The Rose and Mackay Textbook of Autoimmune Diseases
- 7th Edition - July 26, 2024
- Imprint: Academic Press
- Editors: M. Eric Gershwin, George C. Tsokos, Betty Diamond
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 2 3 9 4 6 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 3 9 4 7 - 2
The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the "3 P’s" of 21st Century medicine: precision, prediction, and preve… Read more
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Request a sales quoteThe Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the "3 P’s" of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients.
This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.
- Provides new research on autoimmune diseases, their diagnosis, prevention, and therapy
- Covers a complete range of all common, rare and new autoimmune diseases, including cancer and COVID
- Extensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseases
- Supplemented with a website that hosts a Podcast per chapter
Researchers, scientists, clinicians, clinical investigators, pathologists, medical students, and graduate students in the biomedical sciences in immunology, rheumatology, genetics, cell biology and molecular biology, Academic institutions especially those researchers active in immunology/oncology/infectious disease and those teaching immunology for graduate and post-graduate degrees, Basic and clinical scientists working in immunology, rheumatology and autoimmune diseases
- Contents to Volume 1
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- List of editors and section editors
- Editors
- Section editors
- Preface
- Part 1: Basic science: development of the immune system with cell lineages
- Chapter 1. Development of adaptive immune cells
- Abstract
- Chapter outline
- Self versus nonself
- Adaptive immune cell development
- Lymphocyte progenitors
- T cell development
- Altered mechanisms of T cell tolerance as promoters of autoimmunity
- B cell development
- Antibody diversity
- Self-reactive B cells are inherently part of the peripheral B cell pool
- Altered mechanisms of B cell tolerance and autoimmunity
- Conclusion
- Acknowledgment
- References
- Chapter 2. Revision to the origins of the mononuclear phagocyte
- Abstract
- Chapter outline
- Key points
- Overview
- Steady-state development of macrophages
- Transcriptional regulation of tissue-resident macrophages
- Common macrophage transcriptional profiles
- M1 and M2 paradigm revisited
- Future directions
- References
- Chapter 3. Tolerance and activation of peripheral B and T cells
- Abstract
- Chapter outline
- B cell central tolerance “checkpoints” in humans
- T cell activation, T-B collaboration, and peripheral B cell tolerance
- Conclusion
- Acknowledgments
- References
- Chapter 4. Genetic alterations leading to autoimmunity
- Abstract
- Chapter outline
- Introduction
- The genetics of autoimmunity before development of the genome-wide association study
- Moving from genetic association to functional mechanism in the post-GWAS era
- The next technology advance: single cell sequencing
- Leveraging polygenic risk scores to predict disease
- Summary
- References
- Chapter 5. Microbiome in autoimmunity
- Abstract
- Chapter outline
- Introduction
- Alterations in the gut microbiome in autoimmune diseases
- Mechanisms
- Interventions
- Conclusion
- References
- Chapter 6. Metabolic control of pathogenesis in autoimmune diseases
- Abstract
- Chapter outline
- Short summary
- Introduction
- Systemic lupus erythematosus
- Mitochondrial oxidative stress underlies mTOR activation in SLE
- Rheumatoid arthritis
- Conclusions
- Acknowledgments
- References
- Chapter 7. Triggers for autoimmunity
- Abstract
- Chapter outline
- Introduction
- Self-antigens that escape tolerance
- Environmental triggers of autoimmunity
- Conclusion
- References
- Chapter 8. Organ damage in autoimmune disease
- Abstract
- Chapter outline
- Introduction
- Initiation of tissue injury
- Chronic tissue injury
- Genetics of tissue injury
- Loss of function
- Implications for therapy
- References
