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Elsevier

Woodhead Publishing

  • Nanolithography

    The Art of Fabricating Nanoelectronic and Nanophotonic Devices and Systems
    • 1st Edition
    • M Feldman
    • English
    Integrated circuits, and devices fabricated using the techniques developed for integrated circuits, have steadily gotten smaller, more complex, and more powerful. The rate of shrinking is astonishing – some components are now just a few dozen atoms wide. This book attempts to answer the questions, “What comes next?” and “How do we get there?”Nanolithograp... outlines the present state of the art in lithographic techniques, including optical projection in both deep and extreme ultraviolet, electron and ion beams, and imprinting. Special attention is paid to related issues, such as the resists used in lithography, the masks (or lack thereof), the metrology needed for nano-features, modeling, and the limitations caused by feature edge roughness. In addition emerging technologies are described, including the directed assembly of wafer features, nanostructures and devices, nano-photonics, and nano-fluidics.This book is intended as a guide to the researcher new to this field, reading related journals or facing the complexities of a technical conference. Its goal is to give enough background information to enable such a researcher to understand, and appreciate, new developments in nanolithography, and to go on to make advances of his/her own.

  • Surface Modification by Solid State Processing

    • 1st Edition
    • Rosa M. Miranda + 4 more
    • English
    Surface Modification by Solid State Processing describes friction-based surfacing techniques for surface modification to improve resistance to corrosion and wear, also changing surface chemistry. Surface conditions are increasingly demanding in industrial applications and surface modification can reduce manufacturing and maintenance costs, leading to improved component performance, reliability and lifetime. Friction-based technologies are promising solid state processing technologies, particularly for light alloys, in the manufacturing of composite surface and functionally graded materials This title is divided into five chapters, and after an introduction the book covers friction surfacing; friction stir processing; surface reinforcements of light alloys; and characterization techniques based on eddy currents.

  • The Coal Handbook: Towards Cleaner Production

    • 1st Edition
    • Dave Osborne
    • English
    Coal is an important fossil fuel resource for many nations due to its large remaining resources, relatively low processing cost and potential high energy intensity. Certain issues surround its utilisation, however, including emissions of pollutants and growing concern about climate change. The two volumes of The coal handbook present a systematic and comprehensive review of coal production and utilisation in industrial applications, from power plants to steel and iron making, with emphasis on cleaner production. Volume 1 Coal production opens with chapters on coal characterisation. Following sections address important coal extraction and preparation technologies and the coal supply chain. After an introductory section exploring the social and economic value of coal and emissions from coal utilisation, Volume 2 concentrates on global coal production and coal use in industry.

  • Transporters in Drug Discovery and Development

    Detailed Concepts and Best Practice
    • 1st Edition
    • Yurong Lai
    • English
    Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.

  • Stem Cell Bioprocessing

    For Cellular Therapy, Diagnostics and Drug Development
    • 1st Edition
    • Tiago G. Fernandes + 2 more
    • English
    Stem cell bioprocessing describes the main large-scale bioprocessing strategies for both stem cell culture and purification, envisaging the application of these cells for regenerative medicine and drug screening. Bioreactor configurations are described, including their applications for stem cell expansion, and stem cell separation techniques such as isolation and purification are discussed. Basic definitions are provided concerning the different types of stem cells, from adult stem cells to the more recent induced pluripotent stem cells. The main characteristics of these different stem cell types are described, alongside the molecular mechanisms underlying their self-renewal and differentiation. The book also focuses on methodologies currently used for in vitro stem cell culture under static conditions, including the challenge of xeno-free culture conditions, as well as culture parameters that influence stem cell culture. Approaches for both stem cell culture and separation in micro-scale conditions are presented, including the use of cellular microarrays for high-throughput screening of the effect of both soluble and extracellular matrix molecules. A further section is dedicated to application of stem cells for regenerative medicine.

  • Drug-Biomembrane Interaction Studies

    The Application of Calorimetric Techniques
    • 1st Edition
    • Rosario Pignatello
    • English
    The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material.Drug-biomem... interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions.

  • Lean Biomanufacturing

    Creating Value through Innovative Bioprocessing Approaches
    • 1st Edition
    • Nigel J Smart
    • English
    With decreasing profit margins, increasing cost pressures, growing regulatory compliance concerns, mounting pressure from generic drugs and increasing anxiety about the future of healthcare reimbursement, pharmaceutical manufacturers are now forced to re-examine and re-assess the way they have been doing things. In order to sustain profitability, these companies are looking to reduce waste (of all kinds), improve efficiency and increase productivity. Many of them are taking a closer look at lean manufacturing as a way to achieve these goals. Lean biomanufacturing re-visits lean principles and then applies them sympathetically - in a highly practical approach - to the specific needs of pharmaceutical processes, which present significantly different challenges to more mainstream manufacturing processes. A major goal of the book is to highlight those problems and issues that appear more specific or unique to biopharmaceutical manufacturing situations and to provide some insights into what challenges are the important ones to solve and what techniques, tools and mechanisms to employ to be successful.Following an introduction to lean biomanufacturing, the book goes on to discuss lean technologies and methods applied in biomanufacturing. Later chapters cover the creation and implementation of the Transition Plan, issues facing the biopharmaceutical industry, creating a lean approach towards biopharmaceutical processes and the contribution of simulation models in developing these processes. The final chapter covers examples of new technology innovations which help facilitate lean biomanufacturing.

