Microbes, Microbial Metabolism and Mucosal Immunity
An Overview
- 1st Edition - August 7, 2024
- Imprint: Academic Press
- Editor: Tanima Bose
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 0 1 4 4 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 0 1 4 5 - 1
Microbes, Microbial Metabolism and Mucosal Immunity: An Overview presents a concise and well-vetted treatise on the study of microbiome and microbial metabolites. This volume… Read more
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Request a sales quoteMicrobes, Microbial Metabolism and Mucosal Immunity: An Overview presents a concise and well-vetted treatise on the study of microbiome and microbial metabolites. This volume is up-to-date with the most recent developments from the last decade. It encompasses the interaction of immunity and microbes — and their metabolites — from different mucosal organs including gastrointestinal system, lung, oral cavity, eye. Along with the efficiency of the immune system in inhibiting the growth and proliferation of microbes, the volume discusses how the mediators of the immune system can be targeted to develop therapies.
This book presents the latest methods, gives broad and systematic coverage of most mucosal systems and diseases, and takes a fresh perspective that looks at the functional aspects of change in the microbiome. The study of microbiome and microbial metabolites and their roles in host mucosal immunology is a rapidly developing area of research. One major way in which the microbiome influences the host is through altered metabolism. Metabolites, readily available to the host, engender significant consequences. Microbial metabolites have been shown to impact the disease processes in both proximal and distal organs, including the brain in several neurocognitive disorders.
This book presents the latest methods, gives broad and systematic coverage of most mucosal systems and diseases, and takes a fresh perspective that looks at the functional aspects of change in the microbiome. The study of microbiome and microbial metabolites and their roles in host mucosal immunology is a rapidly developing area of research. One major way in which the microbiome influences the host is through altered metabolism. Metabolites, readily available to the host, engender significant consequences. Microbial metabolites have been shown to impact the disease processes in both proximal and distal organs, including the brain in several neurocognitive disorders.
- Offers a concise solution for the study of microbiome, microbial metabolism, and mucosal immunology
- Presents contemporary studies that incorporate the latest research methods
- Gives a broad and systematic accounting of most mucosal systems and diseases
- Looks at the functional aspects of changes to the microbiome as well as specific changes to microbiota
- Affords entry-level and advanced readers with the theory and knowledge needed for further research
Researchers, graduate students, pharma scientists and medical practitioners with an interest in microbes and immunity, including neurologists, infection specialists, rheumatologists, and immunologists, dieticians and medical doctors.
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- About the editor
- About the authors
- Preface
- Acknowledgments
- Chapter 1. Intestinal barrier immunity: key players in the gut microbial “meet and greet or get-rid” event
- Abstract
- 1.1 Barrier maintenance
- 1.2 Physical and chemical barriers
- 1.3 Immune surveillance—the ultimate biological barrier
- 1.4 Immune surveillance by the adaptive immune system
- 1.5 Conventional T cells in intestinal immunity
- 1.6 The role of unconventional T cells in intestinal immunity
- 1.7 Dysregulation of barrier immunity
- 1.8 Conclusion
- Abbreviations
- References
- Further readings
- Chapter 2. Gut–brain communication through microbes
- Abstract
- 2.1 Introduction
- 2.2 Metabolic and endocrine signaling pathways
- 2.3 Neuroactive molecules
- 2.4 γ-aminobutyric acid
- 2.5 Neural signaling—the vagus nerve
- 2.6 The hypothalamic–pituitary adrenal axis
- 2.7 Immune signaling and immune system activation
- 2.8 Impacts of the microbiome on central nervous system biology