- Chapter 9. Therapeutic strategies for treating autoimmune disease
- Abstract
- Chapter outline
- Immunosuppression versus targeted therapy
- B cell depletion
- T cell-directed therapy
- Cytokine blockade
- Small molecule immune inhibitors
- Immunoablation and reconstitution
- Antigen-specific therapy
- Conclusion
- References
- Part 2: Rheumatology
- Chapter 10. Systemic lupus erythematosus
- Abstract
- Chapter outline
- Introduction
- History
- Disease diagnosis and classification
- Epidemiology, genetics, and the environment
- Pathogenesis
- Clinical features
- Future directions
- References
- Chapter 11. Systemic sclerosis (scleroderma)
- Abstract
- Chapter outline
- Definition and classification
- Epidemiology and etiology
- Sex bias, ethnic background and mortality trends
- Environmental factors
- Pathogenesis
- Genetic associations
- Pathology
- Clinical features
- Pulmonary features
- Gastrointestinal involvement
- Renal involvement: scleroderma renal crisis
- Cardiac involvement
- Musculoskeletal complications
- Less recognized disease manifestations
- Biomarkers and autoantibodies in systemic sclerosis
- Screening and follow-up evaluation
- Management of patients with systemic sclerosis
- Natural history and prognosis
- References
- Chapter 12. Antiphospholipid syndrome
- Abstract
- Chapter outline
- Historical perspective
- Geoepidemiology
- Pathogenesis
- Genetics
- Diagnosis, screening, and prevention
- Management
- Pregnancy
- Risk assessment in antiphospholipid syndrome
- Future directions
- References
- Chapter 13. Sjögren’s disease
- Abstract
- Chapter outline
- Historical perspectives
- Establishing classification criteria for the disease
- Epidemiology
- Clinical presentation
- Disease course and prognosis
- Pathophysiology of Sjögren’s syndrome
- Autoimmune epithelitis
- The use of mouse models in the study of Sjögren’s syndrome
- Diagnosis and management
- References
- Chapter 14. Rheumatoid arthritis
- Abstract
- Chapter outline
- Introduction
- Clinical, pathologic, and epidemiologic features
- Autoimmune features
- Genetic characteristics
- In vivo models
- Pathogenetic effector mechanisms
- Concluding remarks—future prospects
- References
- Chapter 15. Juvenile idiopathic arthritis
- Abstract
- Chapter outline
- Introduction
- Definition and classification
- Epidemiology
- Pathogenesis
- Clinical features
- Future directions
- References
- Chapter 16. Spondyloarthritis
- Abstract
- Chapter outline
- Introduction
- Clinical features and treatment
- References
- Chapter 17. Autoimmune myositis
- Abstract
- Chapter outline
- Defining autoimmune myositis
- Clinical and pathological descriptions of different phenotypes, including immune-mediated necrotizing myopathy
- Characteristic pathology, but significant overlap between phenotypes
- Epidemiological clues into mechanism
- Specific autoantibodies are strongly associated with phenotype, making them useful probes of disease mechanism
- Mechanisms of disease
- Therapeutic insights
- Concluding remarks
- References
- Chapter 18. Relapsing polychondritis
- Abstract
- Chapter outline
- Introduction
- Historical note
- Epidemiology
- Genetics and pathogenesis
- Clinical features and diagnosis
- Systemic manifestations
- Clinical evaluation
- Ear and nose manifestations
- Laryngotracheal and pulmonary manifestations
- Musculoskeletal manifestations
- Ocular manifestations
- Cutaneous manifestations
- Renal involvement
- Cardiovascular manifestations
- Neurological manifestations
- Association with other diseases
- Laboratory findings
- Imaging
- Differential diagnosis
- Assessment of disease activity and damage
- Treatment
- Nonsteroidal anti-inflammatory agents, colchicine and dapsone
- Corticosteroids
- Second-line therapies
- Biologic agents
- Surgical intervention
- Prognostic factors
- Summary
- References
- Chapter 19. IgG4-related disease
- Abstract
- Chapter outline
- Introduction
- Historical aspects
- Epidemiology
- Pathology
- Pathophysiology
- Serum IgG4 concentrations
- Autoimmune features
- Genetics
- An animal model
- Clinical features and disease associations
