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Elsevier

Woodhead Publishing

  • Medical Robotics

    Minimally Invasive Surgery
    • 1st Edition
    • Paula Gomes
    • English
    Advances in research have led to the use of robotics in a range of surgical applications. Medical robotics: Minimally invasive surgery provides authoritative coverage of the core principles, applications and future potential of this enabling technology.Beginning with an introduction to robot-assisted minimally invasive surgery (MIS), the core technologies of the field are discussed, including localization and tracking technologies for medical robotics. Key applications of robotics in laparoscopy, neurology, cardiovascular interventions, urology and orthopaedics are considered, as well as applications for ear, nose and throat (ENT) surgery, vitreoretinal surgery and natural orifice transluminal endoscopic surgery (NOTES). Microscale mobile robots for the circulatory system and mesoscale robots for the gastrointestinal tract are investigated, as is MRI-based navigation for in vivo magnetic microrobots. Finally, the book concludes with a discussion of ethical issues related to the use of robotics in surgery.With its distinguished editor and international team of expert contributors, Medical robotics: Minimally invasive surgery is a comprehensive guide for all those working in the research, design, development and application of medical robotics for surgery. It also provides an authoritative introduction for academics and medical practitioners working in this field.

  • Therapeutic Antibody Engineering

    Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry
    • 1st Edition
    • William R Strohl + 1 more
    • English
    The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering.

  • Commercializing the Stem Cell Sciences

    • 1st Edition
    • Olivia Harvey
    • English
    Promising new developments in biomedical technology such as stem cell science are widely endorsed by governments keen to reduce spiralling healthcare costs, clinicians focused on patient care, and patients demanding revolutionary new treatments. Commercializing the stem cell sciences offers a comparative analysis of the commercial methods adopted in the global stem cell industries. It seeks to establish whether there is an optimum commercial model and to examine what emerging companies can learn from their predecessors. Following an introduction to stem cell sciences and the problems involved in their commercialization, the book begins with a discussion of stem cell treatments from a global perspective, and the role of innovation in the commercialization of biotechnology in general. In the second half of the book, chapters focus on the different strategies that can be employed and their relative risks and values, before a conclusion that looks at potential new developments in the field.

  • The Design and Manufacture of Medical Devices

    • 1st Edition
    • J. Paulo Davim + 1 more
    • English
    Medical devices play an important role in the field of medical and health technology, and encompass a wide range of health care products. Directive 2007/47/EC defines a medical device as any instrument, apparatus, appliance, software, material or other article, whether used alone or in combination, including the software intended by its manufacturer to be used specifically for diagnostic and/or therapeutic purposes and necessary for its proper application, intended by the manufacturer to be used for human beings. The design and manufacture of medical devices brings together a range of articles and case studies dealing with medical device R&D. Chapters in the book cover materials used in medical implants, such as Titanium Oxide, polyurethane, and advanced polymers; devices for specific applications such as spinal and craniofacial implants, and other issues related to medical devices, such as precision machining and integrated telemedicine systems.

  • Dynamics of Tethered Satellite Systems

    • 1st Edition
    • Vladimir Aslanov + 1 more
    • English
    Aimed at engineering students and professionals working in the field of mechanics of space flight, this book examines space tether systems – one of the most forward-thinking directions of modern astronautics. The main advantage of this technology is the simplicity, profitability and ecological compatibility: space tethers allow the execution of various manoeuvers in orbit without costs of jet fuel due to the use of gravitational and electromagnetic fields of the Earth. This book will acquaint the reader with the modern state of the space tether’s dynamics, with specific attention on the research projects of the nearest decades. This book presents the most effective mathematical models and the methods used for the analysis and prediction of space tether systems’ motion; attention is also given to the influence of the tether on spacecraft’s motion, to emergencies and chaotic modes.

  • Leveraging Information Technology for Optimal Aircraft Maintenance, Repair and Overhaul (MRO)

    • 1st Edition
    • Anant Sahay
    • English
    Aircraft maintenance, repair and overhaul (MRO) requires unique information technology to meet the challenges set by today’s aviation industry. How do IT services relate to aircraft MRO, and how may IT be leveraged in the future?Leveraging Information Technology for Optimal Aircraft Maintenance, Repair and Overhaul (MRO) responds to these questions, and describes the background of current trends in the industry, where airlines are tending to retain aircraft longer on the one hand, and rapidly introducing new genres of aircraft such as the A380 and B787, on the other. This book provides industry professionals and students of aviation MRO with the necessary principles, approaches and tools to respond effectively and efficiently to the constant development of new technologies, both in general and within the aviation MRO profession. This book is designed as a primer on IT services for aircraft engineering professionals and a handbook for IT professionals servicing this niche industry, highlighting the unique information requirements for aviation MRO and delving into detailed aspects of information needs from within the industry.

