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Elsevier

Elsevier Science

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 40
    • English
    This volume features accounts of the biological rationale, design and clinical potential of drug molecules; summaries of structure-activity relationships in topical areas of medicinal chemistry and extensive references to the biology, medicinal chemistry and clinical aspects of each topic.

  • Clathrochelates

    Synthesis, Structure and Properties
    • 1st Edition
    • Y.Z. Voloshin + 2 more
    • English
    Clathrochelates are compounds which contain a metal ion encapsulated within a three dimensional cage of macrobicyclic ligand atoms. Within this cage the metal has unique properties and is to a great extent isolated from environmental factors. Such complexes are suitable as models of the most essential biological systems, membrane transport, electron carriers, highly selective and sensitive analytical reagents, catalysts for photochemical and redox processes, cation and anion receptors, etc. The aim of this monograph is to generalize and analyze experimental and theoretical data on clathrochelates in order to promote further research in this promising field of chemistry.Chapter 1 gives general concepts of complexes with encapsulated metal ions, discusses basic specific features of these compounds, considers and characterizes the main types of compounds with encapsulated metal ions and the main classes of clathrochelates, and includes the current nomenclature. Chapter 2 deals with the pathways of clathrochelate synthesis and the general procedures for the synthesis of macrobicyclic tris-dioximates, phosphorus-containin... tris-diiminates, sepulchrates, sarcophagi-nates, and polyene and other types of clathrochelate complexes. Chapter 3 concerns studies of the electronic and spatial structure of clathrochelate complexes. In Chapter 4, the kinetics and mechanism of synthesis and decomposition reactions of macrobicyclic tris-dioximates, sarcophaginates, and sepulchrates in solution and gas phases are discussed. Chapter 5 considers the electrochemical, photochemical, and some other characteristics of clathrochelates and their applications associated with these characteristics. Finally, the practical applications of the unique properties of clathrochelates and perspectives on the synthesis of new clathrochelates are described in Chapters 6 and 7, respectively.

  • Advances in DNA Sequence-Specific Agents

    • 1st Edition
    • Volume 4
    • B.J. Chapman
    • English
    This series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interaction are likely to play an increasingly important role. Accordingly, manuscripts have been solicited from experts covering a diverse range of fields, reflecting the cross-disciplinary and dynamic nature of the series.Volume 4 describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders, bulged DNA microenvironments as molecular targets, DNA sequence specific binding by short peptides and the analysis of DNA-protein interactions using DNase I footprinting methodology.Features include:• Expert contributors from the Biomedical world• Emerging areas of drug design and therapeutic applications• Nucleic acid-protein interactions• Color graphics of molecular modeling analyses• New and emerging methodologies

  • Sensing, Signaling and Cell Adaptation

    • 1st Edition
    • Volume 3
    • J.M. Storey + 1 more
    • English
    In this volume of Cell and Molecular Responses to Stress articles provide up-to-date information on key areas of signal sensing (sensing of pain, heat, cold, light, infrared radiation), molecules involved in the intracellular transmission of these signals, metabolic responses to stress including changes in gene expression and production of specialized proteins that aid cell responses to factors including interrupted blood supply (ischemia), oxygen limitation (hypoxia/anoxia), freezing and dehydration, amino acid limitation, radiation and processing drugs. There are chapters which also provide insights into new technologies (such as cDNA arrays), analysis of metabolic control theory (a key method for analysing stress effects on cells), and examine how enzymes evolve in the face of stress.

  • Elsevier's Dictionary of Advertising

    In English, German, French and Russian
    • 1st Edition
    • S.G. Manoilova + 1 more
    • English
    The dynamic business of advertising is quite fascinating as it encompasses an eclectic diversity of fields and activities. Spanning from matters of budgeting, discounts and commissions to creativity, the art of words and images, it communicates to consumers a viable, marketable message. To cover such a diverse spectrum, this dictionary provides the users with terminology from the various spheres that interact to form the ever-expanding vocabulary of modern advertising: marketing and market research, creativity (graphic design, text writing and concept development, photography and film-making basics), media, prepress and typography. This dictionary will be of good use to students of advertising, advertising professionals (account executives, graphic designers, copywriters, media planners etc.), as well as to a wide range of business people.