- Classification criteria
- Treatment
- Perspectives
- References
- Part 3: Nephrology
- Chapter 20. Necrotizing arteritis and small-vessel vasculitis
- Abstract
- Chapter outline
- Introduction
- Historical background
- Polyarteritis nodosa
- Kawasaki’s disease
- Anti-neutrophil cytoplasmic autoantibody vasculitis
- Cryoglobulinemic vasculitis
- IgA Vasculitis (Henoch-Schonlein purpura)
- Concluding remarks—future prospects
- References
- Chapter 21. Large and medium vessel vasculitides
- Abstract
- Chapter outline
- Vasculitides of large and medium-sized blood vessels
- Giant cell arteritis
- Historic background
- Clinical, pathologic, and epidemiologic features
- The vascular lesion
- Epidemiology
- Genetic features
- Pathogenic mechanisms
- Macrophages (Mⱷ) in giant cell arteritis
- Neoangiogenesis of microvascular networks and intimal hyperplasia
- Treatment, monitoring, and outcome
- Takayasu arteritis
- Historic background
- Concluding remarks – future perspectives
- Acknowledgment
- References
- Chapter 22. Autoimmune diseases of the kidney
- Abstract
- Chapter outline
- Introduction
- Historical perspective
- Definition of disease
- Lupus nephritis (covered extensively in chapter 10)
- Geoepidemiology
- Pathogenesis
- Clinical features, disease associations, treatment, and outcomes
- Summary
- References
- Part 4: Hematology
- Chapter 23. Autoimmune hemolytic anemia
- Abstract
- Chapter outline
- Introduction
- Historical background
- Classification
- Diagnostic pathway
- Warm-antibody autoimmune hemolytic anemia
- Cold-antibody autoimmune hemolytic anemia
- Atypical autoimmune hemolytic anemia
- Autoimmune hemolytic anemia in pregnancy
- Supportive therapeutic measures
- The future
- References
- Chapter 24. Acquired aplastic anemia
- Abstract
- Chapter outline
- Introduction
- Disease history
- Definition and classification
- Epidemiology
- Pathogenesis
- Triggers and predisposing factors for acquired aplastic anemia
- Clinical manifestations
- Diagnostic evaluation
- Treatment
- Conclusions and future directions
- References
- Chapter 25. Autoimmune clotting dysfunction
- Abstract
- Chapter outline
- Introduction
- Prothrombotic disorders
- Anticoagulant disorders
- Conclusion and future aspects
- COVID-19 and hypercoagulability
- References
- Chapter 26. Immune thrombocytopenia
- Abstract
- Chapter outline
- Introduction
- Disease history
- Definition and classification
- Geoepidemiology
- Pathogenesis
- Treatment
- Future directions
- References
- Chapter 27. Thrombotic thrombocytopenic purpura
- Abstract
- Chapter outline
- Introduction
- Disease history
- Epidemiology
- Definition, classification, and terminology
- Pathogenesis
- Animal models
- Clinical and laboratory features
- Evaluation and diagnosis
- Treatment for immune-mediated thrombotic thrombocytopenic purpura
- Therapy for congenital thrombotic thrombocytopenic purpura
- Special populations
- Future directions
- Glossary
- References
- Chapter 28. Macrophage activation syndrome
- Abstract
- Chapter outline
- Introduction
- Environmental factors and triggers
- Immunology and genetics
- Hormonal influences
- Treatment
- Future directions
- References
- Chapter 29. Autoimmune leukopenia
- Abstract
- Chapter outline
- Introduction
- Autoimmune neutropenia
- Lymphopenia and antilymphocyte antibodies in autoimmune diseases
- References
- Part 5: Endocrinology
- Chapter 30. Autoimmune thyroid diseases
- Abstract
- Chapter outline
- Introduction
- Chronic autoimmune thyroiditis
- In vivo models
- Clinical features
- Morbidity and mortality
- Graves’ disease
- Acknowledgments
- Conflict of interest
- References
- Chapter 31. Autoimmune (Type 1) diabetes
- Abstract
- Chapter outline
- Introduction
- Epidemiology
- Diagnostic criteria and classification of diabetes
- Etiology
- Pathogenesis
- Preclinical models of type 1 diabetes
- Primary prevention
- Secondary prevention
- Intervention
- Conclusions and future directions
- References
- Chapter 32. Adrenalitis
- Abstract
- Chapter outline
- Historical notes
- Anatomy and physiology of the adrenals
