in Autoimmune Rheumatic Diseases, Volume Six addresses autoimmune diseases classified under the category of rheumatic diseases. Rheumatic diseases are heterogeneous groups of disorders in which inflammation affects not only joints, but also tendons, ligaments and bones. This updated release focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, osteoarthritis and Sjogren’s syndrome, and will be of interest to researchers, students and clinicians interested in autoimmune diseases, especially rheumatic diseases. From an introduction to rheumatic diseases to diagnostic laboratory tests, and from the microbiota-immunity to cell-based therapies, the bench to bedside approach to rheumatic diseases is the main subject of discussion in this comprehensive resource.

Comparative Mammalian Immunology

1st Edition
February 9, 2023
Ian R Tizard
English
Paperback
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eBook
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Comparative Mammalian Immunology: The Evolution and Diversity of the Immune Systems of Mammals provides a review on the current knowledge of mammalian immune systems from a comparative viewpoint. This reference encompasses recent work on the immune systems of marine mammals, bats and marsupials in addition to other lesser-known species, with the immune systems of humans and laboratory mice as components of chapters on primates and rodents respectively. The book also makes use of the most recent studies on the genomic sequences of the mammals to identify both common and unique features of each mammal's immune system. The book elucidates the complex, but coordinated and controlled series of interactions involving cells and molecules that has evolved to protect the host against disease. Mammals consist of a highly diverse group of animals in which the immune system has been subjected to a variety of selective pressures. This is reflected in differences in the organization and function of their immune systems, and is especially seen in those gene families characterized by complexity and polymorphism.

Novel Methods and Pathways in Cancer Glycobiology Research

1st Edition
Volume 157
February 2, 2023
Charles J Dimitroff + 1 more
English
Hardback
9 7 8 - 0 - 3 2 3 - 9 9 1 7 7 - 3
eBook
9 7 8 - 0 - 3 2 3 - 9 9 1 7 8 - 0

Cancer glycobiology is a blazing hot area of cancer research with aberrant post-translational glycosylations on lipids and proteins considered critical for cancer development and metastasis. The NIH/NCI Alliance of Glycobiologists for Cancer Research is a consortium of (10) tumor glycobiology laboratories funded to investigate how cancer-associated glycans (CAG) impact the development and metastasis of cancer. The hope of this momentous effort is to discover CAGs for use as novel biomarkers to detect early-stage cancer or its aggressive behavior or, alternatively, as novel molecular targets with the promise of a curative approach to cancer therapy. The mission of the ‘Alliance’ is to study structure and function of CAGs in cancer development and to provide clinically useful biomarkers for detecting cancer early or the potential of metastasis. This charge has stimulated extensive collaborations across US and International institutions to accelerate discovery of glycan-based biomarkers to the forefront of NCI's efforts to diagnose early-stage cancer and provide curative anti-cancer therapies. The main goals of these research efforts are: 1. To identify and study how cancer-associated glycans functionally impact cancer growth and metastasis2. To identify cancer-associated glycans that can serve as biomarkers for the detection or progression of cancer3. To develop cancer-associated glycans as novel therapeutic targets for the treatment and cure of cancer This volume consists of (9) chapters, one from each funded laboratory, that reviews new methods and mechanisms highlighting glycoconjugates and their roles as cancer biomarkers and/or anti-cancer therapeutic targets.

Introductory Immunology

3rd Edition
February 2, 2023
Jeffrey K. Actor
English
Paperback
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eBook
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Introductory Immunology: Basic Concepts for Interdisciplinary Applications, 3rd Edition, is a completely updated, revised, and expanded concise, conceptual approach to understanding the immune systems as a primary defense to maintain health and homeostasis. This expanded version includes the aspects of microbiology and related immune defense mechanisms important in combating disease, as well critical components related to the field of vaccine development. Immunology as a subject is no longer confined to the realms of "immunology" or "microbiology" studies. Indeed, the subject matter has become increasingly important to understand complex mechanisms found within a wider range of biological systems. This book aims specifically at educated audiences who do not have a deep understanding of medical, biochemical, or cellular knowledge. The overall text will present concepts that portray a comprehensive picture of the natural defenses to infectious agents as well as provide an introduction to mechanisms that lead to autoimmune dysfunction. In addition, immunological diseases will be detailed, with the goal of allowing the readers to gain sufficient knowledge to make sound choices for clinical decisions to affect treatment outcomes. This new edition expands on the existing chapters, focusing on updating the previous text. It has been expanded to include knowledge on effector mechanisms addressing components inherent within cellular responses that are either newly discovered, or missing from the previous edition. It has an extra emphasis on aspects related to mechanisms important in combating microbial agents and critical sections on how vaccines protect against pathogenic invaders to limit associated pathology. The goal is that Introductory Immunology will become the preferred provider of core knowledge in immunology to build a foundation to explore components of the human immune system that work together to confer and understand dysregulation that causes clinical diseases. This book serves as a basic platform to define therapeutic interventions by: creating appreciation for components of the human immune system to work together to confer lifelong protection; providing a core knowledge in immunology to build a foundation to explore mechanisms involved in clinical disease, and defining functional aspects of immunological terms to permit the reader easy access to comprehend specific topics; presenting introduction to complex immunological concepts in a concise and easy manner that relates to clinical disease; breaking down all of immunology into manageable, logically digestible building blocks, and providing a map to explore overlapping mechanisms of immune protective responses; providing a platform to readers without medical, biochemical, or cellular expertise to understand and appreciate how immunology controls homeostasis and protects against pathogens.

Autoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination

1st Edition
Volume 1
December 3, 2022
Yehuda Shoenfeld + 1 more
English
Paperback
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eBook
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Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination covers all aspects of what is perhaps the most dramatic health crisis in the history of modern medicine. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised major concerns about the association between the virus and various autoimmune manifestations. Over 15 distinct autoantibodies and above 10 different autoimmune diseases were found to develop in COVID-19 patients. Moreover, evidence about recovered COVID-19 patients demonstrates that persistent systemic symptoms, which are believed to have an autoimmune-related mechanism, do exist. As it is of great importance to recognize those autoimmune manifestations of COVID-19 and post-COVID-19 syndrome to properly cope with their outcomes in the ongoing pandemic and the long-term post-pandemic period, this book fulfills a vital need in the medical community.

Advances in Immunology

1st Edition
Volume 156
November 19, 2022
Frederick W. Alt + 1 more
English
Hardback
9 7 8 - 0 - 3 2 3 - 9 8 9 4 7 - 3
eBook
9 7 8 - 0 - 3 2 3 - 9 8 9 4 8 - 0

Advances in Immunology, Volume 156, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology, with this volume covering self-referential immune recognition through C-type lectin receptors, genetic susceptibility to autoimmunity, activation and regulation of the cGAS-STING pathway and the implications of IL-15 trans-presentation on the immune response.

Advances in Immunology

1st Edition
Volume 155
November 7, 2022
Frederick W. Alt + 1 more
English
Hardback
9 7 8 - 0 - 3 2 3 - 9 8 9 4 5 - 9
eBook
9 7 8 - 0 - 3 2 3 - 9 8 9 4 6 - 6

Advances in Immunology, Volume 155, the latest release in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors. Sections of note cover B cell/GC material.