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Woodhead Publishing

Electricity Transmission, Distribution and Storage Systems
1st Edition
Ziad Melhem
English
Electricity transmission and distribution systems carry electricity from suppliers to demand sites. During transmission materials ageing and performance issues can lead to losses amounting to about 10% of the total generated electricity. Advanced grid technologies are therefore in development to sustain higher network efficiency, while also maintaining power quality and security.Electricity transmission, distribution and storage systems presents a comprehensive review of the materials, architecture and performance of electricity transmission and distribution networks, and the application and integration of electricity storage systems.The first part of the book reviews the fundamental issues facing electricity networks, with chapters discussing Transmission and Distribution (T&D) infrastructure, reliability and engineering, regulation and planning, the protection of T&D networks and the integration of distributed energy resources to the grid. Chapters in part two review the development of transmission and distribution system, with advanced concepts such as FACTS and HVDC, as well as advanced materials such as superconducting material and network components. This coverage is extended in the final section with chapters reviewing materials and applications of electricity storage systems for use in networks, for renewable and distributed generation plant, and in buildings and vehicles, such as batteries and other advanced electricity storage devices.With its distinguished editor, Electricity transmission, distribution and storage systems is an essential reference for materials and electrical engineers, energy consultants, T&D systems designers and technology manufacturers involved in advanced transmission and distribution.
Advances in Wind Turbine Blade Design and Materials
1st Edition
Povl Brondsted + 1 more
English
Wind energy is gaining critical ground in the area of renewable energy, with wind energy being predicted to provide up to 8% of the world’s consumption of electricity by 2021. Advances in wind turbine blade design and materials reviews the design and functionality of wind turbine rotor blades as well as the requirements and challenges for composite materials used in both current and future designs of wind turbine blades.Part one outlines the challenges and developments in wind turbine blade design, including aerodynamic and aeroelastic design features, fatigue loads on wind turbine blades, and characteristics of wind turbine blade airfoils. Part two discusses the fatigue behavior of composite wind turbine blades, including the micromechanical modelling and fatigue life prediction of wind turbine blade composite materials, and the effects of resin and reinforcement variations on the fatigue resistance of wind turbine blades. The final part of the book describes advances in wind turbine blade materials, development and testing, including biobased composites, surface protection and coatings, structural performance testing and the design, manufacture and testing of small wind turbine blades.Advances in wind turbine blade design and materials offers a comprehensive review of the recent advances and challenges encountered in wind turbine blade materials and design, and will provide an invaluable reference for researchers and innovators in the field of wind energy production, including materials scientists and engineers, wind turbine blade manufacturers and maintenance technicians, scientists, researchers and academics.
Orphan Drugs
Understanding the Rare Disease Market and its Dynamics
1st Edition
Elizabeth Hernberg-Ståhl + 1 more
English
This authoritative and comprehensive book makes the reader familiar with the processes of bringing orphan drugs to the global market. There are between 5,000 and 7,000 rare diseases and the number of patients suffering from them is estimated to be more than 50 million in the US and Europe. Before the orphan drug legislation enacted in the US in 1983, there was a limited interest from industry to develop treatment for very small patient groups. One of the difficulties is, of course, that similar levels of investment are needed from a pharmaceutical company to bring a drug to the market for both small and large patient groups.The journey from application of an orphan drug designation to a reimbursed market- approved drug is long and many obstacles occur during the journey.After reading the book, readers will: Understand who the players/stakeholders are in the rare orphan disease field and their specific needs and concerns: patients and patient organizations, researchers and treating physicians within the field, industry, regulatory and reimbursement bodies* Understand the strong partnership between the different players and the various initiatives to improve and increase access to treatment for patients; minimizing the gap between numbers of known diseases, orphan designations, approved drugs and paid drugs.The book also provides short practical case stories from patients and researchers, as well as representatives from industry and authorities on the challenges they came across in developing orphan drugs or getting access to orphan drugs.
Gene therapy
Potential Applications of Nanotechnology
1st Edition
Surendra Nimesh
English
Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors form condensed complexes with DNA which result in shielding against enzymatic degradation and enhanced cellular targeting. Advantages including easy manipulatibility, high stability, low cost and high payload, mean that nanoparticles from various polymers have been exploited. Gene therapy gives a systematic account of the many aspects of nanotechnology mediated gene therapy, from the preparation of nanoparticles to physicochemical characterization, and follows with applications in in vitro and in vivo models. This book emphasizes the various aspects of nanotechnology-based gene therapy, with initial chapters detailing the tools and techniques available for preparation and in vitro and in vivo characterization of nanoparticles. Later chapters provide exhaustive details on polymeric systems employed for gene therapy.
Metabolomics in Food and Nutrition
1st Edition
Bart C Weimer + 1 more
English
Metabolomics enables valuable information about the biochemical composition of foods to be rapidly obtained. Since the biochemical profile of food largely determines key food properties such as flavour and shelf life, the information gained using metabolomics-based methods will enable greater control of food quality and also help to determine the relationship between diet and health. Metabolomics in food and nutrition provides an overview of their current and potential use in the food industry.Part one reviews equipment, methods and data interpretation in metabolomics including the use of nuclear magnetic resonance (NMR), statistical methods in metabolomics, and metabolic reconstruction databases and their application to metabolomics research. Part two explores applications of metabolomics in humans, plants and food. Chapters discuss metabolomics in nutrition, human samples for health assessments, and current methods for the analysis of human milk oligosaccharides (HMOs) and their novel applications. Further chapters highlight metabolomic analysis of plants and crops, metabolomics for the safety assessment of genetically modified (GM) crops, and applications of metabolomics in food science including food composition and quality, sensory and nutritional attributes.With its distinguished editors and team of expert contributors, Metabolomics in food and nutrition is a technical resource for industrial researchers in the food and nutrition sectors interested in the potential of metabolomics methods and academics and postgraduate students working in the area.