- Epidemiology of Addison’s disease and of autoimmune adrenalitis
- Autoimmune Addison’s disease (adrenalitis)
- Acknowledgments
- References
- Chapter 33. Autoimmune polyendocrine syndromes
- Abstract
- Chapter outline
- Historic background
- Autoimmune polyendocrine syndromes type1 (APS-1)
- Immumodys; regulation polyendocrinopathy enteropathy X-linked (IPEX)
- Autoantibodies in diagnosis of autoimmune polyendocrine syndromes
- Genetics of autoimmune polyendocrine syndromes
- Pathogenic mechanisms
- Concluding remarks – future prospects
- References
- Chapter 34. Autoimmune gastritis and pernicious anemia
- Abstract
- Chapter outline
- Introduction
- Epidemiology and clinical presentation
- Genetic features
- Pathogenesis
- Diagnosis
- Assessing the neoplastic risk
- Concluding remarks – future prospects
- References
- Chapter 35. Autoimmune hypophysitis
- Abstract
- Chapter outline
- Definition and classification
- Historical notes
- Epidemiology and body of literature
- Clinical features
- Pathological features
- Autoimmune features
- Genetic and environmental influences
- Animal models
- Diagnosis
- Treatment
- Outcome
- A comparison between primary hypophysitis and hypophysitis secondary to immune checkpoint inhibitors
- Concluding remarks – future perspectives
- References
- Chapter 36. Autoimmune primary ovarian insufficiency
- Abstract
- Chapter outline
- Introduction
- Ovarian autoimmunity and primary ovarian insufficiency
- Diagnosis of autoimmune primary ovarian insufficiency
- Treatment of primary ovarian insufficiency
- Conclusions
- References
- Chapter 37. Endometriosis as an autoimmune disease
- Abstract
- Chapter outline
- Introduction
- Disease history
- Disease definition and classification criteria
- Geoepidemiology
- Pathogenesis
- The immunology of endometriosis
- Animal models
- Clinical features
- Pathology
- Diagnosis
- Treatment
- Morbidity
- Future directions in endometriosis
- References
- Chapter 38. Primary hypoparathyroidism or non-surgical hypoparathyroidism
- Abstract
- Chapter outline
- Biological effect of parathyroid hormone
- Classification and etiopathology of non-surgical hypoparathyroidism
- Epidemiology of non-surgical-IpoPTH
- Clinical presentation of hypoparathyroidism
- Complications of chronic hypoparathyroidism
- Diagnosis of hypoparathyroidism
- Initial assessment
- Treatment and follow-up
- Hypoparathyroidism in pregnancy
- References
- Contents to Volume 2
- Part 6: GI and liver
- Chapter 39. Celiac disease
- Abstract
- Chapter outline
- Introduction
- Disease history
- Geoepidemiology
- Clinical diagnosis
- Maintenance after diagnosis
- Celiac disease as an autoimmune disease
- Pathogenesis of celiac disease
- In vitro and in vivo models of celiac disease
- Novel therapies for celiac disease
- Future directions for celiac research
- References
- Chapter 40. Inflammatory bowel disease
- Abstract
- Chapter outline
- Introduction
- History of inflammatory bowel disease
- Epidemiology
- Clinical features
- Histopathologic features
- The etiology of inflammatory bowel disease
- Genetics
- Diagnostics
- Treatment
- Future directions
- References
- Chapter 41. Autoimmune gastrointestinal dysmotility
- Abstract
- Chapter outline
- Introduction
- Disease history and etiologies
- Pathophysiology
- Conclusion
- Future directions
- Acknowledgments
- Disclosures
- References
- Chapter 42. Autoimmune pancreatitis
- Abstract
- Chapter outline
- Introduction
- Disease definition
- Epidemiology
- Pathogenesis
- Pancreatitis
- Type 1 autoimmune pancreatitis
- Genetics
- Clinical features
- Clinical features and disease course
- Serologic features
- Imaging features
- Pediatric presentation
- Checkpoint inhibitor related autoimmune pancreatitis
- Diagnostic criteria
- International Consensus Diagnostic Criteria
- Japanese criteria
- Treatment
- Induction
- Maintenance
- Relapse
- Procedural intervention
- Treatment of special populations
- Prognosis
- Future directions
- Acknowledgment
- References
- Chapter 43. Primary sclerosing cholangitis and IgG4-associated cholangitis
- Abstract
- Chapter outline
- Introduction