  • Protein Folding in Silico

    Protein Folding Versus Protein Structure Prediction
    • 1st Edition
    • Irena Roterman-Konieczna
    • English
    Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts to simulate as far as possible the folding process as it takes place in vivo, and attempts to construct a mechanistic model on the basis of the predictions made. The opening chapters discuss the early stage intermediate and late stage intermediate models, followed by a discussion of structural information that affects the interpretation of the folding process. The second half of the book covers a variety of topics including ligand binding site recognition, the "fuzzy oil drop" model and its use in simulation of the polypeptide chain, and misfolded proteins. The book ends with an overview of a number of other ab initio methods for protein structure predictions and some concluding remarks.

  • Functional Materials for Sustainable Energy Applications

    • 1st Edition
    • J A Kilner + 3 more
    • English
    Global demand for low cost, efficient and sustainable energy production is ever increasing. Driven by recent discoveries and innovation in the science and technology of materials, applications based on functional materials are becoming increasingly important. Functional materials for sustainable energy applications provides an essential guide to the development and application of these materials in sustainable energy production.Part one reviews functional materials for solar power, including silicon-based, thin-film, and dye sensitized photovoltaic solar cells, thermophotovoltaic device modelling and photoelectrochemical cells. Part two focuses on functional materials for hydrogen production and storage. Functional materials for fuel cells are then explored in part three where developments in membranes, catalysts and membrane electrode assemblies for polymer electrolyte and direct methanol fuel cells are discussed, alongside electrolytes and ion conductors, novel cathodes, anodes, thin films and proton conductors for solid oxide fuel cells. Part four considers functional materials for demand reduction and energy storage, before the book concludes in part five with an investigation into computer simulation studies of functional materials.With its distinguished editors and international team of expert contributors, Functional materials for sustainable energy applications is an indispensable tool for anyone involved in the research, development, manufacture and application of materials for sustainable energy production, including materials engineers, scientists and academics in the rapidly developing, interdisciplinary field of sustainable energy.

  • Probabilistic Safety Assessment for Optimum Nuclear Power Plant Life Management (PLiM)

    Theory and Application of Reliability Analysis Methods for Major Power Plant Components
    • 1st Edition
    • Gennadij V Arkadov + 2 more
    • English
    Probabilistic safety assessment methods are used to calculate nuclear power plant durability and resource lifetime. Successful calculation of the reliability and ageing of components is critical for forecasting safety and directing preventative maintenance, and Probabilistic safety assessment for optimum nuclear power plant life management provides a comprehensive review of the theory and application of these methods.Part one reviews probabilistic methods for predicting the reliability of equipment. Following an introduction to key terminology, concepts and definitions, formal-statistical and various physico–statistical approaches are discussed. Approaches based on the use of defect-free models are considered, along with those using binomial distribution and models based on the residual defectiveness of structural materials. The practical applications of probabilistic methods for strength reliability are subsequently explored in part two. Probabilistic methods for increasing the reliability and safety of nuclear power plant components are investigated, as are the use of such methods for optimising non-destructive tests, hydraulic tests, technical certification and planned-preventative maintenance. Finally, the book concludes with information on the use of probabilistic methods in ensuring leak tightness of nuclear power plant steam generator heat exchanger pipes.With its distinguished authors, Probabilistic safety assessment for optimum nuclear power plant life management is a valuable reference for all nuclear plant designers, operators, nuclear safety engineers and managers, as well as academics and researchers in this field.

  • Sterilisation of Biomaterials and Medical Devices

    • 1st Edition
    • Sophie Lerouge + 1 more
    • English
    The effective sterilisation of any material or device to be implanted in or used in close contact with the human body is essential for the elimination of harmful agents such as bacteria. Sterilisation of biomaterials and medical devices reviews established and commonly used technologies alongside new and emerging processes.Following an introduction to the key concepts and challenges involved in sterilisation, the sterilisation of biomaterials and medical devices using steam and dry heat, ionising radiation and ethylene oxide is reviewed. A range of non-traditional sterilisation techniques, such as hydrogen peroxide gas plasma, ozone and steam formaldehyde, is then discussed together with research in sterilisation and decontamination of surfaces by plasma discharges. Sterilisation techniques for polymers, drug-device products and tissue allografts are then reviewed, together with antimicrobial coatings for ‘self-sterilisation’ and the challenge presented by prions and endotoxins in the sterilisation of reusable medical devices. The book concludes with a discussion of future trends in the sterilisation of biomaterials and medical devices.With its distinguished editors and expert team of international contributors, Sterilisation of biomaterials and medical devices is an essential reference for all materials scientists, engineers and researchers within the medical devices industry. It also provides a thorough overview for academics and clinicians working in this area.

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