  • The Coal Handbook: Towards Cleaner Production

    Volume 1: Coal Production
    • 1st Edition
    • Dave Osborne
    • English
    Coal is an important fossil fuel resource for many nations due to its large remaining resources, relatively low production and processing cost and potential high energy intensity. Certain issues surround its utilisation, however, including emissions of pollutants and growing concern about climate change. The coal handbook: Towards cleaner production Volume 1 reviews the coal production supply chain from analysis to extraction and distribution.Part one explores coal characterisation and introduces the industrial use of coal as well as coal formation, petrography, reserves, sampling and analysis. Part two moves on to review coal extraction and preparation. Chapters highlight advances in coal mining technology, underground coal gas extraction, coal sizing, comminution and cleaning, and solid-liquid separation technologies for coal. Further chapters focus on economic factors affecting coal preparation, post-treatment of coal, coal tailings treatment, and the optimisation, simulation and control of coal preparation plants. Finally, part three considers aspects of the coal supply chain including the management approach and individual functions such as coal blending and homogenisation, transportation and handling along the entire supply chain.With its distinguished editor and international team of expert contributors, The coal handbook Volumes 1 and 2 is a comprehensive and invaluable resource for professionals in the coal mining, preparation, and utilisation industry, those in the power sector, including plant operators and engineers, and researchers and academics interested in this field.

  • Subsea Optics and Imaging

    • 1st Edition
    • John Watson + 1 more
    • English
    The use of optical methodology, instrumentation and photonics devices for imaging, vision and optical sensing is of increasing importance in understanding our marine environment. Subsea optics can make an important contribution to the protection and sustainable management of ocean resources and contribute to monitoring the response of marine systems to climate change. This important book provides an authoritative review of key principles, technologies and their applications.The book is divided into three parts. The first part provides a general introduction to the key concepts in subsea optics and imaging, imaging technologies and the development of ocean optics and colour analysis. Part two reviews the use of subsea optics in environmental analysis. An introduction to the concepts of underwater light fields is followed by an overview of coloured dissolved organic matter (CDOM) and an assessment of nutrients in the water column. This section concludes with discussions of the properties of subsea bioluminescence, harmful algal blooms and their impact and finally an outline of optical techniques for studying suspended sediments, turbulence and mixing in the marine environment. Part three reviews subsea optical systems technologies. A general overview of imaging and visualisation using conventional photography and video leads onto advanced techniques like digital holography, laser line-scanning and range-gated imaging as well as their use in controlled observation platforms or global observation networks. This section also outlines techniques like Raman spectroscopy, hyperspectral sensing and imaging, laser Doppler anemometry (LDA) and particle image velocimetry (PIV), optical fibre sensing and LIDAR systems. Finally, a chapter on fluorescence methodologies brings the volume to a close.With its distinguished editor and international team of contributors, Subsea optics and imaging is a standard reference for those researching, developing and using subsea optical technologies as well as environmental scientists and agencies concerned with monitoring the marine environment.

  • The Coal Handbook: Towards Cleaner Production

    Volume 2: Coal Utilisation
    • 1st Edition
    • Dave Osborne
    • English
    Coal remains an important fossil fuel resource for many nations due to its large remaining resources, relatively low production and processing cost and potential high energy intensity. Certain issues surround its utilisation, however, including emissions of pollutants and growing concern about climate change. The coal handbook: Towards cleaner production Volume 2 explores global coal use in industry.Part one is an introductory section which reviews the social and economic value of coal, emissions from coal utilisation, the handling, impact and utilisation of coal waste, and an exploration of emerging and future issues around industrial coal utilization. Chapters in part two highlight coal resources, production and use in established markets as well as the emerging markets of Brazil, the Russian Federation, India, Indonesia, and China. Part three focuses specifically on coal utilisation in industry. Chapters consider thermal coal utilisation, coal use in iron and steel metallurgy, advances in pulverised fuel technology, and the evaluation of coal for thermal and metallurgical applications. Further chapters explore coal utilisation in the cement and concrete industries, coal gasification and conversion, and value-in-use assessment for thermal and metallurgical coal. A final chapter summarises the anticipated future pathway towards sustainable, long-term coal use, suggesting transitions that will be needed to ensure cleaner utilisation for many decades to come.With its distinguished editor and international team of expert contributors, The coal handbook Volumes 1 and 2 is a comprehensive and invaluable resource for professionals in the coal mining, preparation, and utilisation industry, those in the power sector, including plant operators and engineers, and researchers and academics interested in this field.

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