- History of primary sclerosing cholangitis and IgG4-associated cholangitis
- Definition of primary sclerosing cholangitis and IgG4-associated cholangitis
- Geoepidemiology
- Pathogenesis
- Genetics
- Environmental factors
- Dysbiosis
- Infectious and antigenic factors
- Immune responses
- Lymphocyte trafficking
- Biliary epithelial cells
- Toxic bile
- Clinical features
- Natural history
- Biomarkers
- Pathology with histology
- Morbidity/mortality
- Stricture management
- Liver transplantation
- Future directions
- References
- Chapter 44. Autoimmune hepatitis
- Abstract
- Chapter outline
- General introduction
- Historical aspects
- Epidemiology
- Clinical features, diagnostic procedures and disease associations
- Pathological features
- Noninvasive fibrosis assessment
- Autoimmune features
- Genetics
- Pathogenic mechanisms
- Animal models
- The severe acute respiratory syndrome coronavirus 2 pandemic
- Treatment
- Perspectives
- References
- Chapter 45. Primary biliary cholangitis
- Abstract
- Chapter outline
- Introduction
- Historical perspective: changing nomenclature from primary biliary “cirrhosis” to primary biliary “cholangitis”
- Epidemiology
- Etiology
- Animal models of primary biliary cholangitis
- Diagnosis
- Symptoms and extrahepatic complications
- Variant syndromes of primary biliary cholangitis
- Treatment
- Management of symptoms of primary biliary cholangitis
- Risk stratification
- Hepatocellular carcinoma
- Liver transplantation
- Future directions
- Acknowledgments
- References
- Part 7: Cardiopulmonary diseases
- Chapter 46. Rheumatic fever and rheumatic heart disease
- Abstract
- Chapter outline
- Clinical, pathological, and epidemiologic features
- Autoimmune features
- Genetic features
- Genetic features
- In vivo and in vitro models
- Pathologic effector mechanisms
- Autoantibodies as potential immunologic markers
- Concluding remarks—future prospects
- References
- Chapter 47. Myocarditis and dilated cardiomyopathy
- Abstract
- Chapter outline
- Historical background
- Myocarditis—clinical, pathologic, and epidemiologic features
- Treatment
- Dilated cardiomyopathy—clinical, pathologic, and epidemiologic features
- Treatment
- Autoimmune features
- Genetic features
- Animal models
- Perspectives
- References
- Chapter 48. Autoimmune interstitial lung disease
- Abstract
- Chapter outline
- Introduction
- Historical background and classification criteria
- Epidemiology
- Pathogenesis
- Radiological patterns
- Pathological patterns
- Natural history
- Clinical features
- Diagnostic biomarkers
- Treatment
- Future directions
- Summary
- Glossary
- References
- Chapter 49. Sarcoidosis—a multisystemic disease
- Abstract
- Chapter outline
- Introduction
- Disease history
- Definition of the disease and classification criteria
- Geoepidemiology
- Pathogenesis
- Clinical presentation
- Differential diagnosis
- Comorbidities
- Morbidity/mortality
- Diagnosis
- Treatment
- Future directions
- References
- Part 8: Ear Nose and Throat
- Chapter 50. Autoimmune inner ear disease
- Abstract
- Chapter outline
- Introduction
- Disease history
- Definition of the disease
- Epidemiology
- Pathogenesis
- Genetics
- Environmental factors
- Future directions: gaps/voids
- References
- Chapter 51. Meniere disease
- Abstract
- Chapter outline
- Definition
- Epidemiology
- Histopathology
- Pathophysiology
- Clinical course
- Clinical variants
- Diagnosis
- Differential diagnosis
- Treatment
- Acknowledgment
- Funding
- References
- Chapter 52. Autoinflammatory inner ear disease (AID)
- Abstract
- Chapter outline
- Introduction
- Disease history
- Geoepidemiology
- Definitions of the disease
- Clinical manifestations
- Morbidity/mortality
- Pathogenesis
- Biomarkers/diagnostics
- Genetics
- Animal models
- Treatment
- Future directions
- References
- Part 9: Ocular autoimmunity
- Chapter 53. Episcleritis and scleritis
- Abstract
- Chapter outline
- Introduction
- Anatomy and definition of episcleritis/scleritis
- Causes and morbidity of episcleritis
- Classification of episcleritis
- Episcleritis laboratory evaluation
- Episcleritis treatment
- Epidemiology