  • Human Papilloma Viruses

    • 1st Edition
    • Volume 8
    • D.J. McCance
    • English
    This book describes up-to-date information on the pathogenesis and molecular biology of human papillomaviruses and describes the mechanistic role of the viruses in epithelial cancers. Included in the book are chapters on the epidemiology of human papillomaviruses, the factors that control replication and transcription and the viral proteins, which are involved in modulating the biology of the host cell leading to cancer. Details of the immune response to the viruses and potential vaccine strategies are discussed.

  • Recent Advances in Nucleosides: Chemistry and Chemotherapy

    • 1st Edition
    • C.K. Chu
    • English
    The book covers up-to-date information on nucleosides and antiviral chemotherapy contributed by the world experts in the field of nucleoside. This book is the result of a meeting honoring Dr. Jack J. Fox, who was one of the pioneers in nucleoside chemistry and chemotherapy. This book consists of 15 excellent chapters in the area, which include topics from recent synthetic methodologies, nucleoside kinase implicated in chemotherapy and drug design, excellent reviews on antiviral agents, nucleoside metabolism/mode of action in parasites, new compounds under clinical and pre-clinical trials, IMPDH inhibitors to review on nucleoside prodrugs.

  • Sampling and Sample Preparation in Field and Laboratory

    Fundamentals and New Directions in Sample Preparation
    • 1st Edition
    • Volume 37
    • Janusz Pawliszyn
    • English
    This title is the first comprehensive book on sampling and modern sample preparation techniques and has several main objectives: to facilitate recognition of sample preparation as both an integral part of the analytical process; to present a fundamental basis and unified theoretical approach for the professional development of sample preparation; to emphasize new developments in sample preparation technology; and to highlight the future impact of sample preparation on new directions in analytical science, particularly automation, miniaturization and field implementation.Until recently, there has been relatively little scientific interest in sampling and sample preparation, however this situation is presently changing as sampling and sample preparation become integral parts of the analytical process with their own unique challenges and research opportunities.Sampli... and Sample Preparation for Field and Laboratory is an essential resource for all analytical chemists, and in particular those involved in method development. Not only does it cover the fundamental aspects of extraction, it also covers applications in various matrices and includes sampling strategies and equipment and how these can be integrated into the analytical process for maximum efficiency.

  • Sampling and Sample Preparation in Field and Laboratory

    Fundamentals and New Directions in Sample Preparation
    • 1st Edition
    • Volume 37
    • Janusz Pawliszyn
    • English
    This title is the first comprehensive book on sampling and modern sample preparation techniques and has several main objectives: to facilitate recognition of sample preparation as both an integral part of the analytical process; to present a fundamental basis and unified theoretical approach for the professional development of sample preparation; to emphasize new developments in sample preparation technology; and to highlight the future impact of sample preparation on new directions in analytical science, particularly automation, miniaturization and field implementation.Until recently, there has been relatively little scientific interest in sampling and sample preparation, however this situation is presently changing as sampling and sample preparation become integral parts of the analytical process with their own unique challenges and research opportunities.Sampli... and Sample Preparation for Field and Laboratory is an essential resource for all analytical chemists, and in particular those involved in method development. Not only does it cover the fundamental aspects of extraction, it also covers applications in various matrices and includes sampling strategies and equipment and how these can be integrated into the analytical process for maximum efficiency.

  • Characterization of Liquids, Nano- and Microparticulates, and Porous Bodies using Ultrasound

    • 1st Edition
    • Volume 24
    • Andrei S. Dukhin + 1 more
    • English
    Two key words define the scope of this book: 'ultrasound' and 'colloids'. Historically, there has been little real communication between disciples of these two fields. Although there is a large body of literature devoted to ultrasound phenomenon in colloids, there is little recognition that such phenomena may be of real importance for both the development, and application, of Colloid Science. From the other side, colloid scientists have not embraced acoustics as an important tool for characterizing colloids. The lack of any serious dialogue between these scientific fields is the biggest motivation behind this book. For colloidal systems, ultrasound provides information on three important areas of particle characterization: Particle sizing, Rheology, and Electrokinetics. This book primarily targets scientists who consider colloids as their major object of interest. As such we emphasize those aspects of acoustics that are important for colloids, and thereby neglect many others. On the other hand, scientists working with ultrasound who are already familiar with the subject will find several important new developments.

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