Sterility, Sterilisation and Sterility Assurance for Pharmaceuticals
Technology, Validation and Current Regulations
1st Edition
Tim Sandle
English
Failure to adequately control any microbial challenge associated within process or product by robust sterilisation will result in a contaminated marketed product, with potential harm to the patient. Sterilisation is therefore of great importance to healthcare and the manufacturers of medical devices and pharmaceuticals. Sterility, sterilisation and sterility assurance for pharmaceuticals examines different means of rendering a product sterile by providing an overview of sterilisation methods including heat, radiation and filtration. The book outlines and discusses sterilisation technology and the biopharmaceutical manufacturing process, including aseptic filling, as well as aspects of the design of containers and packaging, as well as addressing the cleanroom environments in which products are prepared. Consisting of 18 chapters, the book comprehensively covers sterility, sterilisation and microorganisms; pyrogenicity and bacterial endotoxins; regulatory requirements and good manufacturing practices; and gamma radiation. Later chapters discuss e-beam; dry heat sterilisation; steam sterilisation; sterilisation by gas; vapour sterilisation; and sterile filtration, before final chapters analyse depyrogenation; cleanrooms; aseptic processing; media simulation; biological indicators; sterility testing; auditing; and new sterilisation techniques.
Radioactive Waste Management and Contaminated Site Clean-Up
Processes, Technologies and International Experience
1st Edition
William E Lee + 2 more
English
Radioactive waste management and contaminated site clean-up reviews radioactive waste management processes, technologies, and international experiences. Part one explores the fundamentals of radioactive waste including sources, characterisation, and processing strategies. International safety standards, risk assessment of radioactive wastes and remediation of contaminated sites and irradiated nuclear fuel management are also reviewed. Part two highlights the current international situation across Africa, Asia, Europe, and North America. The experience in Japan, with a specific chapter on Fukushima, is also covered. Finally, part three explores the clean-up of sites contaminated by weapons programmes including the USA and former USSR.Radioactive waste management and contaminated site clean-up is a comprehensive resource for professionals, researchers, scientists and academics in radioactive waste management, governmental and other regulatory bodies and the nuclear power industry.
The Funding of Biopharmaceutical Research and Development
1st Edition
David R Williams
English
The funding of biopharmaceutical research and development provides a comprehensive critical review of the funding of research and development (R&D) in the human biopharmaceutical market sector. It addresses both private and public funding sources available in the US and internationally. The biopharmaceutical market is among the most research-intensive market sectors globally. Clinical researchers face a multitude of public and private funding options with respect to bringing their idea or innovation to market. These funding options are continually changing and complex, and are expected to decrease in the near future. A lack of understanding of the scale, scope, and inner workings of the funding aspects of R&D can, at times, act as a barrier for all involved, and can slow down or even eliminate the R&D process. The book lessens these barriers by describing the theoretical underpinnings, present practice, and trends in R&D funding in this market sector, both in the US and internationally. This includes a review and discussion of public-private partnership activity and their inner-workings, noting the complementary relationship between public and private funding. The book also contains an overview of the inner-workings of strategic alliance activity, including the advantages and disadvantages for each party. It goes on to provide an outline of venture capital activity, detailing the methods by which venture capital firms raise capital and are organized, a description of the venture capital-entrepreneur arrangement, and the effects of this arrangement. The book also presents an overview of the IPO process and the various fates of firms going public.
Microfluidic Devices for Biomedical Applications
1st Edition
Xiujun (James) Li + 1 more
English
Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications.The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis.Microfluid... devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.
Food Microstructures
Microscopy, Measurement and Modelling
1st Edition
Vic Morris + 1 more
English
The development of high-quality foods with desirable properties for both consumers and the food industry requires a comprehensive understanding of food systems and the control and rational design of food microstructures. Food microstructures reviews best practice and new developments in the determination of food microstructure.After a general introduction, chapters in part one review the principles and applications of various spectroscopy, tomography and microscopy techniques for revealing food microstructure, including nuclear magnetic resonance (NMR) methods, environmental scanning electron, probe, photonic force, acoustic, light, confocal and infrared microscopies. Part two explores the measurement, analysis and modelling of food microstructures. Chapters focus on rheology, tribology and methods for modelling and simulating the molecular, cellular and granular microstructure of foods, and for developing relationships between microstructure and mechanical and rheological properties of food structures. The book concludes with a useful case study on electron microscopy.Written by leading professionals and academics in the field, Food microstructures is an essential reference work for researchers and professionals in the processed foods and nutraceutical industries concerned with complex structures, the delivery and controlled release of nutrients, and the generation of improved foods. The book will also be of value to academics working in food science and the emerging field of soft matter.

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