- Pathogenesis of scleritis
- Causes and morbidity of scleritis
- Classification of scleritis
- Animal models
- Scleritis workup
- Treatment for scleritis
- Current clinical trials
- References
- Chapter 54. Anterior uveitis
- Abstract
- Chapter outline
- Introduction
- Disease history
- Geo-epidemiology
- Genetic and autoimmune
- Infectious causes
- Clinical picture
- Management
- References
- Chapter 55. Pediatric uveitis
- Abstract
- Chapter outline
- Introduction
- Disease history
- Disease definition and classification
- Geoepidemiology
- Pathogenesis
- Clinical features
- Masquerades
- Treatment
- Future directions
- References
- Chapter 56. Intermediate uveitis
- Abstract
- Chapter outline
- Introduction
- Disease history
- Classification criteria
- GeoEpidemiology
- Pathogenesis
- Systemic associations
- Infectious associations
- Clinical features
- Morbidity and mortality
- Treatment
- Medical
- Surgery
- Future directions
- References
- Chapter 57. White dot syndromes
- Abstract
- Chapter outline
- Introduction
- Disease history
- Definition of the disease
- GeoEpidemiology
- Pathogenesis
- Genetics
- Clinical features
- Natural history
- Symptoms
- Pathology with histology
- Morbidity/mortality
- Treatment
- Future directions
- References
- Chapter 58. Panuveitis
- Abstract
- Chapter outline
- Introduction
- Sympathetic ophthalmia
- Vogt–Koyanagi–Harada disease
- Behçet’s disease
- Sarcoidosis
- Conclusion
- Acknowledgments
- References
- Chapter 59. Regional corticosteroid therapy for noninfectious uveitis
- Abstract
- Chapter outline
- Introduction
- Anatomic classification of uveitis
- Regional corticosteroid treatment by route of administration
- Summary
- References
- Part 10: Autoimmune diseases of the skin
- Chapter 60. Autoimmune bullous skin disorders
- Abstract
- Chapter outline
- Introduction
- Chapter 61. Pemphigus
- Abstract
- Chapter outline
- Disease history, definition, and classification
- Geoepidemiology
- Pemphigus vulgaris
- Pemphigus foliaceus
- Concluding remarks
- Chapter 62. Bullous pemphigoid
- Abstract
- Chapter outline
- Disease history
- Definition
- Geoepidemiology
- Pathogenesis
- Clinical features
- References
- Chapter 63. Dermatitis herpetiformis
- Abstract
- Chapter outline
- Introduction and disease history
- Clinical features and diagnosis
- References
- Chapter 64. Cutaneous lupus erythematosus
- Abstract
- Chapter outline
- Introduction
- Disease history
- Definition and classification criteria
- Geoepidemiology
- Animal models
- Morbidity/mortality
- Topical and localized therapies
- Systemic treatment for cutaneous lupus erythematosus
- Surgical treatment for cutaneous lupus erythematosus
- Future directions
- References
- Chapter 65. Vasculitis from the dermatologist’s perspective
- Abstract
- Chapter outline
- Overview of vasculitis
- Small vessel vasculitis
- IgA vasculitis
- Urticarial vasculitis
- Acute hemorrhagic edema of infancy
- Erythema elevatum diutinum
- Granuloma faciale
- Small to medium vessel vasculitis
- Cryoglobulinemias
- Antineutrophilic cytoplasmic antibody-associated vasculitides
- Granulomatosis with polyangiitis
- Microscopic polyangiitis
- Eosinophilic granulomatosis with polyangiitis
- Medium vessel vasculitis
- Kawasaki’s disease
- Large vessel vasculitis
- Temporal arteritis (giant cell arteritis)
- Takayasu arteritis
- Vasculitis associated with systemic disease
- Conclusion
- References
- Chapter 66. Psoriasis
- Abstract
- Chapter outline
- Introduction
- History of psoriasis
- Defining psoriasis
- Geo-epidemiology of psoriasis
- Genetics of psoriasis
- Animal models of psoriasis
- Immunopathogenesis
- Clinical features of psoriasis
- Treatment
- References
- Chapter 67. Cutaneous graft-versus-host disease
- Abstract
- Chapter outline
- Introduction and historical aspects
- Definition and classification of graft-versus-host disease
- Clinical manifestations of graft-versus-host disease
- References
- Chapter 68. Vitiligo
- Abstract
- Chapter outline
- Introduction
- Disease history
- Pathogenesis
- Environmental factors
- Hormonal influences
- Effector mechanisms
