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Elsevier

Elsevier Science

  • Experimental Methods in Kinetic Studies

    • 1st Edition
    • Bohdan Wojciechowski + 1 more
    • English
    This book is a guide to kinetic studies of reaction mechanisms. It reviews conventional reactor types and data collection methods, and introduces a new methodology for data collection using Temperature Scanning Reactors (TSR). It provides a theoretical and practical approach to temperature scanning (TS) methodology and supports a revival of kinetic studies as a useful approach to the fundamental understanding of chemical reaction mechanisms and the consequential reaction kinetics.

  • Exercise Physiology

    • 1st Edition
    • Charles M Tipton
    • English

  • Godunov-type Schemes

    An Introduction for Engineers
    • 1st Edition
    • V. Guinot
    • English
    Godunov-type schemes appear as good candidates for the next generation of commercial modelling software packages, the capability of which to handle discontinuous solution will be a basic requirement. It is in the interest of practising engineers and developers to be familiar with the specific features of discontinuous wave propagation problems and to be aware of the possibilities offered by Godunov-type schemes for their solution. This book aims to present the principles of such schemes in a way that is easily understandable to practising engineers.The features of hyperbolic conservation laws and their solutions are presented in the first two chapters. The principles of Godunov-type schemes are outlined in a third chapter. Chapters 4 and 5 cover the application of the original Godunov scheme to scalar laws and to hyperbolic systems of conservation laws respectively. Chapter 6 is devoted to higher-order schemes in one dimension of space. The design of such a scheme is described for the general case and applied to some well-known schemes such as the MUSCL and PPM schemes. Chapter 7 focuses on multidimensional problems. The classical alternate directions and finite volume approaches are presented together with the wave splitting technique that is described in depth with an application to two-dimensional systems. Chapter 8 deals with large-time step algorithms. These include front tracking-based methods, explicit-implicit techniques and the time-line interpolation technique. Three appendices provide notions on accuracy and stability issues, Riemann solvers and the user instructions for the computational codes provided in the enclosed CD-ROM.

  • High Throughput Bioanalytical Sample Preparation

    Methods and Automation Strategies
    • 1st Edition
    • Volume 5
    • David Wells + 1 more
    • English
    High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques.The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates.Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff.

  • Advances in the Bonded Composite Repair of Metallic Aircraft Structure

    • 1st Edition
    • A.A. Baker + 2 more
    • English
    The availability of efficient and cost-effective technologies to repair or extend the life of aging military airframes is becoming a critical requirement in most countries around the world, as new aircraft becoming prohibitively expensive and defence budgets shrink. To a lesser extent a similar situation is arising with civil aircraft, with falling revenues and the high cost of replacement aircraft.This book looks at repair/reinforcement technology, which is based on the use of adhesively bonded fibre composite patches or doublers and can provide cost-effective life extension in many situations. From the scientific and engineering viewpoint, whilst simple in concept, this technology can be quite challenging particularly when used to repair primary structure. This is due to it being based on interrelated inputs from the fields of aircraft design, solid mechanics, fibre composites, structural adhesive bonding, fracture mechanics and metal fatigue. The technologies of non-destructive inspection (NDI) and, more recently smart materials, are also included. Operational issues are equally critical, including airworthiness certification, application technology (including health and safety issues), and training.Including contributions from leading experts in Canada, UK, USA and Australia, this book discusses most of these issues and the latest developments. Most importantly, it contains real histories of application of this technology to both military and civil aircraft.

  • Caloric Restriction: A Key to Understanding and Modulating Aging

    • 1st Edition
    • Volume 1
    • E.J. Masoro
    • English
    For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages. What is the reason for this change in the usual pattern of aging? The evidence is overwhelming that the life extension results from a slowing of aging processes. And the factor responsible is the decrease in caloric intake. The obvious question: How does this factor work? A good question - and the reason that research on the anti-aging action of caloric restriction is today one of the most studied research areas in biological gerontology. For it is felt that if the biological mechanisms of the anti-aging action of caloric restriction can be uncovered, we would gain an understanding of the basic nature of aging processes, which would, in turn, yield possible interventions in human aging. This book aims to provide the growing number of researchers in this field (faculty, postdoctoral trainees, and graduate students) with a detailed knowledge of what is known about caloric restriction within the frame of gerontology, as well as insights on future of this field.

  • World Fuel Cells - An Industry Profile with Market Prospects to 2010

    • 1st Edition
    • G. Weaver
    • English
    The first edition of World Fuel Cells - Market Prospects to 2010 examines the development of the fuel cell business to 2010. The report analyses the trends in markets, technologies and industry structure and profiles all the major players. World Fuel Cells - Market Prospects to 2010 includes a fuel cell industry overview, market figures and forecasts to 2010, with analysis, a review of fuel cell technology, company profiles of key fuel cell developers and a directory of manufacturers. The market report is designed to assist with business plans, R&D and manufacturing strategies. It will be an indispensable aid for managers responsible for business development, technology assessment and market research.For a PDF version of the report please call Sarah Proom on +44 (0) 1865 843181 for price details.

  • Profile of the International Pump Industry - Market Prospects to 2007

    • 5th Edition
    • R. Reidy
    • English
    This fifth edition of Profile of the International Pump Industry - Market Prospects to 2007 reviews the markets, technological trends, and major manufacturers of industrial pumps. Profile of the International Pump Industry covers both the international pump industry and its associated market, illustrating the structure of the industry, highlighting developments, identifying future trends, and looking at recent mergers and acquisitions. Market estimates and forecasts to 2007, by region and pump type, are presented along with an analysis of the main end-user markets for industrial pumps, and a technology overview. Forty leading international pump manufacturers are profiled and a Top 20 league table of pump manufacturers, ranked by sales of pumps, is given. A directory of pump manufacturing companies and an index of companies by product type are also included.

  • Peptide Receptors, Part II

    • 1st Edition
    • Volume 20
    • A. Bjorklund + 2 more
    • English
    Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complementwith chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry.... derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-recepto... complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.

  • Studies in Natural Products Chemistry

    Bioactive Natural Products, Part H
    • 1st Edition
    • Volume 27
    • Atta-ur- Rahman
    • English
    Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. The significance, therefore, of the 28th volume in the Studies in Natural Product Chemistry series, edited by Professor Atta-ur-Rahman, cannot be overestimated.This volume, in accordance with previous volumes, presents us with cutting-edge contributions of great importance. The first paper presents over 100 compounds obtained from Broussonetia spp., and discusses biological activities. This is followed by similar contributions dealing with the genus Licania and Ginkgo biloba. Additional papers describe in detail a number of interesting and important natural compounds or structural classes: retinoids, tetramic acid metabolites, isoprenylated flavonoids, plant polyphenols, crocin, marcfortine and paraherquamide, acaricides, podolactones, triterpene glycosides and sulfur-containing marine compounds. An additional paper focuses on the antitumor activities of lipids, and a final contribution deals with natural product amelioration of cancer chemotherapy-induced adverse reactions.

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