- 2.9 Conclusions and future directions
- Abbreviation
- References
- Chapter 3. Role of gut microbes in shaping neonatal immunity and beyond
- Abstract
- 3.1 Introduction
- 3.2 Prenatal and postnatal establishment of microbiome
- 3.3 Prenatal vaccination and protection against specific pathogens
- 3.4 Streptococcus pneumoniae vaccine
- 3.5 Group A Streptococcus vaccine
- 3.6 Conclusions
- Abbreviation
- References
- Chapter 4. Respiratory microbiome
- Abstract
- 4.1 Respiratory microbiome during development and homeostasis
- 4.2 Respiratory mycobiome and virome
- 4.3 Microbiota dysbiosis in respiratory diseases
- 4.4 Methods for the sampling and assessment of the respiratory microbiome
- 4.5 Immunomodulatory role of lung microbiome in mammalian hosts
- 4.6 Therapeutic implications of the lung microbiome
- 4.7 Concluding remarks
- Abbreviations
- References
- Chapter 5. Oral immune system and microbes
- Abstract
- 5.1 Introduction
- 5.2 The oral microbiome
- 5.3 The oral immune system
- 5.4 Factors influencing the oral microbiome and the host immunity
- 5.5 Oral microbiome and host immunity in health
- 5.6 Oral microbiome and host immunity dysbiosis in diseases
- 5.7 Conclusions
- Acknowledgments
- Abbreviations
- References
- Chapter 6. The eye and the microbiome
- Abstract
- 6.1 Introduction
- 6.2 Relationships between gut and ocular surface microbiome composition and eye disease
- 6.3 Conclusion
- Financial support
- Conflict of interest
- Abbreviations
- References
- Chapter 7. Commensal virome and mycobiome
- Abstract
- 7.1 Introduction
- 7.2 Characterization of the virome and the mycobiome
- 7.3 Specific strategies for studying the virome
- 7.4 Specific strategies for studying the mycobiome
- 7.5 Distribution of the virome and mycobiome in the human body
- 7.6 Virome and mycobiome acquisition and development
- 7.7 Trans-kingdom interactions
- 7.8 Conclusions and future directions
- Abbreviations
- References
- Chapter 8. Microbiome and the COVID-19 pandemic
- Abstract
- 8.1 Introduction
- 8.2 Microbiome characteristics in COVID-19
- 8.3 Intestinal microbiome
- 8.4 Upper respiratory tract microbiome
- 8.5 Lower respiratory tract microbiome
- 8.6 Oral microbiome
- 8.7 Pediatric microbiome characteristics in COVID-19
- 8.8 Review of analytic methods for COVID-19 microbiome data
- 8.9 Microbiome-based prevention and intervention approaches in COVID-19
- 8.10 Conclusion
- Abbreviations
- References
- Author Index
- Subject Index and Keywords
- Edition: 1
- Published: August 7, 2024
- No. of pages (Paperback): 404
- No. of pages (eBook): 230
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323901444
- eBook ISBN: 9780323901451
TB
Tanima Bose
Dr. Tanima Bose, Institute for Clinical Neuroimmunology, University of Munich, Germany
Tanima Bose has been working in the field of immunology for almost 15+ years. After finishing her PhD in the interaction of ion channels in immune cells from Leibniz Institute for Neuroimmunology in collaboration with the Clinical Immunology Department in Magdeburg, Germany, she expanded her research internationally in Singapore, USA, Australia before returning to the University of Munich, Germany. Her research focuses on the tissue-resident and memory immune cells, and their role in autoimmune, allergic, and neuroimmunological disease. She is finishing her habilitation and will continue teaching in the field of mucosal immunology. She hopes that Pharma companies will be encouraged by her translational research.
Along with her academic work, Tanima Bose is very active in editing, writing, and public speaking. She has written numerous research papers (20+), book chapters (5+), protocols, and blogs and has been part of the editorial team of several journals (10+). In her free time, she likes to inspire women more in scientific activities; one example is her participation in Soapbox Science (https://munichsoapboxscience.com/soapbox-science-2020/10/).
Affiliations and expertise
Institute of Clinical Neuroimmunology, University of Munich (LMU), Großhaderner Straße 9, 82152 Munich, GermanyRead Microbes, Microbial Metabolism and Mucosal Immunity on ScienceDirect