- Animal models
- Clinical features
- Nonsegmental vitiligo
- Future direction (what is still needed)
- References
- Chapter 69. Alopecia areata
- Abstract
- Chapter outline
- Introduction
- Disease history
- Definition and classification of alopecia areata
- Geoepidemiology
- Pathogenesis
- Clinical features
- Treatment
- Future directions
- References
- Chapter 70. Chronic spontaneous urticaria
- Abstract
- Chapter outline
- Introduction
- Disease history
- Definition
- Epidemiology
- Etiology
- Pathogenesis
- Clinical features
- Diagnostic strategies
- Treatment
- Future directions
- Acknowledgments
- Glossary
- References
- Chapter 71. Skin involvement in other autoimmune diseases
- Abstract
- Chapter outline
- Adult-onset Still’s disease
- Eosinophilic fasciitis
- Behcet’s syndrome
- Dermatomyositis
- Eosinophilic fasciitis
- Rheumatoid arthritis
- Sjogren’s syndrome
- Systemic sclerosis
- References
- Part 11: Autoimmune disorders of the neurologic system
- Chapter 72. Multiple sclerosis
- Abstract
- Chapter outline
- Introduction and historical background
- Clinical features and disease phenotypes
- Clinically isolated syndrome
- Relapsing remitting multiple sclerosis
- Radiologically isolated syndrome
- Silent progression
- Diagnostic criteria
- Epidemiology and causes of multiple sclerosis
- Geographic and environmental factors
- Genetic factors
- Viral factors
- Immunology and pathology
- Immunology
- Imaging
- Management of multiple sclerosis
- Disease modifying treatments
- Anti-CD20 agents
- Symptomatic management of multiple sclerosis
- Pregnancy and hormonal influences in multiple sclerosis
- Biomarkers
- Diagnostic biomarkers
- Treatment associated biomarkers
- Disease activity biomarkers
- Future directions
- Conclusions
- References
- Chapter 73. Neuromyelitis optica spectrum disorder and other central nervous system inflammatory diseases
- Abstract
- Chapter outline
- Introduction
- Aquaporin-4 IgG seropositive neuromyelitis optica spectrum disorder
- Myelin oligodendrocyte glycoprotein antibody associated disease
- Glial fibrillary acidic protein autoimmunity
- References
- Chapter 74. Pediatric multiple sclerosis and acute disseminated encephalomyelitis
- Abstract
- Chapter outline
- History of pediatric multiple sclerosis and other acquired demyelinating disorders
- Acute disseminated encephalomyelitis
- Acute disseminated encephalomyelitis secondary to MOGAD
- Additional clinical presentations in pediatric MOGAD
- When ADEM is not associated with MOG
- ADEM prognosis and treatment
- Pediatric multiple sclerosis
- Epidemiology
- Gender, age, ethnicity
- Radiologically isolated syndrome
- Pediatric relapsing-remitting multiple sclerosis
- Prognosis/long-term outcomes
- Psychosocial issues in pediatric multiple sclerosis
- Neuroimaging
- Multiple sclerosis treatment
- References
- Chapter 75. Paraneoplastic neurological syndromes
- Abstract
- Chapter outline
- Introduction
- Diagnostic criteria: paraneoplastic neurological syndromes-care score
- Epidemiology
- Antibody and antigenic targets: distribution and functions
- Clinical features
- High-risk phenotypes
- Intermediate-risk phenotypes
- Considerations regarding antibody testing
- Cancer screening
- Pathophysiology
- Effector mechanisms of the immune response
- The role of immune checkpoint inhibitors
- Treatment and prognosis
- Future directions
- References
- Chapter 76. Autoimmune encephalitis
- Abstract
- Chapter outline
- Introduction
- Historical background
- Epidemiology
- Clinical features and specific neuronal autoantibodies
- Diagnostics
- Pathogenesis
- Treatment
- Future directions
- References
- Chapter 77. Central nervous system manifestations of systemic autoimmune diseases
- Abstract
- Chapter outline
- Introduction
- Immune-mediated inflammatory diseases: systemic lupus erythematosus, scleroderma, rheumatoid arthritis, and Sjogren’s syndrome
- Neurosarcoidosis
- Systemic vasculitides: small vessel vasculitis, medium vessel vasculitis, large vessel vasculitis, and variable vessel vasculitis
- Immunoglobulin G4-related disease
- Miscellaneous conditions
- Summary
- Acknowledgments
- References
- Chapter 78. Peripheral neuropathies
- Abstract
- Chapter outline
- Introduction
- Acute neuropathies: the Guillain–Barré syndrome
- Chronic neuropathies: chronic inflammatory demyelinating polyradiculoneuropathy
- Concluding remarks and future prospects
- Patient support and education
- Acknowledgments
- References
- Chapter 79. Autoimmune disorders of the neuromuscular junction
- Abstract
- Chapter outline
- Introduction
- Historical background
- Definition of autoimmune neuromuscular junction disorders
- Epidemiology of autoimmune neuromuscular junction disorders
- Myasthenia gravis
- Lambert-Eaton syndrome
- Neuromyotonia
- Future directions
- References
- Chapter 80. The autoimmune myopathies
- Abstract
- Chapter outline
- Introduction
- Disease history and classification
- Epidemiology
- Pathogenesis and genetic predisposition
- Clinical presentation of autoimmune myopathies except inclusion body myositis
- Clinical presentation of inclusion body myositis
- Differential diagnosis of autoimmune myopathy/myositis
- Investigations
- Treatments
- Prognosis
- Concluding remarks
- References
- Index for Volumes 1 and 2
- Edition: 7
- Published: July 26, 2024
- Imprint: Academic Press
- No. of pages: 1840
- Language: English
- Hardback ISBN: 9780443239465
- eBook ISBN: 9780443239472
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M. Eric Gershwin
M. Eric Gershwin, MD, is chief of the division of rheumatology, allergy, and clinical immunology at the University of California at Davis. Gershwin is currently working to further understand the molecular basis of immune regulation in autoimmunity. He also studies the molecular-genetic basis of autoimmune liver disease. Gershwin is interested in the molecular and genetics tools being utilized to study the genes that contribute to a patient's susceptibility to lupus and the cellular and subcellular mechanisms that lead to immune disease.
Affiliations and expertise
Distinguished Professor of Medicine, The Jack and Donald Chia Professor of Medicine and Chief, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, USAGT
George C. Tsokos
George C. Tsokos, MD, is a Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center. Dr Tsokos has served as President of the Clinical Immunology Society, on the boards of directors for the American College of Rheumatology and the Lupus Foundation of America, member/chair of multiple federal study sections, and editor/member of the editorial boards for top scientific journals. He has received several awards, including a MERIT from NIH, the Lee C. Howley Sr. Prize, the Evelyn V. Hess, the Distinguished Basic Investigator Award from the American College of Rheumatology, the Lupus Insight Prize from the Lupus Research Alliance, and the Carol Nachman Prize for Rheumatology. He is a Master of the American College of Physicians and the American College of Rheumatology, a member of American Association of Physicians and Fellow of AAAS.
Affiliations and expertise
Professor of Medicine at Harvard Medical School and Chief of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical CenterBD
Betty Diamond
Dr. Betty Diamond graduated with a BA from Harvard University and an MD from Harvard Medical School. Dr. Diamond has headed the rheumatology divisions at Albert Einstein School of Medicine and at Columbia University Medical Center. She also directed the Medical Scientist Training Program at Albert Einstein School of Medicine for many years. She is currently director of the Institute of Molecular Medicine at The Feinstein Institutes for Medical Research and director of the PhD and MD/PhD programs of the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. Dr. Diamond is a fellow of the American Association for the Advancement of Science (AAAS) and a member of the National Academy of Medicine and the National Academy of Sciences.
Affiliations and expertise
Institute of Molecular Medicine, Feinstein Institutes for Medical Research, New York, NY, USARead The Rose and Mackay Textbook of Autoimmune Diseases on ScienceDirect